2012 © Institute for Molecular Medicine Finland FIMM
Principal Investigator Matej Orešič
Principal Investigator:
Research Proffessor Matej Orešič, PhD
Primary Affiliation:
VTT Technical Research Centre of Finland
Title of the FIMM-Specific Research Project:
Metabolic stress and autoimmunity in health and disease
Abstract:
Metabolomics systematically studies the metabolome, i.e., the small molecules in cells, tissues and biofluids. New analytical methods combined with bioinformatics provide a way to measure the extended metabolome. The metabolic phenotype is sensitive to subtle but pathogenically relevant factors such as age, lifestyle, nutrition and the microbe environment of the gut. Changes in the concentrations of metabolites may thus reflect both genetic and environmental factors influencing later susceptibility to chronic diseases.
We are investigating
- How are the genetic and environmental factors imprinted in the metabolome;
- The mechanisms by which alterations of metabolome lead to (patho)physiological changes at the systems level;
- Discovery and functional characterization of metabolic markers for multiple diseases or responses to interventions and environmental challenges.
We are relying on metabolomics techniques to characterize the metabolome, combined with systems biology strategies to investigate, e.g., how changes in gene expression or in gut microbial composition alter the metabolic phenotypes. Current biomedical interests include metabolic and autoimmune diseases, and cancer.Contact information
Publications:
- M. Orešič, T. Seppänen-Laakso, L. Yetukuri, F. Bäckhed, V. Hänninen, Gut microbiota affects lens and retinal lipid composition, Exp. Eye Res. 89, 604-607 (2009).
- J. Tang, C. Y. Tan, M. Orešič, A. Vidal-Puig, Integrating post-genomic approaches as a strategy to advance our understanding of health and disease, Genome Med. 1, e35 (2009).
- A. Kotronen, V. R. Velagapudi, L. Yetukuri, J. Westerbacka, R. Bergholm, K. Ekroos, J. Makkonen, M.-R. Taskinen, M. Orešič, H. Yki-Järvinen, Saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations, Diabetologia 52(4), 684-690 (2009).
- P. V. Gopalacharyulu, V. R. Velagapudi, E. Lindfors, Eran Halperin, M. Orešič, Dynamic network topology changes in functional modules predict responses to oxidative stress in yeast, Mol. BioSyst. 5, 276-287 (2009).
- M. Orešič, S. Simell, M. Sysi-Aho, K. Näntö-Salonen, T. Seppänen-Laakso, V. Parikka, M. Katajamaa, A. Hekkala, I. Mattila, P. Keskinen, L. Yetukuri, A. Reinikainen, J. Lähde, T. Suortti, J. Hakalax, T. Simell, H. Hyöty, R. Veijola, J. Ilonen, R. Lahesmaa, M. Knip, O. Simell, Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes, J. Exp. Med. 205(13), 2975-2984 (2008). (commentary) (Faculty of 1000 Biology evaluation)
- M. Orešič, V. Hänninen, A. Vidal-Puig, Lipidomics: a new window to biomedical frontiers, Trends Biotechnol. 26(12), 647-652 (2008).
- J. Nikkilä, M. Sysi-Aho, A. Ermolov, T. Seppänen-Laakso, O. Simell, S. Kaski, M. Orešič, Gender dependent progression of systemic metabolic states in early childhood, Mol. Syst. Biol. 4, e197 (2008).
- M. Sysi-Aho, A. Vehtari, V. Velagapudi, J. Westerbacka, L. Yetukuri, R. Bergholm, M.-R. Taskinen, H. Yki-Järvinen, M. Orešič, Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles, Bioinformatics 23, i519-i528 (2007).
- L. Yetukuri, M. Katajamaa, G. Medina-Gomez, T. Seppänen-Laakso, A. Vidal Puig, and M. Orešič, Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis, BMC Syst. Biol. 1, e12 (2007).
- K. H. Pietiläinen, M. Sysi-Aho, A. Rissanen, T. Seppänen-Laakso, H. Yki-Järvinen, J. Kaprio, and M. Orešič, Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects - a monozygotic twin study, PLoS ONE 2(2), e218 (2007).
- R. Laaksonen, M. Katajamaa, H. Päivä, M. Sysi-Aho, L. Saarinen, P. Junni, D. Lütjohann, J. Smet, R. Van Coster, T. Seppänen-Laakso, T. Lehtimäki, J. Soini, M. Orešič, A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin induced changes in muscle, PLoS ONE 1(1): e97 (2006).
- M. Katajamaa, J. Miettinen, and M. Orešič, MZmine: Toolbox for processing and visualization of mass spectrometry based molecular profile data, Bioinformatics 22, 634-636 (2006).
Contact Information
Matej Orešič
Chief Research Scientist
VTT Technical Research Centre of Finland
Tietotie 2
FIN-02044 VTT, Finland
Phone: +358-20-722 4491
Fax: +358-20-722 7071 (Attn. Matej Orešič)
Email: matej.oresic(at)vtt.fi
Research group page: http://sysbio.vtt.fi/