The "Think Different" seminar series is organized by doctoral students at FIMM. For the series, researchers working on exciting new ideas are invited once a month to give a talk and hopefully encourage the audience to think different.
On 20 March:
Roman Jerala: Designable modularity in synthetic biology: from design of cellular gene circuits to new protein folds
Proteins that could self-assemble into a predetermined shape, isn’t that cool! DNA origami is now a passe, Protein origami is here!
As a part of the FIMM "Think different" seminar series, we are delighted to invite you to hear the extremely interesting work of Roman Jerala on Designable modularity in synthetic biology: from design of cellular gene circuits to new protein folds. Roman Jerala is Professor of Biotechnology at the University of Ljubljana, Slovenia. His research group has generated the first de novo self-assembling polypeptide nanostructured polyhedra. He and his colleagues have designed and built a protein that folds itself into a tetrahedron — a pyramid with a triangular base — and he says that the strategy could be used to make a wide range of other shapes. His lab has been now pioneering the work of synthesizing proteins that do not even exist in nature. This fascinating work in protein origami has provided the basis for the construction of new polypeptide folds. Prof Roman Jerala is also well known as the leader of the Slovenian team who won the Grand Prize several times at the iGEM Synthetic Biology competition. So! Do come to attend this talk and hear what are the possibilities that protein origami has in store for biological research.
1: Gradišar H, Božič S, Doles T, Vengust D, Hafner-Bratkovič I, Mertelj A, WebbB, Šali A, Klavžar S, Jerala R. Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments. Nat Chem Biol. 2013 Jun;9(6):362-6.
2: Gaber R, Lebar T, Majerle A, Šter B, Dobnikar A, Benčina M, Jerala R.Designable DNA-binding domains enable construction of logic circuits in mammalian cells. Nat Chem Biol. 2014 Mar;10(3):203-8.
3: Lebar T, Bezeljak U, Golob A, Jerala M, Kadunc L, Pirš B, Stražar M, Vučko D, Zupančič U, Benčina M, Forstnerič V, Gaber R, Lonzarić J, Majerle A, Oblak A, Smole A, Jerala R. A bistable genetic switch based on designable DNA-binding domains. Nat Commun. 2014 Sep 29;5:5007.
4: Avbelj M, Wolz OO, Fekonja O, Benčina M, Repič M, Mavri J, Krüger J, Schärfe C, Delmiro Garcia M, Panter G, Kohlbacher O, Weber AN, Jerala R. Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization. Blood. 2014 Dec 18;124(26):3896-904
For further information, please contact:
FIMM-EMBL PhD Student