Davide Danovi (MD, PhD, Principal Scientist, King's College London/HipSci project):
Phenotyping stem cells from healthy volunteers and patients using high content analysis platforms
Davide Danovi holds an MD from University of Milan and a PhD in Molecular Oncology from the European Institute of Oncology where he demonstrated the causative role of the HdmX protein in human cancer. He completed his postdoctoral training working with Prof. Austin Smith and Dr. Steve Pollard at the University of Cambridge and at University College London where he developed a screening platform to isolate compounds active on human neural stem cells from normal or brain tumour samples. Prior to his current role, he worked as principal scientist at a novel biotechnology company founded to isolate drugs for regenerative medicine using innovative stem cell technologies. Currently Davide and the team works in the framework of the Human Induced Pluripotent Stem Cells Initiative (HipSci) project, funded by the Wellcome Trust and MRC. They provide a dedicated laboratory space for collaborative cell phenotyping to study how intrinsic and extrinsic signals impact on human cells to develop assays for disease modeling and drug discovery and to identify new disease mechanisms.
For further info please visit the Human Induced Pluripotent Stem Cells Initiative website.
Kilpinen et al., Common genetic variation drives molecular heterogeneity in human iPSCs, Nature 2017
Leha et al., A high-content platform to characterise human induced pluripotent stem cell lines, Methods 2016
The seminar is part of a one day High-Content Screening Symposium.