FIMM Seminar

Welcome to FIMM Seminar on Thursday 14 May, 2009 at 13.00-14.00
(Biomedicum Helsinki 1, Lecture Hall 3, Ground Floor; Haartmaninkatu 8,
00290 Helsinki).

FIMM Group Leader Applicant PhD Denis Kainov (Laboratoire National de
Santé Institute of Immunology, Luxembourg) will give a presentation
entitled

Molecular basis for group A trichothiodystrophy.

Abstract
Group A trichothiodystrophy is a human genetic disease caused by mutations
in Tfb5 subunit of the transcription/ DNA repair factor TFIIH. Whereas the
genetic cause of the disease has been known for a while the molecular
basis of group A trichothiodystrophy has only been recently elucidated.
This presentation describes biochemical and structural analysis of the
Tfb5 protein and its interacting partner Tfb2, another subunit of TFIIH
and provides a basis for comprehending why mutations that weaken Tfb5/Tfb2
interactions can lead to a reduced concentration of TFIIH and cause the
disease.

About the speaker
Dennis Kainov, PhD, started his scientific career in the lab of Nick
Matvienko, Institute of Protein Research, Russia, where he studied
regulation of gene expression in bacterial restriction-modification
system. During 2001-2005 Dennis did his PhD in the lab of Dennis Bamford,
Institute of Biotechnology, University of Helsinki. His thesis work
concentrated on numerous aspect of the RNA bacteriophages of the
Cystoviridae family and resulted in 14 publications. Dennis then became an
EMBO fellow in the Jean-Marc Egly's lab, IGBMC, Strasbourg, where he
elucidated the molecular basis of group A Trichotyodystrophy - a human
genetic disease. Currently he is developing a new biochemistry strategy
to treat influenza A virus infection in the Institute of Immunology,
Luxembourg.For full list of publications please see:
http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=DetailsSearch&term=kainov+d&log$=activity

No pre-registration needed.

Olli Kallioniemi
Director, FIMM