Clinical Informatics and Image-based Diagnostics
The goal of our current studies is to promote implementation of new decision-support technology, as well as improve the flow of information from basic research to the clinic.
The group has developed an online risk calculator - "Prognomics" - for personalized prediction of cancer outcome. The risk calculator is an extension of our previously published "case-match" method (1) and is connected to a database with molecular, as well as clinical and outcome data on more than 5 million cases from 15 countries. Survival estimates can be retrieved for all major cancers and the extensive database allows for estimation of risk even in rare subgroups. The case-match approach is also used for explorative analysis of novel biomarkers and is linked to our image analysis system described below.
The other major strategic research area is image based diagnostics, with special focus on microscopy images. In collaboration with the Machine Vision Group at the University of Oulu, we are exploring high-throughput computer assisted methods for automated analysis of digitized cancer tissue and microbiological samples. Methods for computerized quantification and segmentation of digitized tumour samples are applied in analysis of tissue microarrays in comprehensive series of breast, prostate and colorectal cancers.