Ongoing EU Research Projects


Horizon 2020 Framework Programme, Research Projects

MedBioinformatics (2015-2018)


The primary aim of the MedBioinformatics (Creating medically-driven integrative bioinformatics applications focused on oncology, CNS disorders and their comorbidities) project is to develop integrative bioinformatics tools and software applications useful and autonomously usable by translational scientists and clinical practitioners for analysing the huge amount of data and knowledge generated in healthcare and biomedical research in order to facilitate translational research and precision medicine. The MedBioinformatics Consortium is composed by 9 highly qualified and experienced European research institutions: PSMAR-IMIM, UCPH, EBI-EMBL, FIMM, UOXF, BMD, UPF, VHIO and Synapse. Contact person at FIMM: Professor Tero Aittokalliohttp://www.medbioinformatics.eu/

Hercules (2016-2021)


HERCULES is a collaboration project focused on finding solutions to drug resistance in high-grade serous ovarian cancer. In this project, samples from patients with high-grade serous ovarian cancer are studies. The samples are analysed using mass cytometry, sequencing and computational tools to find optimal biomarkers that would allow the identification of different cell populations from tissue samples. The use of single-cell sequencing for DNA and RNA allows for an unprecedented level of information to be gained from the tumour cell populations. Fresh patient samples and cell lines established from them will be used for examining the cancer cells’ response to anti-cancer drugs. The data from these experiments will be used to establish computational models and develop computational tools to predict the most effective drug combinations to kill the cell populations. The key results will be validated using existing high-grade serous ovarian cancer data together with fresh samples, old biobank samples and in vivo models. Based on the results, a prototype of a commercial test for predicting the best drug combinations to individual patients will be developed. University of Helsinki/Professor Sampsa Hautaniemi is the coordinator of the project. Contact persons at FIMM: Professor Tero Aittokallio and FIMM-EMBL Group Leader Krister Wennerberg. http://www.project-hercules.eu/


Seventh Framework Programme, Research Projects


CENTER-TBI 2013-2020


CENTER-TBI (Collaborative European Neuro Trauma Effectiveness Research in TBI) aims to improve the care for patients with Traumatic Brain Injury (TBI). It brings 38 leading organizations and forms part of the larger global initiative InTBIR: International Initiative for Traumatic Brain Injury. With support from the European Commission through FP7, CENTER-TBI will collect dataset from patients and use emerging technologies (biomarkers, genomics and advanced MR imaging) for better characterization of TBI and for Comparative Effectiveness Research (CER). The project will exploit the heterogeneity in biology, care, and outcome of TBI, to discover novel pathophysiology, refine disease characterization, and identify effective clinical interventions. FIMM participates in the Genomics work package which aims to identify genetic drivers of progression and recover in TBI and related clinical disease using existing and/or de novo genotype and sequence data. Largely FIMM contributes statistics and bioinformatics expertise for disease genetic association studies, imputation on large-scale genetic dataset and risk prediction. Contact persons at FIMM: Professors Samuli Ripatti and Aarno Palotie. https://www.center-tbi.eu/



Migraine, a common brain disorder, affects 15% of all European citizens including children, ranks among the WHO top 12 of most disabling and undertreated disorders, and is responsible for the highest socio-economic burden of any brain ailment in Europe. The EUROHEADPAIN: Mechanisms and Treatment of Migraine and its Chronification project aims to improve understanding of migraine attacks and their progression to chronic conditions, and to seek solutions for better diagnosis and treatment. The project involves 13 partners from eight European countries, Australia and the USA. FIMM leads the genetic analysis work package with aims to identify genetic risk factors and unravel molecular pathways for migraine pain using existing and new genotype datasets.  Through FIMM PI, Professor Aarno Palotie, EUROHEADPAIN together with the International Headache Genetic Consortium (IHGC), chaired by Professor Palotie, will build the largest genotype dataset of migraine samples world-wide. Contact persons at FIMM: Dr. Maija Wessman and Professor Aarno Palotie. http://www.euroheadpain.org/


PREDECT (2011—2016)

PREDECT is an IMI-funded partnership between nine academic, three SME and nine EU pharmaceutical company partners, developing advanced, complex in vitro and in vivo models for breast, prostate and lung cancers. Newly developed organotypic cell cultures, attempting to closely mimic in vivo tumours, will be investigated for their improved potential to validate therapeutic targets, applying molecular pathology and systems biology methods to compare the circuitry of resting and perturbed states. PREDECT has built a Europe-wide biobank of cancer model systems and a  web microscopy-based tissue microarray   data sharing system as a collaborative platform between academia and industry. FIMM/University of Helsinki is the academic coordinator of the project, which currently consists of around 60 researchers in around 27 laboratories. Contact persons at FIMM: Group Leader Emmy Verschuren (academic coordinator of PREDECT), Professor Olli Kallioniemi and Research Director Johan Lundin. http://www.predect.eu/



Last updated: 20.12.2016 - 09:43