Round table thematic science talks and discussions 3
Table 23: Bacterial peptidoglycan signalling in inflammation, brain development and behaviour
Location: Room 1
Leaders: Felipe Cava (MIMS), Emilio Bueno (MIMS), Akhilesh Yadav (MIMS)
The ability to detect harmful pathogens and eradicate them is essential for the survival of an organism. Recognition of bacterial peptidoglycan by pattern recognition receptors (PRRs) activates inflammatory signaling pathways and the stimulation of an immune response. Recent studies have revealed that peptidoglycan derived from the commensal gut microbiota can be translocated into the brain to modulate brain development and behavior. We will discuss the central activation of PRRs by peptidoglycan as one of the signaling pathways mediating the
communication between the gut microbiota and the developing brain and its relation with infection processes.
Table 24: Cancer cell biophysics
Location: Room 2
Leaders: Irep Gözen (NCMM)
Table 25: Membrane networks and structure
Location: Room 3
Leaders: Poul Nissen (DANDRITE), Linda Sandblad (MIMS), J. Preben Morth (NCMM)
We will discuss experimental approaches such as cryo-electron tomography, correlative fluorescence microscopy and X-ray/neutron scattering to investigate distributed patterns and higher order structure, function and dynamics of membrane proteins and biomembranes.
Table 26: Optogenetic approach to understanding the neural circuits of behaviours
Location: Room 4
Leaders: Sadegh Nabavi (DANDRITE), Anne von Philipsborn (DANDRITE), Duda Kvitsiani (DANDRITE)
Understanding neural circuits is fundamental to the understanding of our behavior. Optogenetic tools have revolutionarized our approach to studying the brain circuits. Now we can manipulate the circuits and understand their behavioral function; an act considered science fiction only10 years ago. Here we will discuss the power of optogenetics in deciphering the circuits from flies all the way up to rodents and primates.
Table 27: Regulatory aspects of diagnostics in precision medicine
Location: Room 6
Leaders: Kjetil Taskén (NCMM), Tuomas Mirtti (FIMM)
Precision medicine is about understanding the (different) molecular causes for disease in each patient and tailor individualized therapeutic approaches. This concept implies that each patient has her or his disease and that it is one disease in each patient rather than in a group of patients. There is a demand that we stratify patient populations to get treatment efficacy. The diagnostic challenges with this approach are 1) what are good (enough) methods, 2) what are suitably specific and sensitive methods, 3) how should they be documented, 4) what are the consequences of introducing diagnostics for patients and 5) can we actually provide patient benefit by introducing additional diagnostic methods.
Table 28: From GWAS to PheWAS
Location: Room 10
Leaders: Matti Pirinen (FIMM), Samuli Ripatti (FIMM), Paavo Häppölä (FIMM)
Phenome-wide association analyses (PheWAS) are used to systematically examine the impact of genetic variants across a broad range of human phenotypes. 45+ years of Finnish health registry data for provides a powerful tool to identify novel molecular disease mechanisms of clinical importance by PheWS analyses. We will present examples of genome-wide health registry-based PheWAS analyses and methods to model the clustering of multivariate phenotypes.
Table 29: Reprogramming blood-derived cancers/differentiation therapy
Location: Room 11
Leaders: Judith Staerk (NCMM), Sigrid Skånland (NCMM), Ella Karjalainen (FIMM)
Hematological malignancies are often closely linked to and driven by cell differentiation anomalies. We will introduce the concept of cellular reprogramming in cancer, with a focus on hematological disease, novel approaches, and how cell differentiation might be exploited in cancer therapy.
Table 30: Using high-throughput transcriptomic and proteomic methods to investigate molecular mechanisms underlying mental disorders
Location: Banquet Hall Side
Leaders: Jane H. Christensen (DANDRITE), Per Qvist (DANDRITE), Veerle Paternoster (DANDRITE), Tue Fryland (DANDRITE)
We have studied the bromodomain containing 1 (BRD1) gene in relation to mental disorders. BRD1 is a scaffold protein forming complexes with histone acetyl transferases to modify the chromatin structure. Thus, it seems to be important in the transcriptional regulation of large gene sets. We will present and discuss our results obtained using high-throughput transcriptomic and proteomic methods to decipher the importance of BRD1 in mice and to delineate its cellular interactions.
Table 31: Grantsmanship
Leaders: Jaakko Kaprio (FIMM)
We will have an open discussion on the do’s and don’t’s of writing grant applications. The discussion will be applicable to researchers at all levels.
Table 32: Science communication
Table 33: The gut microbiota in health and disease
Leaders: Andrea Puhar (MIMS), David A. Cisneros (MIMS), Riitta Sallinen (FIMM)
After a general introduction on the mammalian gut and its inhabiting microbes (AP), we will discuss how bacteria achieve and maintain colonisation of the gut (DAC), how the bacterial composition changes in time and what the consequences on our health and wellness are based on longitudinal studies in volunteers (RS).