Location

FIMM publications 2014

Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells.

Mishel P, Bychkov D, Kallio-Kokko H, Valkonen M, Kantele A, Mattila P, Almusa H, Jalovaara P, Kainov D;

Genome Announc. 2014 Dec 24;2(6). pii: e01349-14. doi: 10.1128/genomeA.01349-14.

Read full article

No Evidence for Genofulme-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index : Results from Meta-Analyses of 80,607 Subjects.

Baumert J, Huang J, McKnight B, Sabater-Lleal M, Steri M, Chu AY, Trompet S, Lopez LM, Fornage M, Teumer A, Tang W, Rudnicka AR, Mälarstig A, Hottenga JJ, Kavousi M, Lahti J, Tanaka T, Hayward C, Huffman JE, Morange PE, Rose LM, Basu S, Rumley A, Stott DJ, Buckley BM, de Craen AJ, Sanna S, Masala M, Biffar R, Homuth G, Silveira A, Sennblad B, Goel A, Watkins H, Müller-Nurasyid M, Rückerl R, Taylor K, Chen MH, de Geus EJ, Hofman A, Witteman JC, de Maat MP, Palotie A, Davies G, Siscovick DS, Kolcic I, Wild SH, Song J, McArdle WL, Ford I, Sattar N, Schlessinger D, Grotevendt A, Franzosi MG, Illig T, Waldenberger M, Lumley T, Tofler GH, Willemsen G, Uitterlinden AG, Rivadeneira F, Räikkönen K, Chasman DI, Folsom AR, Lowe GD, Westendorp RG, Slagboom PE, Cucca F, Wallaschofski H, Strawbridge RJ, Seedorf U, Koenig W, Bis JC, Mukamal KJ, van Dongen J, Widen E, Franco OH, Starr JM, Liu K, Ferrucci L, Polasek O, Wilson JF, Oudot-Mellakh T, Campbell H, Navarro P, Bandinelli S, Eriksson J, Boomsma DI, Dehghan A, Clarke R, Hamsten A, Boerwinkle E, Jukema JW, Naitza S, Ridker PM, Völzke H, Deary IJ, Reiner AP, Trégouët DA, O'Donnell CJ, Strachan DP, Peters A, Smith NL.

PLoS One. 2014 Dec 31;9(12):e111156. doi: 10.1371/journal.pone.0111156. eCollection 2014. 

Read full article

No Evidence for Genome-Wide Interactions on Plasma Fibrinogen by Smoking, Alcohol Consumption and Body Mass Index: Results from Meta-Analyses of 80,607 Subjects

Baumert J, Huang J, McKnight B, Sabater-Lleal M, Steri M, Chu AY, Trompet S, Lopez LM, Fornage M, Teumer A, Tang W, Rudnicka AR, Mälarstig A, Hottenga JJ, Kavousi M, Lahti J, Tanaka T, Hayward C, Huffman JE, Morange PE, Rose LM, Basu S, Rumley A, Stott DJ, Buckley BM, de Craen AJ, Sanna S, Masala M, Biffar R, Homuth G, Silveira A, Sennblad B, Goel A, Watkins H, Müller-Nurasyid M, Rückerl R, Taylor K, Chen MH, de Geus EJ, Hofman A, Witteman JC, de Maat MP, Palotie A, Davies G, Siscovick DS, Kolcic I, Wild SH, Song J, McArdle WL, Ford I, Sattar N, Schlessinger D, Grotevendt A, Franzosi MG, Illig T, Waldenberger M, Lumley T, Tofler GH, Willemsen G, Uitterlinden AG, Rivadeneira F, Räikkönen K, Chasman DI, Folsom AR, Lowe GD, Westendorp RG, Slagboom PE, Cucca F, Wallaschofski H, Strawbridge RJ, Seedorf U, Koenig W, Bis JC, Mukamal KJ, van Dongen J, Widen E, Franco OH, Starr JM, Liu K, Ferrucci L, Polasek O, Wilson JF, Oudot-Mellakh T, Campbell H, Navarro P, Bandinelli S, Eriksson J, Boomsma DI, Dehghan A, Clarke R, Hamsten A, Boerwinkle E, Jukema JW, Naitza S, Ridker PM, Völzke H, Deary IJ, Reiner AP, Trégouët DA, O'Donnell CJ, Strachan DP, Peters A, Smith NL.

PLoS One. 2014 Dec 31;9(12):e111156. doi: 10.1371/journal.pone.0111156. eCollection 2014.

Read full article

Suppression of BRCA1 sensitizes cells to proteasome inhibitors.

Gu Y, Bouwman P, Greco D, Saarela J, Yadav B, Jonkers J, Kuznetsov SG;

Cell Death Dis. 2014 Dec 18;5:e1580. doi: 10.1038/cddis.2014.537.

Read full article

Molecular mechanisms of nasal epithelium in rhinitis and rhinosinusitis.

Toppila-Salmi S, van Drunen CM, Fokkens WJ, Golebski K, Mattila P, Joenvaara S, Renkonen J, Renkonen R;

Curr Allergy Asthma Rep. 2015 Feb;15(2):495. doi: 10.1007/s11882-014-0495-8.

Read full article

Bioluminescent Cell-Based NAD(P)/NAD(P)H Assays for Rapid Dinucleotide Measurement and Inhibitor Screening.

Vidugiriene J, Leippe D, Sobol M, Vidugiris G, Zhou W, Meisenheimer P, Gautam P, Wennerberg K, Cali JJ;

Assay Drug Dev Technol. 2014 Nov-Dec;12(9-10):514-26. doi: 10.1089/adt.2014.605.

Read full article

Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8(+) T-cell response, prominent infiltration of CD8(+) lymphocytes and Th1 type polarization.

Ranki, Tuuli; Joensuu, Timo; Jaeger, Elke; Karbach, Julia; Wahle, Claudia; Kairemo, Kalevi; Alanko, Tuomo; Partanen, Kaarina; Turkki, Riku; Linder, Nina; Lundin, Johan; Ristimaki, Ari; Kankainen, Matti; Hemminki, Akseli; Backman, Charlotta; Dienel, Kasper; von Euler, Mikael; Haavisto, Elina; Hakonen, Tiina; Juhila, Juuso; Jaderberg, Magnus; Priha, Petri; Vassilev, Lotta; Vuolanto, Antti; Pesonen, Sari.

OncoImmunology, Vol. 3, No. 10, 958937, 2014.

Read full article

KSHV Viral Cyclin Interferes with T-Cell Development and Induces Lymphoma through CDK6 and Notch Activation in vivo.

Pekkonen P, Järviluoma A, Zinovkina N, Cvrljevic A, Prakash S, Westermarck J, Evan GI, Cesarman E, Verschuren EW, Ojala PM;

Cell Cycle. 2014;13(23):3670-84. doi: 10.4161/15384101.2014.964118.

Read full article

Metabolic Signatures of Adiposity in Young Adults : Mendelian Randomization Analysis and Effects of Weight Change.

Würtz P, Wang Q, Kangas AJ, Richmond RC, Skarp J, Tiainen M, Tynkkynen T, Soininen P, Havulinna AS, Kaakinen M, Viikari JS, Savolainen MJ, Kähönen M, Lehtimäki T, Männistö S, Blankenberg S, Zeller T, Laitinen J, Pouta A, Mäntyselkä P, Vanhala M, Elliott P, Pietiläinen KH, Ripatti S, Salomaa V, Raitakari OT, Järvelin MR, Smith GD, Ala-Korpela M.

PLoS Med. 2014 Dec 9;11(12):e1001765. doi: 10.1371/journal.pmed.1001765. eCollection 2014 Dec. 

Read full article

Comparative genomics of Lactobacillus crispatus suggests novel mechanisms for the competitive exclusion of Gardnerella vaginalis.

Ojala T, Kankainen M, Castro J, Cerca N, Edelman S, Westerlund-Wikström B, Paulin L, Holm L, Auvinen P.

BMC Genomics. 2014 Dec 5;15:1070. doi: 10.1186/1471-2164-15-1070.

Read full article

Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers

Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, Åsvold BO, Gabrielsen ME, Campbell A, Marioni R, Kumari M, Hällfors J, Männistö S, Marques-Vidal P, Kaakinen M, Cavadino A, Postmus I, Husemoen LL, Skaaby T, Ahluwalia TS, Treur JL, Willemsen G, Dale C, Wannamethee SG, Lahti J, Palotie A, Räikkönen K, Kisialiou A, McConnachie A, Padmanabhan S, Wong A, Dalgård C, Paternoster L, Ben-Shlomo Y, Tyrrell J, Horwood J, Fergusson DM, Kennedy MA, Frayling T, Nohr EA, Christiansen L, Ohm Kyvik K, Kuh D, Watt G, Eriksson J, Whincup PH, Vink JM, Boomsma DI, Davey Smith G, Lawlor D, Linneberg A, Ford I, Jukema JW, Power C, Hyppönen E, Jarvelin MR, Preisig M, Borodulin K, Kaprio J, Kivimaki M, Smith BH, Hayward C, Romundstad PR, Sørensen TI, Munafò MR, Sattar N.

PLoS Genet. 2014 Dec 4;10(12):e1004799. doi: 10.1371/journal.pgen.1004799. eCollection 2014 Dec.

Read full article

International Network of Twin Registries (INTR) : Building a Platform for International Collaboration.

Buchwald D, Kaprio J, Hopper JL, Sung J, Goldberg J, Fortier I, Busjhan A, Sumathipala A, Cozen W, Mack T, Craig JM, Harris JR.

Twin Res Hum Genet. 2014 Dec;17(6):574-7. doi: 10.1017/thg.2014.67.

Read full article

International Network of Twin Registries (INTR): Building a Platform for International Collaboration

Buchwald D, Kaprio J, Hopper JL, Sung J, Goldberg J, Fortier I, Busjhan A, Sumathipala A, Cozen W, Mack T, Craig JM, Harris JR.

Twin Res Hum Genet. 2014 Dec;17(6):574-7. doi: 10.1017/thg.2014.67.

Read full article

DataSHIELD: taking the analysis to the data, not the data to the analysis

Gaye A, Marcon Y, Isaeva J, LaFlamme P, Turner A, Jones EM, Minion J, Boyd AW, Newby CJ, Nuotio ML, Wilson R, Butters O, Murtagh B, Demir I, Doiron D, Giepmans L, Wallace SE, Budin-Ljøsne I, Oliver Schmidt C, Boffetta P, Boniol M, Bota M, Carter KW, deKlerk N, Dibben C, Francis RW, Hiekkalinna T, Hveem K, Kvaløy K, Millar S, Perry IJ, Peters A, Phillips CM, Popham F, Raab G, Reischl E, Sheehan N, Waldenberger M, Perola M, van den Heuvel E, Macleod J, Knoppers BM, Stolk RP, Fortier I, Harris JR, Woffenbuttel BH, Murtagh MJ, Ferretti V, Burton PR.

Int J Epidemiol. 2014 Dec;43(6):1929-44. doi: 10.1093/ije/dyu188. Epub 2014 Sep 26.

Read full article

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support

Boutter J, Huang Y, Marovca B, Vonderheit A, Grotzer MA, Eckert C, Cario G, Wollscheid B, Horvath P, Bornhauser BC, Bourquin JP.

Oncotarget. 2014 Nov 30;5(22):11501-12.

Read full article

Circulating miR-21, miR-146a and Fas ligand respond to postmenopausal estrogen-based hormone replacement therapy - A study with monozygotic twin pairs.

Kangas R, Pöllänen E, Rippo MR, Lanzarini C, Prattichizzo F, Niskala P, Jylhävä J, Sipilä S, Kaprio J, Procopio AD, Capri M, Franceschi C, Olivieri F, Kovanen V.

Mech Ageing Dev. 2014 Dec 15;143-144:1-8. doi: 10.1016/j.mad.2014.11.001. Epub 2014 Nov 28.

Read full article

BBMRI-ERIC as a resource for pharmaceutical and life science industries: the development of biobank-based Expert Centres.

van Ommen GJ, Törnwall O, Bréchot C, Dagher G, Galli J, Hveem K, Landegren U, Luchinat C, Metspalu A, Nilsson C, Solesvik OV, Perola M, Litton JE, Zatloukal K.

Eur J Hum Genet. 2014 Nov 19. doi: 10.1038/ejhg.2014.235. [Epub ahead of print]

Read full article

Role of ultrasensitive prostate-specific antigen in the follow-up of prostate cancer after radical prostatectomy

Seikkula H, Syvänen KT, Kurki S, Mirtti T, Taimen P, Laato M, Boström PJ.

Urol Oncol. 2014 Nov 18. pii: S1078-1439(14)00353-6. doi: 10.1016/j.urolonc.2014.10.010. [Epub ahead of print]

Read full article

Regularized Machine Learning in the Genetic Prediction of Complex Traits.

Okser S, Pahikkala T, Airola A, Salakoski T, Ripatti S, Aittokallio T;

PLoS Genet. 2014 Nov 13;10(11):e1004754. doi: 10.1371/journal.pgen.1004754. eCollection 2014

Read full article

Synaptic, transcriptional and chromatin genes disrupted in autism

De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Ercument Cicek A, Kou Y, Liu L, Fromer M, Walker S, Singh T, Klei L, Kosmicki J, Fu SC, Aleksic B, Biscaldi M, Bolton PF, Brownfeld JM, Cai J, Campbell NG, Carracedo A, Chahrour MH, Chiocchetti AG,

Nature. 2014 Nov 13;515(7526):209-15. doi: 10.1038/nature13772. Epub 2014 Oct 29.

Read full article

Quantitative profiling of bile acids in blood, adipose tissue, intestine, and gall bladder samples using ultra high performance liquid chromatography-tandem mass spectrometry

Jäntti SE, Kivilompolo M, Ohrnberg L, Pietiläinen KH, Nygren H, Orešič M, Hyötyläinen T.

Anal Bioanal Chem. 2014 Dec;406(30):7799-815. doi: 10.1007/s00216-014-8230-9. Epub 2014 Nov 12.

Read full article

Extendable blocking probe in reverse transcription for analysis of RNA variants with superior selectivity.

Ho TH, Dang KX, Lintula S, Hotakainen K, Feng L, Olkkonen VM, Verschuren EW, Tenkanen T, Haglund C, Kolho KL, Stenman UH, Stenman J;

Nucleic Acids Res 2014 Nov 5. pii: gku1048. [Epub ahead of print]

Read full article

Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases.

Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium.

Am J Hum Genet. 2014 Nov 6;95(5):535-52. doi: 10.1016/j.ajhg.2014.10.004. Epub 2014 Nov 6.

Read full article

Students' performance during practical examination on whole slide images using view path tracking.

Walkowski S, Lundin M, Szymas J, Lundin J;

Diagn Pathol. 2014 Oct 30;9(1):208. [Epub ahead of print]

Read full article

Androgen receptor interacting protein HSPBAP1 facilitates growth of prostate cancer cells in androgen-deficient conditions.

Saeed K, Ostling P, Björkman M, Mirtti T, Alanen K, Vesterinen T, Sankila A, Lundin J, Lundin M, Rannikko A, Nordling S, Mpindi JP, Kohonen P, Iljin K, Kallioniemi O, Rantala JK;

Int J Cancer. 2014 Oct 30. doi: 10.1002/ijc.29303. [Epub ahead of print]

Read full article

Exploring Viewing Behavior Data from Whole Slide Images to Predict Correctness of Students' Answers during Practical Exams in Oral Pathology.

Walkowski S, Lundin M, Szymas J, Lundin J.

Anal Cell Pathol (Amst). 2014;2014:706470. doi: 10.1155/2014/706470. Epub 2014 Nov 26.

Read full article

Factors Associated with Recovery from Anorexia Nervosa : A Population-Based Study.

Keski-Rahkonen A, Raevuori A, Bulik CM, Hoek HW, Rissanen A, Kaprio J.

Int J Eat Disord. 2014 Mar;47(2):117-23. doi: 10.1002/eat.22168. Epub 2013 Oct 30.

Read full article

Allele-specific regulation of DISC1 expression by miR-135b-5p

Rossi M, Kilpinen H, Muona M, Surakka I, Ingle C, Lahtinen J, Hennah W, Ripatti S, Hovatta I.

Eur J Hum Genet. 2014 Jun;22(6):840-3. doi: 10.1038/ejhg.2013.246. Epub 2013 Oct 30.

Read full article

Synaptic, transcriptional and chromatin genes disrupted in autism

De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Cicek AE, Kou Y, Liu L, Fromer M, Walker S, Singh T, Klei L, Kosmicki J, Shih-Chen F, Aleksic B, Biscaldi M, Bolton PF, Brownfeld JM, Cai J, Campbell NG, Carracedo A, Chahrour MH, Chiocchetti AG, Coon H, Crawford EL, Curran SR, Dawson G, Duketis E, Fernandez BA, Gallagher L, Geller E, Guter SJ, Hill RS, Ionita-Laza J, Jimenz Gonzalez P, Kilpinen H, Klauck SM, Kolevzon A, Lee I, Lei I, Lei J, Lehtimäki T, Lin CF, Ma'ayan A, Marshall CR, McInnes AL, Neale B, Owen MJ, Ozaki N, Parellada M, Parr JR, Purcell S, Puura K, Rajagopalan D, Rehnström K, Reichenberg A, Sabo A, Sachse M, Sanders SJ, Schafer C, Schulte-Rüther M, Skuse D, Stevens C, Szatmari P, Tammimies K, Valladares O, Voran A, Li-San W, Weiss LA, Willsey AJ, Yu TW, Yuen RK; DDD Study; Homozygosity Mapping Collaborative for Autism; UK10K Consortium, Cook EH, Freitag CM, Gill M, Hultman CM, Lehner T, Palotie A, Schellenberg GD, Sklar P, State MW, Sutcliffe JS, Walsh CA, Scherer SW, Zwick ME, Barett JC, Cutler DJ, Roeder K, Devlin B, Daly MJ, Buxbaum JD.

Nature. 2014 Nov 13;515(7526):209-15. doi: 10.1038/nature13772. Epub 2014 Oct 29.

Read full article

A former career as a male elite athlete-does it protect against type 2 diabetes in later life?

Laine MK, Eriksson JG, Kujala UM, Wasenius NS, Kaprio J, Bäckmand HM, Peltonen M, Mertsalmi TH, Sarna S

Diabetologia. 2014 Feb;57(2):270-4. doi: 10.1007/s00125-013-3105-8. Epub 2013 Nov 21. PubMed PMID: 24257894.

Read full article

Fatty fish consumption and risk of latent autoimmune diabetes in adults.

Löfvenborg JE, Andersson T, Carlsson PO, Dorkhan M, Groop L, Martinell M, Tuomi T, Wolk A, Carlsson S.

Nutr Diabetes. 2014 Oct 20;4:e139. doi: 10.1038/nutd.2014.36.

Read full article

The Challenges of Genome-Wide Interaction Studies : Lessons to Learn from the Analysis of HDL Blood Levels

van Leeuwen EM, Smouter FA, Kam-Thong T, Karbalai N, Smith AV, Harris TB, Launer LJ, Sitlani CM, Li G, Brody JA, Bis JC, White CC, Jaiswal A, Oostra BA, Hofman A, Rivadeneira F, Uitterlinden AG, Boerwinkle E, Ballantyne CM, Gudnason V, Psaty BM, Cupples LA, Järvelin MR, Ripatti S, Isaacs A, Müller-Myhsok B, Karssen LC, van Duijn CM

PLoS One. 2014 Oct 20;9(10):e109290. doi: 10.1371/journal.pone.0109290. eCollection 2014.

Read full article

Long-term consistency of diurnal-type preferences among men.

Broms U, Pitkäniemi J, Bäckmand H, Heikkilä K, Koskenvuo M, Peltonen M, Sarna S, Vartiainen E, Kaprio J, Partonen T.

Chronobiol Int. 2014 Mar;31(2):182-8. doi: 10.3109/07420528.2013.836534. Epub 2013 Oct 16.

Read full article

A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity

Lim ET, Liu YP, Chan Y, Tiinamaija T, Käräjämäki A, Madsen E; Go-T2D Consortium, Altshuler DM, Raychaudhuri S, Groop L, Flannick J, Hirschhorn JN, Katsanis N, Daly MJ

Am J Hum Genet. 2014 Nov 6;95(5):509-20. Epub 2014 Oct 16.

Read full article

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis : the CARTA consortium.

Taylor AE, Fluharty ME, Bjørngaard JH, Gabrielsen ME, Skorpen F, Marioni RE, Campbell A, Engmann J, Mirza SS, Loukola A, Laatikainen T, Partonen T, Kaakinen M, Ducci F, Cavadino A, Husemoen LL, Ahluwalia TS, Jacobsen RK, Skaaby T, Ebstrup JF, Mortensen EL, Minica CC, Vink JM, Willemsen G, Marques-Vidal P, Dale CE, Amuzu A, Lennon LT, Lahti J, Palotie A, Räikkönen K, Wong A, Paternoster L, Wong AP, Horwood LJ, Murphy M, Johnstone EC, Kennedy MA, Pausova Z, Paus T, Ben-Shlomo Y, Nohr EA, Kuh D, Kivimaki M, Eriksson JG, Morris RW, Casas JP, Preisig M, Boomsma DI, Linneberg A, Power C, Hyppönen E, Veijola J, Jarvelin MR, Korhonen T, Tiemeier H, Kumari M, Porteous DJ, Hayward C, Romundstad PR, Smith GD, Munafò MR.

BMJ Open. 2014 Oct 7;4(10):e006141. doi: 10.1136/bmjopen-2014-006141. 

Read full article

Defining the role of common variation in the genomic and biological architecture of adult human height.

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC, Scherag A, Vinkhuyzen AA, Westra HJ, Winkler TW, Workalemahu T, Zhao JH, Absher D, Albrecht E, Anderson D, Baron J, Beekman M, Demirkan A, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Fraser RM, Goel A, Gong J, Justice AE, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Lui JC, Mangino M, Mateo Leach I, Medina-Gomez C, Nalls MA, Nyholt DR, Palmer CD, Pasko D, Pechlivanis S, Prokopenko I, Ried JS, Ripke S, Shungin D, Stancáková A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Afzal U, Arnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Bolton JL, Böttcher Y, Boyd HA, Bruinenberg M, Buckley BM, Buyske S, Caspersen IH, Chines PS, Clarke R, Claudi-Boehm S, Cooper M, Daw EW, De Jong PA, Deelen J, Delgado G, Denny JC, Dhonukshe-Rutten R, Dimitriou M, Doney AS, Dörr M, Eklund N, Eury E, Folkersen L, Garcia ME, Geller F, Giedraitis V, Go AS, Grallert H, Grammer TB, Gräßler J, Grönberg H, de Groot LC, Groves CJ, Haessler J, Hall P, Haller T, Hallmans G, Hannemann A, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hemani G, Henders AK, Hillege HL, Hlatky MA, Hoffmann W, Hoffmann P, Holmen O, Houwing-Duistermaat JJ, Illig T, Isaacs A, James AL, Jeff J, Johansen B, Johansson Å, Jolley J, Juliusdottir T, Junttila J, Kho AN, Kinnunen L, Klopp N, Kocher T, Kratzer W, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Lu Y, Lyssenko V, Magnusson PK, Mahajan A, Maillard M, McArdle WL, McKenzie CA, McLachlan S, McLaren PJ, Menni C, Merger S, Milani L, Moayyeri A, Monda KL, Morken MA, Müller G, Müller-Nurasyid M, Musk AW, Narisu N, Nauck M, Nolte IM, Nöthen MM, Oozageer L, Pilz S, Rayner NW, Renstrom F, Robertson NR, Rose LM, Roussel R, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Schunkert H, Scott RA, Sehmi J, Seufferlein T, Shi J, Silventoinen K, Smit JH, Smith AV, Smolonska J, Stanton AV, Stirrups K, Stott DJ, Stringham HM, Sundström J, Swertz MA, Syvänen AC, Tayo BO, Thorleifsson G, Tyrer JP, van Dijk S, van Schoor NM, van der Velde N, van Heemst D, van Oort FV, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Waldenberger M, Wennauer R, Wilkens LR

Nat Genet. 2014 Nov;46(11):1173-86. doi: 10.1038/ng.3097. Epub 2014 Oct 5.

Read full article

Genetic Instability of Influenza pH1N1 Viruses.

Jalovaara P, Bychkov D, Ahtiainen L, Kallio-Kokko H, Valkonen M, Kantele A, Mattila P, Almusa H, Kallioniemi O, Kainov D;

Genome Announc. 2014 Oct 2;2(5). pii: e00841-14. doi: 10.1128/genomeA.00841-14.

Read full article

Small Molecule BMH-Compounds That Inhibit RNA Polymerase I and Cause Nucleolar Stress

Peltonen K, Colis L, Liu H, Jäämaa S, Zhang Z, Af Hällström T, Moore HM, Sirajuddin P, Laiho M.

Mol Cancer Ther. 2014 Nov;13(11):2537-46. doi:10.1158/1535-7163.MCT-14-0256. Epub 2014 Oct 2.

Read full article

De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies.

EuroEPINOMICS-RES Consortium. Electronic address: euroepinomics-RES@ua.ac.be, Epilepsy Phenome/Genome Project, Epi4K Consortium, EuroEPINOMICS-RES Consortium, Epilepsy Phenome/Genome Project, Epi4K Consortium;

Am J Hum Genet. 2014 Oct 2;95(4):360-70. doi: 10.1016/j.ajhg.2014.08.013. Epub 2014 Sep 25.

Read full article

Reappraisal of known malaria resistance loci in a large multicenter study

Malaria Genomic Epidemiology Network; Malaria Genomic Epidemiology Network, Rockett, Kirk A.; Clarke, Geraldine M.; Fitzpatrick, Kathryn; Hubbart, Christina; Jeffreys, Anna E.; Rowlands, Kate; Craik, Rachel; Jallow, Muminatou; Conway, David J.; Bojang, Kalifa A.; Pinder, Margaret; Usen, Stanley; Sisay-Joof, Fatoumatta; Sirugo, Giorgio; Toure, Ousmane; Thera, Mahamadou A.; Konate, Salimata; Sissoko, Sibiry; Niangaly, Amadou; Poudiougou, Belco; Mangano, Valentina D.; Bougouma, Edith C.; Sirima, Sodiomon B.; Modiano, David; Amenga-Etego, Lucas N.; Ghansah, Anita; Koram, Kwadwo A.; Wilson, Michael D.; Enimil, Anthony; Evans, Jennifer; Amodu, Olukemi; Olaniyan, Subulade; Apinjoh, Tobias; Mugri, Regina; Ndi, Andre; Ndila, Carolyne M.; Uyoga, Sophie; Macharia, Alexander; Peshu, Norbert; Williams, Thomas N.; Manjurano, Alphaxard; Riley, Eleanor; Drakeley, Chris; Reyburn, Hugh; Nyirongo, Vysaul; Kachala, David; Molyneux, Malcolm; Dunstan, Sarah J.; Phu, Nguyen Hoan; Quyen, Nguyen Thi Ngoc; Thai, Cao Quang; Hien, Tran Tinh; Manning, Laurens; Laman, Moses; Siba, Peter; Karunajeewa, Harin; Allen, Steve; Allen, Angela; Davis, Timothy M. E.; Michon, Pascal; Mueller, Ivo; Green, Angie; Molloy, Sile; Johnson, Kimberly J.; Kerasidou, Angeliki; Cornelius, Victoria; Hart, Lee; Vanderwal, Aaron; SanJoaquin, Miguel; Band, Gavin; Le, Si Quang; Pirinen, Matti; Sepulveda, Nuno; Spencer, Chris C. A.; Clark, Taane G.; Agbenyega, Tsiri; Achidi, Eric; Doumbo, Ogobara; Farrar, Jeremy; Marsh, Kevin; Taylor, Terrie; Kwiatkowski, Dominic P.; Netwo,

Nat Genet. 2014 Nov;46(11):1197-204. doi: 10.1038/ng.3107. Epub 2014 Sep 28.

Read full article

Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7.

Foroud T, Lai D, Koller D, Van't Hof F, Kurki MI, Anderson CS, Brown RD Jr, Connolly ES, Eriksson JG, Flaherty M, Fornage M, von Und Zu Fraunberg M, Gaál EI, Laakso A, Hernesniemi J, Huston J, Jääskeläinen JE, Kiemeney LA, Kivisaari R, Kleindorfer D, Ko N, Lehto H, Mackey J, Meissner I, Moomaw CJ, Mosley TH, Moskala M, Niemelä M, Palotie A, Pera J, Rinkel G, Ripke S, Rouleau G, Ruigrok Y, Sauerbeck L, Słowik A, Vermeulen SH, Woo D, Worrall BB, Broderick J; Familial Intracranial Aneurysm Study Investigators.

Stroke. 2014 Nov;45(11):3194-9. doi: 10.1161/STROKEAHA.114.006096. Epub 2014 Sep 25. 

Read full article

How much oxycodone is needed for adequate analgesia after breast cancer surgery: Effect of the OPRM1 118A>G polymorphism.

Cajanus K, Kaunisto MA, Tallgren M, Jokela R, Kalso E;

J Pain. 2014 Sep 16. pii: S1526-5900(14)00911-0. doi: 10.1016/j.jpain.2014.09.002. [Epub ahead of print]

Read full article

Neolithic dairy farming at the extreme of agriculture in northern Europe.

Cramp LJ, Evershed RP, Lavento M, Halinen P, Mannermaa K, Oinonen M, Kettunen J, Perola M, Onkamo P, Heyd V.

Proc Biol Sci. 2014 Sep 22;281(1791):20140819. doi: 10.1098/rspb.2014.0819.

Read full article

Statistical detection of quantitative protein biomarkers provides insights into signaling networks de-regulated in acute myeloid leukemia.

Elo LL, Karjalainen R, Ohman T, Hintsanen P, Nyman TA, Heckman CA, Aittokallio T;

Proteomics. 2014 Sep 11. doi: 10.1002/pmic.201300460. [Epub ahead of print]

Read full article

A Gain-of-Function Mutation of the SCN5A Gene Causes Exercise-Induced Polymorphic Ventricular Arrhythmias.

Swan H, Amarouch MY, Leinonen J, Marjamaa A, Kucera JP, Laitinen-Forsblom PJ, Lahtinen AM, Palotie A, Kontula K, Toivonen L, Abriel H, Widen E;

Circ Cardiovasc Genet. 2014 Sep 10. pii: CIRCGENETICS.114.000703. [Epub ahead of print]

Read full article

Mutation Update: The Spectra of Nebulin Variants and Associated Myopathies.

Lehtokari VL, Kiiski K, Sandaradura SA, Laporte J, Repo P, Frey JA, Donner K, Marttila M, Saunders C, Barth PG, den Dunnen JT, Beggs A, Clarke NF, North KN, Laing NG, Romero NB, Winder TL, Pelin K, Wallgren-Pettersson C;

Hum Mutat. 2014 Sep 10. doi: 10.1002/humu.22693. [Epub ahead of print]

Read full article

The Host Nonsense-Mediated mRNA Decay Pathway Restricts Mammalian RNA Virus Replication

Balistreri G, Horvath P, Schweingruber C, Zünd D, McInerney G, Merits A, Mühlemann O, Azzalin C, Helenius A.

Cell Host Microbe. 2014 Sep 10;16(3):403-11. doi: 10.1016/j.chom.2014.08.007.

Read full article

Three-dimensional models of cancer for pharmacology and cancer cell biology : Capturing tumor complexity in vitro/ex vivo

Hickman JA, Graeser R, de Hoogt R, Vidic S, Brito C, Gutekunst M, van der Kuip H; IMI PREDECT Consortium

Biotechnol J. 2014 Sep;9(9):1115-28. doi: 10.1002/biot.201300492. Review.

Read full article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium; Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium; Mexican American Type 2 Diabetes (MAT2D) Consortium; Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium, Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abecasis GR, Adair LS, Almgren P, Atalay M, Aung T, Baldassarre D, Balkau B, Bao Y, Barnett AH, Barroso I, Basit A, Been LF, Beilby J, Bell GI, Benediktsson R, Bergman RN, Boehm BO, Boerwinkle E, Bonnycastle LL, Burtt N, Cai Q, Campbell H, Carey J, Cauchi S, Caulfield M, Chan JC, Chang LC, Chang TJ, Chang YC, Charpentier G, Chen CH, Chen H, Chen YT, Chia KS, Chidambaram M, Chines PS, Cho NH, Cho YM, Chuang LM, Collins FS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Danesh J, Das D, de Faire U, Dedoussis G, Deloukas P, Dimas AS, Dina C, Doney AS, Donnelly PJ, Dorkhan M, van Duijn C, Dupuis J, Edkins S, Elliott P, Emilsson V, Erbel R, Eriksson JG, Escobedo J, Esko T, Eury E, Florez JC, Fontanillas P, Forouhi NG, Forsen T, Fox C, Fraser RM, Frayling TM, Froguel P, Frossard P, Gao Y, Gertow K, Gieger C, Gigante B, Grallert H, Grant GB, Grrop LC, Groves CJ, Grundberg E, Guiducci C, Hamsten A, Han BG, Hara K, Hassanali N, Hattersley AT, Hayward C, Hedman AK, Herder C, Hofman A, Holmen OL, Hovingh K, Hreidarsson AB, Hu C, Hu FB, Hui J, Humphries SE, Hunt SE, Hunter DJ, Hveem K, Hydrie ZI, Ikegami H, Illig T, Ingelsson E, Islam M, Isomaa B, Jackson AU, Jafar T, James A, Jia W, Jöckel KH, Jonsson A, Jowett JB, Kadowaki T, Kang HM, Kanoni S, Kao WH, Kathiresan S, Kato N, Katulanda P, Keinanen-Kiukaanniemi KM, Kelly AM, Khan H, Khaw KT, Khor CC, Kim HL, Kim S, Kim YJ, Kinnunen L, Klopp N, Kong A, Korpi-Hyövälti E, Kowlessur S, Kraft P, Kravic J, Kristensen MM, Krithika S, Kumar A, Kumate J, Kuusisto J, Kwak SH, Laakso M, Lagou V, Lakka TA, Langenberg C, Langford C, Lawrence R, Leander K, Lee JM, Lee NR, Li M, Li X, Li Y, Liang J, Liju S, Lim WY, Lind L, Lindgren CM, Lindholm E, Liu CT, Liu JJ, Lobbens S, Long J, Loos RJ, Lu W, Luan J, Lyssenko V, Ma RC, Maeda S, Mägi R, Männisto S, Matthews DR, Meigs JB, Melander O, Metspalu A, Meyer J, Mirza G, Mihailov E, Moebus S, Mohan V, Mohlke KL, Morris AD, Mühleisen TW, Müller-Nurasyid M, Musk B, Nakamura J, Nakashima E, Navarro P,

Nat Genet. 2014 Mar;46(3):234-44. doi: 10.1038/ng.2897. Epub 2014 Feb 9. 

Read full article

Cohort Profile: The National Academy of Sciences-National Research Council Twin Registry (NAS-NRC Twin Registry)

Gatz M, Harris JR, Kaprio J, McGue M, Smith NL, Snieder H, Spiro A 3rd, Butler DA; for the Institute of Medicine Committee on Twins Studies.

Int J Epidemiol. 2014 Sep 1. pii: dyu181. [Epub ahead of print]

Read full article

Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis.

Khan SA, Virtanen S, Kallioniemi OP, Wennerberg K, Poso A, Kaski S;

Bioinformatics. 2014 Sep 1;30(17):i497-i504. doi: 10.1093/bioinformatics/btu456.

Read full article

GLP-1 Responses Are Heritable and Blunted in Acquired Obesity With High Liver Fat and Insulin Resistance.

Matikainen N, Bogl LH, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Holst JJ, Pietiläinen KH.

Diabetes Care. 2014;37(1):242-51. doi: 10.2337/dc13-1283. Epub 2013 Aug 29.

Read full article

A Malaria Diagnostic Tool Based on Computer Vision Screening and Visualization of Plasmodium falciparum Candidate Areas in Digitized Blood Smears.

Linder N, Turkki R, Walliander M, Mårtensson A, Diwan V, Rahtu E, Pietikäinen M, Lundin M, Lundin J;

PLoS One. 2014 Aug 21;9(8):e104855. doi: 10.1371/journal.pone.0104855. eCollection 2014.

Read full article

A metabolic view on menopause and ageing.

Auro K, Joensuu A, Fischer K, Kettunen J, Salo P, Mattsson H, Niironen M, Kaprio J, Eriksson JG, Lehtimäki T, Raitakari O, Jula A, Tiitinen A, Jauhiainen M, Soininen P, Kangas AJ, Kähönen M, Havulinna AS, Ala-Korpela M, Salomaa V, Metspalu A, Perola M.

Nat Commun. 2014 Aug 21;5:4708. doi: 10.1038/ncomms5708.

Read full article

Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions.

Huhtinen K, Saloniemi-Heinonen T, Keski-Rahkonen P, Desai R, Laajala D, Ståhle M, Häkkinen MR, Awosanya M, Suvitie P, Kujari H, Aittokallio T, Handelsman DJ, Auriola S, Perheentupa A, Poutanen M;

J Clin Endocrinol Metab. 2014 Aug 19:jc20141913. [Epub ahead of print]

Read full article

Mobility limitation and changes in personal goals among older women.

Saajanaho M, Viljanen A, Read S, Eronen J, Kaprio J, Jylhä M, Rantanen T.

J Gerontol B Psychol Sci Soc Sci. 2014 Aug 14. pii: gbu094. [Epub ahead of print] 

Read full article

Low-Expression Variant of Fatty Acid-Binding Protein 4 Favors Reduced Manifestations of Atherosclerotic Disease and Increased Plaque Stability.

Saksi J, Ijäs P, Mäyränpää MI, Nuotio K, Isoviita PM, Tuimala J, Lehtonen-Smeds E, Kaste M, Jula A, Sinisalo J, Nieminen MS, Lokki ML, Perola M, Havulinna AS, Salomaa V, Kettunen J, Jauhiainen M, Kovanen PT, Lindsberg PJ.

Circ Cardiovasc Genet. 2014 Oct;7(5):588-98. doi: 10.1161/CIRCGENETICS.113.000499. Epub 2014 Aug 13.

Read full article

Genome-wide association study of sleep duration in the Finnish population.

Ollila HM, Kettunen J, Pietiläinen O, Aho V, Silander K, Kronholm E, Perola M, Lahti J, Räikkönen K, Widen E, Palotie A, Eriksson JG, Partonen T, Kaprio J, Salomaa V, Raitakari O, Lehtimäki T, Sallinen M, Härmä M, Porkka-Heiskanen T, Paunio T;

J Sleep Res. 2014 Aug 11. doi: 10.1111/jsr.12175. [Epub ahead of print]

Read full article

Ovarian endometriosis signatures established through discovery and directed mass spectrometry analysis.

Vehmas AP, Muth-Pawlak D, Huhtinen K, Saloniemi-Heinonen T, Jaakkola K, Laajala TD, Kaprio H, Suvitie PA, Aittokallio T, Siitari H, Perheentupa A, Poutanen M, Corthals GL;

J Proteome Res. 2014 Aug 6. [Epub ahead of print]

Read full article

FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals.

Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renström F, Lin X, Ängquist LH, Huang J, Liu Z, Li Y, Asif Ali M, Xu M, Ahluwalia TS, Boer JM, Chen P, Daimon M, Eriksson J, Perola M, Friedlander Y, Gao YT, Heppe DH, Holloway JW, Houston DK, Kanoni S, Kim YM, Laaksonen MA, Jääskeläinen T, Lee NR, Lehtimäki T, Lemaitre RN, Lu W, Luben RN, Manichaikul A, Männistö S, Marques-Vidal P, Monda KL, Ngwa JS, Perusse L, van Rooij FJ, Xiang YB, Wen W, Wojczynski MK, Zhu J, Borecki IB, Bouchard C, Cai Q, Cooper C, Dedoussis GV, Deloukas P, Ferrucci L, Forouhi NG, Hansen T, Christiansen L, Hofman A, Johansson I, Jørgensen T, Karasawa S, Khaw KT, Kim MK, Kristiansson K, Li H, Lin X, Liu Y, Lohman KK, Long J, Mikkilä V, Mozaffarian D, North K, Pedersen O, Raitakari O, Rissanen H, Tuomilehto J, van der Schouw YT, Uitterlinden AG, Zillikens MC, Franco OH, Shyong Tai E, Ou Shu X, Siscovick DS, Toft U, Verschuren WM, Vollenweider P, Wareham NJ, Witteman JC, Zheng W, Ridker PM, Kang JH, Liang L, Jensen MK, Curhan GC, Pasquale LR, Hunter DJ, Mohlke KL, Uusitupa M, Cupples LA, Rankinen T, Orho-Melander M, Wang T, Chasman DI, Franks PW, Sørensen TI, Hu FB, Loos RJ, Nettleton JA, Qi L.

Hum Mol Genet. 2014 Dec 20;23(25):6961-72. doi: 10.1093/hmg/ddu411. Epub 2014 Aug 7.

Read full article

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ, Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL, Wagenknecht L, Yang L, Snively BM, Palmer ND, Mudgal P, Langefeld CD, Keene KL, Freedman BI, Mychaleckyj JC, Nayak U, Raffel LJ, Goodarzi MO, Chen YD, Taylor HA Jr, Correa A, Sims M, Couper D, Pankow JS, Boerwinkle E, Adeyemo A, Doumatey A, Chen G, Mathias RA, Vaidya D, Singleton AB, Zonderman AB, Igo RP Jr, Sedor JR; FIND Consortium, Kabagambe EK, Siscovick DS, McKnight B, Rice K, Liu Y, Hsueh WC, Zhao W, Bielak LF, Kraja A, Province MA, Bottinger EP, Gottesman O, Cai Q, Zheng W, Blot WJ, Lowe WL, Pacheco JA, Crawford DC; eMERGE Consortium; DIAGRAM Consortium, Grundberg E; MuTHER Consortium, Rich SS, Hayes MG, Shu XO, Loos RJ, Borecki IB, Peyser PA, Cummings SR, Psaty BM, Fornage M, Iyengar SK, Evans MK, Becker DM, Kao WH, Wilson JG, Rotter JI, Sale MM, Liu S, Rotimi CN, Bowden DW; MEta-analysis of type 2 DIabetes in African Americans Consortium.

PLoS Genet. 2014 Aug 7;10(8):e1004517. doi: 10.1371/journal.pgen.1004517. eCollection 2014 Aug.

Read full article

A framework for the interpretation of de novo mutation in human disease

Samocha KE, Robinson EB, Sanders SJ, Stevens C, Sabo A, McGrath LM, Kosmicki JA, Rehnström K, Mallick S, Kirby A, Wall DP, MacArthur DG, Gabriel SB, DePristo M, Purcell SM, Palotie A, Boerwinkle E, Buxbaum JD, Cook EH Jr, Gibbs RA, Schellenberg GD, Sutcliffe JS, Devlin B, Roeder K, Neale BM, Daly MJ

Nat Genet. 2014 Sep;46(9):944-50. doi: 10.1038/ng.3050. Epub 2014 Aug 3. PubMed PMID: 25086666; PubMed Central PMCID: PMC4222185.

Read full article

A framework for the interpretation of de novo mutation in human disease.

Samocha KE, Robinson EB, Sanders SJ, Stevens C, Sabo A, McGrath LM, Kosmicki JA, Rehnström K, Mallick S, Kirby A, Wall DP, MacArthur DG, Gabriel SB, DePristo M, Purcell SM, Palotie A, Boerwinkle E, Buxbaum JD, Cook EH Jr, Gibbs RA, Schellenberg GD, Sutcliffe JS, Devlin B, Roeder K, Neale BM, Daly MJ.

Nat Genet. 2014 Sep;46(9):944-50. doi: 10.1038/ng.3050. Epub 2014 Aug 3.

Read full article

Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis.

Paraboschi EM, Rimoldi V, Soldà G, Tabaglio T, Dall'Osso C, Saba E, Vigliano M, Salviati A, Leone M, Benedetti MD, Fornasari D, Saarela J, De Jager P, Patsopoulos NA, D'Alfonso S, Gemmati D, Duga S, Asselta R;

Hum Mol Genet. 2014 Jul 30. pii: ddu392. [Epub ahead of print]

Read full article

Dyspnea and All-Cause Mortality : 28-yr Follow-up Study among Adult Twins.

Waller K, Kaprio J, Kujala UM.

Med Sci Sports Exerc. 2014 Aug;46(8):1538-45. doi: 10.1249/MSS.0000000000000255.

Read full article

Genetics of regular exercise and sedentary behaviors.

de Geus EJ, Bartels M, Kaprio J, Lightfoot JT, Thomis M.

Twin Res Hum Genet. 2014 Aug;17(4):262-71. doi: 10.1017/thg.2014.42. Review.

Read full article

Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.

Lim ET, Würtz P, Havulinna AS, Palta P, Tukiainen T, Rehnström K, Esko T, Mägi R, Inouye M, Lappalainen T, Chan Y, Salem RM, Lek M, Flannick J, Sim X, Manning A, Ladenvall C, Bumpstead S, Hämäläinen E, Aalto K, Maksimow M, Salmi M, Blankenberg S, Ardissino D, Shah S, Horne B, McPherson R, Hovingh GK, Reilly MP, Watkins H, Goel A, Farrall M, Girelli D, Reiner AP, Stitziel NO, Kathiresan S, Gabriel S, Barrett JC, Lehtimäki T, Laakso M, Groop L, Kaprio J, Perola M, McCarthy MI, Boehnke M, Altshuler DM, Lindgren CM, Hirschhorn JN, Metspalu A, Freimer NB, Zeller T, Jalkanen S, Koskinen S, Raitakari O, Durbin R, MacArthur DG, Salomaa V, Ripatti S, Daly MJ, Palotie A

PLoS Genet. 2014 Jul 31;10(7):e1004494. doi:10.1371/journal.pgen.1004494. eCollection 2014 Jul.

Read full article

Describing the genetic architecture of epilepsy through heritability analysis.

Speed D, O'Brien TJ, Palotie A, Shkura K, Marson AG, Balding DJ, Johnson MR;

Brain. 2014 Jul 26. pii: awu206. [Epub ahead of print]

Read full article

Complement activation and regulation in preeclamptic placenta.

Lokki AI, Heikkinen-Eloranta J, Jarva H, Saisto T, Lokki ML, Laivuori H, Meri S;

Front Immunol. 2014 Jul 9;5:312. doi: 10.3389/fimmu.2014.00312. eCollection 2014.

Read full article

Genetic determinants of common epilepsies : a meta-analysis of genome-wide association studies.

Anney, Richard J. L.; Avbersek, Andreja; Balding, David; Baum, Larry; Becker, Felicitas; Berkovic, Samuel F.; Bradfield, Jonathan P.; Brody, Lawrence C.; Buono, Russell J.; Catarino, Claudia B.; Cavalleri, Gianpiero L.; Cherny, Stacey S.; Chinthapalli, Krishna; Coffey, Alison J.; Compston, Alastair; Cossette, Patrick; de Haan, Gerrit-Jan; De Jonghe, Peter; de Kovel, Carolien G. F.; Delanty, Norman; Depondt, Chantal; Dlugos, Dennis J.; Doherty, Colin P.; Elger, Christian E.; Ferraro, Thomas N.; Feucht, Martha; Franke, Andre; French, Jacqueline; Gaus, Verena; Goldstein, David B.; Gui, Hongsheng; Guo, Youling; Hakonarson, Hakon; Hallmann, Kerstin; Heinzen, Erin L.; Helbig, Ingo; Hjalgrim, Helle; Jackson, Margaret; Jamnadas-Khoda, Jennifer; Janz, Dieter; Johnson, Michael R.; Kaelviaeinen, Reetta; Kantanen, Anne-Mari; Kasperaviciute, Dalia; Trenite, Dorothee Kasteleijn-Nolst; Koeleman, Bobby P. C.; Kunz, Wolfram S.; Kwan, Patrick; Lau, Yu Lung; Lehesjoki, Anna-Elina; Lerche, Holger; Leu, Costin; Lieb, Wolfgang; Lindhout, Dick; Lo, Warren; Lowenstein, Daniel H.; Malovini, Alberto; Marson, Anthony G.; McCormack, Mark; Mills, James L.; Moerzinger, Martina; Moller, Rikke S.; Molloy, Anne M.; Muhle, Hiltrud; Newton, Mark; Ng, Ping-Wing; Noethen, Markus M.; Nuernberg, Peter; O'Brien, Terence J.; Oliver, Karen L.; Palotie, Aarno; Pangilinan, Faith; Pernhorst, Katharina; Petrovski, Slave; Privitera, Michael; Radtke, Rodney; Reif, Philipp S.; Rosenow, Felix; Ruppert, Ann-Kathrin; Sander, Thomas; Scattergood, Theresa; Schachter, Steven; Schankin, Christoph; Scheffer, Ingrid E.; Schmitz, Bettina; Schoch, Susanne; Sham, Pak C.; Sisodiya, Sanjay; Smith, David F.; Smith, Philip E.; Speed, Doug; Sperling, Michael R.; Steffens, Michael; Stephani, Ulrich; Striano, Pasquale; Stroink, Hans; Surges, Rainer; Tan, K. Meng; Thomas, G. Neil; Todaro, Marian; Tostevin, Anna; Tozzi, Rossana; Trucks, Holger; Visscher, Frank; von Spiczak, Sarah; Walley, Nicole M.; Weber, Yvonne G.; Wei, Zhi; Whelan, Christopher; Yang, Wanling; Zara, Federico; Zimprich, Fritz; Int League Epilepsy Consortium Com; KORA Study Grp.

Lancet Neurol. 2014 Sep;13(9):893-903. doi: 10.1016/S1474-4422(14)70171-1. Epub 2014 Jul 30. 

Read full article

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants.

Broer L, Raschenberger J, Deelen J, Mangino M, Codd V, Pietiläinen KH, Albrecht E, Amin N, Beekman M, de Craen AJ, Gieger C, Haun M, Henneman P, Herder C, Hovatta I, Laser A, Kedenko L, Koenig W, Kollerits B, Moilanen E, Oostra BA, Paulweber B, Quaye L, Rissanen A, Roden M, Surakka I, Valdes AM, Vuolteenaho K, Thorand B, van Dijk KW, Kaprio J, Spector TD, Slagboom PE, Samani NJ, Kronenberg F, van Duijn CM, Ladwig KH.

Eur J Epidemiol. 2014 Sep;29(9):629-38. doi: 10.1007/s10654-014-9940-1. Epub 2014 Jul 27.

Read full article

Biological insights from 108 schizophrenia-associated genetic loci.

Schizophrenia Working Group of the Psychiatric Genomics Consortium;

Read full article

Metabolically healthy and unhealthy obese - the 2013 Stock Conference report.

Samocha-Bonet D, Dixit VD, Kahn CR, Leibel RL, Lin X, Nieuwdorp M, Pietiläinen KH, Rabasa-Lhoret R, Roden M, Scherer PE, Klein S, Ravussin E.

Obes Rev. 2014 Sep;15(9):697-708. doi: 10.1111/obr.12199. Epub 2014 Jul 25.

Read full article

Integrative and Personalized QSAR Analysis in Cancer by Kernelized Bayesian Matrix Factorization.

Ammad-Ud-Din M, Georgii E, Gönen M, Laitinen T, Kallioniemi O, Wennerberg K, Poso A, Kaski S;

J Chem Inf Model. 2014 Jul 21. [Epub ahead of print]

Read full article

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Perry JR, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI, Esko T, Thorleifsson G, Albrecht E, Ang WQ, Corre T, Cousminer DL, Feenstra B, Franceschini N, Ganna A, Johnson AD, Kjellqvist S, Lunetta KL, McMahon G, Nolte IM, Paternoster L, Porcu E, Smith AV, Stolk L, Teumer A, Tšernikova N, Tikkanen E, Ulivi S, Wagner EK, Amin N, Bierut LJ, Byrne EM, Hottenga JJ, Koller DL, Mangino M, Pers TH, Yerges-Armstrong LM, Hua Zhao J, Andrulis IL, Anton-Culver H, Atsma F, Bandinelli S, Beckmann MW, Benitez J, Blomqvist C, Bojesen SE, Bolla MK, Bonanni B, Brauch H, Brenner H, Buring JE, Chang-Claude J, Chanock S, Chen J, Chenevix-Trench G, Collée JM, Couch FJ, Couper D, Coviello AD, Cox A, Czene K, D'adamo AP, Davey Smith G, De Vivo I, Demerath EW, Dennis J, Devilee P, Dieffenbach AK, Dunning AM, Eiriksdottir G, Eriksson JG, Fasching PA, Ferrucci L, Flesch-Janys D, Flyger H, Foroud T, Franke L, Garcia ME, García-Closas M, Geller F, de Geus EE, Giles GG, Gudbjartsson DF, Gudnason V, Guénel P, Guo S, Hall P, Hamann U, Haring R, Hartman CA, Heath AC, Hofman A, Hooning MJ, Hopper JL, Hu FB, Hunter DJ, Karasik D, Kiel DP, Knight JA, Kosma VM, Kutalik Z, Lai S, Lambrechts D, Lindblom A, Mägi R, Magnusson PK, Mannermaa A, Martin NG, Masson G, McArdle PF, McArdle WL, Melbye M, Michailidou K, Mihailov E, Milani L, Milne RL, Nevanlinna H, Neven P, Nohr EA, Oldehinkel AJ, Oostra BA, Palotie A, Peacock M, Pedersen NL, Peterlongo P, Peto J, Pharoah PD, Postma DS, Pouta A, Pylkäs K, Radice P, Ring S, Rivadeneira F, Robino A, Rose LM, Rudolph A, Salomaa V, Sanna S, Schlessinger D, Schmidt MK, Southey MC, Sovio U, Stampfer MJ, Stöckl D, Storniolo AM, Timpson NJ, Tyrer J, Visser JA, Vollenweider P, Völzke H, Waeber G, Waldenberger M, Wallaschofski H, Wang Q, Willemsen G, Winqvist R, Wolffenbuttel BH, Wright MJ; Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines Cohort Study; InterAct Consortium; Early Growth Genetics (EGG) Consortium, Boomsma DI, Econs MJ, Khaw KT, Loos RJ, McCarthy MI, Montgomery GW, Rice JP, Streeten EA, Thorsteinsdottir U, van Duijn CM, Alizadeh BZ, Bergmann S, Boerwinkle E, Boyd HA, Crisponi L, Gasparini P, Gieger C, Harris TB, Ingelsson E, Järvelin MR, Kraft P, Lawlor D, Metspalu A, Pennell CE, Ridker PM, Snieder H, Sørensen TI, Spector TD, Strachan DP, Uitterlinden AG, Wareham NJ, Widen E, Zygmunt M, Murray A, Easton DF, Stefansson K, Murabito JM, Ong KK.

Nature. 2014 Oct 2;514(7520):92-7. doi: 10.1038/nature13545. Epub 2014 Jul 23.

Read full article

Mitochondrial EFTs defects in juvenile-onset Leigh disease, ataxia, neuropathy, and optic atrophy.

Ahola S, Isohanni P, Euro L, Brilhante V, Palotie A, Pihko H, Lönnqvist T, Lehtonen T, Laine J, Tyynismaa H, Suomalainen A;

Neurology. 2014 Jul 18. pii: 10.1212/WNL.0000000000000716. [Epub ahead of print]

Read full article

Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-223 expressions : a study on postmenopausal monozygotic twin pairs.

Olivieri F, Ahtiainen M, Lazzarini R, Pöllänen E, Capri M, Lorenzi M, Fulgenzi G, Albertini MC, Salvioli S, Alen MJ, Kujala UM, Borghetti G, Babini L, Kaprio J, Sipilä S, Franceschi C, Kovanen V, Procopio AD.

Aging Cell. 2014 Oct;13(5):850-61. doi: 10.1111/acel.12245. Epub 2014 Jul 18. 

Read full article

PhosFox: a bioinformatics tool for peptide-level processing of LC-MS/MS-based phosphoproteomic data.

Söderholm S, Hintsanen P, Ohman T, Aittokallio T, Nyman TA;

Proteome Sci. 2014 Jun 26;12:36. doi: 10.1186/1477-5956-12-36. eCollection 2014.

Read full article

Estimating telomere length from whole genome sequence data.

Ding Z, Mangino M, Aviv A, Spector T, Durbin R, UK10K Consortium;

Nucleic Acids Res. 2014 May;42(9):e75. doi: 10.1093/nar/gku181. Epub 2014 Mar 7.

Read full article

Phosphoproteomics Combined with Quantitative 14-3-3-affinity Capture Identifies SIRT1 and RAI as Novel Regulators of Cytosolic dsRNA Recognition Pathway.

Ohman T, Soderholm S, Hintsanen P, Valimaki E, Lietzen N, MacKintosh C, Aittokallio T, Matikainen S, Nyman TA;

Mol Cell Proteomics. 2014 Oct;13(10):2604-17. doi: 10.1074/mcp.M114.038968. Epub 2014 Jul 5.

Read full article

Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin.

olton JL, Hayward C, Direk N, Lewis JG, Hammond GL, Hill LA, Anderson A, Huffman J, Wilson JF, Campbell H, Rudan I, Wright A, Hastie N, Wild SH, Velders FP, Hofman A, Uitterlinden AG, Lahti J, Räikkönen K, Kajantie E, Widen E, Palotie A, Eriksson JG, Kaakinen M, Järvelin MR, Timpson NJ, Davey Smith G, Ring SM, Evans DM, St Pourcain B, Tanaka T, Milaneschi Y, Bandinelli S, Ferrucci L, van der Harst P, Rosmalen JG, Bakker SJ, Verweij N, Dullaart RP, Mahajan A, Lindgren CM, Morris A, Lind L, Ingelsson E, Anderson LN, Pennell CE, Lye SJ, Matthews SG, Eriksson J, Mellstrom D, Ohlsson C, Price JF, Strachan MW, Reynolds RM, Tiemeier H, Walker BR; CORtisol NETwork (CORNET) Consortium.

PLoS Genet. 2014 Jul 10;10(7):e1004474. doi: 10.1371/journal.pgen.1004474. eCollection 2014 Jul.

Read full article

The Orientation and Dynamics of Estradiol and Estradiol Oleate in Lipid Membranes and HDL Disc Models

Vogel A, Scheidt HA, Feller SE, Metso J, Badeau RM, Tikkanen MJ, Wähälä K, Jauhiainen M, Huster D

Biophys J. 2014 Jul 1;107(1):114-25. doi: 10.1016/j.bpj.2014.04.060.

Read full article

Genetic Determinants of Circulating Interleukin-1 Receptor Antagonist Levels and Their Association With Glycemic Traits.

Herder C, Nuotio ML, Shah S, Blankenberg S, Brunner EJ, Carstensen M, Gieger C, Grallert H, Jula A, Kähönen M, Kettunen J, Kivimäki M, Koenig W, Kristiansson K, Langenberg C, Lehtimäki T, Luotola K, Marzi C, Müller C, Peters A, Prokisch H, Raitakari O, Rathmann W, Roden M, Salmi M, Schramm K, Swerdlow D, Tabak AG, Thorand B, Wareham N, Wild PS, Zeller T, Hingorani AD, Witte DR, Kumari M, Perola M, Salomaa V.

 Diabetes. 2014 Dec;63(12):4343-59. doi: 10.2337/db14-0731. Epub 2014 Jun 26.

Read full article

Association of vitamin D status with arterial blood pressure and hypertension risk : a mendelian randomisation study

Vimaleswaran KS, Cavadino A, Berry DJ; LifeLines Cohort Study investigators, Jorde R, Dieffenbach AK, Lu C, Alves AC, Heerspink HJ, Tikkanen E, Eriksson J, Wong A, Mangino M, Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D, Zgaga L, Thiering E, Vitart V, Fraser RM, Huffman JE, de Boer RA, Schöttker B, Saum KU, McCarthy MI, Dupuis J, Herzig KH, Sebert S, Pouta A, Laitinen J, Kleber ME, Navis G, Lorentzon M, Jameson K, Arden N, Cooper JA, Acharya J, Hardy R, Raitakari O, Ripatti S, Billings LK, Lahti J, Osmond C, Penninx BW, Rejnmark L, Lohman KK, Paternoster L, Stolk RP, Hernandez DG, Byberg L, Hagström E, Melhus H, Ingelsson E, Mellström D, Ljunggren O, Tzoulaki I, McLachlan S, Theodoratou E, Tiesler CM, Jula A, Navarro P, Wright AF, Polasek O; International Consortium for Blood Pressure (ICBP); Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium; Global Blood Pressure Genetics (Global BPGen) consortium; Caroline Hayward, Wilson JF, Rudan I, Salomaa V, Heinrich J, Campbell H, Price JF, Karlsson M, Lind L, Michaëlsson K, Bandinelli S, Frayling TM, Hartman CA, Sørensen TI, Kritchevsky SB, Langdahl BL, Eriksson JG, Florez JC, Spector TD, Lehtimäki T, Kuh D, Humphries SE, Cooper C, Ohlsson C, März W, de Borst MH, Kumari M, Kivimaki M, Wang TJ, Power C, Brenner H, Grimnes G, van der Harst P, Snieder H, Hingorani AD, Pilz S, Whittaker JC, Järvelin MR, Hyppönen E.

Lancet Diabetes Endocrinol. 2014 Sep;2(9):719-29. doi: 10.1016/S2213-8587(14)70113-5. Epub 2014 Jun 25.

Read full article

Structural Genomic Variation as Risk Factor for Idiopathic Recurrent Miscarriage

Nagirnaja L, Palta P, Kasak L, Rull K, Christiansen OB, Nielsen HS, Steffensen R, Esko T, Remm M, Laan M.

Hum Mutat. 2014 Aug;35(8):972-82. doi:10.1002/humu.22589. Epub 2014 Jun 24.

Read full article

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, Dörr M, Müller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC, Isaacs A, Newhouse SJ, Evans DS, Post WS, Waggott D, Lyytikäinen LP, Hicks AA, Eisele L, Ellinghaus D, Hayward C, Navarro P, Ulivi S, Tanaka T, Tester DJ, Chatel S, Gustafsson S, Kumari M, Morris RW, Naluai ÅT, Padmanabhan S, Kluttig A, Strohmer B, Panayiotou AG, Torres M, Knoflach M, Hubacek JA, Slowikowski K, Raychaudhuri S, Kumar RD, Harris TB, Launer LJ, Shuldiner AR, Alonso A, Bader JS, Ehret G, Huang H, Kao WH, Strait JB, Macfarlane PW, Brown M, Caulfield MJ, Samani NJ, Kronenberg F, Willeit J; CARe Consortium; COGENT Consortium, Smith JG, Greiser KH, Meyer Zu Schwabedissen H, Werdan K, Carella M, Zelante L, Heckbert SR, Psaty BM, Rotter JI, Kolcic I, Polašek O, Wright AF, Griffin M, Daly MJ; DCCT/EDIC, Arnar DO, Hólm H, Thorsteinsdottir U; eMERGE Consortium, Denny JC, Roden DM, Zuvich RL, Emilsson V, Plump AS, Larson MG, O'Donnell CJ, Yin X, Bobbo M, D'Adamo AP, Iorio A, Sinagra G, Carracedo A, Cummings SR, Nalls MA, Jula A, Kontula KK, Marjamaa A, Oikarinen L, Perola M, Porthan K, Erbel R, Hoffmann P, Jöckel KH, Kälsch H, Nöthen MM; HRGEN Consortium, den Hoed M, Loos RJ, Thelle DS, Gieger C, Meitinger T, Perz S, Peters A, Prucha H, Sinner MF, Waldenberger M, de Boer RA, Franke L, van der Vleuten PA, Beckmann BM, Martens E, Bardai A, Hofman N, Wilde AA, Behr ER, Dalageorgou C, Giudicessi JR, Medeiros-Domingo A, Barc J, Kyndt F, Probst V, Ghidoni A, Insolia R, Hamilton RM, Scherer SW, Brandimarto J, Margulies K, Moravec CE, del Greco M F, Fuchsberger C, O'Connell JR, Lee WK, Watt GC, Campbell H, Wild SH, El Mokhtari NE, Frey N, Asselbergs FW, Mateo Leach I, Navis G, van den Berg MP, van Veldhuisen DJ, Kellis M, Krijthe BP, Franco OH, Hofman A, Kors JA, Uitterlinden AG, Witteman JC, Kedenko L, Lamina C, Oostra BA, Abecasis GR, Lakatta EG, Mulas A, Orrú M, Schlessinger D, Uda M, Markus MR, Völker U, Snieder H, Spector TD, Ärnlöv J, Lind L, Sundström J, Syvänen AC, Kivimaki M, Kähönen M, Mononen N, Raitakari OT, Viikari JS, Adamkova V, Kiechl S, Brion M, Nicolaides AN, Paulweber B, Haerting J, Dominiczak AF, Nyberg F, Whincup PH, Hingorani AD, Schott JJ, Bezzina CR, Ingelsson E, Ferrucci L, Gasparini P, Wilson JF, Rudan I, Franke A, Mühleisen TW, Pramstaller PP, Lehtimäki TJ,

Nat Genet. 2014 Aug;46(8):826-36. doi: 10.1038/ng.3014. Epub 2014 Jun 22.

Read full article

Castration Induces Up-Regulation of Intratumoral Androgen Biosynthesis and Androgen Receptor Expression in an Orthotopic VCaP Human Prostate Cancer Xenograft Model.

Knuuttila M, Yatkin E, Kallio J, Savolainen S, Laajala TD, Aittokallio T, Oksala R, Häkkinen M, Keski-Rahkonen P, Auriola S, Poutanen M, Mäkelä S;

Am J Pathol. 2014 Aug;184(8):2163-73. doi: 10.1016/j.ajpath.2014.04.010. Epub 2014 Jun 17.

Read full article

Germline Mutation of RPS20, Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency.

Nieminen TT, O'Donohue MF, Wu Y, Lohi H, Scherer SW, Paterson AD, Ellonen P, Abdel-Rahman WM, Valo S, Mecklin JP, Järvinen HJ, Gleizes PE, Peltomäki P;

Gastroenterology. 2014 Sep;147(3):595-598.e5. doi: 10.1053/j.gastro.2014.06.009. Epub 2014 Jun 15.

Read full article

Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.

Ramos A, Rodríguez-Seoane C, Rosa I, Trossbach SV, Ortega-Alonso A, Tomppo L, Ekelund J, Veijola J, Järvelin MR, Alonso J, Veiga S, Sawa A, Hennah W, García A, Korth C, Requena JR;

Hum Mol Genet. 2014 Nov 15;23(22):5859-65. doi: 10.1093/hmg/ddu303. Epub 2014 Jun 16.

Read full article

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits

Thomson PA, Parla JS, McRae AF, Kramer M, Ramakrishnan K, Yao J, Soares DC, McCarthy S, Morris SW, Cardone L, Cass S, Ghiban E, Hennah W, Evans KL, Rebolini D, Millar JK, Harris SE, Starr JM, MacIntyre DJ; Generation Scotland, McIntosh AM, Watson JD, Deary IJ, Visscher PM, Blackwood DH, McCombie WR, Porteous DJ.

Mol Psychiatry. 2014 Jun;19(6):668-75. Epub 2013 Jun 4.

Read full article

Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity.

Scott RA, Fall T, Pasko D, Barker A, Sharp SJ, Arriola L, Balkau B, Barricarte A, Barroso I, Boeing H, Clavel-Chapelon F, Crowe FL, Dekker JM, Fagherazzi G, Ferrannini E, Forouhi NG, Franks PW, Gavrila D, Giedraitis V, Grioni S, Groop LC, Kaaks R, Key TJ, Kühn T, Lotta LA, Nilsson PM, Overvad K, Palli D, Panico S, Quirós JR, Rolandsson O, Roswall N, Sacerdote C, Sala N, Sánchez MJ, Schulze MB, Siddiq A, Slimani N, Sluijs I, Spijkerman AM, Tjonneland A, Tumino R, van der A DL, Yaghootkar H; RISC Study Group; EPIC-InterAct Consortium, McCarthy MI, Semple RK, Riboli E, Walker M, Ingelsson E, Frayling TM, Savage DB, Langenberg C, Wareham NJ.

Diabetes. 2014 Dec;63(12):4378-87. doi: 10.2337/db14-0319. Epub 2014 Jun 19.

Read full article

Depressive symptoms and career-related goal appraisals: Genetic and Environmental correlations and interactions

Salmela-Aro K, Read S, Vuoksimaa E, Korhonen T, Dick DM, Kaprio J, Rose RJ.

Twin Res Hum Genet. 2014 Aug;17(4):236-43. doi:10.1017/thg.2014.33. Epub 2014 Jun 16.

Read full article

Genome-wide association analysis identifies six new loci associated with forced vital capacity.

Loth DW, Artigas MS, Gharib SA, Wain LV, Franceschini N, Koch B, Pottinger TD, Smith AV, Duan Q, Oldmeadow C, Lee MK, Strachan DP, James AL, Huffman JE, Vitart V, Ramasamy A, Wareham NJ, Kaprio J, Wang XQ, Trochet H, Kähönen M, Flexeder C, Albrecht E, Lopez LM, de Jong K, Thyagarajan B, Alves AC, Enroth S, Omenaas E, Joshi PK, Fall T, Viñuela A, Launer LJ, Loehr LR, Fornage M, Li G, Wilk JB, Tang W, Manichaikul A, Lahousse L, Harris TB, North KE, Rudnicka AR, Hui J, Gu X, Lumley T, Wright AF, Hastie ND, Campbell S, Kumar R, Pin I, Scott RA, Pietiläinen KH, Surakka I, Liu Y, Holliday EG, Schulz H, Heinrich J, Davies G, Vonk JM, Wojczynski M, Pouta A, Johansson A, Wild SH, Ingelsson E, Rivadeneira F, Völzke H, Hysi PG, Eiriksdottir G, Morrison AC, Rotter JI, Gao W, Postma DS, White WB, Rich SS, Hofman A, Aspelund T, Couper D, Smith LJ, Psaty BM, Lohman K, Burchard EG, Uitterlinden AG, Garcia M, Joubert BR, McArdle WL, Musk AB, Hansel N, Heckbert SR, Zgaga L, van Meurs JB, Navarro P, Rudan I, Oh YM, Redline S, Jarvis DL, Zhao JH, Rantanen T, O'Connor GT, Ripatti S, Scott RJ, Karrasch S, Grallert H, Gaddis NC, Starr JM, Wijmenga C, Minster RL, Lederer DJ, Pekkanen J, Gyllensten U, Campbell H, Morris AP, Gläser S, Hammond CJ, Burkart KM, Beilby J, Kritchevsky SB, Gudnason V, Hancock DB, Williams OD, Polasek O, Zemunik T, Kolcic I, Petrini MF, Wjst M, Kim WJ, Porteous DJ, Scotland G, Smith BH, Viljanen A, Heliövaara M, Attia JR, Sayers I, Hampel R, Gieger C, Deary IJ, Boezen HM, Newman A, Jarvelin MR, Wilson JF, Lind L, Stricker BH, Teumer A, Spector TD, Melén E, Peters MJ, Lange LA, Barr RG, Bracke KR, Verhamme FM, Sung J, Hiemstra PS, Cassano PA, Sood A, Hayward C, Dupuis J, Hall IP, Brusselle GG, Tobin MD, London SJ.

Nat Genet. 2014 Jul;46(7):669-77. doi: 10.1038/ng.3011. Epub 2014 Jun 15. 

Read full article

Role of Nicotine Dependence in the Association between the Dopamine Receptor Gene DRD3 and Major Depressive Disorder

Korhonen T, Loukola A, Wedenoja J, Nyman E, Latvala A, Broms U, Häppölä A, Paunio T, Schrage AJ, Vink JM, Mbarek H, Boomsma DI, Penninx BW, Pergadia ML, Madden PA, Kaprio J.

PLoS One. 2014 Jun 13;9(6):e98199. doi: 10.1371/journal.pone.0098199. eCollection 2014.

Read full article

Vitamin B12-dependent taurine synthesis regulates growth and bone mass.

Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Wilkinson D, Santhanam B, Sarper N, Clare S, Vassiliou GS, Velagapudi VR, Dougan G, Yadav VK;

J Clin Invest. 2014 Jul;124(7):2988-3002. doi: 10.1172/JCI72606. Epub 2014 Jun 9.

Read full article

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM, Prados MD, Lachance DH, O'Neill BP, Sicotte H, Eckel-Passow JE; ENGAGE Consortium Telomere Group, van der Harst P, Wiencke JK, Samani NJ, Jenkins RB, Wrensch MR.

Nat Genet. 2014 Jul;46(7):731-5. doi: 10.1038/ng.3004. Epub 2014 Jun 8.

Read full article

Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies.

Yadav B, Pemovska T, Szwajda A, Kulesskiy E, Kontro M, Karjalainen R, Majumder MM, Malani D, Murumägi A, Knowles J, Porkka K, Heckman C, Kallioniemi O, Wennerberg K, Aittokallio T;

Sci Rep. 2014 Jun 5;4:5193. doi: 10.1038/srep05193.

Read full article

Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes

Andersen MK, Sterner M, Forsén T, Käräjämäki A, Rolandsson O, Forsblom C, Groop PH, Lahti K, Nilsson PM, Groop L, Tuomi T

Diabetologia. 2014 Sep;57(9):1859-68. doi: 10.1007/s00125-014-3287-8. Epub 2014 Jun 7.

Read full article

DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells.

Laos M, Anttonen T, Kirjavainen A, af Hällström T, Laiho M, Pirvola U.

Aging (Albany NY). 2014 Jun;6(6):496-510.

Read full article

Global Analysis of S-nitrosylation Sites in the Wild Type (APP) Transgenic Mouse Brain-Clues for Synaptic Pathology.

Zaręba-Kozioł M, Szwajda A, Dadlez M, Wysłouch-Cieszyńska A, Lalowski M.

Mol Cell Proteomics. 2014 Sep;13(9):2288-305. doi: 10.1074/mcp.M113.036079. Epub 2014 Jun 3.

Read full article

Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.

Ko A, Cantor RM, Weissglas-Volkov D, Nikkola E, Reddy PM, Sinsheimer JS, Pasaniuc B, Brown R, Alvarez M, Rodriguez A, Rodriguez-Guillen R, Bautista IC, Arellano-Campos O, Muñoz-Hernández LL, Salomaa V, Kaprio J, Jula A, Jauhiainen M, Heliövaara M, Raitakari O, Lehtimäki T, Eriksson JG, Perola M, Lohmueller KE, Matikainen N, Taskinen MR, Rodriguez-Torres M, Riba L, Tusie-Luna T, Aguilar-Salinas CA, Pajukanta P.

Nat Commun. 2014 Jun 2;5:3983. doi: 10.1038/ncomms4983.

Read full article

A community effort to assess and improve drug sensitivity prediction algorithms

Costello JC, Heiser LM, Georgii E, Gönen M, Menden MP, Wang NJ, Bansal M, Ammad-ud-din M, Hintsanen P, Khan SA, Mpindi JP, Kallioniemi O, Honkela A, Aittokallio T, Wennerberg K; NCI DREAM Community, Collins JJ, Gallahan D, Singer D, Saez-Rodriguez J, Kaski S, Gray JW, Stolovitzky G

Nat Biotechnol. 2014 Dec;32(12):1202-12.  Epub 2014 Jun 1

Read full article

Genetic risk load according to the site of intracranial aneurysms.

van 't Hof FN, Kurki MI, Kleinloog R, de Bakker PI, von und zu Fraunberg M, Jääskeläinen JE, Gaál EI, Lehto H, Kivisaari R, Laakso A, Niemelä M, Hernesniemi J, Brouwer MC, van de Beek D, Rinkel GJ, Ruigrok YM.

Neurology. 2014 Jul 1;83(1):34-9. doi: 10.1212/WNL.0000000000000547. Epub 2014 May 30. 

Read full article

Association Between Eating Disorders and Migraine May be Explained by Major Depression.

Mustelin L, Raevuori A, Kaprio J, Keski-Rahkonen A.

Int J Eat Disord. 2014 Dec;47(8):884-7. doi: 10.1002/eat.22311. Epub 2014 May 30.

Read full article

Selectivity in Genetic Association with Sub-classified Migraine in Women

Chasman DI, Anttila V, Buring JE, Ridker PM, Schürks M, Kurth T; International Headache Genetics Consortium.

PLoS Genet. 2014 May 22;10(5):e1004366. doi:10.1371/journal.pgen.1004366. eCollection 2014 May.

Read full article

Gene-Lifestyle Interaction and Type 2 Diabetes : The EPIC InterAct Case-Cohort Study.

Langenberg C, Sharp SJ, Franks PW, Scott RA, Deloukas P, Forouhi NG, Froguel P, Groop LC, Hansen T, Palla L, Pedersen O, Schulze MB, Tormo MJ, Wheeler E, Agnoli C, Arriola L, Barricarte A, Boeing H, Clarke GM, Clavel-Chapelon F, Duell EJ, Fagherazzi G, Kaaks R, Kerrison ND, Key TJ, Khaw KT, Kröger J, Lajous M, Morris AP, Navarro C, Nilsson PM, Overvad K, Palli D, Panico S, Quirós JR, Rolandsson O, Sacerdote C, Sánchez MJ, Slimani N, Spijkerman AM, Tumino R, van der A DL, van der Schouw YT, Barroso I, McCarthy MI, Riboli E, Wareham NJ.

PLoS Med. 2014 May 20;11(5):e1001647. doi: 10.1371/journal.pmed.1001647. eCollection 2014 May.

Read full article

Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight : a Big Mac challenge.

Bondia-Pons I, Maukonen J, Mattila I, Rissanen A, Saarela M, Kaprio J, Hakkarainen A, Lundbom J, Lundbom N, Hyötyläinen T, Pietiläinen KH, Orešič M.

 FASEB J. 2014 May 20. pii: fj.14-250167. [Epub ahead of print] 

Read full article

Persistence or Change in Leisure-Time Physical Activity Habits and Waist Gain During Early Adulthood : A Twin-Study.

Rottensteiner M, Pietiläinen KH, Kaprio J, Kujala UM.

Obesity (Silver Spring). 2014 Sep;22(9):2061-70. doi: 10.1002/oby.20788. Epub 2014 May 16.

Read full article

Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium : an application of Item Response Theory.

van den Berg SM, de Moor MH, McGue M, Pettersson E, Terracciano A, Verweij KJ, Amin N, Derringer J, Esko T, van Grootheest G, Hansell NK, Huffman J, Konte B, Lahti J, Luciano M, Matteson LK, Viktorin A, Wouda J, Agrawal A, Allik J, Bierut L, Broms U, Campbell H, Smith GD, Eriksson JG, Ferrucci L, Franke B, Fox JP, de Geus EJ, Giegling I, Gow AJ, Grucza R, Hartmann AM, Heath AC, Heikkilä K, Iacono WG, Janzing J, Jokela M, Kiemeney L, Lehtimäki T, Madden PA, Magnusson PK, Northstone K, Nutile T, Ouwens KG, Palotie A, Pattie A, Pesonen AK, Polasek O, Pulkkinen L, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Seppälä I, Slutske WS, Smyth DC, Sorice R, Starr JM, Sutin AR, Tanaka T, Verhagen J, Vermeulen S, Vuoksimaa E, Widen E, Willemsen G, Wright MJ, Zgaga L, Rujescu D, Metspalu A, Wilson JF, Ciullo M, Hayward C, Rudan I, Deary IJ, Räikkönen K, Arias Vasquez A, Costa PT, Keltikangas-Järvinen L, van Duijn CM, Penninx BW, Krueger RF, Evans DM, Kaprio J, Pedersen NL, Martin NG, Boomsma DI.

Behav Genet. 2014 Jul;44(4):295-313. doi: 10.1007/s10519-014-9654-x. Epub 2014 May 15. 

Read full article

Sleep duration and insulin resistance in individuals without type 2 diabetes : The PPP-Botnia Study

Pyykkönen AJ, Isomaa B, Pesonen AK, Eriksson JG, Groop L, Tuomi T, Räikkönen K.

Ann Med. 2014 Aug;46(5):324-9. doi:10.3109/07853890.2014.902226. Epub 2014 May 9.

Read full article

Microsatellite Polymorphism in the Heme Oxygenase-1 Promoter Is Associated With Nonsevere and Late-Onset Preeclampsia.

Kaartokallio T, Klemetti MM, Timonen A, Uotila J, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Lakkisto P, Laivuori H;

Hypertension. 2014 Jul;64(1):172-7. doi: 10.1161/HYPERTENSIONAHA.114.03337. Epub 2014 May 5.

Read full article

The Heritability of Prostate Cancer in the Nordic Twin Study of Cancer

Hjelmborg JB, Scheike T, Holst K, Skytthe A, Penney KL, Graff RE, Pukkala E, Christensen K, Adami HO, Holm NV, Nuttall E, Hansen S, Hartman M, Czene K, Harris JR, Kaprio J, Mucci LA.

Cancer Epidemiol Biomarkers Prev. 2014 Nov;23(11):2303-10. doi:10.1158/1055-9965.EPI-13-0568. Epub 2014 May 8.

Read full article

The contribution of educational class in improving accuracy of cardiovascular risk prediction across European regions: The MORGAM Project Cohort Component.

Ferrario MM, Veronesi G, Chambless LE, Tunstall-Pedoe H, Kuulasmaa K, Salomaa V, Borglykke A, Hart N, Söderberg S, Cesana G, for the MORGAM Project;

Heart. 2014 Aug;100(15):1179-87. doi: 10.1136/heartjnl-2013-304664. Epub 2014 May 1.

Read full article

Partial-filling affinity capillary electrophoresis and quartz crystal microbalance with adsorption energy distribution calculations in the study of biomolecular interactions with apolipoprotein E as interaction partner.

Lipponen K, Tähkä S, Samuelsson J, Jauhiainen M, Metso J, Cilpa-Karhu G, Fornstedt T, Kostiainen M, Riekkola ML.

Anal Bioanal Chem. 2014 Jul;406(17):4137-46. doi: 10.1007/s00216-014-7821-9. Epub 2014 May 2.

Read full article

Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.

Cousminer DL, Stergiakouli E, Berry DJ, Ang W, Groen-Blokhuis MM, Körner A, Siitonen N, Ntalla I, Marinelli M, Perry JR, Kettunen J, Jansen R, Surakka I, Timpson NJ, Ring S, Mcmahon G, Power C, Wang C, Kähönen M, Viikari J, Lehtimäki T, Middeldorp CM, Hulshoff Pol HE, Neef M, Weise S, Pahkala K, Niinikoski H, Zeggini E, Panoutsopoulou K, Bustamante M, Penninx BW; ReproGen Consortium, Murabito J, Torrent M, Dedoussis GV, Kiess W, Boomsma DI, Pennell CE, Raitakari OT, Hyppönen E, Davey Smith G, Ripatti S, McCarthy MI, Widén E; Early Growth Genetics Consortium.

Hum Mol Genet. 2014 Aug 15;23(16):4452-64. doi: 10.1093/hmg/ddu150. Epub 2014 Apr 25.

Read full article

Quality control and conduct of genome-wide association meta-analyses.

Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Mägi R, Ferreira T, Fall T, Graff M, Justice AE, Luan J, Gustafsson S, Randall JC, Vedantam S, Workalemahu T, Kilpeläinen TO, Scherag A, Esko T, Kutalik Z, Heid IM, Loos RJ; Genetic Investigation of Anthropometric Traits (GIANT) Consortium.

Nat Protoc. 2014 May;9(5):1192-212. doi: 10.1038/nprot.2014.071. Epub 2014 Apr 24.

Read full article

A homogeneous quenching resonance energy transfer assay for the kinetic analysis of the GTPase nucleotide exchange reaction.

Kopra K, Ligabue A, Wang Q, Syrjänpää M, Blaževitš O, Veltel S, van Adrichem AJ, Hänninen P, Abankwa D, Härmä H.

Anal Bioanal Chem. 2014 Jul;406(17):4147-56. doi:10.1007/s00216-014-7795-7. Epub 2014 Apr 24.

Read full article

Simulation of Finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland

Wang SR, Agarwala V, Flannick J, Chiang CW, Altshuler D; GoT2D Consortium, Hirschhorn JN.

Am J Hum Genet. 2014 May 1;94(5):710-20. doi: 10.1016/j.ajhg.2014.03.019. Epub 2014 Apr 24.

Read full article

Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.

Denisova OV, Söderholm S, Virtanen S, Von Schantz C, Bychkov D, Vashchinkina E, Desloovere J, Tynell J, Ikonen N, Theisen LL, Nyman TA, Matikainen S, Kallioniemi O, Julkunen I, Muller CP, Saelens X, Verkhusha VV, Kainov DE;

Antimicrob Agents Chemother. 2014 Jul;58(7):3689-96. doi: 10.1128/AAC.02798-13. Epub 2014 Apr 21.

Read full article

Multi-ethnic fine-mapping of 14 central adiposity loci.

Liu CT, Buchkovich ML, Winkler TW, Heid IM; African Ancestry Anthropometry Genetics Consortium; GIANT Consortium, Borecki IB, Fox CS, Mohlke KL, North KE, Adrienne Cupples L.

Hum Mol Genet. 2014 Sep 1;23(17):4738-44. doi: 10.1093/hmg/ddu183. Epub 2014 Apr 23. 

Read full article

Towards a molecular systems model of coronary artery disease.

Abraham G, Bhalala OG, de Bakker PI, Ripatti S, Inouye M;

Curr Cardiol Rep. 2014;16(6):488. doi: 10.1007/s11886-014-0488-1.

Read full article

De novo mutations in HCN1 cause early infantile epileptic encephalopathy.

Nava C, Dalle C, Rastetter A, Striano P, de Kovel CG, Nabbout R, Cancès C, Ville D, Brilstra EH, Gobbi G, Raffo E, Bouteiller D, Marie Y, Trouillard O, Robbiano A, Keren B, Agher D, Roze E, Lesage S, Nicolas A, Brice A, Baulac M, Vogt C, El Hajj N, Schneider E, Suls A, Weckhuysen S, Gormley P, Lehesjoki AE, De Jonghe P, Helbig I, Baulac S, Zara F, Koeleman BP; EuroEPINOMICS RES Consortium, Haaf T, LeGuern E, Depienne C.

Nat Genet. 2014 Jun;46(6):640-5. doi: 10.1038/ng.2952. Epub 2014 Apr 20.

Read full article

Associations of physical activity, fitness, and body composition with heart rate variability-based indicators of stress and recovery on workdays: a cross-sectional study.

Teisala T, Mutikainen S, Tolvanen A, Rottensteiner M, Leskinen T, Kaprio J, Kolehmainen M, Rusko H, Kujala UM.

J Occup Med Toxicol. 2014 Apr 18;9:16. doi: 10.1186/1745-6673-9-16. eCollection 2014.

Read full article

A study of sedentary behaviour in the older Finnish twin cohort: a cross sectional analysis

Piirtola M, Kaprio J, Ropponen A

Biomed Res Int. 2014;2014:209140. Epub 2014 Apr 15

Read full article

Association between physical and motor development in childhood: A longitudinal study of Japanese twins.

Silventoinen K, Pitkäniemi J, Latvala A, Kaprio J, Yokoyama Y.

Twin Res Hum Genet. 2014 Jun;17(3):192-8. doi:10.1017/thg.2014.16. Epub 2014 Apr 15.

Read full article

TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli.

Munne PM, Gu Y, Tumiati M, Gao P, Koopal S, Uusivirta S, Sawicki J, Wei GH, Kuznetsov SG;

Sci Rep. 2014 Apr 11;4:4663. doi: 10.1038/srep04663.

Read full article

Bayesian Latent Variable Collapsing Model for Detecting Rare Variant Interaction Effect in Twin Study.

He L, Sillanpää MJ, Ripatti S, Pitkäniemi J;

Genet Epidemiol. 2014 May;38(4):310-24. doi: 10.1002/gepi.21804. Epub 2014 Apr 9.

Read full article

Naturally Occurring Human Phosphorylcholine Antibodies Are Predominantly Products of Affinity-Matured B Cells in the Adult.

Fiskesund R, Steen J, Amara K, Murray F, Szwajda A, Liu A, Douagi I, Malmström V, Frostegård J.

J Immunol. 2014 May 15;192(10):4551-9. doi: 10.4049/jimmunol.1303035. Epub 2014 Apr 11.

Read full article

Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data.

Chen GB, Lee SH, Brion MJ, Montgomery GW, Wray NR, Radford-Smith GL, Visscher PM, International IBD Genetics Consortium;

Hum Mol Genet. 2014 Sep 1;23(17):4710-20. doi: 10.1093/hmg/ddu174. Epub 2014 Apr 11. PubMed PMID: 24728037.

Read full article

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.

Khan NA, Auranen M, Paetau I, Pirinen E, Euro L, Forsström S, Pasila L, Velagapudi V, Carroll CJ, Auwerx J, Suomalainen A;

EMBO Mol Med. 2014 Apr 6;6(6):721-31. doi: 10.1002/emmm.201403943.

Read full article

Polygenic scores predict alcohol problems in an independent sample and show moderation by the environment.

Salvatore JE, Aliev F, Edwards AC, Evans DM, Macleod J, Hickman M, Lewis G, Kendler KS, Loukola A, Korhonen T, Latvala A, Rose RJ, Kaprio J, Dick DM.

Genes (Basel). 2014 Apr 10;5(2):330-46. doi:10.3390/genes5020330.

Read full article

Novel Lignan and Stilbenoid Mixture Shows Anticarcinogenic Efficacy in Preclinical PC-3M-luc2 Prostate Cancer Model.

Yatkin E, Polari L, Laajala TD, Smeds A, Eckerman C, Holmbom B, Saarinen NM, Aittokallio T, Mäkelä SI;

PLoS One. 2014 Apr 3;9(4):e93764. doi: 10.1371/journal.pone.0093764. eCollection 2014.

Read full article

Novel TBL1XR1, EPHA7 and SLFN12 mutations in a Sezary syndrome patient discovered by whole exome sequencing.

Andersson E, Eldfors S, Edgren H, Ellonen P, Väkevä L, Ranki A, Mustjoki S;

Exp Dermatol. 2014 May;23(5):366-8. doi: 10.1111/exd.12405.

Read full article

A novel transcript, VNN1-AB, as a biomarker for colorectal cancer.

Løvf M, Nome T, Bruun J, Eknaes M, Bakken AC, Mpindi JP, Kilpinen S, Rognum TO, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI;

Int J Cancer. 2014 Nov 1;135(9):2077-84. doi: 10.1002/ijc.28855. Epub 2014 Mar 29.

Read full article

Strategy for Standardization of Preeclampsia Research Study Design.

Myatt L, Redman CW, Staff AC, Hansson S, Wilson ML, Laivuori H, Poston L, Roberts JM, for the Global Pregnancy CoLaboratory (COLAB);

Hypertension. 2014 Jun;63(6):1293-301. doi: 10.1161/HYPERTENSIONAHA.113.02664. Epub 2014 Mar 31.

Read full article

A central role for GRB10 in regulation of islet function in man

Prokopenko I, Poon W, Mägi R, Prasad B R, Salehi SA, Almgren P, Osmark P, Bouatia-Naji N, Wierup N, Fall T, Stančáková A, Barker A, Lagou V, Osmond C, Xie W, Lahti J, Jackson AU, Cheng YC, Liu J, O'Connell JR, Blomstedt PA, Fadista J, Alkayyali S, Dayeh T, Ahlqvist E, Taneera J, Lecoeur C, Kumar A, Hansson O, Hansson K, Voight BF, Kang HM, Levy-Marchal C, Vatin V, Palotie A, Syvänen AC, Mari A, Weedon MN, Loos RJ, Ong KK, Nilsson P, Isomaa B, Tuomi T, Wareham NJ, Stumvoll M, Widen E, Lakka TA, Langenberg C, Tönjes A, Rauramaa R, Kuusisto J, Frayling TM, Froguel P, Walker M, Eriksson JG, Ling C, Kovacs P, Ingelsson E, McCarthy MI, Shuldiner AR, Silver KD, Laakso M, Groop L, Lyssenko V

PLoS Genet. 2014 Apr 3;10(4):e1004235

Read full article

JC Polyomavirus Infection Is Strongly Controlled by Human Leucocyte Antigen Class II Variants.

Sundqvist E, Buck D, Warnke C, Albrecht E, Gieger C, Khademi M, Lima Bomfim I, Fogdell-Hahn A, Link J, Alfredsson L, Søndergaard HB, Hillert J; International Multiple Sclerosis Genetics Consortium, Oturai AB, Hemme B, Kockum I, Olsson T.

PLoS Pathog. 2014 Apr 24;10(4):e1004084. doi: 10.1371/journal.ppat.1004084. eCollection 2014 Apr.

Read full article

Full-Genome Sequences of Influenza H3N2 Virus Strains Isolated from Finnish Patients during the 2012-2013 Epidemic Season.

Lakspere T, Kallio-Kokko H, Kantele A, Mattila P, Almusa H, Kainov D, Kakkola L;

Genome Announc. 2014 Mar 27;2(2). pii: e00039-14. doi: 10.1128/genomeA.00039-14.

Read full article

Asetyylisalisyylihappo ja pre-eklampsian ehkäisy

Villa PM, Kajantie E, Laivuori H;

 2014;130(3):243-50.

Read full article

Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias.

Sarhadi VK, Lahti L, Scheinin I, Ellonen P, Kettunen E, Serra M, Scotlandi K, Picci P, Knuutila S;

Genes Chromosomes Cancer. 2014 Jul;53(7):579-88. doi: 10.1002/gcc.22168. Epub 2014 Mar 24.

Read full article

Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression.

Marttinen P, Pirinen M, Sarin AP, Gillberg J, Kettunen J, Surakka I, Kangas AJ, Soininen P, O'Reilly PF, Kaakinen M, Kähönen M, Lehtimäki T, Ala-Korpela M, Raitakari OT, Salomaa V, Järvelin MR, Ripatti S, Kaski S;

Bioinformatics. 2014 Jul 15;30(14):2026-34. doi: 10.1093/bioinformatics/btu140. Epub 2014 Mar 24.

Read full article

The High Throughput Biomedicine unit at the Institute for Molecular Medicine Finland: High throughput screening meets precision medicine.

Pietiäinen V, Saarela J, Schantz-Fant CV, Turunen L, Ostling P, Wennerberg K;

Comb Chem High Throughput Screen. 2014 May;17(4):377-86.

Read full article

Evaluation of HLA-DRB1 imputation using a Finnish dataset

Vlachopoulou E, Lahtela E, Wennerström A, Havulinna AS, Salo P, Perola M, Salomaa V, Nieminen MS, Sinisalo J, Lokki ML.

Tissue Antigens. 2014 May;83(5):350-5. doi:10.1111/tan.12343. Epub 2014 Mar 26.

Read full article

Biclustering Methods: Biological Relevance and Application in Gene Expression Analysis.

Oghabian A, Kilpinen S, Hautaniemi S, Czeizler E.

PLoS One. 2014 Mar 20;9(3):e90801. doi: 10.1371/journal.pone.0090801. eCollection 2014.

Read full article

High Birth Weight Is Associated With Obesity and Increased Carotid Wall Thickness in Young Adults The Cardiovascular Risk in Young Finns Study.

Skilton MR, Siitonen N, Würtz P, Viikari JS, Juonala M, Seppälä I, Laitinen T, Lehtimäki T, Taittonen L, Kähönen M, Celermajer DS, Raitakari OT.

Arterioscler Thromb Vasc Biol. 2014 May;34(5):1064-8. doi: 10.1161/ATVBAHA.113.302934. Epub 2014 Mar 13.

Read full article

Smoking, nicotine dependence and nicotine intake by socio-economic status and marital status

Pennanen M, Broms U, Korhonen T, Haukkala A, Partonen T, Tuulio-Henriksson A, Laatikainen T, Patja K, Kaprio J.

Addict Behav. 2014 Jul;39(7):1145-51. doi: 10.1016/j.addbeh.2014.03.005. Epub 2014 Mar 13.

Read full article

A supportive family environment in childhood enhances the level and heritability of sense of coherence in early adulthood.

Silventoinen K, Volanen SM, Vuoksimaa E, Rose RJ, Suominen S, Kaprio J.

Soc Psychiatry Psychiatr Epidemiol. 2014 Dec;49(12):1951-60. doi: 10.1007/s00127-014-0851-y. Epub 2014 Mar 12.

Read full article

Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: data from the Norwegian HUNT2 study.

Kvehaugen AS, Melien O, Holmen OL, Laivuori H, Dechend R, Staff AC;

BMC Med Genet. 2014 Mar 5;15:28. doi: 10.1186/1471-2350-15-28.

Read full article

Physical work load and psychological stress of daily activities as predictors of disability pension due to musculoskeletal disorders.

Ropponen A, Svedberg P, Koskenvuo M, Silventoinen K, Kaprio J.

Scand J Public Health. 2014 Mar 7;42(4):370-376. [Epub ahead of print]

Read full article

A comparison of anthropometric, metabolic, and reproductive characteristics of young adult women from opposite-sex and same-sex twin pairs

Korsoff P, Bogl LH, Korhonen P, Kangas AJ, Soininen P, Ala-Korpela M, Rose RJ, Kaaja R, Kaprio J

Front Endocrinol (Lausanne). 2014 Mar 7;5:28. doi 10.3389/fendo.2014.00028. eCollection 2014. PubMed PMID: 24639667; PubMed Central PMCID: PMC3945783

Read full article

Attenuated and Protease-Profile Modified Sendai Virus Vectors as a New Tool for Virotherapy of Solid Tumors.

Zimmermann M, Armeanu-Ebinger S, Bossow S, Lampe J, Smirnow I, Schenk A, Lange S, Weiss TS, Neubert W, Lauer UM, Bitzer M.

PLoS One. 2014 Mar 5;9(3):e90508. doi: 10.1371/journal.pone.0090508. eCollection 2014.

Read full article

Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons.

Fischer K, Kettunen J, Würtz P, Haller T, Havulinna AS, Kangas AJ, Soininen P, Esko T, Tammesoo ML, Mägi R, Smit S, Palotie A, Ripatti S, Salomaa V, Ala-Korpela M, Perola M, Metspalu A;

PLoS Med. 2014 Feb 25;11(2):e1001606. doi: 10.1371/journal.pmed.1001606. eCollection 2014.

Read full article

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.

Flannick J, Thorleifsson G, Beer NL, Jacobs SB, Grarup N, Burtt NP, Mahajan A, Fuchsberger C, Atzmon G, Benediktsson R, Blangero J, Bowden DW, Brandslund I, Brosnan J, Burslem F, Chambers J, Cho YS, Christensen C, Douglas DA, Duggirala R, Dymek Z, Farjoun Y, Fennell T, Fontanillas P, Forsén T, Gabriel S, Glaser B, Gudbjartsson DF, Hanis C, Hansen T, Hreidarsson AB, Hveem K, Ingelsson E, Isomaa B, Johansson S, Jørgensen T, Jørgensen ME, Kathiresan S, Kong A, Kooner J, Kravic J, Laakso M, Lee JY, Lind L, Lindgren CM, Linneberg A, Masson G, Meitinger T, Mohlke KL, Molven A, Morris AP, Potluri S, Rauramaa R, Ribel-Madsen R, Richard AM, Rolph T, Salomaa V, Segrè AV, Skärstrand H, Steinthorsdottir V, Stringham HM, Sulem P, Tai ES, Teo YY, Teslovich T, Thorsteinsdottir U, Trimmer JK, Tuomi T, Tuomilehto J, Vaziri-Sani F, Voight BF, Wilson JG, Boehnke M, McCarthy MI, Njølstad PR, Pedersen O; Go-T2D Consortium; T2D-GENES Consortium, Groop L, Cox DR, Stefansson K, Altshuler D.

Nat Genet. 2014 Apr;46(4):357-63. doi: 10.1038/ng.2915. Epub 2014 Mar 2. 

Read full article

Genetics and smoking

Loukola A, Hällfors J, Korhonen T, Kaprio J.

Curr Addict Rep. 2014 Mar 1;1(1):75-82. 

Read full article

Serum hyperglycosylated human chorionic gonadotrophin at 14-17 weeks of gestation does not predict preeclampsia.

Keikkala E, Ranta JK, Vuorela P, Leinonen R, Laivuori H, Väisänen S, Marttala J, Romppanen J, Pulkki K, Stenman UH, Heinonen S;

Prenat Diagn. 2014 Jul;34(7):699-705. doi: 10.1002/pd.4335. Epub 2014 Feb 17.

Read full article

Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells.

Pavet V, Shlyakhtina Y, He T, Ceschin DG, Kohonen P, Perälä M, Kallioniemi O, Gronemeyer H;

Cell Death Dis. 2014 Jan 30;5:e1043. doi: 10.1038/cddis.2014.5.

Read full article

Massive Withdrawal Symptoms and Affective Vulnerability Are Associated with Variants of the CHRNA4 Gene in a Subgroup of Smokers.

Lazary J, Dome P, Csala I, Kovacs G, Faludi G, Kaunisto M, Dome B;

PLoS One. 2014 Jan 30;9(1):e87141. doi: 10.1371/journal.pone.0087141. eCollection 2014.

Read full article

Chromosome x-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.

Tukiainen T, Pirinen M, Sarin AP, Ladenvall C, Kettunen J, Lehtimäki T, Lokki ML, Perola M, Sinisalo J, Vlachopoulou E, Eriksson JG, Groop L, Jula A, Järvelin MR, Raitakari OT, Salomaa V, Ripatti S;

PLoS Genet. 2014 Feb 6;10(2):e1004127. doi: 10.1371/journal.pgen.1004127. eCollection 2014.

Read full article

Making sense of large-scale kinase inhibitor bioactivity datasets: a comparative and integrative analysis.

Tang J, Szwajda A, Shakyawar S, Xu T, Hintsanen P, Wennerberg K, Aittokallio T;

J Chem Inf Model. 2014 Mar 24;54(3):735-43. doi: 10.1021/ci400709d. Epub 2014 Feb 21.

Read full article

High prevalence of GPRC5A germline mutations in BRCA1-mutant breast cancer patients.

Sokolenko AP, Bulanova DR, Iyevleva AG, Aleksakhina SN, Preobrazhenskaya EV, Ivantsov AO, Kuligina ES, Mitiushkina NV, Suspitsin EN, Yanus GA, Zaitseva OA, Yatsuk OS, Togo AV, Kota P, Dixon JM, Larionov AA, Kuznetsov SG, Imyanitov EN;

Int J Cancer. 2014 May 15;134(10):2352-8. doi: 10.1002/ijc.28569. Epub 2014 Jan 27.

Read full article

Using ancestry-informative markers to identify fine structure across 15 populations of European origin.

Huckins LM, Boraska V, Franklin CS, Floyd JA, Southam L; GCAN; WTCCC3, Sullivan PF, Bulik CM, Collier DA, Tyler-Smith C, Zeggini E, Tachmazidou I; GCAN; WTCCC3

Eur J Hum Genet. 2014 Oct;22(10):1190-200. doi: 10.1038/ejhg.2014.1. Epub 2014 Feb 19.

Read full article

Antifungal application of nonantifungal drugs.

Stylianou M, Kulesskiy E, Lopes JP, Granlund M, Wennerberg K, Urban CF;

Antimicrob Agents Chemother. 2014;58(2):1055-62. doi: 10.1128/AAC.01087-13. Epub 2013 Nov 25.

Read full article

Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza.

Atkins C, Evans CW, Nordin B, Patricelli MP, Reynolds R, Wennerberg K, Noah JW;

J Biomol Screen. 2014 Jan 24;19(6):936-946. [Epub ahead of print]

Read full article

Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease.

Medici M, Porcu E, Pistis G, Teumer A, Brown SJ, Jensen RA, Rawal R, Roef GL, Plantinga TS, Vermeulen SH, Lahti J, Simmonds MJ, Husemoen LL, Freathy RM, Shields BM, Pietzner D, Nagy R, Broer L, Chaker L, Korevaar TI, Plia MG, Sala C, Völker U, Richards JB, Sweep FC, Gieger C, Corre T, Kajantie E, Thuesen B, Taes YE, Visser WE, Hattersley AT, Kratzsch J, Hamilton A, Li W, Homuth G, Lobina M, Mariotti S, Soranzo N, Cocca M, Nauck M, Spielhagen C, Ross A, Arnold A, van de Bunt M, Liyanarachchi S, Heier M, Grabe HJ, Masciullo C, Galesloot TE, Lim EM, Reischl E, Leedman PJ, Lai S, Delitala A, Bremner AP, Philips DI, Beilby JP, Mulas A, Vocale M, Abecasis G, Forsen T, James A, Widen E, Hui J, Prokisch H, Rietzschel EE, Palotie A, Feddema P, Fletcher SJ, Schramm K, Rotter JI, Kluttig A, Radke D, Traglia M, Surdulescu GL, He H, Franklyn JA, Tiller D, Vaidya B, de Meyer T, Jørgensen T, Eriksson JG, O'Leary PC, Wichmann E, Hermus AR, Psaty BM, Ittermann T, Hofman A, Bosi E, Schlessinger D, Wallaschofski H, Pirastu N, Aulchenko YS, de la Chapelle A, Netea-Maier RT, Gough SC, Meyer Zu Schwabedissen H, Frayling TM, Kaufman JM, Linneberg A, Räikkönen K, Smit JW, Kiemeney LA, Rivadeneira F, Uitterlinden AG, Walsh JP, Meisinger C, den Heijer M, Visser TJ, Spector TD, Wilson SG, Völzke H, Cappola A, Toniolo D, Sanna S, Naitza S, Peeters RP.

PLoS Genet. 2014 Feb 27;10(2):e1004123. doi: 10.1371/journal.pgen.1004123. eCollection 2014 Feb.

Read full article

Suppressed Bone Turnover in Obesity : A Link to Energy Metabolism? A Case-Control Study

Viljakainen H, Ivaska KK, Paldánius P, Lipsanen-Nyman M, Saukkonen T, Pietiläinen KH, Andersson S, Laitinen K, Mäkitie O.

J Clin Endocrinol Metab. 2014 Jun;99(6):2155-63. doi: 10.1210/jc.2013-3097. Epub 2014 Feb 27.

Read full article

Pharmacologic Suppression of JAK1/2 by JAK1/2 Inhibitor AZD1480 Potently Inhibits IL-6-Induced Experimental Prostate Cancer Metastases Formation.

Gu L, Talati P, Vogiatzi P, Romero-Weaver AL, Abdulghani J, Liao Z, Leiby B, Hoang DT, Mirtti T, Alanen K, Zinda M, Huszar D, Nevalainen MT.

Mol Cancer Ther. 2014 May;13(5):1246-58. doi: 10.1158/1535-7163.MCT-13-0605. Epub 2014 Feb 27.

Read full article

Genetic and Environmental Influences on Cardiovascular Disease Risk Factors : A Study of Chinese Twin Children and Adolescents.

Ji F, Ning F, Duan H, Kaprio J, Zhang D, Zhang D, Wang S, Qiao Q, Sun J, Liang J, Pang Z, Silventoinen K.

Twin Res Hum Genet. 2014 Apr;17(2):72-9. doi: 10.1017/thg.2014.5. Epub 2014 Feb 27. 

Read full article

Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia

Kontro M, Kuusanmäki H, Eldfors S, Burmeister T, Andersson EI, Bruserud O, Brümmendorf TH, Edgren H, Gjertsen BT, Itälä-Remes M, Lagström S, Lohi O, Lundán T, Martí JM, Majumder MM, Parsons A, Pemovska T, Rajala H, Vettenranta K, Kallioniemi O, Mustjoki S, Porkka K, Heckman CA

Leukemia. 2014 Aug;28(8):1738-42. doi: 10.1038/leu.2014.89. Epub 2014 Feb 27.

Read full article

Adolescent Alcohol Abuse and Adverse Adult Outcomes : Evaluating Confounds with Drinking-Discordant Twins.

Heinonen S, Saarinen L, Naukkarinen J, Rodríguez A, Frühbeck G, Hakkarainen A, Lundbom J, Lundbom N, Vuolteenaho K, Moilanen E, Arner P, Hautaniemi S, Suomalainen A, Kaprio J, Rissanen A, Pietiläinen KH.

Int J Obes (Lond). 2014 Nov;38(11):1423-31. doi: 10.1038/ijo.2014.31. Epub 2014 Feb 19.

Read full article

Adipocyte morphology and implications for metabolic derangements in acquired obesity.

Heinonen S, Saarinen L, Naukkarinen J, Rodríguez A, Frühbeck G, Hakkarainen A, Lundbom J, Lundbom N, Vuolteenaho K, Moilanen E, Arner P, Hautaniemi S, Suomalainen A, Kaprio J, Rissanen A, Pietiläinen KH.

Int J Obes (Lond). 2014 Nov;38(11):1423-31. doi: 10.1038/ijo.2014.31. Epub 2014 Feb 19.

Read full article

PSEUDOMARKER 2.0 : efficient computation of likelihoods using NOMAD.

Gertz EM, Hiekkalinna T, Digabel SL, Audet C, Terwilliger JD, Schäffer AA.

BMC Bioinformatics. 2014 Feb 17;15:47. doi: 10.1186/1471-2105-15-47.

Read full article

Associations between maternal level of education and occupational status with placental glucocorticoid regeneration and sensitivity.

Räikkönen K, O'Reilly JR, Pesonen AK, Kajantie E, Villa P, Laivuori H, Hämäläinen E, Seckl JR, Reynolds RM.

Clin Endocrinol (Oxf). 2014 Aug;81(2):175-82. doi:10.1111/cen.12412. Epub 2014 Feb 13.

Read full article

ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays

Joensuu M, Belevich I, Rämö O, Nevzorov I, Vihinen H, Puhka M, Witkos TM, Lowe M, Vartiainen MK, Jokitalo E.

Mol Biol Cell. 2014 Apr;25(7):1111-26. doi: 10.1091/mbc.E13-12-0712. Epub 2014 Feb 12.

Read full article

Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu.

Leitsalu L, Haller T, Esko T, Tammesoo ML, Alavere H, Snieder H, Perola M, Ng PC, Mägi R, Milani L, Fischer K, Metspalu A.

Int J Epidemiol. 2014 Feb 11. [Epub ahead of print]

Read full article

A genome-wide association study of anorexia nervosa

Boraska V, Franklin CS, Floyd JA, Thornton LM, Huckins LM, Southam L, Rayner NW, Tachmazidou I, Klump KL, Treasure J, Lewis CM, Schmidt U, Tozzi F, Kiezebrink K, Hebebrand J, Gorwood P, Adan RA, Kas MJ, Favaro A, Santonastaso P, Fernández-Aranda F, Gratacos M, Rybakowski F, Dmitrzak-Weglarz M, Kaprio J, Keski-Rahkonen A, Raevuori A, Van Furth EF, Slof-Op 't Landt MC, Hudson JI, Reichborn-Kjennerud T, Knudsen GP, Monteleone P, Kaplan AS, Karwautz A, Hakonarson H, Berrettini WH, Guo Y, Li D, Schork NJ, Komaki G, Ando T, Inoko H, Esko T, Fischer K, Männik K, Metspalu A, Baker JH, Cone RD, Dackor J, DeSocio JE, Hilliard CE, O'Toole JK, Pantel J, Szatkiewicz JP, Taico C, Zerwas S, Trace SE, Davis OS, Helder S, Bühren K, Burghardt R, de Zwaan M, Egberts K, Ehrlich S, Herpertz-Dahlmann B, Herzog W, Imgart H, Scherag A, Scherag S, Zipfel S, Boni C, Ramoz N, Versini A, Brandys MK, Danner UN, de Kovel C, Hendriks J, Koeleman BP, Ophoff RA, Strengman E, van Elburg AA, Bruson A, Clementi M, Degortes D, Forzan M, Tenconi E, Docampo E, Escaramís G, Jiménez-Murcia S, Lissowska J, Rajewski A, Szeszenia-Dabrowska N, Slopien A, Hauser J, Karhunen L, Meulenbelt I, Slagboom PE, Tortorella A, Maj M, Dedoussis G, Dikeos D, Gonidakis F, Tziouvas K, Tsitsika A, Papezova H, Slachtova L, Martaskova D, Kennedy JL, Levitan RD, Yilmaz Z, Huemer J, Koubek D, Merl E, Wagner G, Lichtenstein P, Breen G, Cohen-Woods S, Farmer A, McGuffin P, Cichon S, Giegling I, Herms S, Rujescu D, Schreiber S, Wichmann HE, Dina C, Sladek R, Gambaro G, Soranzo N, Julia A, Marsal S, Rabionet R, Gaborieau V, Dick DM, Palotie A, Ripatti S, Widén E, Andreassen OA, Espeseth T, Lundervold A, Reinvang I, Steen VM, Le Hellard S, Mattingsdal M, Ntalla I, Bencko V, Foretova L, Janout V, Navratilova M, Gallinger S, Pinto D, Scherer SW, Aschauer H, Carlberg L, Schosser A, Alfredsson L, Ding B, Klareskog L, Padyukov L, Courtet P, Guillaume S, Jaussent I, Finan C, Kalsi G, Roberts M, Logan DW, Peltonen L, Ritchie GR, Barrett JC; Wellcome Trust Case Control Consortium 3, Estivill X, Hinney A, Sullivan PF, Collier DA, Zeggini E, Bulik CM

A genome-wide association study of anorexia nervosa. Mol Psychiatry. 2014 Oct;19(10):1085-94. doi: 10.1038/mp.2013.187. Epub 2014 Feb 11. PubMed PMID: 4514567; PubMed Central PMCID: PMC4325090.

Read full article

Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors ex vivo and in vitro studies.

Vetvik KK, Sonerud T, Lindeberg M, Lüders T, Størkson RH, Jonsdottir K, Frengen E, Pietiläinen KH, Bukholm I.

Metabolism. 2014 May;63(5):672-81. doi: 10.1016/j.metabol.2014.02.001. Epub 2014 Feb 10.

Read full article

Cross-sectional and longitudinal associations of circulating omega-3 and omega-6 fatty acids with lipoprotein particle concentrations and sizes: population-based cohort study with 6-year follow-up.

Mäntyselkä P, Niskanen L, Kautiainen H, Saltevo J, Würtz P, Soininen P, Kangas AJ, Ala-Korpela M, Vanhala M.

Lipids Health Dis. 2014 Feb 7;13:28. doi: 10.1186/1476-511X-13-28.

Read full article

The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies

van Vliet-Ostaptchouk JV, Nuotio ML, Slagter SN, Doiron D, Fischer K, Foco L, Gaye A, Gögele M, Heier M, Hiekkalinna T, Joensuu A, Newby C, Pang C, Partinen E, Reischl E, Schwienbacher C, Tammesoo ML, Swertz MA, Burton P, Ferretti V, Fortier I, Giepmans L, Harris JR, Hillege HL, Holmen J, Jula A, Kootstra-Ros JE, Kvaløy K, Holmen TL, Männistö S, Metspalu A, Midthjell K, Murtagh MJ, Peters A, Pramstaller PP, Saaristo T, Salomaa V, Stolk RP, Uusitupa M, van der Harst P, van der Klauw MM, Waldenberger M, Perola M, Wolffenbuttel BH

BMC Endocr Disord. 2014 Feb 1;14:9. doi:10.1186/1472-6823-14-9.

Read full article

Drinking, smoking, and educational achievement : Cross-lagged associations from adolescence to adulthood.

Latvala A, Rose RJ, Pulkkinen L, Dick DM, Korhonen T, Kaprio J.

Drug Alcohol Depend. 2014 Apr 1;137:106-13. doi:10.1016/j.drugalcdep.2014.01.016. Epub 2014 Jan 31.

Read full article

Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci.

Service SK, Teslovich TM, Fuchsberger C, Ramensky V, Yajnik P, Koboldt DC, Larson DE, Zhang Q, Lin L, Welch R, Ding L, McLellan MD, O'Laughlin M, Fronick C, Fulton LL, Magrini V, Swift A, Elliott P, Jarvelin MR, Kaakinen M, McCarthy MI, Peltonen L, Pouta A, Bonnycastle LL, Collins FS, Narisu N, Stringham HM, Tuomilehto J, Ripatti S, Fulton RS, Sabatti C, Wilson RK, Boehnke M, Freimer NB.

PLoS Genet. 2014 Jan 30;10(1):e1004147. doi: 10.1371/journal.pgen.1004147. eCollection 2014.

Read full article

Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

Antila H, Autio H, Turunen L, Harju K, Tammela P, Wennerberg K, Yli-Kauhaluoma J, Huttunen HJ, Castrén E, Rantamäki T.

J Neurosci Methods. 2014 Jan 30;222:142-6. doi: 10.1016/j.jneumeth.2013.11.001.

Read full article

High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms.

Kurki MI, Gaál EI, Kettunen J, Lappalainen T, Menelaou A, Anttila V, van 't Hof FN, von Und Zu Fraunberg M, Helisalmi S, Hiltunen M, Lehto H, Laakso A, Kivisaari R, Koivisto T, Ronkainen A, Rinne J, Kiemeney LA, Vermeulen SH, Kaunisto MA, Eriksson JG, Aromaa A, Perola M, Lehtimäki T, Raitakari OT, Salomaa V, Gunel M, Dermitzakis ET, Ruigrok YM, Rinkel GJ, Niemelä M, Hernesniemi J, Ripatti S, de Bakker PI, Palotie A, Jääskeläinen JE.

 PLoS Genet. 2014 Jan 30;10(1):e1004134. doi: 10.1371/journal.pgen.1004134. eCollection 2014 Jan.

Read full article

De novo mutations in schizophrenia implicate synaptic networks.

Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O'Donovan MC.

Nature. 2014 Feb 13;506(7487):179-84. doi:10.1038/nature12929. Epub 2014 Jan 22.

Read full article

ssociation between serum fatty acids and lipoprotein subclass profile in healthy young adults: exploring common genetic and environmental factors.

Jelenkovic A, Bogl LH, Rose RJ, Kangas AJ, Soininen P, Ala-Korpela M, Kaprio J, Silventoinen K.

Atherosclerosis. 2014 Apr;233(2):394-402. doi:10.1016/j.atherosclerosis.2013.12.053. Epub 2014 Jan 21.

Read full article

Full-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Finnish Patients from 2009 to 2013.

Lakspere T, Tynell J, Kaloinen M, Vanlede M, Parsons A, Ikonen N, Kallio-Kokko H, Kantele A, Mattila P, Almusa H, Julkunen I, Kainov D, Kakkola L.

Genome Announc. 2014 Jan 16;2(1). pii: e01004-13. doi:10.1128/genomeA.01004-13.

Read full article

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.

Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H, Laumen H.

Cell. 2014 Jan 16;156(1-2):343-58. doi: 10.1016/j.cell.2013.10.058.

Read full article

A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility

Damotte V, Guillot-Noel L, Patsopoulos NA, Madireddy L, El Behi M

Genes Immun. 2014 Mar;15(2):126-32. doi: 10.1038/gene.2013.70. Epub 2014 Jan 16. PubMed PMID: 24430173

Read full article

A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.

Damotte V, Guillot-Noel L, Patsopoulos NA, Madireddy L, El Behi M; International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium 2, De Jager PL, Baranzini SE, Cournu-Rebeix I, Fontaine B.

Genes Immun. 2014 Mar;15(2):126-32. doi:10.1038/gene.2013.70. Epub 2014 Jan 16.

Read full article

Managing clinically significant findings in research: the UK10K example.

Kaye J, Hurles M, Griffin H, Grewal J, Bobrow M, Timpson N, Smee C, Bolton P, Durbin R, Dyke S, Fitzpatrick D, Kennedy K, Kent A, Muddyman D, Muntoni F, Raymond LF, Semple R, Spector T, UK 10K;

Read full article

High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth.

Leivonen SK, Sahlberg KK, Mäkelä R, Due EU, Kallioniemi O, Børresen-Dale AL, Perälä M.

Mol Oncol. 2014 Feb;8(1):93-104. doi: 10.1016/j.molonc.2013.10.001. Epub 2013 Oct 11.

Read full article

PPISURV: a novel bioinformatics tool for uncovering the hidden role of specific genes in cancer survival outcome.

Antonov AV, Krestyaninova M, Knight RA, Rodchenkov I, Melino G, Barlev NA.

Oncogene. 2014 Mar 27;33(13):1621-8. doi: 10.1038/onc.2013.119. Epub 2013 May 20. 

Read full article

Characterising metabolically healthy obesity in weight-discordant monozygotic twins.

Naukkarinen J, Heinonen S, Hakkarainen A, Lundbom J, Vuolteenaho K, Saarinen L, Hautaniemi S, Rodriguez A, Frühbeck G, Pajunen P, Hyötyläinen T, Orešič M, Moilanen E, Suomalainen A, Lundbom N, Kaprio J, Rissanen A, Pietiläinen KH.

Diabetologia. 2014 Jan;57(1):167-76. doi: 10.1007/s00125-013-3066-y. Epub 2013 Oct 8.

Read full article

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.

Goris A, van Setten J, Diekstra F, Ripke S, Patsopoulos NA, Sawcer SJ; International Multiple Sclerosis Genetics Consortium, van Es M; Australia and New Zealand MS Genetics Consortium, Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown RH Jr, Shatunov A, Leigh N, Al-Chalabi A, Shaw CE, Traynor BJ, Chiò A, Restagno G, Mora G, Ophoff RA, Oksenberg JR, Van Damme P, Compston A, Robberecht W, Dubois B, van den Berg LH, De Jager PL, Veldink JH, de Bakker PI.

Hum Mol Genet. 2014 Apr 1;23(7):1916-22. doi: 10.1093/hmg/ddt574. Epub 2013 Nov 13.

Read full article

Common variant at 16p11.2 conferring risk of psychosis.

Steinberg S, de Jong S, Mattheisen M, Costas J, Demontis D, Jamain S, Pietiläinen OP, Lin K, Papiol S, Huttenlocher J, Sigurdsson E, Vassos E, Giegling I, Breuer R, Fraser G, Walker N, Melle I, Djurovic S, Agartz I, Tuulio-Henriksson A, Suvisaari J, Lönnqvist J, Paunio T, Olsen L, Hansen T, Ingason A, Pirinen M, Strengman E; GROUP, Hougaard DM, Orntoft T, Didriksen M, Hollegaard MV, Nordentoft M, Abramova L, Kaleda V, Arrojo M, Sanjuán J, Arango C, Etain B, Bellivier F, Méary A, Schürhoff F, Szoke A, Ribolsi M, Magni V, Siracusano A, Sperling S, Rossner M, Christiansen C, Kiemeney LA, Franke B, van den Berg LH, Veldink J, Curran S, Bolton P, Poot M, Staal W, Rehnstrom K, Kilpinen H, Freitag CM, Meyer J, Magnusson P, Saemundsen E, Martsenkovsky I, Bikshaieva I, Martsenkovska I, Vashchenko O, Raleva M, Paketchieva K, Stefanovski B, Durmishi N, Pejovic Milovancevic M, Lecic Tosevski D, Silagadze T, Naneishvili N, Mikeladze N, Surguladze S, Vincent JB, Farmer A, Mitchell PB, Wright A, Schofield PR, Fullerton JM, Montgomery GW, Martin NG, Rubino IA, van Winkel R, Kenis G, De Hert M, Réthelyi JM, Bitter I, Terenius L, Jönsson EG, Bakker S, van Os J, Jablensky A, Leboyer M, Bramon E, Powell J, Murray R, Corvin A, Gill M, Morris D, O'Neill FA, Kendler K, Riley B; Wellcome Trust Case Control Consortium 2, Craddock N, Owen MJ, O'Donovan MC, Thorsteinsdottir U, Kong A, Ehrenreich H, Carracedo A, Golimbet V, Andreassen OA, Børglum AD, Mors O, Mortensen PB, Werge T, Ophoff RA, Nöthen MM, Rietschel M, Cichon S, Ruggeri M, Tosato S, Palotie A, St Clair D, Rujescu D, Collier DA, Stefansson H, Stefansson K.

Mol Psychiatry. 2014 Jan;19(1):108-14. doi:10.1038/mp.2012.157. Epub 2012 Nov 20. 

Read full article

Data sharing in large research consortia: experiences and recommendations from ENGAGE.

Budin-Ljøsne I, Isaeva J, Knoppers BM, Tassé AM, Shen HY, McCarthy MI, Harris JR; ENGAGE Consortium.

Eur J Hum Genet. 2014 Mar;22(3):317-21. doi:10.1038/ejhg.2013.131. Epub 2013 Jun 19.

Read full article

Genetics of disc-related disorders : current findings and lessons from other complex diseases

Näkki A, Battié MC, Kaprio J

Eur Spine J. 2014 Jun;23 Suppl 3:S354-63. doi: 10.1007/s00586-013-2878-2.

Read full article

The many faces of diabetes: a disease with increasing heterogeneity

Tuomi T, Santoro N, Caprio S, Cai M, Weng J, Groop L.

Lancet. 2014 Mar 22;383(9922):1084-94. doi: 10.1016/S0140-6736(13)62219-9.

Read full article

Genome-wide association study identifies three novel loci for type 2 diabetes.

Hara K, Fujita H, Johnson TA, Yamauchi T, Yasuda K, Horikoshi M, Peng C, Hu C, Ma RC, Imamura M, Iwata M, Tsunoda T, Morizono T, Shojima N, So WY, Leung TF, Kwan P, Zhang R, Wang J, Yu W, Maegawa H, Hirose H; DIAGRAM consortium, Kaku K, Ito C, Watada H, Tanaka Y, Tobe K, Kashiwagi A, Kawamori R, Jia W, Chan JC, Teo YY, Shyong TE, Kamatani N, Kubo M, Maeda S, Kadowaki T.

Hum Mol Genet. 2014 Jan 1;23(1):239-46. doi: 10.1093/hmg/ddt399. Epub 2013 Aug 14.

Read full article

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.

Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R; UK10K Consortium, Duchen MR, Muntoni F, Sheridan E.

Nat Genet. 2014 Feb;46(2):188-93. doi: 10.1038/ng.2851. Epub 2013 Dec 15.

Read full article

Lifetime physical activity and cancer incidence-A cohort study of male former elite athletes in Finland.

Sormunen J, Bäckmand HM, Sarna S, Kujala UM, Kaprio J, Dyba T, Pukkala E.

J Sci Med Sport. 2014 Sep;17(5):479-84. doi: 10.1016/j.jsams.2013.10.239. Epub 2013 Oct 26.

Read full article

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy

Speed D, Hoggart C, Petrovski S, Tachmazidou I, Coffey A, Jorgensen A, Eleftherohorinou H, De Iorio M, Todaro M, De T, Smith D, Smith PE, Jackson M, Cooper P, Kellett M, Howell S, Newton M, Yerra R, Tan M, French C, Reuber M, Sills GE, Chadwick D, Pirmohamed M, Bentley D, Scheffer I, Berkovic S, Balding D, Palotie A, Marson A, O'Brien TJ, Johnson MR.

Hum Mol Genet. 2014 Jan 1;23(1):247-58. doi:10.1093/hmg/ddt403. Epub 2013 Aug 19.

Read full article

Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis.

He T, Haapa-Paananen S, Kaminskyy VO, Kohonen P, Fey V, Zhivotovsky B, Kallioniemi O, Perälä M.

Oncogene. 2014 Jul 3;33(27):3538-49. doi: 10.1038/onc.2013.313. Epub 2013 Sep 9.

Read full article

Impact of a very low-energy diet on the fecal microbiota of obese individuals.

Simões CD, Maukonen J, Scott KP, Virtanen KA, Pietiläinen KH, Saarela M.

Eur J Nutr. 2014 Sep;53(6):1421-9. doi: 10.1007/s00394-013-0645-0. Epub 2013 Dec 31.

Read full article

Identifying flavor preference subgroups. Genetic basis and related eating behavior traits.

Törnwall O, Silventoinen K, Hiekkalinna T, Perola M, Tuorila H, Kaprio J.

Appetite. 2014 Apr;75:1-10. doi: 10.1016/j.appet.2013.11.020. Epub 2013 Dec 19.

Read full article

A technique to increase protein yield in a rabbit reticulocyte lysate translation system.

Anastasina M, Terenin I, Butcher SJ, Kainov DE.

Biotechniques. 2014 Jan;56(1):36-9. doi: 10.2144/000114125.

Read full article

Motives for physical activity among active and inactive persons in their mid-30s.

Aaltonen S, Rottensteiner M, Kaprio J, Kujala UM.

Scand J Med Sci Sports. Volume 24, Issue 4, pages 727–735, August 2014. Epub ahead of print 2013 Jan 17. doi: 10.1111/sms.12040. 

Read full article

Telomere length in circulating leukocytes is associated with lung function and disease

Albrecht E, Sillanpää E, Karrasch S, Alves AC, Codd V, Hovatta I, Buxton JL, Nelson CP, Broer L, Hägg S, Mangino M, Willemsen G, Surakka I, Ferreira MA, Amin N, Oostra BA, Bäckmand HM, Peltonen M, Sarna S, Rantanen T, Sipilä S, Korhonen T, Madden PA, Gieger C, Jörres RA, Heinrich J, Behr J, Huber RM, Peters A, Strauch K, Wichmann HE, Waldenberger M, Blakemore AI, de Geus EJ, Nyholt DR, Henders AK, Piirilä PL, Rissanen A, Magnusson PK, Viñuela A, Pietiläinen KH, Martin NG, Pedersen NL, Boomsma DI, Spector TD, van Duijn CM, Kaprio J, Samani NJ, Jarvelin MR, Schulz H.

Eur Respir J. 2014 Apr;43(4):983-92. doi:10.1183/09031936.00046213. Epub 2013 Dec 5.

Read full article

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells.

Costantino L, Sotiriou SK, Rantala JK, Magin S, Mladenov E, Helleday T, Haber JE, Iliakis G, Kallioniemi OP, Halazonetis TD.

Science. 2014 Jan 3;343(6166):88-91. doi: 10.1126/science.1243211. Epub 2013 Dec 5.

Read full article

Genome-wide association study on detailed profiles of smoking behavior and nicotine dependence in a twin sample.

Loukola A, Wedenoja J, Keskitalo-Vuokko K, Broms U, Korhonen T, Ripatti S, Sarin AP, Pitkäniemi J, He L, Häppölä A, Heikkilä K, Chou YL, Pergadia ML, Heath AC, Montgomery GW, Martin NG, Madden PA, Kaprio J.

Mol Psychiatry. 2014 May;19(5):615-24. doi: 10.1038/mp.2013.72. Epub 2013 Jun 11. 

Read full article

Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).

Lencz T, Knowles E, Davies G, Guha S, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, Mukherjee S, DeRosse P, Lundervold A, Steen VM, John M, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Ikeda M, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Donohoe G, Morris D, Corvin A, Gill M, Pendleton N, Iwata N, Darvasi A, Bitsios P, Rujescu D, Lahti J, Hellard SL, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK.

Mol Psychiatry. 2014 Feb;19(2):168-74. doi: 10.1038/mp.2013.166. Epub 2013 Dec 17.

Read full article

Last updated: 29.07.2014 - 08:48