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2009 © Institute for Molecular Medicine Finland FIMM

Publications 2009-2010

General Publications 2009

FIMM Annual Report 2009

Scientific Publications 2009-2010

Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J et al: Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Mol Oncol 2009, 3(1):9-17.

Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T et al: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 2009, 41(1):47-55.

Autio R, Kilpinen S, Saarela M, Kallioniemi O, Hautaniemi S, Astola J: Comparison of Affymetrix data normalization methods using 6,926 experiments across five array generations. BMC Bioinformatics 2009, 10 Suppl 1:S24.

Barrett JC, Lee JC, Lees CW, Prescott NJ, Anderson CA, Phillips A, Wesley E, Parnell K, Zhang H, Drummond H et al: Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet 2009, 41(12):1330-1334.

Battie MC, Videman T, Kaprio J, Gibbons LE, Gill K, Manninen H, Saarela J, Peltonen L: The Twin Spine Study: contributions to a changing view of disc degeneration. Spine J 2009, 9(1):47-59.

Benyamin B, McRae AF, Zhu G, Gordon S, Henders AK, Palotie A, Peltonen L, Martin NG, Montgomery GW, Whitfield JB et al: Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. Am J Hum Genet 2009, 84(1):60-65.

Bonetti A, Koivisto K, Pirttila T, Elovaara I, Reunanen M, Laaksonen M, Ruutiainen J, Peltonen L, Rantamaki T, Tienari PJ: A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. J Neuroimmunol 2009, 208(1-2):119-124.

Brennan DJ, Ek S, Doyle E, Drew T, Foley M, Flannelly G, O'Connor DP, Gallagher WM, Kilpinen S, Kallioniemi OP et al: The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer. Eur J Cancer 2009, 45(8):1510-1517.

Brookes AJ, Chanock SJ, Hudson TJ, Peltonen L, Abecasis G, Kwok PY, Scherer SW: Genomic variation in a global village: report of the 10th annual Human Genome Variation Meeting 2008. Hum Mutat 2009, 30(7):1134-1138.

Brookes AJ, Lehvaslaiho H, Muilu J, Shigemoto Y, Oroguchi T, Tomiki T, Mukaiyama A, Konagaya A, Kojima T, Inoue I et al: The phenotype and genotype experiment object model (PaGE-OM): a robust data structure for information related to DNA variation. Hum Mutat 2009, 30(6):968-977.

Chambers JC, Zhang W, Li Y, Sehmi J, Wass MN, Zabaneh D, Hoggart C, Bayele H, McCarthy MI, Peltonen L et al: Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nat Genet 2009, 41(11):1170-1172.

Chasman DI, Pare G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Malarstig A et al: Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet 2009, 5(11):e1000730.

Come C, Laine A, Chanrion M, Edgren H, Mattila E, Liu X, Jonkers J, Ivaska J, Isola J, Darbon JM et al: CIP2A is associated with human breast cancer aggressivity. Clin Cancer Res 2009, 15(16):5092-5100.

De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J et al: The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A 2009, 106(13):5264-5269.

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL et al: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet, 42(2):105-116.

Elliott P, Chambers JC, Zhang W, Clarke R, Hopewell JC, Peden JF, Erdmann J, Braund P, Engert JC, Bennett D et al: Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA 2009, 302(1):37-48.

Erdmann J, Grosshennig A, Braund PS, Konig IR, Hengstenberg C, Hall AS, Linsel-Nitschke P, Kathiresan S, Wright B, Tregouet DA et al: New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 2009, 41(3):280-282.

Hayry V, Makinen LK, Atula T, Sariola H, Makitie A, Leivo I, Keski-Santti H, Lundin J, Haglund C, Hagstrom J: Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue. Br J Cancer.

Hellquist A, Zucchelli M, Lindgren CM, Saarialho-Kere U, Jarvinen TM, Koskenmies S, Julkunen H, Onkamo P, Skoog T, Panelius J et al: Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE). PLoS One 2009, 4(12):e8037.

Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, Blackwood D, Curtis D, Deary IJ, Harris SE et al: DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry 2009, 14(9):865-873.

Honkala H, Lahtela J, Fox H, Gentile M, Pakkasjarvi N, Salonen R, Wartiovaara K, Jauhiainen M, Kestila M: Unraveling the disease pathogenesis behind lethal hydrolethalus syndrome revealed multiple changes in molecular and cellular level. Pathogenetics 2009, 2(1):2.

 

Iljin K, Ketola K, Vainio P, Halonen P, Kohonen P, Fey V, Grafstrom RC, Perala M, Kallioniemi O: High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res 2009, 15(19):6070-6078.

Ingason A, Giegling I, Cichon S, Hansen T, Rasmussen HB, Nielsen J, Jurgens G, Muglia P, Hartmann AM, Strengman E et al: A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Hum Mol Genet.

Ingason A, Rujescu D, Cichon S, Sigurdsson E, Sigmundsson T, Pietilainen OP, Buizer-Voskamp JE, Strengman E, Francks C, Muglia P et al: Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Mol Psychiatry 2009.

Jakkula E, Leppa V, Sulonen AM, Varilo T, Kallio S, Kemppinen A, Purcell S, Koivisto K, Tienari P, Sumelahti ML et al: Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene. Am J Hum Genet, 86(2):285-291.

Jalanko A, Braulke T: Neuronal ceroid lipofuscinoses. Biochim Biophys Acta 2009, 1793(4):697-709.

Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M et al: Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet 2009.

Kainov DE, Selth LA, Svejstrup JQ, Egly JM, Poterzsman A: Interacting partners of the Tfb2 subunit from yeast TFIIH. DNA Repair (Amst), 9(1):33-39.

Kallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttila T, Reunanen M, Bronnikov D et al: Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Hum Mol Genet 2009, 18(9):1670-1683.

Karvanen J, Silander K, Kee F, Tiret L, Salomaa V, Kuulasmaa K, Wiklund PG, Virtamo J, Saarela O, Perret C et al: The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol 2009, 33(3):237-246.

Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H et al: Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 2009, 41(3):334-341.

Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T et al: Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2009, 41(1):56-65.

Kemlink D, Polo O, Frauscher B, Gschliesser V, Hogl B, Poewe W, Vodicka P, Vavrova J, Sonka K, Nevsimalova S et al: Replication of restless legs syndrome loci in three European populations. J Med Genet 2009, 46(5):315-318.

Kemppinen A, Suvela M, Tienari PJ, Elovaara I, Koivisto K, Pirttila T, Reunanen M, Rautakorpi I, Hillert J, Lundmark F et al: MYO9B polymorphisms in multiple sclerosis. Eur J Hum Genet 2009, 17(6):840-843.

Keskitalo K, Broms U, Heliovaara M, Ripatti S, Surakka I, Perola M, Pitkaniemi J, Peltonen L, Aromaa A, Kaprio J: Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. Hum Mol Genet 2009, 18(20):4007-4012.

Kettunen J, Perola M, Martin NG, Cornes BK, Wilson SG, Montgomery GW, Benyamin B, Harris JR, Boomsma D, Willemsen G et al: Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci. Int J Obes (Lond) 2009, 33(11):1235-1242.

Kettunen J, Silander K, Saarela O, Amin N, Muller M, Timpson N, Surakka I, Ripatti S, Laitinen J, Hartikainen AL et al: European lactase persistence genotype shows evidence of association with increase in body mass index. Hum Mol Genet.

Kilpinen H, Ylisaukko-oja T, Rehnstrom K, Gaal E, Turunen JA, Kempas E, von Wendt L, Varilo T, Peltonen L: Linkage and linkage disequilibrium scan for autism loci in an extended pedigree from Finland. Hum Mol Genet 2009, 18(15):2912-2921.

Kinnari TJ, Aarnisalo AA, Rihkanen H, Lundin J, Jero J: Can head position after anesthesia cause occlusion of the tympanostomy tube? J Otolaryngol Head Neck Surg, 39(1):1-4.

Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M et al: Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 2009, 5(6):e1000504.

Lappalainen T, Hannelius U, Salmela E, von Dobeln U, Lindgren CM, Huoponen K, Savontaus ML, Kere J, Lahermo P: Population structure in contemporary Sweden--a Y-chromosomal and mitochondrial DNA analysis. Ann Hum Genet 2009, 73(1):61-73.

Lappalainen T, Salmela E, Andersen PM, Dahlman-Wright K, Sistonen P, Savontaus ML, Schreiber S, Lahermo P, Kere J: Genomic landscape of positive natural selection in Northern European populations. Eur J Hum Genet 2009.

Laurila PP, Naukkarinen J, Kristiansson K, Ripatti S, Kauttu T, Silander K, Salomaa V, Perola M, Karhunen PJ, Barter PJ et al: Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis. Arterioscler Thromb Vasc Biol, 30(2):346-352.

 

Lebreton M, Barnes A, Miettunen J, Peltonen L, Ridler K, Veijola J, Tanskanen P, Suckling J, Jarvelin MR, Jones PB et al: The brain structural disposition to social interaction. Eur J Neurosci 2009, 29(11):2247-2252.

Leivonen SK, Makela R, Ostling P, Kohonen P, Haapa-Paananen S, Kleivi K, Enerly E, Aakula A, Hellstrom K, Sahlberg N et al: Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines. Oncogene 2009, 28(44):3926-3936.

Linder N, Martelin E, Lundin M, Louhimo J, Nordling S, Haglund C, Lundin J: Xanthine oxidoreductase - clinical significance in colorectal cancer and in vitro expression of the protein in human colon cancer cells. Eur J Cancer 2009, 45(4):648-655.

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM et al: Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 2009, 5(6):e1000508.

Lindh E, Rosmaraki E, Berg L, Brauner H, Karlsson MC, Peltonen L, Hoglund P, Winqvist O: AIRE deficiency leads to impaired iNKT cell development. J Autoimmun, 34(1):66-72.

Lundin M, Szymas J, Linder E, Beck H, de Wilde P, van Krieken H, Garcia Rojo M, Moreno I, Ariza A, Tuzlali S et al: A European network for virtual microscopy--design, implementation and evaluation of performance. Virchows Arch 2009, 454(4):421-429.

Main H, Lee KL, Yang H, Haapa-Paananen S, Edgren H, Jin S, Sahlgren C, Kallioniemi O, Poellinger L, Lim B et al: Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells. Exp Cell Res 2009.

Marjamaa A, Newton-Cheh C, Porthan K, Reunanen A, Lahermo P, Vaananen H, Jula A, Karanko H, Swan H, Toivonen L et al: Common candidate gene variants are associated with QT interval duration in the general population. J Intern Med 2009, 265(4):448-458.

Marjamaa A, Salomaa V, Newton-Cheh C, Porthan K, Reunanen A, Karanko H, Jula A, Lahermo P, Vaananen H, Toivonen L et al: High prevalence of four long QT syndrome founder mutations in the Finnish population. Ann Med 2009, 41(3):234-240.

McCarroll SA, Bradner JE, Turpeinen H, Volin L, Martin PJ, Chilewski SD, Antin JH, Lee SJ, Ruutu T, Storer B et al: Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease. Nat Genet 2009, 41(12):1341-1344.

McEvoy BP, Montgomery GW, McRae AF, Ripatti S, Perola M, Spector TD, Cherkas L, Ahmadi KR, Boomsma D, Willemsen G et al: Geographical structure and differential natural selection among North European populations. Genome Res 2009, 19(5):804-814.

Mero IL, Lorentzen AR, Ban M, Smestad C, Celius EG, Aarseth JH, Myhr KM, Link J, Hillert J, Olsson T et al: A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis. Eur J Hum Genet 2009.

Muggerud AA, Edgren H, Wolf M, Kleivi K, Dejeux E, Tost J, Sorlie T, Kallioniemi O: Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line. BMC Med Genomics 2009, 2:26.

Naukkarinen J, Nilsson E, Koistinen HA, Soderlund S, Lyssenko V, Vaag A, Poulsen P, Groop L, Taskinen MR, Peltonen L: Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias. Circ Cardiovasc Genet 2009, 2(5):522-529.

Nelis M, Esko T, Magi R, Zimprich F, Zimprich A, Toncheva D, Karachanak S, Piskackova T, Balascak I, Peltonen L et al: Genetic structure of Europeans: a view from the North-East. PLoS One 2009, 4(5):e5472.

Nevo J, Mattila E, Pellinen T, Yamamoto DL, Sara H, Iljin K, Kallioniemi O, Bono P, Heikkila P, Joensuu H et al: Mammary-derived growth inhibitor alters traffic of EGFR and induces a novel form of cetuximab resistance. Clin Cancer Res 2009, 15(21):6570-6581.

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S et al: Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009.

Newton-Cheh C, Larson MG, Vasan RS, Levy D, Bloch KD, Surti A, Guiducci C, Kathiresan S, Benjamin EJ, Struck J et al: Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet 2009, 41(3):348-353.

Ng MY, Levinson DF, Faraone SV, Suarez BK, DeLisi LE, Arinami T, Riley B, Paunio T, Pulver AE, Irmansyah et al: Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry 2009, 14(8):774-785.

Nyman ES, Loukola A, Varilo T, Ekelund J, Veijola J, Joukamaa M, Taanila A, Pouta A, Miettunen J, Freimer N et al: Impact of the dopamine receptor gene family on temperament traits in a population-based birth cohort. Am J Med Genet B Neuropsychiatr Genet 2009, 150B(6):854-865.

Olkkonen VM, Hynynen R: Interactions of oxysterols with membranes and proteins. Mol Aspects Med 2009, 30(3):123-133.

Ollila HM, Soronen P, Silander K, Palo OM, Kieseppa T, Kaunisto MA, Lonnqvist J, Peltonen L, Partonen T, Paunio T: Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. Mol Psychiatry 2009, 14(4):351-353.

Palo OM, Soronen P, Silander K, Varilo T, Tuononen K, Kieseppa T, Partonen T, Lonnqvist J, Paunio T, Peltonen L: Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population. Am J Med Genet B Neuropsychiatr Genet 2009.

Paunio T, Arajarvi R, Terwilliger JD, Hiekkalinna T, Haimi P, Partonen T, Lonnqvist J, Peltonen L, Varilo T: Linkage analysis of schizophrenia controlling for population substructure. Am J Med Genet B Neuropsychiatr Genet 2009, 150B(6):827-835.

Pergadia ML, Agrawal A, Loukola A, Montgomery GW, Broms U, Saccone SF, Wang JC, Todorov AA, Heikkila K, Statham DJ et al: Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. Am J Med Genet B Neuropsychiatr Genet 2009, 150B(7):950-959.

Perttila J, Merikanto K, Naukkarinen J, Surakka I, Martin NW, Tanhuanpaa K, Grimard V, Taskinen MR, Thiele C, Salomaa V et al: OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. J Mol Med 2009, 87(8):825-835.

Pietilainen OP, Paunio T, Loukola A, Tuulio-Henriksson A, Kieseppa T, Thompson P, Toga AW, van Erp TG, Silventoinen K, Soronen P et al: Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins. Am J Med Genet B Neuropsychiatr Genet 2009, 150B(5):683-692.

Plunkett J, Feitosa MF, Trusgnich M, Wangler MF, Palomar L, Kistka ZA, DeFranco EA, Shen TT, Stormo AE, Puttonen H et al: Mother's genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth. Hum Hered 2009, 68(3):209-219.

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y et al: Variants in MTNR1B influence fasting glucose levels. Nat Genet 2009, 41(1):77-81.

Rehnstrom K, Ylisaukko-oja T, Nummela I, Ellonen P, Kempas E, Vanhala R, von Wendt L, Jarvela I, Peltonen L: Allelic variants in HTR3C show association with autism. Am J Med Genet B Neuropsychiatr Genet 2009, 150B(5):741-746.

Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, Zhao JH, Ramasamy A, Zhai G, Vitart V et al: Genome-wide association study identifies five loci associated with lung function. Nat Genet, 42(1):36-44.

Reveille JD, Sims AM, Danoy P, Evans DM, Leo P, Pointon JJ, Jin R, Zhou X, Bradbury LA, Appleton LH et al: Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet, 42(2):123-127.

Ripatti S, Becker T, Bickeboller H, Dominicus A, Fischer C, Humphreys K, Jonasdottir G, Moreau Y, Olsson M, Ploner A et al: GENESTAT: an information portal for design and analysis of genetic association studies. Eur J Hum Genet 2009, 17(4):533-536.

Rujescu D, Ingason A, Cichon S, Pietilainen OP, Barnes MR, Toulopoulou T, Picchioni M, Vassos E, Ettinger U, Bramon E et al: Disruption of the neurexin 1 gene is associated with schizophrenia. Hum Mol Genet 2009, 18(5):988-996.

 

Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M et al: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 2009, 41(1):35-46.

Salmela AL, Pouwels J, Varis A, Kukkonen AM, Toivonen P, Halonen PK, Perala M, Kallioniemi O, Gorbsky GJ, Kallio MJ: Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint. Carcinogenesis 2009, 30(6):1032-1040.

Sammalisto S, Hiekkalinna T, Schwander K, Kardia S, Weder AB, Rodriguez BL, Doria A, Kelly JA, Bruner GR, Harley JB et al: Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects. Eur J Hum Genet 2009, 17(2):258-266.

Sara H, Kallioniemi O, Nees M: A decade of cancer gene profiling: from molecular portraits to molecular function. Methods Mol Biol, 576:61-87.

Schmiedt ML, Bessa C, Heine C, Ribeiro MG, Jalanko A, Kyttala A: The neuronal ceroid lipofuscinosis protein CLN5: new insights into cellular maturation, transport, and consequences of mutations. Hum Mutat, 31(3):356-365.

Siitonen HA, Sotkasiira J, Biervliet M, Benmansour A, Capri Y, Cormier-Daire V, Crandall B, Hannula-Jouppi K, Hennekam R, Herzog D et al: The mutation spectrum in RECQL4 diseases. Eur J Hum Genet 2009, 17(2):151-158.

Silander K, Tang H, Myles S, Jakkula E, Timpson NJ, Cavalli-Sforza L, Peltonen L: Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease. Genome Med 2009, 1(5):51.

Sipila T, Kananen L, Greco D, Donner J, Silander K, Terwilliger JD, Auvinen P, Peltonen L, Lonnqvist J, Pirkola S et al: An Association Analysis of Circadian Genes in Anxiety Disorders. Biol Psychiatry.

 

Soderholm PP, Koskela AH, Lundin JE, Tikkanen MJ, Adlercreutz HC: Plasma pharmacokinetics of alkylresorcinol metabolites: new candidate biomarkers for whole-grain rye and wheat intake. Am J Clin Nutr 2009, 90(5):1167-1171.

Soranzo N, Spector TD, Mangino M, Kuhnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M et al: A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet 2009, 41(11):1182-1190.

Soronen P, Ollila HM, Antila M, Silander K, Palo OM, Kieseppa T, Lonnqvist J, Peltonen L, Tuulio-Henriksson A, Partonen T et al: Replication of GWAS of bipolar disorder: association of SNPs near CDH7 with bipolar disorder and visual processing. Mol Psychiatry, 15(1):4-6.

Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ, Kaakinen M, Laitinen J, Haukka J, Pillas D et al: Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet 2009, 5(3):e1000409.

Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietilainen OP, Mors O, Mortensen PB et al: Common variants conferring risk of schizophrenia. Nature 2009, 460(7256):744-747.

Steinberg S, Mors O, Borglum AD, Gustafsson O, Werge T, Mortensen PB, Andreassen OA, Sigurdsson E, Thorgeirsson TE, Bottcher Y et al: Expanding the range of ZNF804A variants conferring risk of psychosis. Mol Psychiatry.

Sulonen AM, Kallio SP, Ellonen P, Suvela M, Elovaara I, Koivisto K, Pirttila T, Reunanen M, Tienari PJ, Palotie A et al: No evidence for shared etiology in two demyelinative disorders, MS and PLOSL. J Neuroimmunol 2009, 206(1-2):86-90.

Tallila J, Salonen R, Kohlschmidt N, Peltonen L, Kestila M: Mutation spectrum of Meckel syndrome genes: one group of syndromes or several distinct groups? Hum Mutat 2009, 30(8):E813-830.

Thorisson GA, Muilu J, Brookes AJ: Genotype-phenotype databases: challenges and solutions for the post-genomic era. Nat Rev Genet 2009, 10(1):9-18.

Tiikkainen P, Markt P, Wolber G, Kirchmair J, Distinto S, Poso A, Kallioniemi O: Critical comparison of virtual screening methods against the MUV data set. J Chem Inf Model 2009, 49(10):2168-2178.

Tiikkainen P, Poso A, Kallioniemi O: Comparison of structure fingerprint and molecular interaction field based methods in explaining biological similarity of small molecules in cell-based screens. J Comput Aided Mol Des 2009, 23(4):227-239.

Tikka-Kleemola P, Kaunisto MA, Hamalainen E, Todt U, Gobel H, Kaprio J, Kubisch C, Farkkila M, Palotie A, Wessman M et al: Genetic association study of endothelin-1 and its receptors EDNRA and EDNRB in migraine with aura. Cephalalgia 2009, 29(11):1224-1231.

Timpson NJ, Tobias JH, Richards JB, Soranzo N, Duncan EL, Sims AM, Whittaker P, Kumanduri V, Zhai G, Glaser B et al: Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Hum Mol Genet 2009, 18(8):1510-1517.

Tomppo L, Hennah W, Lahermo P, Loukola A, Tuulio-Henriksson A, Suvisaari J, Partonen T, Ekelund J, Lonnqvist J, Peltonen L: Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol Psychiatry 2009, 65(12):1055-1062.

Tomppo L, Hennah W, Miettunen J, Jarvelin MR, Veijola J, Ripatti S, Lahermo P, Lichtermann D, Peltonen L, Ekelund J: Association of variants in DISC1 with psychosis-related traits in a large population cohort. Arch Gen Psychiatry 2009, 66(2):134-141.

Turpeinen H, Volin L, Nikkinen L, Ojala P, Palotie A, Saarela J, Partanen J: Genetic similarity of chromosome 6 between patients receiving hematopoietic stem cell transplantation and HLA matched sibling donors. Haematologica 2009, 94(4):528-535.

Videman T, Saarela J, Kaprio J, Nakki A, Levalahti E, Gill K, Peltonen L, Battie MC: Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing. Arthritis Rheum 2009, 60(2):470-481.

Vink JM, Smit AB, de Geus EJ, Sullivan P, Willemsen G, Hottenga JJ, Smit JH, Hoogendijk WJ, Zitman FG, Peltonen L et al: Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet 2009, 84(3):367-379.

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