FIMM

P.O. Box 20
FI-00014
University of Helsinki
Finland

Contacts

2009 © Institute for Molecular Medicine Finland FIMM

Publications 2008

General Publications 2008

FIMM Annual Report 2008

FIMM Vuosikertomus 2008

Scientific Publications by Group Leader 2008

Kallioniemi Olli

Sundvall M, Iljin K, Kilpinen S, Sara H, Kallioniemi OP, Elenius K. Role of ErbB4 in breast cancer. J Mammary Gland Biol Neoplasia. 3:259-68, 2008 Review.

Björkman M, Iljin K, Halonen P, Sara H, Kaivanto E, Nees M, Kallioniemi OP. Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer. Int J Cancer 123:2774-81, 2008

Kilpinen S, Autio R, Ojala K, Iljin K, Bucher E, Sara H, Pisto T, Saarela M, Skotheim RI, Björkman M, Mpindi JP, Haapa-Paananen S, Vainio P, Edgren H, Wolf M, Astola J, Nees M, Hautaniemi S, Kallioniemi O. Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. Genome Biol. 9:R139, 2008

Pellinen T, Tuomi S, Arjonen A, Wolf M, Edgren H, Meyer H, Grosse R, Kitzing T, Rantala JK, Kallioniemi O, Fässler R, Kallio M, Ivaska J. Integrin trafficking regulated by Rab21 is necessary for cytokinesis. Dev Cell. 15:371-85, 2008

Comparison of Affymetrix data normalization methods using 6,926 experiments across five array generations. Autio R, Kilpinen S, Saarela M, Kallioniemi O, Hautaniemi S, Astola J. BMC Bioinformatics. 30;10 Suppl 1:S24, 2009

Brennan DJ, Ek S, Doyle E, Drew T, Foley M, Flannelly G, O'Connor DP, Gallagher WM, Kilpinen S, Kallioniemi OP, Jirstrom K, O'Herlihy C, Borrebaeck CA. The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer. Eur J Cancer. 45:1510-7, 2009

Muggerud AA, Edgren H, Wolf M, Kleivi K, Dejeux E, Tost J, Sørlie T, Kallioniemi O. Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line. BMC Med Genomics. 11;2:26,2009

Peltonen-Palotie Leena

M. Alimohammadi, P. Björklund, Å. Hallgren, N. Pöntynen, G. Szinnai, N. Shikama, M.P. Keller, O. Ekwall, S.A. Kinkel, E.S. Husebye, J. Gustafsson, F. Rorsman, L. Peltonen, C. Betterle, J. Perheentupa, G. Åkerström, G. Westin, H.S. Scott, G. Holländer, O. Kämpe: Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen. N Engl J Med 358:10;28-38, 2008.

V. Anttila, DR. Nyholt, M. Kallela, V. Artto, S. Vepsäläinen, E Jakkula, A. Wennerström, P. Tikka-Kleemola, MA. Kaunisto, E. Hämäläinen, E. Widén, J. Terwilliger, K. Merikangas, GW. Montgomery, NG. Martin, M. Daly, J. Kaprio, L. Peltonen, M. Färkkilä, M. Wessman, A. Palotie: Consistently Replicating Locus Linked to Migraine on 10q22-q23. Am J Hum Genet May;82(5):1051-63. (Epub Apr 16) 2008.

Y.S. Aulchenko, S. Ripatti, I. Lindqvist, D. Boomsma, I. Heid, C. Pattaro, A. Cecile, J.W. Janssens, J.F. Wilson, I. Rudan, Å. Johansson, T. Spector, N.G Martin, N.L Pedersen, F. Marroni, K. Ohm Kyvik, J. Kaprio, A. Hofman, P. Elliott, C. Gieger, A. Isaacs, C. Hayward, V. Vitart, I. Jonasson, E.J.G. Sijbrands, N. Freimer, T. Meitinger, A.G. Uitterlinden, J. Saharinen, M. Perola, J.C.M. Witteman, P.P. Pramstaller, M-R. Järvelin, U. Gyllensten, H. Campbel, A. Wright, N. Hastie, B.A. Oostra, F. Kronenberg, C.M. van Duijn, L. Peltonen for the ENGAGE consortium: Genome-wide association study in 16 European population cohorts: Major loci determining lipid levels and coronary heart disease risk. Nature Genetics Dec 7. [Epub ahead of print]

K. Auro, K. Kristiansson, B. Zethelius, C. Berne, M-R. L. Lannfelt, Taskinen, M. Jauhianen, M. Perola, L. Peltonen, A-C. Syvänen: USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study. Diabetologia Mar;51(3):464-72 (Epub Dec21, 2007) 2008.

B. Benyamin, M. Perola, B.K. Comes, P.A. Madden, A. Palotie, G.W. Montgomery, L. Peltonen, N.G. Martin, P.M. Visscher: Within-family outliers: segregating alleles or environmental effects? A linkage analysis of height from 5815 sibling pairs. Eur J Hum Genet Apr;16(4):516-24 (Epub Jan16), 2008.

D. Booth, R. Heard, G. Stewart, A. Goris, R. Dobosi, B. Dubois, A. Oturai, H.B. Soendergaard, F. Sellebjerg, J. Saarela, V. Leppä, A. Palotie, L. Peltonen, B. Fontaine, I. Cournu-Rebeix, F. Clerget-Darpoux, M.C. Babron, F. Weber, F. Holsboer, B. Müller-Myhsok, P. Rieckmann, A. Kroner, C. Graham, K. Vandenbroeck, S: Hawkins, S. D'Alfonso, L. Bergamaschi, P. Naldi, F.R. Guerini, M. Salvetti, D. Galimberti, R. Hintzen C. van Duijn, A.R. Lorentzen, E.G. Celius, H.F. Harbo, A. Spurkland, F. Cucca, M.G. Marrosu, M. Comabella, X. Montalban, P. Villoslada, T. Olsson, I. Kockum, J. Hillert, M. Ban, A. Walton, S. Sawcer, A. Compston, C. Hawkins, T. Mihalova, N. Robertson, G. Ingram, P.L. De Jager, D.A. Hafler, J. Rioux, M. Daly, L. Barcellos, A. Ivinson, M. Pericak-Vance, J. Oksenberg, S.L. Hauser, J. McCauley, D. Sexton, J. Haines. International Multiple Sclerosis Genetics Consortium (IMSGC): Refining genetic associations in multiple sclerosis. Lancet Neurol Jul; 7(7):567.569, 2008.

J. Donner, S. Pirkola, K. Silander, L. Kananen, J. Terwilliger, J. Lönnqvist, L. Peltonen, I. Hovatta: An Association Analysis of Murine Anxiety Genes in Humans Implicates Novel Candidate Genes for Anxiety Disorders . Biol Psychiatry Oct 15;64(8):672-80 (Epub Jul 17). 2008.

N.S. Enattah, T.G. Jensen, M. Nielsen, R. Lewinski, M. Kuokkanen, H. Rasinperä, H. El-Shanti, J.K. Seo, M. Alifrangis, I.F. Khalil, A. Natah, A. Ali, S. Natah, D. Comas, S.Q. Mehdi, L. Groop, E.M. Vestergaard, F. Imtiaz, M.S. Rashed, B. Meyer, J. Troelsen, L. Peltonen: Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaption to milk culture. Am J Hum Genet 82(1):57-82 (Epub Jan10), 2008.

S. Hässler, L. Peltonen, S. Sandler, O. Wingvist: Aire Deficiency Causes Increased Susceptibility to Streptozotocin-induced Murine Type 1 Diabetes. Scand J Immunol Jun; 67(6):569-80. (Epub Apr8) 2008.

W. Hennah, P. Thompson, A. McQuillin, N. Bass, A. Loukola, A. Anjorin, D. Blackwood, D. Curtis, I.J. Deary, S.E. Harris, E.T. Isometsä, J. Lawrence, J. Lönnqvist, W. Muir, A. Palotie, T. Partonen, T. Paunio, E-M. Pylkkö, M. Robinson, P. Soronen, K. Suominen, J. Suvisaari, D. St Clair, H. Gurling, L. Peltonen, D. Porteous: DISC1 association, heterogeneity and allelic interplay in schizophrenia and bipolar disorder. Mol Psychiatry Epub Mar04, 2008.

E. Jakkula, K. Rehnström, T. Varilo, O.P.H. Pietiläinen, T. Paunio, N. Pedersen, U. deFaire, M-R Järvelin, J. Saharinen, N. Freimer, S. Ripatti, S. Purcell, A. Collins, M.J. Daly, A. Palotie, L. Peltonen: The genome-wide patterns of variation expose significant substructure in a founder population. Am J Hum Genet 83 (6):787-794, 2008.

J. Karvanen, K. Silander, F. Kee, L. Tiret, V. Salomaa, K. Kuulasmaa, P-G. Wiklund, J. Virtamo, O. Saarela, M. Perola, L. Peltonen, F. Cambien, J. Erdmann, N.J. Samani, H. Schunkert, A. Evans for the MORGAM project: The impact of newly-identified loci for coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol. Oct 31. [Epub ahead of print], 2008.

S. Kathiresan, O. Melander, C. Guiducci, A. Surti, N.P. Burtt, M.J. Rieder, G.M. Cooper, C. Roos, B.F. Voight, A.S. Havulinna, B. Wahlstrand, T. Hedner, D. Corella, E.S. Tai, J.M. Ordovas, G. Berglund, E. Vartiainen, P. Jousilahti, B. Hedblad, M-R. Taskinen, C. Newton-Cheh, V. Salomaa, L. Peltonen, L. Groop, D.M. Altshuler, M. Orho-Melander: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet Feb:40(2):189-97 (Epub Jan13), corrigendum: Nov;40(11):1384, 2008.

S. Kathiresan, C.J. Willer G. Peloso, S. Demissie, K. Musunuru, E. Schadt, L. Kaplan, D. Bennett, Y. Li, T. Tanaka, B.F. Voight, L.L. Bonnycastle, A. U. Jackson, G. Crawford, A. Surti, C. Guiducci, N. Burtt, S. Parish, R. Clarke, D. Zelenika, K. A Kubalanza, M. A Morken, L. J. Scott, H. M. Stringham, P. Galan, A. J Swift, J. Kuusisto, R. N. Bergman, J. Sundvall, M. Laakso, L. Ferrucci, P. Scheet, S. Sanna, M. Uda, Q. Yang, K. Lunetta, J. Dupuis, P.I. deBakker, C. J. O'Donnell, J. C Chambers, J. S. Kooner, S. Hercberg, P. Meneton, E.G. Lakatta, A. Scuteri, D. Schlessinger, J. Tuomilehto, F. S. Collins, Leif Groop, D. Altshuler, R. Collins, G.M. Lathrop, O. Melander, V. Salomaa, L. Peltonen, M. Orho-Melander, J.M. Ordovas, M.Boehnke, G. R.Q1 Abecasis, K. L. Mohlke & L. A. Cupples: Common variants at 30 loci contribute to polygenic dyslipidemia. Nature Genetics Dec 7. [Epub ahead of print], 2008.

H. Kilpinen, Ylisaukko-Oja T, Hennah W, Palo OM, Varilo T, Vanhala R, Nieminen-von Wendt T, von Wendt L, Paunio T, Peltonen L: Association of DISC1 with Autism and Asperger syndrome. Mol Psychiatry. 2008 Feb;13(2):187-96. Epub 2007 Jun 19.

G. Lettre, AU. Jackson, C. Gieger, FR. Schumacher, SI. Berndt, Sanna S, S. Eyheramendy, BF. Voight, JL. Butler, C. Guiducci, T. Illig, R. Hackett, IM. Heid, KB. Jacobs, V. Lyssenko, M. Uda; The Diabetes Genetics Initiative; FUSION; KORA; The Prostate, Lung Colorectal and Ovarian Cancer Screening Trial; The Nurses' Health Study; SardiNIA, M. Boehnke, SJ. Chanock, LC. Groop, FB. Hu, B. Isomaa, P. Kraft, L. Peltonen, V. Salomaa, D. Schlessinger, DJ. Hunter, RB. Hayes, GR. Abecasis, HE. Wichmann, KL. Mohlke, JN. Hirschhorn: Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet May;40(5):584-91 (Epub April6) 2008.

E. Lindh, SM. Lind, E. Lindmark, S. Hässler, J. Perheentupa, L. Peltonen, O. Winqvist, MC. Karlsson: AIRE regulates T-cell-independent B-cell responses through BAFF. Proc Natl Acad Sci U S A. Nov 25;105(47):18466-71. (Epub 2008 Nov 14), 2008.

A. Loukola, U. Broms, H. Maunu, E. Widén, K. Heikkilä, M. Siivola, A. Salo, M.L. Pergadia, E. Nyman, S. Sammalisto, M. Perola, A. Agrawal, A.C. Heath, N.G. Martin, P.A.F. Madden, L. Peltonen, J. Kaprio: Linkage of nicotine dependence and smoking behavior on 10q, 7q, and 11p in twins with homogeneous genetic background. Pharmacogenomics J (Epub Jun;8(3):209-19 (Epub Jun5, 2007) 2008.

A.T. Lu, M.N. Ogdie, M-R. Järvelin, I.K. Moilanen, S.K. Loo, J.T. McCracken, J.J. McGough, M.H. Yang, L. Peltonen, S.F. Nelson, R.M. Cantor, S.L. Smalley: Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder. Am J Med Genet part B, Neuropsychiatr Genet Dec 5;147B(8):1488-94, 2008.

PE. Lundmark, U. Liljedahl, DI. Boomsma, H. Mannila, NG. Martin, A. Palotie, L. Peltonen, M. Perola, TD. Spector, AC. Syvänen: Evaluation of HapMap data in six populations of European descent. Eur J Hum Genet 16:1142-1150 (Epub April9) 2008.

PK. Magnusson, M. Boman, U. de Faire, M. Perola, L. Peltonen, NL. Pedersen: Genome-wide search fof QTLs for apolipoprotein A-I level in elderly Sweeish DZ twins: evidence of female-specific locus on 15q11-13. Eur J Hum Genet 16:1103-1110 (Epub Mar05), 2008.

L. Mustelin, KH. Pietiläinen, A. Rissanen, AR. Sovijarvi, P. Piirila, J. Naukkarinen, L. Peltonen, J. Kaprio, H. Yki-Jarvinen: Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity. Am J Physiol Endocrinol Metab Jul;295(1):E148-54. (Epub May6), 2008.

H.O. Nousiainen, M. Kestilä, N. Pakkasjärvi, H. Honkala, S. Kuure, J. Tallila, K. Vuopala, J. Ignatius, R. Herva, L. Peltonen: Mutations in mRNA export mediator GLE1L result in a fetal motoneuron disease. Nat Genet Feb;40(2):155-7 (Jan 20.), 2008.

D.R. Nyholt, K.S. LaForge, M. Kallela, K. Alakurtti, V. Anttila, M. Färkkilä, E. Hämäläinen, J. Kaprio, M.A. Kaunisto, A.C Heath, G.W. Montgomery, H. Göbel, U. Todt, M.D. Ferrari, L.J. Launer, R.R. Frants, G.M. Terwindt, B. de Vries, W.M. Verschuren, J. Brand, T. Freilinger, V. Pfaffenrath, A. Straube, D.G. Ballinger, Y. Zhan, M.J. Daly, D.R. Cox, M. Dichgans, A.M. van der Maagdenberg, C. Kubisch, N.G. Martin, M. Wessman, L. Peltonen, A. Palotie: A high-density association screen of 155 ion transport genes for involvement with common migraine. Hum Mol Genet Nov.1; 17 (21), 3318-3331. (Epup:Aug 2) 2008.

C.G.S. Palmer, E. Mallery, J.A. Turunen, H-J. Hsieh, L. Peltonen, J. Lönnqvist, A. Woodward, J.S. Sinsheimer: Effect of rhesus D incompatilibity on schizophrenia depends on offspring sex. Schizophr Res Sep;104(1-3):135-45. (Epub:Aug 9), 2008.

KH. Pietiläinen, J. Naukkarinen, A. Rissanen, J. Saharinen, P. Ellonen, H. Keränen, A. Suomalainen, A. Götz, T. Suortti, H. Yki-Järvinen, M. Orešič, J. Kaprio, L. Peltonen: Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity. PLoS Med 5(3):e51 (Epub Mar 11), 2008.

OP. Pietiläinen, T. Paunio, A. Loukola, A. Tuulio-Henriksson, T. Kieseppä, P. Thompson, AW. Toga, TG. van Erp, K. Silventoinen, P. Soronen, W. Hennah, JA. Turunen, J. Wedenoja, OM. Palo, K. Silander, J. Lönnqvist, J. Kaprio, TD. Cannon, L. Peltonen.: Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins. Am J Med Genet B Neuropsychiatr Genet Dec 2. [Epub ahead of print] 2008.

I. Prokopenko, C. Langenberg, J. Florez, R. Saxena, N. Soranzo, G. Thorleifsson, R. Loos, A. Manning, A. Jackson, Y. Aulchenko, S. Potter, M. Erdos, S. Sanna, J-J. Hottenga, E. Wheeler, M. Kaakinen, V. Lyssenko, W-M Chen, K. Ahmadi, J. Beckmann, R. Bergman, M. Bochud, L. Bonnycastle, T. Buchanan, A. Cao, L. Coin, A. Cervino, F. Collins, L. Crisponi, E. de Geus, A. Dehghan, P. Deloukas, P. Elliott, N. Freimer, V. Gateva, C. Herder, A. Hofman, T. Hughes, S. Hunt, T. Illig, M. Inouye, B. Isomaa, T. Johnson, A. Kong, Noha lim, U. Lindblad, C.M. Lindgren, O. McCann, K. Mohlke, S. Naitza, M. Orru, A. Pouta, J. Randall, W. Rathmann, J. Saramies, P. Scheet, L. Scott, A. Scuteri, S. Sharp, E. Sijbrands, J. Smit, K. Song, V. Steinthorsdottir, H. Stringham, T. Tuomi, J. Tuomilehto, A. Uitterlinden, B. Voight, D. Waterworth, H-E. Wichmann, G. Willemsen, J. Witteman, X. Yuan, J. Zao, E. Zeggini, D. Schlessinger, M. Sandhu, D. Boomsma, M. Uda, T. Spector, B. Penninx, D. Altshuler, P. Vollenweider, M-R. Järvelin, E. Lakatta, G. Waeber, C. Fox, L. Peltonen, L. Groop, V. Mooser, L. Cupples, U. Thorsteinsdottir, M. Boehnke, I. Barroso, C. van Duijn, J. Dupuis, R. Watanabe, K. Stefansson, M. McCarthy, N. Wareham, J. Meigs, G. Abecasis: Variants in the melatonin receptor 1B gene (MTNR1B)influence fasting glucose level. Nature Genetics Dec 7. [Epub ahead of print]

N. Pöntynen, M. Strengell, N. Sillanpää, J. Saharinen, I. Ulmanen, I. Julkunen, L. Peltonen: Critical immunological pathways are downregulated in APECED patient dendritic cells. J Mol Med Oct;86(10):1139-52. (Epub:Jul 4.) 2008.

K. Rehnström, T. Ylisaukko-oja, R. Vanhala, L. von Wendt, L. Peltonen, I. Hovatta: No association between common variants in glyoxalase 1 and autism spectrum disorders. Am J Med Genet B Neuropsyciatr Genet Jan 5;147(1):124-7. (Epub 2007 Aug22), 2008.

Rehnström K, Ylisaukko-oja T, Nummela I, Ellonen P, Kempas E, Vanhala R, von Wendt L, Järvelä I, Peltonen L. Allelic variants in HTR3C show association with autism. Am J Med Genet B Neuropsychiatr Genet Nov 26. [Epub ahead of print], 2008.

C. Sabatti, SK. Service, AL. Hartikainen, A. Pouta, S. Ripatti, J. Brodsky, CG. Jones, NA. Zaitlen, T. Varilo, M. Kaakinen, U. Sovio, A. Ruokonen, J. Laitinen, E. Jakkula, L. Coin, C. Hoggart, A. Collins, H. Turunen, S. Gabriel, P. Elliot, MI. McCarthy, MJ. Daly, MR. Järvelin, NB. Freimer, L. Peltonen: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nature Genetics Dec 7. [Epub ahead of print], 2008.

S. Sammalisto, T. Hiekkalinna, K. Schwander, S. Kardia, A.B. Weder, B.L. Rodriguez, A. Doria, J.A. Kelly, G.R. Bruner, J.B. Harley, S. Redline, E.K. Larkin, S.R. Patel, A.J.H. Ewan, J.L. Weber, M. Perola, L. Peltonen: Genome-wide Linkage Screen for Stature and Body-mass Index in 3.032 Families - Evidence for Sex- and Population-specific Genetic Effects. Eur J Hum Genet 2008 Sep 10. [Epub ahead of print]

C. von Schantz, J. Saharinen, O. Kopra, JD. Cooper, M. Gentile, I. Hovatta, L. Peltonen, A. Jalanko: Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases. BMC Genomics Mar28;9(1):146, 2008.

K. Silander, M. Alanne, K. Kristiansson, O. Saarela, S. Ripatti, K. Auro, J. Karvanen, S. Kulathinal, M. Niemelä, P. Ellonen, E. Vartiainen, P. Jousilahti, J. Saarela, K. Kuulasmaa, A. Evans, M. Perola, V. Salomaa, L. Peltonen. Gender Differences in Genetic Risk Profiles for Cardiovascular Disease. PLOS One, 3(10):e3615. (Epub 2008 Oct 31). 2008.

P. Soronen, K. Silander, M. Antila, O.M. Palo, A. Tuulio-Henriksson, T. Kieseppä, P. Ellonen, J. Wedenoja, JA. Turunen, O.P. Pietiläinen, W. Hennah, J. Lönnqvist, L. Peltonen, T. Partonen, T. Paunio: Association of a Nonsynonymous Variant of DAOA with Visuospatial Ability in a Bipolar Family Sample. Biol Psychiatry Sep 1;64(5):438-42. (Epub May 7), 2008.

A-M. Sulonen, S.P. Kallio, P. Ellonen, M. Suvela, I. Elovaara, K. Koivisto, T. Pirttilä, M. Reunanen, P.J. Tienari, A. Palotie, L. Peltonen, J. Saarela: No evidence for shared etiology in two demyelinative disorders, MS and PLOSL. J Neuroimmunol. Nov 17. [Epub ahead of print], 2008.

J. Tallila, E. Jakkula, L. Peltonen, R. Salonen, M. Kestilä: Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzle: Am J Hum Genet Jun;82(6):1361-7. 2008.

K. Valli-Jaakola, E. Suviolahti, C. Schalin-Jäntti, S. Ripatti, K. Silander, L. Oksanen, V. Salomaa, L. Peltonen, K. Kontula: Further Evidence For the Role of ENPP1 in Obesity: Association With Morbid Obesity in Finns. Obesity 16, 2113-2119 (EpubJun 12.) 2008.

J. Wedenoja, A. Loukola, A. Tuulio-Henriksson, T. Paunio, J. Ekelund, K. Silander, T. Varilo, K. Heikkilä, J. Suvisaari, T. Partonen, J. Lönnqvist, L. Peltonen: Replication of Linkage on Chromosome 7q22 and Association of the Regional Reelin Gene with Working Memory in Schizophrenia Families. Mol Psychiatry 3: 673-684, 2008.

Yleiskatsaukset

K. Kristiansson, J. Naukkarinen, L. Peltonen: Isolated populations and complex disease gene identification. Genome Biology, 9(8):109. 2008

Saarela Janna

Turpeinen H, Volin L, Nikkinen L, Ojala P, Palotie A, Saarela J, Partanen J. Genetic similarity of chromosome 6 between patients receiving hematopoietic stem cell transplantation and HLA matched sibling donors. Haematologica. 2009 Apr;94(4):528-35.

De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA. The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5264-9.

Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen AR, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L, Saarela J. Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Hum Mol Genet. 2009 May 1;18(9):1670-83.

Videman T, Saarela J, Kaprio J, Näkki A, Levälahti E, Gill K, Peltonen L, Battié MC. Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing. Arthritis Rheum. 2009 Feb;60(2):470-81.

Kemppinen A, Suvela M, Tienari PJ, Elovaara I, Koivisto K, Pirttilä T, Reunanen M, Rautakorpi I, Hillert J, Lundmark F, Oturai A, Ryder L, Harbo HF, Celius EG, Palotie A, Daly M, Peltonen L, Saarela J. MYO9B polymorphisms in multiple sclerosis. Eur J Hum Genet. 2009 Jan 14.

Sulonen AM, Kallio SP, Ellonen P, Suvela M, Elovaara I, Koivisto K, Pirttilä T, Reunanen M, Tienari PJ, Palotie A, Peltonen L, Saarela J. No evidence for shared etiology in two demyelinative disorders, MS and PLOSL. J Neuroimmunol. 2009 Jan 3;206(1-2):86-90.

Silander K, Alanne M, Kristiansson K, Saarela O, Ripatti S, Auro K, Karvanen J, Kulathinal S, Niemelä M, Ellonen P, Vartiainen E, Jousilahti P, Saarela J, Kuulasmaa K, Evans A, Perola M, Salomaa V, Peltonen L. Gender differences in genetic risk profiles for cardiovascular disease. PLoS ONE. 2008;3(10):e3615.

Hallast P, Saarela J, Palotie A, Laan M. High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes. BMC Evol Biol. 2008 Jul 7;8:195.

Refining genetic associations in multiple sclerosis. International Multiple Sclerosis Genetics Consortium (IMSGC). Lancet Neurol. 2008 Jul;7(7):567-9.

Terwilliger Joseph D.

Linkage analysis of schizophrenia controlling for population substructure. Paunio T, Arajärvi R, Terwilliger JD, Hiekkalinna T, Haimi P, Partonen T, Lönnqvist J, Peltonen L, Varilo T. Am J Med Genet B Neuropsychiatr Genet. 2008

An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders. Donner J, Pirkola S, Silander K, Kananen L, Terwilliger JD, Lönnqvist J, Peltonen L, Hovatta I. Biol Psychiatry. 2008 Oct 15;64(8):672-80

Palotie Aarno

McEvoy BP, Montgomery GW, McRae AF, Ripatti S, Perola M, Spector TD, Cherkas L, Ahmadi KR, Boomsma D, Willemsen G, Hottenga JJ, Pedersen NL, Magnusson PK, Kyvik KO, Christensen K, Kaprio J, Heikkilä K, Palotie A, Widen E, Muilu J, Syvänen AC, Liljedahl U, Hardiman O, Cronin S, Peltonen L, Martin NG, Visscher PM. Geographical structure and differential natural selection among North European populations.Genome Res. 2009 May;19(5):804-14. Epub 2009 Mar 5.

Williams FM, Carter AM, Kato B, Falchi M, Bathum L, Surdulescu G, Kyvik KO, Palotie A, Spector TD, Grant PJ; EuroCLOT Investigators. Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):600-5. Epub 2009 Jan 15.

Jakkula E, Rehnström K, Varilo T, Pietiläinen OP, Paunio T, Pedersen NL, deFaire U, Järvelin MR, Saharinen J, Freimer N, Ripatti S, Purcell S, Collins A, Daly MJ, Palotie A, Peltonen L. The genome-wide patterns of variation expose significant substructure in a founder population. Am J Hum Genet. 2008 Dec;83(6):787-94.

Marjamaa A, Newton-Cheh C, Porthan K, Reunanen A, Lahermo P, Väänänen H, Jula A, Karanko H, Swan H, Toivonen L, Nieminen MS, Viitasalo M, Peltonen L, Oikarinen L, Palotie A, Kontula K, Salomaa V. Common candidate gene variants are associated with QT interval duration in the general population. J Intern Med. 2009 Apr;265(4):448-58.

Wehkalampi K, Widén E, Laine T, Palotie A, Dunkel L. Association of the timing of puberty with a chromosome 2 locus. J Clin Endocrinol Metab. 2008 Dec;93(12):4833-9.

Nyholt DR, LaForge KS, Kallela M, Alakurtti K, Anttila V, Färkkilä M, Hämaläinen E, Kaprio J, Kaunisto MA, Heath AC, Montgomery GW, Göbel H, Todt U, Ferrari MD, Launer LJ, Frants RR, Terwindt GM, de Vries B, Verschuren WM, Brand J, Freilinger T, Pfaffenrath V, Straube A, Ballinger DG, Zhan Y, Daly MJ, Cox DR, Dichgans M, van den Maagdenberg AM, Kubisch C, Martin NG, Wessman M, Peltonen L, Palotie A. A high-density association screen of 155 ion transport genes for involvement with common migraine. Hum Mol Genet. 2008 Nov 1;17(21):3318-31.

Hallast P, Saarela J, Palotie A, Laan M. High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes. BMC Evol Biol. 2008 Jul 7;8:195.

Niemelä M, Frösen J, Hernesniemi J, Dashti R, Palotie A. Molecular pathology of aneurysms. Surg Neurol. 2008 Jul;70(1):36-8. Epub 2008 Apr 28.

Anttila V, Nyholt DR, Kallela M, Artto V, Vepsäläinen S, Jakkula E, Wennerström A, Tikka-Kleemola P, Kaunisto MA, Hämäläinen E, Widén E, Terwilliger J, Merikangas K, Montgomery GW, Martin NG, Daly M, Kaprio J, Peltonen L, Färkkilä M, Wessman M, Palotie A. Consistently replicating locus linked to migraine on 10q22-q23. Am J Hum Genet. 2008 May;82(5):1051-63.

Lundmark PE, Liljedahl U, Boomsma DI, Mannila H, Martin NG, Palotie A, Peltonen L, Perola M, Spector TD, Syvänen AC. Evaluation of HapMap data in six populations of European descent. Eur J Hum Genet. 2008 Sep;16(9):1142-50.

Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, Blackwood D, Curtis D, Deary IJ, Harris SE, Isometsä ET, Lawrence J, Lönnqvist J, Muir W, Palotie A, Partonen T, Paunio T, Pylkkö E, Robinson M, Soronen P, Suominen K, Suvisaari J, Thirumalai S, Clair DS, Gurling H, Peltonen L, Porteous D. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry. 2008 Mar 4.

Wehkalampi K, Widén E, Laine T, Palotie A, Dunkel L. Patterns of inheritance of constitutional delay of growth and puberty in families of adolescent girls and boys referred to specialist pediatric care. J Clin Endocrinol Metab. 2008 Mar;93(3):723-8

Li KC, Palotie A, Yuan S, Bronnikov D, Chen D, Wei X, Choi OW, Saarela J, Peltonen L. Finding disease candidate genes by liquid association. Genome Biol. 2007;8(10):R205.

Oswell G, Kaunisto MA, Kallela M, Hämäläinen E, Anttila V, Kaprio J, Färkkilä M, Wessman M, Palotie A. No association of migraine to the GABA-A receptor complex on chromosome 15. Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):33-6.

Jalanko Anu

Progressive thalamocortical neuron loss in Cln5 deficient mice: Distinct effects in Finnish variant late infantile NCL. Schantz C, Kielar C, Hansen SN, Pontikis CC, Alexander NA, Kopra O, Jalanko A, Cooper JD. Neurobiol Dis. 2009 May;34(2):308-19.

Palmitoyl protein thioesterase 1 modulates tumor necrosis factor alpha-induced apoptosis. Tardy C, Sabourdy F, Garcia V, Jalanko A, Therville N, Levade T, Andrieu-Abadie N.Biochim Biophys Acta. 2009 Apr 5. [Epub ahead of print]

Neuronal ceroid lipofuscinoses. Jalanko A, Braulke T. Biochim Biophys Acta. 2009 Apr;1793(4):697-709. Epub 2008 Nov 24.

Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex. Uusi-Rauva K, Luiro K, Tanhuanpää K, Kopra O, Martín-Vasallo P, Kyttälä A, Jalanko A. Exp Cell Res. 2008 Sep 10;314(15):2895-905. Epub 2008 Jun 28.

Brain gene expression profiles of Cln1 and Cln5 deficient mice unravels common molecular pathways underlying neuronal degeneration in NCL diseases. von Schantz C, Saharinen J, Kopra O, Cooper JD, Gentile M, Hovatta I, Peltonen L, Jalanko A. BMC Genomics. 2008 Mar 28;9:146.

Stress-induced expression of a novel variant of human fumarate hydratase (FH).

Lehtonen HJ, Ylisaukko-Oja SK, Kiuru M, Karhu A, Lehtonen R, Vanharanta S, Jalanko A, Aaltonen LA, Launonen V. Gene Expr. 2007;14(2):59-69.

Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism. Lyly A, Marjavaara SK, Kyttälä A, Uusi-Rauva K, Luiro K, Kopra O, Martinez LO, Tanhuanpää K, Kalkkinen N, Suomalainen A, Jauhiainen M, Jalanko A. Hum Mol Genet. 2008 May 15;17(10):1406-17. Epub 2008 Feb 1.

Lahermo Päivi

Lappalainen T, Salmela E, Andersen PM, Dahlman-Wrigth K, Sistonen P, Savontaus ML, Schreiber S, Lahermo P, Kere J: Genomic Landscape of Positive Natural Selection in North European Populations. Submitted 17.4.2009 (Eur J Hum Genet)

Kettunen J, Silander K, Saarela O, Anttila V, Laitinen J, Hartikainen A-L, Pouta A, Lahermo P. Männistö S, Jula A, Virtamo J, Salomaa V, Smith G D, McCarthy MI, Järvelin M-R, Perola M, Peltonen L: Caucasian Lactase Persistance Allele is Associated with Increase in Body Mass Index. Submitted (Nat Genet)

Tomppo L, Hennah W, Lahermo P, Loukola A, Tuulio-Henriksson A, Suvisaari J, Partonen T, Ekelund J, Lönnqvist J, Peltonen L: Association Between Genes of Disrupted Schizophrenia 1 (DISC1) interactors and Schizophrenia Supports the Role of the DISC1 Pathway in the Etiology of Major Mental Illness. Biol Psychiatry 2009 Feb 27 [Epub ahead of print]

Tomppo L, Hennah W, Miettunen J, Järvelin MR, Veijola J, Ripatti S, Lahermo P, Palotie A, Lichtermann D, Peltonen L, Ekelund J: Association of variants in DISC1 with psychosis related traits in a large population cohort. Archives of Gen Psych 2009:66(2):134-41 IF 15.976

Marjamaa A, Salomaa V, Newton-Cheh C, Porthan K, Reunanen A, Karanko H, Jula A, Lahermo P, Vaananen H, Toivonen L, Swan H, Viitasalo M, Nieminen MS, Peltonen L, Oikarainen L, Palotie A, Kontula K: High prevalence of four long QT syndrome founder mutations in the Finnish population. Ann Med 2009, 21:1-8.

Lappalainen T, Hannelius U, Salmela E, von Döbeln U, Lindgren CM, Huoponen K, Savontaus ML, Kere J, Lahermo P: Population structure in contemporary Sweden - a Y chromosomal and mitochondrial DNA analysis. Ann Hum Genet 2009 Jan 73(1):61-73.

Hannelius U, Salmela E, Lappalainen T, Guillot G, Lindgren CM, von Döbeln U, Lahermo P, Kere J: Population substructure in Finland and Sweden revealed by a small number of unlinked autosomal SNPs. BMC Genetics 2008,9:54, IF 1.582

Marjamaa A, Newton-Cheh C, Porthan K, reunanen A, Lahermo P, Väänänen H, Jula A, Karanko H, Swan H, Toivonen L, Nieminen MS, Viitasalo M, Peltonen L, Oikarainen L, Palotie A, Kontula K, Salomaa V.: Common candidate gene variants are associated with long QT interval duration in the general population. J Intern Med 2008: Oct 25.

Salmela E, Lappalainen T, Fransson I, Andersen PM, Dahlman-Wright K, Fiebig A, Sistonen P, Savontaus ML, Schreiber S, Kere J, Lahermo P.: Genome-wide analysis of single nucleotide polymorphisms uncovers population structure in Northern Europe. PLoS ONE, 2008:3(10)e3519

Lappalainen T, Laitinen V, Salmela E, Anderson P, Huoponen K, Savontaus ML, Lahermo P: Migration Waves to the Baltic Sea Region. Ann Hum Genet 2008: 78:337-348, IF 2.727

Muilu Juha

Thorisson GA, Muilu J, Brookes AJ. Genotype-phenotype databases: challenges and solutions for the post-genomic era. Nat Rev Genet. 2009 Jan;10(1):9-18. Review.

Ripatti Samuli

Geographical structure and differential natural selection among North European populations. McEvoy BP, Montgomery GW, McRae AF, Ripatti S, Perola M, Spector TD, Cherkas L, Ahmadi KR, Boomsma D, Willemsen G, Hottenga JJ, Pedersen NL, Magnusson PK, Kyvik KO, Christensen K, Kaprio J, Heikkilä K, Palotie A, Widen E, Muilu J, Syvänen AC, Liljedahl U, Hardiman O, Cronin S, Peltonen L, Martin NG, Visscher PM. Genome Res. 2009 May;19(5):804-14. Epub 2009 Mar 5.

Association of variants in DISC1 with psychosis-related traits in a large population cohort. Tomppo L, Hennah W, Miettunen J, Järvelin MR, Veijola J, Ripatti S, Lahermo P, Lichtermann D, Peltonen L, Ekelund J. Arch Gen Psychiatry. 2009 Feb;66(2):134-41.

The genome-wide patterns of variation expose significant substructure in a founder population. Jakkula E, Rehnström K, Varilo T, Pietiläinen OP, Paunio T, Pedersen NL, deFaire U, Järvelin MR, Saharinen J, Freimer N, Ripatti S, Purcell S, Collins A, Daly MJ, Palotie A, Peltonen L. Am J Hum Genet. 2008 Dec;83(6):787-94.

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T, Martin NG, Pedersen NL, Kyvik KO, Kaprio J, Hofman A, Freimer NB, Jarvelin MR, Gyllensten U, Campbell H, Rudan I, Johansson A, Marroni F, Hayward C, Vitart V, Jonasson I, Pattaro C, Wright A, Hastie N, Pichler I, Hicks AA, Falchi M, Willemsen G, Hottenga JJ, de Geus EJ, Montgomery GW, Whitfield J, Magnusson P, Saharinen J, Perola M, Silander K, Isaacs A, Sijbrands EJ, Uitterlinden AG, Witteman JC, Oostra BA, Elliott P, Ruokonen A, Sabatti C, Gieger C, Meitinger T, Kronenberg F, Döring A, Wichmann HE, Smit JH, McCarthy MI, van Duijn CM, Peltonen L; ENGAGE Consortium. Nat Genet. 2009 Jan;41(1):47-55. Epub 2008 Dec 7.

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, Sovio U, Ruokonen A, Laitinen J, Jakkula E, Coin L, Hoggart C, Collins A, Turunen H, Gabriel S, Elliot P, McCarthy MI, Daly MJ, Järvelin MR, Freimer NB, Peltonen L. Nat Genet. 2009 Jan;41(1):35-46. Epub 2008 Dec 7.

GENESTAT: an information portal for design and analysis of genetic association studies. Ripatti S, Becker T, Bickeböller H, Dominicus A, Fischer C, Humphreys K, Jonasdottir G, Moreau Y, Olsson M, Ploner A, Sheehan N, Van Steen K, Baur M, van Duijn C, Palmgren J.Eur J Hum Genet. 2009 Apr;17(4):533-6. Epub 2008 Nov 12.

Gender differences in genetic risk profiles for cardiovascular disease. Silander K, Alanne M, Kristiansson K, Saarela O, Ripatti S, Auro K, Karvanen J, Kulathinal S, Niemelä M, Ellonen P, Vartiainen E, Jousilahti P, Saarela J, Kuulasmaa K, Evans A, Perola M, Salomaa V, Peltonen L. PLoS ONE. 2008;3(10):e3615. Epub 2008 Oct 31.

A random change point model for assessing variability in repeated measures of cognitive function. Dominicus A, Ripatti S, Pedersen NL, Palmgren J. Stat Med. 2008 Nov 29;27(27):5786-98.

Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns. Valli-Jaakola K, Suviolahti E, Schalin-Jäntti C, Ripatti S, Silander K, Oksanen L, Salomaa V, Peltonen L, Kontula K. Obesity (Silver Spring). 2008 Sep;16(9):2113-9.

Widén Elisabeth

Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ, Kaakinen M, Laitinen J, Haukka J, Pillas D, Tzoulaki I, Molitor J, Hoggart C, Coin LJ, Whittaker J, Pouta A, Hartikainen AL, Freimer NB, Widen E, Peltonen L, Elliott P, McCarthy MI, Jarvelin MR.Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet. 2009 ;5:e1000409

McEvoy BP, Montgomery GW, McRae AF, Ripatti S, Perola M, Spector TD, Cherkas L, Ahmadi KR, Boomsma D, Willemsen G, Hottenga JJ, Pedersen NL, Magnusson PK, Kyvik KO, Christensen K, Kaprio J, Heikkilä K, Palotie A, Widen E, Muilu J, Syvänen AC, Liljedahl U, Hardiman O, Cronin S, Peltonen L, Martin NG, Visscher PM.Geographical structure and differential natural selection among North European populations. Genome Res. 2009 May;19:804-14

Wehkalampi K, Widén E, Laine T, Palotie A, Dunkel L.Association of the timing of puberty with a chromosome 2 locus. J Clin Endocrinol Metab. 2008;93:4833-9

Anttila V, Nyholt DR, Kallela M, Artto V, Vepsäläinen S, Jakkula E, Wennerström A, Tikka-Kleemola P, Kaunisto MA, Hämäläinen E, Widén E, Terwilliger J, Merikangas K, Montgomery GW, Martin NG, Daly M, Kaprio J, Peltonen L, Färkkilä M, Wessman M, Palotie A. Consistently replicating locus linked to migraine on 10q22-q23.Am J Hum Genet. 2008;82:1051-63.