Kati Donner, Ph.D., Docent, is a Senior Researcher at FIMM’s Genomics Unit. The unit provides large-scale genotyping, expression, methylation and cell line authentication services for national and international research groups. Her work includes project planning and management, data handling, analysis, method development and quality assessment. Kati Donner has a strong background in human genetics of monogenic and complex diseases. She received her Ph.D. in 2007 in the genetic background of a rare muscle disorder called nemaline myopathy and worked as a post-doc at HUS studying the genetic mechanisms underlying monogenic and complex forms of human hypertension and response to antihypertensive drugs. She became a Docent in 2012. Her main research interest still lies in the field of genetics of human hypertension and blood pressure response to antihypertensive drugs. She is also actively participating in teaching human genetics at the University of Helsinki.
Donner, K. M., Hiltunen, T. P., Jänne, O. A., Sane, T. & Kontula, K. Generalized glucocorticoid resistance caused by a novel two nucleotide deletion in the hormone binding domain of the glucocorticoid receptor gene NR3C1. Eur J Endocrinol, 10:K9-K18, 2013
Turner ST, Boerwinkle E, O'Connell JR, Bailey KR, Gong Y, Chapman AB, McDonough CW, Beitelshees AL, Schwartz GL, Gums JG, Padmanabhan S, Hiltunen TP, Citterio L, Donner KM, Hedner T, Lanzani C, Melander O, Saarela J, Ripatti S, Wahlstrand B, Manunta P, Kontula K, Dominiczak AF, Cooper-DeHoff RM, Johnson JA. Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. Hypertension. 62(2):391-7. 2013
Lehtokari, V-L., Kiiski, K., Sandaradura, S., Laporte, J., Repo, P., Frey, J., Donner, K., Marttila, M., Saunders, C., Barth, P. G., den Dunnen, J., Beggs, A., Clarke, N., North, K. N., Laing, N., Romero, N. B., Winder, T., Pelin, P. & Wallgren-Pettersson, C. Mutation update: the spectra of nebulin variants and associated myopathies. Human Mutation, 35:1418-26, 2014.
Kovanen, L., Donner, K., Kaunisto, M. & Partonen, T. CRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome. Hypertension Research, doi: 10.1038/hr, 2014
Hiltunen TP, Donner KM, Sarin AP, Saarela J, Ripatti S, Chapman AB, Gums JG, Gong Y, Cooper-DeHoff RM, Frau F, Glorioso V, Zaninello R, Salvi E, Glorioso N, Boerwinkle E, Turner ST, Johnson JA, Kontula KK. Pharmacogenomics of hypertension: a genome-wide, placebo-controlled cross-over study, using four classes of antihypertensive drugs. J Am Heart Assoc. 2015