Horizon 2020 Framework Programme, Research Projects
HERCULES is a collaboration project focused on finding solutions to drug resistance in high-grade serous ovarian cancer. In this project, samples from patients with high-grade serous ovarian cancer are studies. The samples are analysed using mass cytometry, sequencing and computational tools to find optimal biomarkers that would allow the identification of different cell populations from tissue samples. The use of single-cell sequencing for DNA and RNA allows for an unprecedented level of information to be gained from the tumour cell populations. Fresh patient samples and cell lines established from them will be used for examining the cancer cells’ response to anti-cancer drugs. The data from these experiments will be used to establish computational models and develop computational tools to predict the most effective drug combinations to kill the cell populations. The key results will be validated using existing high-grade serous ovarian cancer data together with fresh samples, old biobank samples and in vivo models. Based on the results, a prototype of a commercial test for predicting the best drug combinations to individual patients will be developed. University of Helsinki/Professor Sampsa Hautaniemi is the coordinator of the project.
Contact persons at FIMM: Professor Tero Aittokallio and FIMM-EMBL Group Leader Krister Wennerberg
More information: http://www.project-hercules.eu/