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FIMM Publications 2016

The Association Between Musculoskeletal Pain and Circulating Ornithine: A Population-Based Study.

Mäntyselkä P, Ali-Sisto T, Kautiainen H, Niskanen L, Viinamäki H, Velagapudi V, Lehto SM.

Pain Med. 2016 Dec 29. pii: pnw285. doi: 10.1093/pm/pnw285. [Epub ahead of print]

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High LYVE-1 positive lymphatic vessel numbers are associated with axillary lymph node metastases and poor outcome in breast cancer.

Bono P, Wasenius VM, Heikkilä P, Lundin J, Jackson DG, Joensuu H.

Clin Cancer Res. 2004 Nov 1;10(21):7144-9.

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Serum calcium and risk of migraine: a Mendelian randomization study.

Yin P, Anttila V, Siewert KM, Palotie A, Davey Smith G, Voight BF.

Hum Mol Genet. 2016 Dec 26. pii: ddw416. doi: 10.1093/hmg/ddw416. [Epub ahead of print].

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Linear parabolic single-crystal diamond refractive lenses for synchrotron X-ray sources.

Terentyev S, Polikarpov M, Snigireva I, Di Michiel M, Zholudev S, Yunkin V, Kuznetsov S, Blank V, Snigirev A.

J Synchrotron Radiat. 2017 Jan 1;24(Pt 1):103-109. doi: 10.1107/S1600577516017331.

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A genome-wide screen for acrophobia susceptibility loci in a Finnish isolate.

isiewicz Z, Hiekkalinna T, Paunio T, Varilo T, Terwilliger JD, Partonen T, Hovatta I.

Sci Rep. 2016 Dec 20;6:39345. doi: 10.1038/srep39345.

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Former male elite athletes have better metabolic health in late life than their controls.

Laine MK, Eriksson JG, Kujala UM, Kaprio J, Loo BM, Sundvall J, Bäckmand HM, Peltonen M, Jula A, Sarna S.

Scand J Med Sci Sports. 2016 Mar;26(3):284-90. doi: 10.1111/sms.12442.

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Maternal Depressive Symptoms During and After Pregnancy and Psychiatric Problems in Children.

Lahti M, Savolainen K, Tuovinen S, Pesonen AK, Lahti J, Heinonen K, Hämäläinen E, Laivuori H, Villa PM, Reynolds RM, Kajantie E, Räikkönen K.

J Am Acad Child Adolesc Psychiatry. 2017 Jan;56(1):30-39.e7. doi: 10.1016/j.jaac.2016.10.007. 

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Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.

Ahola-Olli AV, Würtz P, Havulinna AS, Aalto K, Pitkänen N, Lehtimäki T, Kähönen M, Lyytikäinen LP, Raitoharju E, Seppälä I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salomaa V, Salmi M, Kettunen J, Raitakari OT.

Am J Hum Genet. 2017 Jan 5;100(1):40-50. doi: 10.1016/j.ajhg.2016.11.007.

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Pilot Study on the Genetic Background of an Active Matrix Metalloproteinase (aMMP-8) Test in Finnish Adolescents.

Heikkinen AM, Raivisto T, Kettunen K, Kovanen L, Haukka J, Pakbaznejad Esmaeili E, Elg J, Gieselmann DR, Rathnayake N, Ruokonen H, Tervahartiala T, Sorsa T.

J Periodontol. 2016 Dec 17:1-10. doi: 10.1902/jop.2016.160441. [Epub ahead of print].

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Extended lymphadenectomy and adjuvant chemotherapy in muscle-invasive bladder cancer treated by radical cystectomy.

Bostrom PJ, Mirtti T, Nurmi M, Laato M, Van Rhijn BWG, Fleshner NE, Finelli A, Jewett MAS, Moore MJ, Sridhar SS, Tannock I, Zlotta A.

J Clin Oncol 30, 2012.

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Leisure-Time Physical Activity and Academic Performance: Cross-Lagged Associations from Adolescence to Young Adulthood.

Aaltonen S, Latvala A, Rose RJ, Kujala UM, Kaprio J, Silventoinen K.

Sci Rep. 2016 Dec 15;6:39215. doi: 10.1038/srep39215.

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Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994.

Jelenkovic A, Hur YM, Sund R, Yokoyama Y, Siribaddana SH, Hotopf M, Sumathipala A, Rijsdijk F, Tan Q, Zhang D, Pang Z, Aaltonen S, Heikkilä K, Öncel SY, Aliev F, Rebato E, Tarnoki AD, Tarnoki DL, Christensen K, Skytthe A, Kyvik KO, Silberg JL, Eaves LJ, Maes HH, Cutler TL, Hopper JL, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Cozen W, Hwang AE, Mack TM, Sung J, Song YM, Yang S, Lee K, Franz CE, Kremen WS, Lyons MJ, Busjahn A, Nelson TL, Whitfield KE, Kandler C, Jang KL, Gatz M, Butler DA, Stazi MA, Fagnani C, D'Ippolito C, Duncan GE, Buchwald D, Derom CA, Vlietinck RF, Loos RJ, Martin NG, Medland SE, Montgomery GW, Jeong HU, Swan GE, Krasnow R, Magnusson PK, Pedersen NL, Dahl-Aslan AK, McAdams TA, Eley TC, Gregory AM, Tynelius P, Baker LA, Tuvblad C, Bayasgalan G, Narandalai D, Lichtenstein P, Spector TD, Mangino M, Lachance G, Bartels M, van Beijsterveldt TC, Willemsen G, Burt SA, Klump KL, Harris JR, Brandt I, Nilsen TS, Krueger RF, McGue M, Pahlen S, Corley RP, Hjelmborg JV, Goldberg JH, Iwatani Y, Watanabe M, Honda C, Inui F, Rasmussen F, Huibregtse BM, Boomsma DI, Sørensen TI, Kaprio J, Silventoinen K.

Elife. 2016 Dec 14;5. pii: e20320. doi: 10.7554/eLife.20320.

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Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration.

EAS Familial Hypercholesterolaemia Studies Collaboration., Vallejo-Vaz AJ, Akram A, Kondapally Seshasai SR, Cole D, Watts GF, Hovingh GK, Kastelein JJ, Mata P, Raal FJ, Santos RD, Soran H, Freiberger T, Abifadel M, Aguilar-Salinas CA, Alnouri F, Alonso R, Al-Rasadi K, Banach M, Bogsrud MP, Bourbon M, Bruckert E, Car J, Ceska R, Corral P, Descamps O, Dieplinger H, Do CT, Durst R, Ezhov MV, Fras Z, Gaita D, Gaspar IM, Genest J, Harada-Shiba M, Jiang L, Kayikcioglu M, Lam CS, Latkovskis G, Laufs U, Liberopoulos E, Lin J, Lin N, Maher V, Majano N, Marais AD, März W, Mirrakhimov E, Miserez AR, Mitchenko O, Nawawi H, Nilsson L, Nordestgaard BG, Paragh G, Petrulioniene Z, Pojskic B, Reiner Ž, Sahebkar A, Santos LE, Schunkert H, Shehab A, Slimane MN, Stoll M, Su TC, Susekov A, Tilney M, Tomlinson B, Tselepis AD, Vohnout B, Widén E, Yamashita S, Catapano AL, Ray KK.

Atheroscler Suppl. 2016 Dec;22:1-32. doi: 10.1016/j.atherosclerosissup.2016.10.001.

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A novel class of somatic mutations in blood detected preferentially in CD8+ cells.

Valori M, Jansson L, Kiviharju A, Ellonen P, Rajala H, Awad SA, Mustjoki S, Tienari PJ.

Clin Immunol. 2016 Dec 5;175:75-81. doi: 10.1016/j.clim.2016.11.018. [Epub ahead of print]

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Branched-Chain Amino Acid Levels Are Related with Surrogates of Disturbed Lipid Metabolism among Older Men.

Kujala UM, Peltonen M, Laine MK, Kaprio J, Heinonen OJ, Sundvall J, Eriksson JG, Jula A, Sarna S, Kainulainen H.

Front Med (Lausanne). 2016 Nov 25;3:57.

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RNA sequencing of chorionic villi from recurrent pregnancy loss patients reveals impaired function of basic nuclear and cellular machinery.

Sõber S, Rull K, Reiman M, Ilisson P, Mattila P, Laan M.

Sci Rep. 2016 Dec 8;6:38439. doi: 10.1038/srep38439. 

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To the Editor: Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia up-regulated 1.

Haapaniemi EM, Fogarty CL, Keskitalo S, Katayama S, Vihinen H, Ilander M, Mustjoki S, Krjutškov K, Lehto M, Hautala T, Eriksson O, Jokitalo E, Velagapudi V, Varjosalo M, Seppänen M, Kere J.

J Allergy Clin Immunol. 2016 Nov 29. pii: S0091-6749(16)31375-6. doi: 10.1016/j.jaci.2016.09.050. [Epub ahead of print]

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KLB is associated with alcohol drinking, and its gene productβ-Klotho is necessary for FGF21 regulation of alcohol preference.

Schumann G, Liu C, O'Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N, Jia T, Preis S, Segura Lepe M, Akira S, Barbieri C, Baumeister S, Cauchi S, Clarke TK, Enroth S, Fischer K, Hällfors J, Harris SE, Hieber S, Hofer E, Hottenga JJ, Johansson Å, Joshi PK, Kaartinen N, Laitinen J, Lemaitre R, Loukola A, Luan J, Lyytikäinen LP, Mangino M, Manichaikul A, Mbarek H, Milaneschi Y, Moayyeri A, Mukamal K, Nelson C, Nettleton J, Partinen E, Rawal R, Robino A, Rose L, Sala C, Satoh T, Schmidt R, Schraut K, Scott R, Smith AV, Starr JM, Teumer A, Trompet S, Uitterlinden AG, Venturini C, Vergnaud AC, Verweij N, Vitart V, Vuckovic D, Wedenoja J, Yengo L, Yu B, Zhang W, Zhao JH, Boomsma DI, Chambers J, Chasman DI, Daniela T, de Geus E, Deary I, Eriksson JG, Esko T, Eulenburg V, Franco OH, Froguel P, Gieger C, Grabe HJ, Gudnason V, Gyllensten U, Harris TB, Hartikainen AL, Heath AC, Hocking L, Hofman A, Huth C, Jarvelin MR, Jukema JW, Kaprio J, Kooner JS, Kutalik Z, Lahti J, Langenberg C, Lehtimäki T, Liu Y, Madden PA, Martin N, Morrison A, Penninx B, Pirastu N, Psaty B, Raitakari O, Ridker P, Rose R, Rotter JI, Samani NJ, Schmidt H, Spector TD, Stott D, Strachan D, Tzoulaki I, van der Harst P, van Duijn CM, Marques-Vidal P, Vollenweider P, Wareham NJ, Whitfield JB, Wilson J, Wolffenbuttel B, Bakalkin G, Evangelou E, Liu Y, Rice KM, Desrivières S, Kliewer SA, Mangelsdorf DJ, Müller CP, Levy D, Elliott P.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14372-14377.

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Consistency in drug response profiling.

Mpindi JP, Yadav B, Östling P, Gautam P, Malani D, Murumägi A, Hirasawa A, Kangaspeska S, Wennerberg K, Kallioniemi O, Aittokallio T.

Nature. 2016 Nov 30;540(7631):E5-E6. doi: 10.1038/nature20171.

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Prevalence and correlates of binge eating disorder related features in the community.

Mustelin L, Bulik CM, Kaprio J, Keski-Rahkonen A.

Appetite. 2017 Feb 1;109:165-171. doi: 10.1016/j.appet.2016.11.032. 

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Metabolic signatures of birthweight in 18 288 adolescents and adults.

Würtz P, Wang Q, Niironen M, Tynkkynen T, Tiainen M, Drenos F, Kangas AJ, Soininen P, Skilton MR, Heikkilä K, Pouta A, Kähönen M, Lehtimäki T, Rose RJ, Kajantie E, Perola M, Kaprio J, Eriksson JG, Raitakari OT, Lawlor DA, Davey Smith G, Järvelin MR, Ala-Korpela M, Auro K.

Int J Epidemiol. 2016 Oct;45(5):1539-1550. 

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High-throughput cell-based compound screen identifies pinosylvin methyl ether and tanshinone IIA as inhibitors of castration-resistant prostate cancer.

Ketola K, Viitala M, Kohonen P, Fey V, Culig Z, Kallioniemi O, Iljin K.

J Mol Biochem. 2016 Mar 30;5(1):12-22.

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First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with pre-eclampsia: a case control study.

Keikkala E, Koskinen S, Vuorela P, Laivuori H, Romppanen J, Heinonen S, Stenman UH.

BMC Pregnancy Childbirth. 2016 Nov 25;16(1):378.

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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.

Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K, Kutalik Z, Lahti J, Luan J, Mägi R, Mahajan A, Mangino M, Medina-Gomez C, Monda KL, Nolte IM, Pérusse L, Prokopenko I, Qi L, Rose LM, Salvi E, Smith MT, Snieder H, Stančáková A, Ju Sung Y, Tachmazidou I, Teumer A, Thorleifsson G, van der Harst P, Walker RW, Wang SR, Wild SH, Willems SM, Wong A, Zhang W, Albrecht E, Couto Alves A, Bakker SJ, Barlassina C, Bartz TM, Beilby J, Bellis C, Bergman RN, Bergmann S, Blangero J, Blüher M, Boerwinkle E, Bonnycastle LL, Bornstein SR, Bruinenberg M, Campbell H, Chen YI, Chiang CW, Chines PS, Collins FS, Cucca F, Cupples LA, D'Avila F, de Geus EJ, Dedoussis G, Dimitriou M, Döring A, Eriksson JG, Farmaki AE, Farrall M, Ferreira T, Fischer K, Forouhi NG, Friedrich N, Gjesing AP, Glorioso N, Graff M, Grallert H, Grarup N, Gräßler J, Grewal J, Hamsten A, Harder MN, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Havulinna AS, Heliövaara M, Hillege H, Hofman A, Holmen O, Homuth G, Hottenga JJ, Hui J, Husemoen LL, Hysi PG, Isaacs A, Ittermann T, Jalilzadeh S, James AL, Jørgensen T, Jousilahti P, Jula A, Marie Justesen J, Justice AE, Kähönen M, Karaleftheri M, Tee Khaw K, Keinanen-Kiukaanniemi SM, Kinnunen L, Knekt PB, Koistinen HA, Kolcic I, Kooner IK, Koskinen S, Kovacs P, Kyriakou T, Laitinen T, Langenberg C, Lewin AM, Lichtner P, Lindgren CM, Lindström J, Linneberg A, Lorbeer R, Lorentzon M, Luben R, Lyssenko V, Männistö S, Manunta P, Leach IM, McArdle WL, Mcknight B, Mohlke KL, Mihailov E, Milani L, Mills R, Montasser ME, Morris AP, Müller G, Musk AW, Narisu N, Ong KK, Oostra BA, Osmond C, Palotie A, Pankow JS, Paternoster L, Penninx BW, Pichler I, Pilia MG, Polašek O, Pramstaller PP, Raitakari OT, Rankinen T, Rao DC, Rayner NW, Ribel-Madsen R, Rice TK, Richards M, Ridker PM, Rivadeneira F, Ryan KA, Sanna S, Sarzynski MA, Scholtens S, Scott RA, Sebert S, Southam L, Sparsø TH, Steinthorsdottir V, Stirrups K, Stolk RP, Strauch K, Stringham HM, Swertz MA, Swift AJ, Tönjes A, Tsafantakis E, van der Most PJ, Van Vliet-Ostaptchouk JV, Vandenput L, Vartiainen E, Venturini C, Verweij N, Viikari JS, Vitart V, Vohl MC, Vonk JM, Waeber G, Widén E, Willemsen G, Wilsgaard T, Winkler TW, Wright AF, Yerges-Armstrong LM, Hua Zhao J, Carola Zillikens M, Boomsma DI, Bouchard C, Chambers JC, Chasman DI, Cusi

D, Gansevoort RT, Gieger C, Hansen T, Hicks AA, Hu F, Hveem K, Jarvelin MR, Kajantie E, Kooner JS, Kuh D, Kuusisto J, Laakso M, Lakka TA, Lehtimäki T, Metspalu A, Njølstad I, Ohlsson C, Oldehinkel AJ, Palmer LJ, Pedersen O, Perola M, Peters A, Psaty BM, Puolijoki H, Rauramaa R, Rudan I, Salomaa V, Schwarz PE, Shudiner AR, Smit JH, Sørensen TI, Spector TD, Stefansson K, Stumvoll M, Tremblay A, Tuomilehto J, Uitterlinden AG, Uusitupa M, Völker U, Vollenweider P, Wareham NJ, Watkins H, Wilson JF, Zeggini E, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, van Duijn CM, Fox C, Groop LC, Heid IM, Hunter DJ, Kaplan RC, McCarthy MI, North KE, O'Connell JR, Schlessinger D, Thorsteinsdottir U, Strachan DP, Frayling T, Hirschhorn JN, Müller-Nurasyid M, Loos RJ.

Nat Commun. 2016 Nov 23;7:13357. doi: 10.1038/ncomms13357.

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Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.

Perkins DO, Pers TH, Pietiläinen O, Pimm J, Pocklington AJ, Powell J, Price A, Pulver AE, Purcell SM, Quested D, Rasmussen HB, Reichenberg A, Reimers MA, Richards AL, Roffman JL, Roussos P, Ruderfer DM, Salomaa V, Sanders AR, Savitz A, Schall U, Schulze TG, Schwab SG, Scolnick EM, Scott RJ, Seidman LJ, Shi J, Silverman JM, Smoller JW, Söderman E, Spencer CC, Stahl EA, Strengman E, Strohmaier J, Stroup TS, Suvisaari J, Svrakic DM, Szatkiewicz JP, Thirumalai S, Tooney PA, Veijola J, Visscher PM, Waddington J, Walsh D, Webb BT, Weiser M, Wildenauer DB, Williams NM, Williams S, Witt SH, Wolen AR, Wormley BK, Wray NR, Wu JQ, Zai CC, Adolfsson R, Andreassen OA, Blackwood DH, Bramon E, Buxbaum JD, Cichon S, Collier DA, Corvin A, Daly MJ, Darvasi A, Domenici E, Esko T, Gejman PV, Gill M, Gurling H, Hultman CM, Iwata N, Jablensky AV, Jönsson EG, Kendler KS, Kirov G, Knight J, Levinson DF, Li QS, McCarroll SA, McQuillin A, Moran JL, Mowry BJ, Nöthen MM, Ophoff RA, Owen MJ, Palotie A, Pato CN, Petryshen TL, Posthuma D, Rietschel M, Riley BP, Rujescu D, Sklar P, St Clair D, Walters JT, Werge T, Sullivan PF, O'Donovan MC, Scherer SW, Neale BM, Sebat J.

Nat Genet. 2017 Jan;49(1):27-35. doi: 10.1038/ng.3725.

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Regulation of Kynurenine Biosynthesis during Influenza Virus Infection.

Gaelings L, Söderholm S, Bugai A, Fu Y, Nandania J, Schepens B, Lorey MB, Tynell J, Vande Ginste L, Le Goffic R, Miller MS, Kuisma M, Marjomäki V, De Brabander J, Matikainen S, Nyman TA, Bamford DH, Saelens X, Julkunen I, Paavilainen H, Hukkanen V, Velagapudi V, Kainov DE.

FEBS J. 2016 Nov 18. doi: 10.1111/febs.13966. [Epub ahead of print]

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Cancer Cell Drug Response Transcriptomes in 3D.

Wennerberg K.

Cell Chem Biol.  2016 Nov 17;23(11):1323-1324. doi: 10.1016/j.chembiol.2016.11.002.

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Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data.

Guinney J, Wang T, Laajala TD, Winner KK, Bare JC, Neto EC, Khan SA, Peddinti G, Airola A, Pahikkala T, Mirtti T, Yu T, Bot BM, Shen L, Abdallah K, Norman T, Friend S, Stolovitzky G, Soule H, Sweeney CJ, Ryan CJ, Scher HI, Sartor O, Xie Y, Aittokallio T, Zhou FL, Costello JC.

Lancet Oncol. 2017 Jan;18(1):132-142. doi: 10.1016/S1470-2045(16)30560-5. 

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Genetic and Environmental Effects on Telomere Length and Lung Function: A Twin Study.

Sillanpää E, Sipilä S, Törmäkangas T, Kaprio J, Rantanen T.

J Gerontol A Biol Sci Med Sci. 2016 Nov 16. pii: glw178. [Epub ahead of print].

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The Value of Filaggrin Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients.

Luukkonen TM, Kiiski V, Ahola M, Mandelin J, Virtanen H, Pöyhönen M, Kivirikko S, Surakka I, Reitamo S, Palotie A, Heliövaara M, Jakkula E, Remitz A.

Acta Derm Venereol. 2016 Nov 14. doi: 10.2340/00015555-2578. [Epub ahead of print].

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Enhanced sensitivity to glucocorticoids in cytarabine resistant AML.

Malani D, Murumägi A, Yadav B, Kontro M, Eldfors S, Kumar A, Karjalainen R, Majumder MM, Ojamies P, Pemovska T, Wennerberg K, Heckman C, Porkka K, Wolf M, Aittokallio T, Kallioniemi O.

Leukemia. 2016 Dec 2. doi: 10.1038/leu.2016.314. [Epub ahead of print]

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c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease.

Lindholm D, Pham DD, Cascone A, Eriksson O, Wennerberg K, Saarma M.

Front Aging Neurosci. 2016 Oct 26;8:254. Review. PubMed PMID: 27833551

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Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems.

Shu L, Zhao Y, Kurt Z, Byars SG, Tukiainen T, Kettunen J, Orozco LD, Pellegrini M, Lusis AJ, Ripatti S, Zhang B, Inouye M, Mäkinen VP, Yang X.

BMC Genomics. 2016 Nov 4;17(1):874. PubMed PMID: 27814671

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Liver Fat and Insulin Sensitivity Define Metabolite Profiles During a Glucose Tolerance Test in Young Adult Twins.

Rämö JT, Kaye SM, Jukarainen S, Bogl LH, Hakkarainen A, Lundbom J, Lundbom N, Rissanen A, Kaprio J, Matikainen N, Pietiläinen KH.

J Clin Endocrinol Metab. 2016 Nov 3:jc20153512. [Epub ahead of print]

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A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents.

Maes HH, Prom-Wormley E, Eaves LJ, Rhee SH, Hewitt JK, Young S, Corley R, McGue M, Iacono WG, Legrand L, Samek DR, Murrelle EL, Silberg JL, Miles DR, Schieken RM, Beunen GP, Thomis M, Rose RJ, Dick DM, Boomsma DI, Bartels M, Vink JM, Lichtenstein P, White V, Kaprio J, Neale MC.

Nicotine Tob Res. 2016 Nov 2. pii: ntw294. [Epub ahead of print]

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Effect of High-Carbohydrate Diet on Plasma Metabolome in Mice with Mitochondrial Respiratory Chain Complex III Deficiency.

Rajendran J, Tomašić N, Kotarsky H, Hansson E, Velagapudi V, Kallijärvi J, Fellman V.

Int J Mol Sci. 2016 Nov 1;17(11). pii: E1824. PubMed PMID: 27809283

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Longitudinal modeling of ultrasensitive and traditional prostate-specific antigen and prediction of biochemical recurrence after radical prostatectomy.

Laajala TD, Seikkula H, Sadat FS, Mirtti T, Boström PJ, Elo LL.

Sci Rep. 2016 Nov 2;6:36161. doi: 10.1038/srep36161.

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Genetic variants linked to education predict longevity.

Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, Adams MJ, Hill WD, Davies G; Social Science Genetic Association Consortium., Nagy R, Amador C, Läll K, Metspalu A, Liewald DC, Campbell A, Wilson JF, Hayward C, Esko T, Porteous DJ, Gale CR, Deary IJ.

Collaborators:

Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P, Chen GB, Emilsson V, Meddens SF, Oskarsson S, Pickrell JK, Thom K, Timshel P, de Vlaming R, Abdellaoui A, Ahluwalia TS, Bacelis J, Baumbach C, Bjornsdottir G, Brandsma JH, Concas MP, Derringer J, Furlotte NA, Galesloot TE, Girotto G, Gupta R, Hall LM, Harris SE, Hofer E, Horikoshi M, Huffman JE, Kaasik K, Kalafati IP, Karlsson R, Kong A, Lahti J, van der Lee SJ, de Leeuw C, Lind PA, Lindgren KO, Liu T, Mangino M, Marten J, Mihailov E, Miller MB, van der Most PJ, Oldmeadow C, Payton A, Pervjakova N, Peyrot WJ, Qian Y, Raitakari O, Rueedi R, Salvi E, Schmidt B, Schraut KE, Shi J, Smith AV, Poot RA, St Pourcain B, Teumer A, Thorleifsson G, Verweij N, Vuckovic D, Wellmann J, Westra HJ, Yang J, Zhao W, Zhu Z, Alizadeh BZ, Amin N, Bakshi A, Baumeister SE, Biino G, Bønnelykke K, Boyle PA, Campbell H, Cappuccio FP, Davies G, De Neve JE, Deloukas P, Demuth I, Ding J, Eibich P, Eisele L, Eklund N, Evans DM, Faul JD, Feitosa MF, Forstner AJ, Gandin I, Gunnarsson B, Halldórsson BV, Harris TB, Heath AC, Hocking LJ, Holliday EG, Homuth G, Horan MA, Hottenga JJ, de Jager PL, Joshi PK, Jugessur A, Kaakinen MA, Kähönen M, Kanoni S, Keltigangas-Järvinen L, Kiemeney LA, Kolcic I, Koskinen S, Kraja AT, Kroh M, Kutalik Z, Latvala A, Launer LJ, Lebreton MP, Levinson DF, Lichtenstein P, Lichtner P, Liewald DC, Loukola A, Madden PA, Mägi R, Mäki-Opas T, Marioni RE, Marques-Vidal P, Meddens GA, McMahon G, Meisinger C, Meitinger T, Milaneschi Y, Milani L, Montgomery GW, Myhre R, Nelson CP, Nyholt DR, Ollier WE, Palotie A, Paternoster L, Pedersen NL, Petrovic KE, Porteous DJ, Räikkönen K, Ring SM, Robino A, Rostapshova O, Rudan I, Rustichini A, Salomaa V, Sanders AR, Sarin AP, Schmidt H, Scott RJ, Smith BH, Smith JA, Staessen JA, Steinhagen-Thiessen E, Strauch K, Terracciano A, Tobin MD, Ulivi S, Vaccargiu S, Quaye L, van Rooij FJ, Venturini C, Vinkhuyzen AA, Völker U, Völzke H, Vonk JM, Vozzi D, Waage J, Ware EB, Willemsen G, Attia JR, Bennett DA, Berger K, Bertram L, Bisgaard H, Boomsma DI, Borecki IB, Bultmann U, Chabris CF, Cucca F, Cusi D, Deary IJ, Dedoussis GV, van Duijn CM, Eriksson JG, Franke B, Franke L, Gasparini P, Gejman PV, Gieger C, Grabe HJ, Gratten J, Groenen PJ, Gudnason V, van der Harst P, Hayward C, Hinds DA, Hoffmann W, Hypponen E, Iacono WG, Jacobsson B, Järvelin MR, Jöckel KH, Kaprio J, Kardia SL, Lehtimäki T, Lehrer SF, Magnusson PK, Martin NG, McGue M, Metspalu A, Pendleton N, Penninx BW, Perola M, Pirastu N, Pirastu M, Polasek O, Posthuma D, Power C, Province MA, Samani NJ, Schlessinger D, Schmidt R, Sørensen TI, Spector TD, Stefansson K, Thorsteinsdottir U, Thurik AR, Timpson NJ, Tiemeier H, Tung JY, Uitterlinden AG, Vitart V, Vollenweider P, Weir DR, Wilson JF, Wright AF, Conley DC, Krueger RF, Smith GD, Hofman A, Laibson DI, Medland SE, Meyer MN, Yang J, Johannesson M, Visscher PM, Esko T, Koellinger PD, Cesarini D, Benjamin DJ.
 

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13366-13371. PubMed PMID: 27799538

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Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia.

Ojamies PN, Kontro M, Edgren H, Ellonen P, Lagström S, Almusa H, Miettinen T, Eldfors S, Tamborero D, Wennerberg K, Heckman C, Porkka K, Wolf M, Kallioniemi O.

Leukemia. 2016 Dec 6. doi: 10.1038/leu.2016.286. [Epub ahead of print]

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Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A; BIOS Consortium., Ahluwalia TS, Albrecht E, Yerges-Armstrong L, Atzmon G, Auro K, Ayers K, Bakshi A, Ben-Avraham D, Berger K, Bergman A, Bertram L, Bielak LF, Bjornsdottir G, Bonder MJ, Broer L, Bui M, Barbieri C, Cavadino A, Chavarro JE, Turman C, Concas MP, Cordell HJ, Davies G, Eibich P, Eriksson N, Esko T, Eriksson J, Falahi F, Felix JF, Fontana MA, Franke L, Gandin I, Gaskins AJ, Gieger C, Gunderson EP, Guo X, Hayward C, He C, Hofer E, Huang H, Joshi PK, Kanoni S, Karlsson R, Kiechl S, Kifley A, Kluttig A, Kraft P, Lagou V, Lecoeur C, Lahti J, Li-Gao R, Lind PA, Liu T, Makalic E, Mamasoula C, Matteson L, Mbarek H, McArdle PF, McMahon G, Meddens SF, Mihailov E, Miller M, Missmer SA, Monnereau C, van der Most PJ, Myhre R, Nalls MA, Nutile T, Kalafati IP, Porcu E, Prokopenko I, Rajan KB, Rich-Edwards J, Rietveld CA, Robino A, Rose LM, Rueedi R, Ryan KA, Saba Y, Schmidt D, Smith JA, Stolk L, Streeten E, Tönjes A, Thorleifsson G, Ulivi S, Wedenoja J, Wellmann J, Willeit P, Yao J, Yengo L, Zhao JH, Zhao W, Zhernakova DV, Amin N, Andrews H, Balkau B, Barzilai N, Bergmann S, Biino G, Bisgaard H, Bønnelykke K, Boomsma DI, Buring JE, Campbell H, Cappellani S, Ciullo M, Cox SR, Cucca F, Toniolo D, Davey-Smith G, Deary IJ, Dedoussis G, Deloukas P, van Duijn CM, de Geus EJ, Eriksson JG, Evans DA, Faul JD, Sala CF, Froguel P, Gasparini P, Girotto G, Grabe HJ, Greiser KH, Groenen PJ, de Haan HG, Haerting J, Harris TB, Heath AC, Heikkilä K, Hofman A, Homuth G, Holliday EG, Hopper J, Hyppönen E, Jacobsson B, Jaddoe VW, Johannesson M, Jugessur A, Kähönen M, Kajantie E, Kardia SL, Keavney B, Kolcic I, Koponen P, Kovacs P, Kronenberg F, Kutalik Z, La Bianca M, Lachance G, Iacono WG, Lai S, Lehtimäki T, Liewald DC; LifeLines Cohort Study., Lindgren CM, Liu Y, Luben R, Lucht M, Luoto R, Magnus P, Magnusson PK, Martin NG, McGue M, McQuillan R, Medland SE, Meisinger C, Mellström D, Metspalu A, Traglia M, Milani L, Mitchell P, Montgomery GW, Mook-Kanamori D, de Mutsert R, Nohr EA, Ohlsson C, Olsen J, Ong KK, Paternoster L, Pattie A, Penninx BW, Perola M, Peyser PA, Pirastu M, Polasek O, Power C, Kaprio J, Raffel LJ, Räikkönen K, Raitakari O, Ridker PM, Ring SM, Roll K, Rudan I, Ruggiero D, Rujescu D, Salomaa V, Schlessinger D, Schmidt H, Schmidt R, Schupf N, Smit J, Sorice R, Spector TD, Starr JM, Stöckl D,

Strauch K, Stumvoll M, Swertz MA, Thorsteinsdottir U, Thurik AR, Timpson NJ, Tung JY, Uitterlinden AG, Vaccargiu S, Viikari J, Vitart V, Völzke H, Vollenweider P, Vuckovic D, Waage J, Wagner GG, Wang JJ, Wareham NJ, Weir DR, Willemsen G, Willeit J, Wright AF, Zondervan KT, Stefansson K, Krueger RF, Lee JJ, Benjamin DJ, Cesarini D, Koellinger PD, den Hoed M, Snieder H, Mills MC.

Nat Genet. 2016 Dec;48(12):1462-1472. doi: 10.1038/ng.3698. Epub 2016 Oct 31. 

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Use of Alcohol and Alcohol-related Morbidity in Finnish Former Elite Athletes.

Kontro TK, Sarna S, Kaprio J, Kujala UM.

Med Sci Sports Exerc. 2017 Mar;49(3):492-499. doi: 10.1249/MSS.0000000000001137. 

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Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.

Jacobsen KK, Nievergelt CM, Zayats T, Greenwood TA, Anttila V, Akiskal HS; BiGS Consortium.; IHG Consortium., Haavik J, Bernt Fasmer O, Kelsoe JR, Johansson S, Oedegaard KJ, Kelsoe JR, Greenwood TA, Nievergelt CM, McKinney R, Shilling PD, Smith EN, Schork NJ, Bloss CS, Nurnberger JI Jr, Edenberg HJ, Foroud T, Koller DL, Gershon ES, Badner JA, Liu C, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Potash J, Coryell W, Rice J, Byerley W, McMahon FJ, Berrettini WH, Zandi PP, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Schulze TG, Wedenoja J, Kaunisto MA, Heikkilä K, Kaprio J, Wessman M, Kallela M, Färkkilä M, Artto V, Aromaa A, Eriksson JG, Winsvold BS, Zwart JA, Gormley P, Palotie A, Kurth T, Rose LM, Buring JE, Ridker PM, Chasman DI, Bettella F, Steinberg S, Stefansson H, Stefansson K, McMahon G, Davey-Smith G, Malik R, Freilinger T, Erich Wichmann H, Dichgans M, Muller-Myhsok B, Meitinger T, de Vries B, Terwindt G, Stam AH, Frants RR, Pelzer N, Weller CM, Zielman R, Ferrari MD, van den Maagdenberg AM, Medland SE, Montgomery GW, Martin NG, Nyholt DR, Todt U, Borck G, Kubisch C, Quaye L, Williams FM, Cherkas L, Koiranen M, Hartikainen AL, Pouta A, Jarvelin MR, Ikram MA, van den Ende J, Uitterlinden AG, Hofman A, Amin N, van Duijn C, Lehtimäki T, Ligthart L, Hottenga JJ, Vink JM, Penninx BW, Boomsma DI, Schürks M, Jakobsson F, Schoenen J, Heath AC, Madden PA, Göbel H, Heinze A, Heinze-Kuhn K, Schreiber S, Anttila V, Daly MJ, Alexander M, Raitakari O, Strachan DP.

J Affect Disord. 2015 Feb 1;172:453-61. doi: 10.1016/j.jad.2014.10.004. Epub 2014 Oct 12.

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Activation of Tryptophan and Phenylalanine Catabolism in the Remission Phase of Allergic Contact Dermatitis: A Pilot Study.

Zinkevičienė A, Kainov D, Girkontaitė I, Lastauskienė E, Kvedarienė V, Fu Y, Anders S, Velagapudi V.

Int Arch Allergy Immunol. 2016;170(4):262-268. Epub 2016 Oct 22. 

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KeepEX, a simple dilution protocol for improving extracellular vesicle yields from urine.

Puhka M, Nordberg ME, Valkonen S, Rannikko A, Kallioniemi O, Siljander P, Af Hällström TM.

Eur J Pharm Sci. 2017 Feb 15;98:30-39. doi: 10.1016/j.ejps.2016.10.021. Epub 2016 Oct 19.

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Overnight Changes in Lung Function of Obese Patients with Obstructive Sleep Apnoea.

Kunos L, Lazar Z, Martinovszky F, Tarnoki AD, Tarnoki DL, Kovacs D, Forgo B, Horvath P, Losonczy G, Bikov A.

Lung. 2017 Feb;195(1):127-133. doi: 10.1007/s00408-016-9957-1. Epub 2016 Oct 21. 

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Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study.

Nowak C, Salihovic S, Ganna A, Brandmaier S, Tukiainen T, Broeckling CD, Magnusson PK, Prenni JE, Wang-Sattler R, Peters A, Strauch K, Meitinger T, Giedraitis V, Ärnlöv J, Berne C, Gieger C, Ripatti S, Lind L, Pedersen NL, Sundström J, Ingelsson E, Fall T.

PLoS Genet. 2016 Oct 21;12(10):e1006379. doi: 10.1371/journal.pgen.1006379. eCollection 2016 Oct.

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NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk.

Jack Antel, Maria Ban, Sergio Baranzini, Lisa Barcellos, Nadia Barizzone, Ashley Beecham, Tone Berge, Luisa Bernardinelli, David Booth, Steffan Bos, Dorothea Buck, Mariusz Butkiewicz, Elisabeth G. Celius, Manuel Comabella, Alastair Compston, Katrina Dedham, Chris Cotsapas, Sandra D’ Alfonso, Phil De Jager, Benedicte Dubois, Pierre Duquette, Bertrand Fontaine, Christiane Gasperi, Elia Gil, An Goris, Pierre Antoine Gourraud, Christiane Graetz, Alexandra Gyllenberg, Georgios Hadjigeorgiou, David Hafler, Deanna Hribko, Jonathan Haines, Hanne Harbo, Stephen Hauser, Shannon Warto, Clive Hawkins, Bernhard Hemmer, Roland Henry, Rogier Hintzen, Dana Horakova, Adrian Ivinson, Melissa Howard, Ilijas Jelcic, Belinda Kaskow, Jun-Ichi Kira, Pavlina Kleinova, Ingrid Kockum, Karolina Kucerova, Christina Lill, Felix Luessi, Sunny Malhotra, Roland Martin, Filippo Martinelli, Takuya Matsushita, Cristin McCabe, Jacob McCauley, Julia Mescheriakkova, Mitja Mitrovic, Stine-Marit Moen, Xavier Montalban, Mark Muhlau, Yuri Nakmura, Jorge Oksenberg, Tomas Olsson, Annette Oturai, Aarno Palotie, Nikolaos Patsopoulos, Jana Pavlicova, Peggy Pericak-Vance, Fredrik Piehl, Isabelle Rebeix, John Rioux, Janna Saarela, Stephen Sawcer, Finn Sellebjerg, Helle Bach Sondergaard, Per Soelberg Sorensen, Mireia Sospedra, Anne Spurkland, Graeme Stewart, Bruce Taylor, Andre Uitterlinden, Cornelia Van Duijn, Frauke Zipp

NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk. Neuron. 2016 Oct 19;92(2):333-335. doi: 10.1016/j.neuron.2016.09.052.

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Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease.

Jakobsdottir J, van der Lee SJ, Bis JC, Chouraki V, Li-Kroeger D, Yamamoto S, Grove ML, Naj A, Vronskaya M, Salazar JL, DeStefano AL, Brody JA, Smith AV, Amin N, Sims R, Ibrahim-Verbaas CA, Choi SH, Satizabal CL, Lopez OL, Beiser A, Ikram MA, Garcia ME, Hayward C, Varga TV, Ripatti S, Franks PW, Hallmans G, Rolandsson O, Jansson JH, Porteous DJ, Salomaa V, Eiriksdottir G, Rice KM, Bellen HJ, Levy D, Uitterlinden AG, Emilsson V, Rotter JI, Aspelund T; Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.; Alzheimer’s Disease Genetic Consortium.; Genetic and Environmental Risk in Alzheimer’s Disease consortium., O'Donnell CJ, Fitzpatrick AL, Launer LJ, Hofman A, Wang LS, Williams J, Schellenberg GD, Boerwinkle E, Psaty BM, Seshadri S, Shulman JM, Gudnason V, van Duijn CM.

PLoS Genet. 2016 Oct 20;12(10):e1006327. doi: 10.1371/journal.pgen.1006327. eCollection 2016 Oct. Erratum in: PLoS Genet. 2016 Nov 28;12 (11):e1006456. 

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Genome-Wide Meta-Analysis of Sciatica in Finnish Population.

Lemmelä S, Solovieva S, Shiri R, Benner C, Heliövaara M, Kettunen J, Anttila V, Ripatti S, Perola M, Seppälä I, Juonala M, Kähönen M, Salomaa V, Viikari J, Raitakari OT, Lehtimäki T, Palotie A, Viikari-Juntura E, Husgafvel-Pursiainen K.

PLoS One. 2016 Oct 20;11(10):e0163877. doi: 10.1371/journal.pone.0163877. eCollection 2016. 

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Genome-wide DNA methylation in saliva and body size of adolescent girls.

Rounge TB, Page CM, Lepistö M, Ellonen P, Andreassen BK, Weiderpass E.

Epigenomics. 2016 Nov;8(11):1495-1505. Epub 2016 Oct 20.

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Quality of life trajectories after diagnosis of gynecologic cancer: a theoretically based approach.

Gonzalez BD, Manne SL, Stapleton J, Myers-Virtue S, Ozga M, Kissane D, Heckman C, Morgan M.

Support Care Cancer. 2017 Feb;25(2):589-598. doi: 10.1007/s00520-016-3443-4. Epub 2016 Oct 19. 

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Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History: Evidence from Monozygotic Twins.

Hautasaari P, Savić AM, Loberg O, Niskanen E, Kaprio J, Kujala UM, Tarkka IM.

Brain Topogr. 2017 Jan;30(1):77-86. doi: 10.1007/s10548-016-0531-1. Epub 2016 Oct 19.

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Middle age self-report risk score predicts cognitive functioning and dementia in 20-40 years.

Vuoksimaa E, Rinne JO, Lindgren N, Heikkilä K, Koskenvuo M, Kaprio J.

Alzheimers Dement (Amst). 2016 Sep 14;4:118-125.

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A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.

de Vries PS, Chasman DI, Sabater-Lleal M, Chen MH, Huffman JE, Steri M, Tang W, Teumer A, Marioni RE, Grossmann V, Hottenga JJ, Trompet S, Müller-Nurasyid M, Zhao JH, Brody JA, Kleber ME, Guo X, Wang JJ, Auer PL, Attia JR, Yanek LR, Ahluwalia TS, Lahti J, Venturini C, Tanaka T, Bielak LF, Joshi PK, Rocanin-Arjo A, Kolcic I, Navarro P, Rose LM, Oldmeadow C, Riess H, Mazur J, Basu S, Goel A, Yang Q, Ghanbari M, Willemsen G, Rumley A, Fiorillo E, de Craen AJ, Grotevendt A, Scott R, Taylor KD, Delgado GE, Yao J, Kifley A, Kooperberg C, Qayyum R, Lopez LM, Berentzen TL, Räikkönen K, Mangino M, Bandinelli S, Peyser PA, Wild S, Trégouët DA, Wright AF, Marten J, Zemunik T, Morrison AC, Sennblad B, Tofler G, de Maat MP, de Geus EJ, Lowe GD, Zoledziewska M, Sattar N, Binder H, Völker U, Waldenberger M, Khaw KT, Mcknight B, Huang J, Jenny NS, Holliday EG, Qi L, Mcevoy MG, Becker DM, Starr JM, Sarin AP, Hysi PG, Hernandez DG, Jhun MA, Campbell H, Hamsten A, Rivadeneira F, Mcardle WL, Slagboom PE, Zeller T, Koenig W, Psaty BM, Haritunians T, Liu J, Palotie A, Uitterlinden AG, Stott DJ, Hofman A, Franco OH, Polasek O, Rudan I, Morange PE, Wilson JF, Kardia SL, Ferrucci L, Spector TD, Eriksson JG, Hansen T, Deary IJ, Becker LC, Scott RJ, Mitchell P, März W, Wareham NJ, Peters A, Greinacher A, Wild PS, Jukema JW, Boomsma DI, Hayward C, Cucca F, Tracy R, Watkins H, Reiner AP, Folsom AR, Ridker PM, O'Donnell CJ, Smith NL, Strachan DP, Dehghan A.

Hum Mol Genet. 2016 Jan 15;25(2):358-70. doi: 10.1093/hmg/ddv454. 

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Quantifying prion disease penetrance using large population control cohorts.

Minikel EV, Vallabh SM, Lek M, Estrada K, Samocha KE, Sathirapongsasuti JF, McLean CY, Tung JY, Yu LP, Gambetti P, Blevins J, Zhang S, Cohen Y, Chen W, Yamada M, Hamaguchi T, Sanjo N, Mizusawa H, Nakamura Y, Kitamoto T, Collins SJ, Boyd A, Will RG, Knight R, Ponto C, Zerr I, Kraus TF, Eigenbrod S, Giese A, Calero M, de Pedro-Cuesta J, Haïk S, Laplanche JL, Bouaziz-Amar E, Brandel JP, Capellari S, Parchi P, Poleggi A, Ladogana A, O'Donnell-Luria AH, Karczewski KJ, Marshall JL, Boehnke M, Laakso M, Mohlke KL, Kähler A, Chambert K, McCarroll S, Sullivan PF, Hultman CM, Purcell SM, Sklar P, van der Lee SJ, Rozemuller A, Jansen C, Hofman A, Kraaij R, van Rooij JG, Ikram MA, Uitterlinden AG, van Duijn CM; Exome Aggregation Consortium (ExAC)., Daly MJ, MacArthur DG.

Sci Transl Med. 2016 Jan 20;8(322):322ra9. doi: 10.1126/scitranslmed.aad5169. 

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Ultra-rare disruptive and damaging mutations influence educational attainment in the general population.

Ganna A, Genovese G, Howrigan DP, Byrnes A, Kurki MI, Zekavat SM, Whelan CW, Kals M, Nivard MG, Bloemendal A, Bloom JM, Goldstein JI, Poterba T, Seed C, Handsaker RE, Natarajan P, Mägi R, Gage D, Robinson EB, Metspalu A, Salomaa V, Suvisaari J, Purcell SM, Sklar P, Kathiresan S, Daly MJ, McCarroll SA, Sullivan PF, Palotie A, Esko T, Hultman CM, Neale BM.

Nat Neurosci. 2016 Dec;19(12):1563-1565. doi: 10.1038/nn.4404. 

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Sleep disruption, chronotype, shift work, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins.

Dickerman BA, Markt SC, Koskenvuo M, Hublin C, Pukkala E, Mucci LA, Kaprio J.

Cancer Causes Control. 2016  Nov;27(11):1361-1370.

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Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.

Heinonen S, Muniandy M, Buzkova J, Mardinoglu A, Rodríguez A, Frühbeck G, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pietiläinen KH.

Diabetologia. 2017 Jan;60(1):169-181.

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No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.

Loley C, Alver M, Assimes TL, Bjonnes A, Goel A, Gustafsson S, Hernesniemi J, Hopewell JC, Kanoni S, Kleber ME, Lau KW, Lu Y, Lyytikäinen LP, Nelson CP, Nikpay M, Qu L, Salfati E, Scholz M, Tukiainen T, Willenborg C, Won HH, Zeng L, Zhang W, Anand SS, Beutner F, Bottinger EP, Clarke R, Dedoussis G, Do R, Esko T, Eskola M, Farrall M, Gauguier D, Giedraitis V, Granger CB, Hall AS, Hamsten A, Hazen SL, Huang J, Kähönen M, Kyriakou T, Laaksonen R, Lind L, Lindgren C, Magnusson PK, Marouli E, Mihailov E, Morris AP, Nikus K, Pedersen N, Rallidis L, Salomaa V, Shah SH, Stewart AF, Thompson JR, Zalloua PA, Chambers JC, Collins R, Ingelsson E, Iribarren C, Karhunen PJ, Kooner JS, Lehtimäki T, Loos RJ, März W, McPherson R, Metspalu A, Reilly MP, Ripatti S, Sanghera DK, Thiery J, Watkins H, Deloukas P, Kathiresan S, Samani NJ, Schunkert H, Erdmann J, König IR.

Sci Rep. 2016 Oct 12;6:35278. doi: 10.1038/srep35278.

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Smoking status as a predictor of antidepressant medication use.

Korhonen T, Ranjit A, Tuulio-Henriksson A, Kaprio J.

J Affect Disord. 2017 Jan 1;207:221-227. doi: 10.1016/j.jad.2016.09.035. 

 

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PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.

Kovanen L, Donner K, Kaunisto M, Partonen T.

J Affect Disord. 2017 Jan 1;207:136-140. doi: 10.1016/j.jad.2016.09.034. 

 

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Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Sieberts SK, Zhu F, García-García J, Stahl E, Pratap A, Pandey G, Pappas D, Aguilar D, Anton B, Bonet J, Eksi R, Fornés O, Guney E, Li H, Marín MA, Panwar B, Planas-Iglesias J, Poglayen D, Cui J, Falcao AO, Suver C, Hoff B, Balagurusamy VS, Dillenberger D, Neto EC, Norman T, Aittokallio T, Ammad-Ud-Din M, Azencott CA, Bellón V, Boeva V, Bunte K, Chheda H, Cheng L, Corander J, Dumontier M, Goldenberg A, Gopalacharyulu P, Hajiloo M, Hidru D, Jaiswal A, Kaski S, Khalfaoui B, Khan SA, Kramer ER, Marttinen P, Mezlini AM, Molparia B, Pirinen M, Saarela J, Samwald M, Stoven V, Tang H, Tang J, Torkamani A, Vert JP, Wang B, Wang T, Wennerberg K, Wineinger NE, Xiao G, Xie Y, Yeung R, Zhan X, Zhao C; Members of the Rheumatoid Arthritis Challenge Consortium., Greenberg J, Kremer J, Michaud K, Barton A, Coenen M, Mariette X, Miceli C, Shadick N, Weinblatt M, de Vries N, Tak PP, Gerlag D, Huizinga TW, Kurreeman F, Allaart CF, Bridges SL Jr, Criswell L, Moreland L, Klareskog L, Saevarsdottir S, Padyukov L, Gregersen PK, Friend S, Plenge R, Stolovitzky G, Oliva B, Guan Y, Mangravite LM.

Nat Commun. 2016 Oct 10;7:13205. doi: 10.1038/ncomms13205.

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An epigenetic clock for gestational age at birth based on blood methylation data.

Knight AK, Craig JM, Theda C, Bækvad-Hansen M, Bybjerg-Grauholm J, Hansen CS, Hollegaard MV, Hougaard DM, Mortensen PB, Weinsheimer SM, Werge TM, Brennan PA, Cubells JF, Newport DJ, Stowe ZN, Cheong JL, Dalach P, Doyle LW, Loke YJ, Baccarelli AA, Just AC, Wright RO, Téllez-Rojo MM, Svensson K, Trevisi L, Kennedy EM, Binder EB, Iurato S, Czamara D, Räikkönen K, Lahti JM, Pesonen AK, Kajantie E, Villa PM, Laivuori H, Hämäläinen E, Park HJ, Bailey LB, Parets SE, Kilaru V, Menon R, Horvath S, Bush NR, LeWinn KZ, Tylavsky FA, Conneely KN, Smith AK.

Genome Biol. 2016 Oct 7;17(1):206.

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Orphan G protein-coupled receptor GPRC5A modulates integrinβ1-mediated epithelial cell adhesion.

Bulanova DR, Akimov YA, Rokka A, Laajala TD, Aittokallio T, Kouvonen P, Pellinen T, Kuznetsov SG.

Cell Adh Migr. 2016 Oct 7:1-13. doi: 10.1080/19336918.2016.1245264. [Epub ahead of print].

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Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk.

Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, Wiemels JL; ENGAGE Consortium Telomere Group., Samani NJ, Wiencke JK, Wrensch MR.

Oncotarget. 2015 Dec 15;6(40):42468-77. doi: 10.18632/oncotarget.6468.

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High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia.

Andersson EI, Tanahashi T, Sekiguchi N, Gasparini VR, Bortoluzzi S, Kawakami T, Matsuda K, Mitsui T, Eldfors S, Bortoluzzi S, Coppe A, Binatti A, Lagström S, Ellonen P, Fukushima N, Nishina S, Senoo N, Sakai H, Nakazawa H, Kwong YL, Loughran TP, Maciejewski JP, Mustjoki S, Ishida F.

Blood. 2016 Nov 17;128(20):2465-2468.

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Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction.

Söderholm S, Fu Y, Gaelings L, Belanov S, Yetukuri L, Berlinkov M, Cheltsov AV, Anders S, Aittokallio T, Nyman TA, Matikainen S, Kainov DE.

Viruses. 2016 Sep 29;8(10). pii: E269. Review. 

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ESICM LIVES 2016: part one : Milan, Italy. 1-5 October 2016.

L. Bos, L. Schouten, L. van Vught, M. Wiewel, D. Ong, O. Cremer, A. Artigas, I. Martin-Loeches, A. Hoogendijk, T. van der Poll, J. Horn, N. Juffermans, M. Schultz, N. de Prost, T. Pham, G. Carteaux, A. Mekontso Dessap, C. Brun-Buisson, E. Fan, G. Bellani, J. Laffey, A. Mercat, L. Brochard, B. Maitre, LUNG SAFE investigators and the ESICM study group, P. A. Howells, D. R. Thickett, C. Knox, D. P. Park, F. Gao, O. Tucker, T. Whitehouse, D. F. McAuley, G. D. Perkins, T. Pham, J. Laffey, G. Bellani, E. Fan, LUNG SAFE Investigators and the ESICM Trials Group, L. Pisani, J. P. Roozeman, F. D. Simonis, A. Giangregorio, L. R. Schouten, S. M. Van der Hoeven, J. Horn, A. Serpa Neto, E. Festic, A. M. Dondorp, S. Grasso, L. D. Bos, M. J. Schultz, M. Koster-Brouwer, D. Verboom, B. Scicluna, K. van de Groep, J. Frencken, M. Schultz, T. van der Poll, M. Bonten, O. Cremer, J. I. Ko, K. S. Kim, G. J. Suh, W. Y. Kwon, K. Kim, J. H. Shin, O. T. Ranzani, E. Prina, R. Menendez, A. Ceccato, R. Mendez, C. Cilloniz, A. Gabarrus, M. Ferrer, A. Torres, A. Urbano, L. A. Zhang, D. Swigon, F. Pike, R. S. Parker, G. Clermont, C. Scheer, S. O. Kuhn, A. Modler, M. Vollmer, C. Fuchs, K. Hahnenkamp, S. Rehberg, M. Gründling, A. Taggu, N. Darang, N. Öveges, I. László, K. Tánczos, M. Németh, G. Lebák, B. Tudor, D. Érces, J. Kaszaki, W. Huber, D. Trásy, Z. Molnár, G. Ferrara, V. S. Kanoore Edul, H. S. Canales, E. Martins, C. Canullán, G. Murias, M. O. Pozo, J. F. Caminos Eguillor, M. G. Buscetti, C. Ince, A. Dubin, H. D. Aya, A. Rhodes, N. Fletcher, R. M. Grounds, M. Cecconi, M. Jacquet-Lagrèze, M. Riche, R. Schweizer, P. Portran, W. Fornier, M. Lilot, J. Neidecker, J. L. Fellahi, A. Escoresca-Ortega, A. Gutiérrez-Pizarraya, L. Charris-Castro, Y. Corcia-Palomo, E. Fernandez-Delgado, J. Garnacho-Montero, C. Roger, L. Muller, L. Elotmani, J. Lipman, J. Y. Lefrant, J. A. Roberts, R. Muñoz-Bermúdez, M. Samper, C. Climent, F. Vasco, V. Sara, S. Luque, N. Campillo, S. Grau Cerrato, J. R. Masclans, F. Alvarez-Lerma, S. Carvalho Brugger, G. Jimenez Jimenez, M. Miralbés Torner, J. Trujillano Cabello, B. Balsera Garrido, X. Nuvials Casals, F. Barcenilla Gaite, M. Vallverdú Vidal, M. Palomar Martínez, V. Gusarov, D. Shilkin, M. Dementienko, E. Nesterova, N. Lashenkova, A. Kuzovlev, M. Zamyatin, A. Demoule, S. Carreira, S. Lavault, O. Palancca, E. Morawiec, J. Mayaux, I. Arnulf, T. Similowski, B. S. Rasmussen, R. G. Maltesen, M. Hanifa, S. Pedersen, S. R. Kristensen, R. Wimmer, M. Panigada, G. Li Bassi,

T. Senussi, F. Idone, E. Aguilera Xiol, C. Travierso, C. Chiurazzi, A. Motos, R. Amaro, Y. Hua, L. Fernández-Barat, O. T. Ranzani, Q. Bobi, M. Rigol, A. Torres, A. Youn, J. Gyung Hwang, M. Muñoz Garach, O. Moreno Romero, M. E. Yuste Ossorio, F. Acosta Diaz, A. M. Perez Bailon, A. Carranza Pinel, L. Peñas Maldonado, C. Teixeira, H. Figueira, R. Oliveira, A. Mota, I. Aragão, O. Kamp, O. Cruciger, M. Aach, C. Kaczmarek, C. Waydhas, T. A. Schildhauer, U. Hamsen, M. Camprubí-Rimblas, L. Chimenti, R. Guillamat-Prats, T. Lebouvier, J. Bringué, J. Tijero, M. N. Gómez, L. Blanch, A. Artigas, G. Tagliabue, M. Ji, J. V. Suneby Jagers, P. A. Easton, R. B. Souza, A. M. A. Liberatore, A. M. C. R. P. F. Martins, J. C. F. Vieira, Y. R. Kang, M. N. Nakamae, I. H. J. Koh, J. Y. Hong, M. H. Shin, M. S. Park, A. Pomprapa, P. A. Pickerodt, M. B. T. Hofferberth, M. Russ, W. Braun, M. Walter, R. Francis, B. Lachmann, S. Leonhardt, I. H. J. Koh, R. B. Souza, A. M. C. R. P. F. Martins, J. C. F. Vieira, A. M. A. Liberatore, A. Landaverde-López, N. A. Canedo-Castillo, A. Esquivel-Chávez, P. C. Arvizu-Tachiquín, L. A. Sánchez-Hurtado, J. A. Baltazar-Torres, V. Cardoso, A. Krystopchuk, S. Castro, L. Melão, S. Firmino, A. Marreiros, C. Granja, S. Almaziad, A. Kubbara, W. Barnett, R. Nakity, W. Alamoudi, R. Altook, T. Tarazi, M. Fida, F. Safi, R. Assaly, A. Santini, M. Milesi, T. Maraffi, P. Pugni, D. T. Andreis, M. Cavenago, L. Gattinoni, A. Protti, G. Perchiazzi, J. B. Borges, S. Bayat, L. Porra, L. Broche, M. Pellegrini, G. Scaramuzzo, G. Hedenstierna, A. Larsson, M. Pellegrini, G. Hedenstierna, A. Roneus, M. Segelsjö, M. C. Vestito, A. Larsson, G. Perchiazzi, E. Gremo, A. Nyberg, M. Castegren, A. Pikwer, T. Yoshida, D. Engelberts, G. Otulakowski, B. Katira, M. Post, N. D. Ferguson, L. Brochard, M. B. P. Amato, B. P. Kavanagh, PLUG Working group, N. Koch, W. Huber, J. Hoellthaler, S. Mair, V. Phillip, R. M. Schmid, A. Beitz, V. Baladrón, F. J. Redondo Calvo, D. Padilla, P. Villarejo, R. Villazala, A. S. Yuste, N. Bejarano, R. J. Steenstra, H. Banierink, J. Hof, I. C. van der Horst, M. W. Nijsten, M. Hoekstra, K. Roedl, F. Sterz, T. Horvatits, K. Horvatits, A. Drolz, H. Herkner, V. Fuhrmann, M. Kott, K. Zitta, B. Brandt, C. Schildhauer, G. Elke, L. Hummitzsch, I. Frerichs, N. Weiler, M. Albrecht, L. Rey González, D. Cabestrero Alonso, A. Blandino Ortiz, R. de Pablo Sánchez, J. Higuera Lucas, K. Roedl, F. Sterz, A. Drolz, K. Horvatits, T. Horvatits, H. Herkner, V. Fuhrmann, T. Horvatits, A. Drolz, K. Roedl, K. Rutter, A. Ferlitsch, G. Fauler, M. Trauner, V. Fuhrmann, T. Horvatits, S. Pischke, L. Fischer, F. Thaiss, M. Koch, K. Bangert, V. Fuhrmann, S. Kluge, A. W. Lohse, B. Nashan, M. Sterneck, S. Faenza, A. Siniscalchi, E. Pierucci, E. Mancini, D. Ricci, C. Gemelli, A. Cuoghi, S. Magnani, M. Atti, F. Sotos, J. Cánovas, A. López, A. Burruezo, D. Torres, M. E. Herrera-Gutierrez, J. Barrueco-Francioni, D. Arias-Verdú, R. Lozano-Saez, G. Quesada-Garcia, G. Seller-Pérez, A. Figueiredo, Y. Anzola, R. Pereira, L. Bento, D. Arias-Verdú, M. Lai, M. Deiana, J. Barrueco-Francioni, M. E. Herrera-Gutierrez, G. Seller-Perez, K. Vardas, S. Ilia, A. Sertedaki, E. Charmadari, C. A. Stratakis, E. Briassouli, D. Goukos, K. Psarra, E. Botoula, S. Tsagarakis, E. Mageira, C. Routsi, S. Nanas, G. Briassoulis, A. Boscolo, D. Bertini, E. Campello, V. Lucchetta, E. Piasentini, C. M. Radu, L. Manesso, P. Simioni, C. Ori, H. Su, Y. M. Lam, K. Willis, V. Pullar, R. P. Hubner, J. L. Tsang, L. García de Guadiana-Romualdo, S. Rebollo-Acebes, P. Esteban-Torrella, R. Jiménez-Sánchez, E. Jiménez-Santos, A. Ortín-Freire, A. Hernando-Holgado, M. D. Albaladejo-Otón, L. Coelho, L. Rabello, J. Salluh, I. Martin-Loeches, A. Rodriguez, S. Nseir, P. Póvoa, TAVeM study Group, E. Varis, V. Pettilä, M. Poukkanen, S. Jacob, S. Karlsson, A. Perner, J. Takala, E. Wilkman, The FINNAKI Study Group, O. H. M. Lundberg, L. Bergenzaun, J. Rydén, M. Rosenqvist, O. Melander, M. S. Chew, E. Rodriguez-Ruiz, R. Hernández Vaquero, A. Lopez Lago, J. L. Garcia Allut, A. Estany Gestal, M. A. Garcia Gonzalez, Y. Kishihara, H. Yasuda, S. Rebollo, L. García de Guadiana-Romualdo, R. Jimenez, P. Esteban Torrella, A. Fernandez, S. Sanchez, A. Ortin, G. Li Bassi, R. Guillamat Prats, A. Artigas, E. Aguilera, D. Marti, O. T. Ranzani, M. Rigol, L. Fernandez, M. Ferrer, I. Martin-Loeches, A. Torres, V. S. Lanziotti, P. Póvoa, L. Pulcheri, M. O. Ribeiro, A. P. Barbosa, J. R. Lapa e Silva, M. Soares, J. I. F. Salluh, I. Palacios Garcia, A. Diaz Martin, M. Gil Marqués, A. Puppo Moreno, A. Gutierrez Pizarraya, J. Pachón Diaz, M. Pachón Ibañez, Y. Smani, M. Mc Connell, L. A. Zhang, R. S. Parker, I. Banerjee, G. Clermont, E. Norberg, J. Oras, A. Cuisinier, C. Maufrais, J. F. Payen, S. Nottin, G. Walther, P. Bouzat, S. Arib, F. Bilotta, R. Badenes, F. Rubulotta, S. Mirek, I. A. Crippa, B. Monfort, E. Stazi, A. Lozano Roig, J. Creteur, F. S. Taccone, S. Magnoni, M. Marando, S. Pifferi, V. Conte, F. Ortolano, M. Carbonara, G. Bertani, E. Scola, M. Cadioli, F. Triulzi, A. Colombo, N. Stocchetti, H. B. Rotzel, A. Serrano Lázaro, D. Aguillón Prada, M. Rodriguez Guimillo, C. Sanchís Piqueras, J. Romero Guia, M. García Simon, A. Mesejo Arizmendi, A. Carratalá, S. El Maraghi, A. Yehia, M. Bakry, A. Shoman, F. N. Backes, M. M. Bianchin, S. R. R. Vieira, A. de Souza, A. N. Backes, C. Klein, M. S. Kalaiselvan, M. K. Renuka, A. S. Arunkumar, A. Lozano, O. Lheureux, R. Badenes, J. L. Vincent, J. Creteur, F. S. Taccone, C. Gallaher, S. Cattlin, S. Gordon, J. Picard, V. Fontana, O. Bond, L. Nobile, J. L. Vincent, J. Creteur, F. S. Taccone, S. Mrozek, L. Delamarre, F. Capilla, T. Al-Saati, O. Fourcade, T. Geeraerts, A. M. Dominguez-Berrot, M. Gonzalez-Vaquero, M. E. Vallejo-Pascual, D. Gupta, B. D. Ivory, M. Chopra, J. McCarthy, C. L. Felderhof, C. MacNeil, F. Rubulotta, P. Waldauf, M. Maggiorini, F. Duska, on behalf of Department of Professional Development, ESICM, R. R. L. Fumis, J. M. Vieira Junior, G. Amarante, A. Skorko, S. Sanders, J. Aron, R. J. Kroll, C. Redfearn, P. Krishnan, J. E. Khalil, F. Kovari, N. Kongpolprom, V. Gulia, E. Lourenço, L. Melão, C. Duro, G. Baptista, A. Alves, B. Arminda, M. Rodrigues, A. Marreiros, C. Granja, J. Hayward, F. Baldwin, R. Gray, P. A. Katinakis, M. Stijf, M. Ten Kleij, M. Jansen-Frederiks, R. Broek, M. de Bruijne, P. E. Spronk, K. Sinha, M. Luney, K. Palmer, L. Keating, M. Abu-Habsa, R. Bahl, N. Baskaralingam, A. Ahmad, L. Kanapeckaite, P. Bhatti, S. Glace, S. Jeyabraba, H. F. Lewis, A. Kostopoulos, M. Raja, A. West, A. Ely, L. M. Turkoglu, P. Zolfaghari, J. P. Baptista, M. P. Marques, P. Martins, J. Pimentel, D. Gupta, Y. C. Su, S. Villacres, M. E. Stone, A. Parsikia, S. Medar, K. P. O’Dea, J. Porter, N. Tirlapur, J. M. Jonathan, S. Singh, M. Takata, Critical Care Research Group, M. Abu-Habsa, A. Ahmad, E. McWhirter, R. Lyon, M. L. Hariz, E. Azmi, J. Alkhan, S. Honeybul, V. Movsisyan, S. Petrikov, Z. Marutyan, I. Aliev, A. Evdokimov, E. Antonucci, T. Merz, C. Hartmann, P. Pelosi, E. Calzia, P. Radermacher, B. Nußbaum, C. Hartmann, M. Huber-Lang, M. Gröger, P. Radermacher, B. Nußbaum, B. Nußbaum, E. Antonucci, E. Calzia, P. Pelosi, P. Radermacher, C. Hartmann, E. Svoren-Jabalera, E. E. Davenport, P. Humburg, J. Knight, C. J. Hinds, I. J. Jun, W. J. Kim, E. H. Lee, G. Besch, A. Perrotti, M. Puyraveau, L. Carteron, M. Baltres, E. Samain, S. Chocron, S. Pili-Floury, E. P. Plata-Menchaca, J. Sabater-Riera, M. Estruch, E. Boza, F. Sbraga, J. Toscana-Fernández, E. Bruguera-Pellicer, J. Ordoñez-Llanos, X. L. Pérez-Fernández, SIRAKI group, P. Cavaleiro, A. Tralhão, M. Arrigo, J.-P. Lopes, M. Lebrun, B. Cholley, J. L. PerezVela, H. MarinMateos, J. J. Jimenez Rivera, M. A. Alcala Llorente, B. Gonzalez De Marcos, F. J. Gonzalez Fernandez, C. Garcia Laborda, D. Fernandez Zamora, Grupo ESBAGA, J. C. Lopez Delgado, C. Imperiali, D. Berbel-Franco, M. Dastis, G. Moreno-Gonzalez, J. Perez-Sanchez, I. Romera-Peregrina, R. Abellan-Lencina, A. Martinez-Pascual, V. Fuentes-Mila, M. Gonzalez-Romero, J. Górka, K. Górka, T. Iwaniec, M. Frołow, K. Polok, J. Fronczek, M. Kózka, J. Musiał, W. Szczeklik, A. González Pérez, P. Florez Ordoñez, A. Giribet, M. A. Alonso Cuervo, R. Alonso Cuervo, M. A. Rodriguez Esteban, L. Iglesias Fraile, C. Ponte Mittelbrum, G. Muñiz Albaiceta, F. Ampatzidou, M. Sileli, G. Kehagioglou, A. Madesis, T. Karaiskos, C. Moursia, H. Maleoglou, K. Leleki, G. Drossos, Z. Uz, Y. Ince, R. Papatella, E. Bulent, P. Guerci, C. Ince, B. De Mol, V. Vicka, D. Gineityte, D. Ringaitiene, I. Norkiene, J. Sipylaite, C. Möller, C. Fleischmann, D. O. Thomas-Rueddel, V. Vlasakov, B. Rochwerg, P. Theurer, L. Gattinoni, K. Reinhart, C. S. Hartog, A. González Pérez, J. Zanabili Al Sibai, P. Martinez Camblor, P. Alvarez Fernandez, J. M. García Gala, J. Silba Guisasola, G. Muñiz Albaiceta, T. Tamura, T. Yatabe, I. Miyajima, K. Yamashita, M. Yokoyama, F. Ampatzidou, G. Kehagioglou, E. Dalampini, M. Nastou, A. Baddour, A. Ignatiadis, T. Asteri, G. Drossos, K. E. Hathorn, S. W. Purtle, C. M. Horkan, F. K. Gibbons, K. B. Christopher, M. V. Viana, T. A. Tonietto, L. A. Gross, V. L. Costa, A. L. J. Tavares, B. O. Lisboa, R. B. Moraes, S. R. Vieira, L. V. Viana, M. J. Azevedo, G. D. Ceniccola, R. S. F. Pequeno, T. P. Holanda, V. S. Mendonça, W. M. C. Araújo, L. S. F. Carvalho, E. Segaran, L. Vickers, K. Brinchmann, I. Wignall, F. Rubulotta, I. De Brito-Ashurst, R. del Olmo, M. J. Esteban, C. Vaquerizo, R. Carreño, V. Gálvez, G. Kaminsky, B. Nieto, M. Fuentes, M. A. De la Torre, E. Torres, A. Alonso, C. Velayos, T. Saldaña, A. Escribá, J. GRIP, R. Kölegård, P. Sundblad, O. Rooyackers, Ben Naser, F. Jaziri, A. Ben Jazia, M. Barghouth, O. Hentati, W. Skouri, M. El Euch, M. Mahfoudhi, S. Turki, K. Ben Abdelghni, Ben Abdallah, B. N. M. Maha, J. Cánovas, F. Sotos, A. López, M. Lorente, A. Burruezo, D. Torres, K. Polok, A. Włudarczyk, J. Górka, A. Hałek, J. 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Y. Kuan, V. Poulose, M. A. Lopez Morales, S. Castro, T. Pires, L. Melão, A. Krystopchuk, I. Pereira, C. Granja, L. U. Taniguchi, E. M. C. Pires, J. M. Vieira, Jr, L. C. P. Azevedo

 

Intensive Care Med Exp. 2016 Sep; 4(Suppl 1): 27. Published online 2016 Sep 29. doi: 10.1186/s40635-016-0098-x

 

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Antibody-supervised deep learning for quantification of tumor-infiltrating immune cells in hematoxylin and eosin stained breast cancer samples.

Turkki R, Linder N, Kovanen PE, Pellinen T, Lundin J.

J Pathol Inform. 2016 Sep 1;7:38. doi: 10.4103/2153-3539.189703. Erratum in: J Pathol Inform. 2016 Sep 28;7:41

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Genome-wide associations for birth weight and correlations with adult disease.

Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikäinen LP, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Hottenga JJ, Vilor-Tejedor N, Joshi PK, Boh ET, Ntalla I, Pitkänen N, Mahajan A, van Leeuwen EM, Joro R, Lagou V, Nodzenski M, Diver LA, Zondervan KT, Bustamante M, Marques-Vidal P, Mercader JM, Bennett AJ, Rahmioglu N, Nyholt DR, Ma RC, Tam CH, Tam WH; CHARGE Consortium Hematology Working Group., Ganesh SK, van Rooij FJ, Jones SE, Loh PR, Ruth KS, Tuke MA, Tyrrell J, Wood AR, Yaghootkar H, Scholtens DM, Paternoster L, Prokopenko I, Kovacs P, Atalay M, Willems SM, Panoutsopoulou K, Wang X, Carstensen L, Geller F, Schraut KE, Murcia M, van Beijsterveldt CE, Willemsen G, Appel EV, Fonvig CE, Trier C, Tiesler CM, Standl M, Kutalik Z, Bonàs-Guarch S, Hougaard DM, Sánchez F, Torrents D, Waage J, Hollegaard MV, de Haan HG, Rosendaal FR, Medina-Gomez C, Ring SM, Hemani G, McMahon G, Robertson NR, Groves CJ, Langenberg C, Luan J, Scott RA, Zhao JH, Mentch FD, MacKenzie SM, Reynolds RM; Early Growth Genetics (EGG) Consortium., Lowe WL, Tönjes A, Stumvoll M, Lindi V, Lakka TA, van Duijn CM, Kiess W, Körner A, Sørensen TI, Niinikoski H, Pahkala K, Raitakari OT, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Melbye M, Campbell H, Wilson JF, Vrijheid M, de Geus EJ, Boomsma DI, Kadarmideen HN, Holm JC, Hansen T, Sebert S, Hattersley AT, Beilin LJ, Newnham JP, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widén E, Kähönen M, Viikari JS, Lehtimäki T, Vollenweider P, Bønnelykke K, Bisgaard H, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, Pisinger C, Pedersen O, Power C, Hyppönen E, Wareham NJ, Hakonarson H, Davies E, Walker BR, Jaddoe VW, Järvelin MR, Grant SF, Vaag AA, Lawlor DA, Frayling TM, Smith GD, Morris AP, Ong KK, Felix JF, Timpson NJ, Perry JR, Evans DM, McCarthy MI, Freathy RM.

Nature. 2016 Oct 13;538(7624):248-252. doi: 10.1038/nature19806.

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Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Kurth T, Ingason A, McMahon G, Ligthart L, Terwindt GM, Kallela M, Freilinger TM, Ran C, Gordon SG, Stam AH, Steinberg S, Borck G, Koiranen M, Quaye L, Adams HH, Lehtimäki T, Sarin AP, Wedenoja J, Hinds DA, Buring JE, Schürks M, Ridker PM, Hrafnsdottir MG, Stefansson H, Ring SM, Hottenga JJ, Penninx BW, Färkkilä M, Artto V, Kaunisto M, Vepsäläinen S, Malik R, Heath AC, Madden PA, Martin NG, Montgomery GW, Kurki MI, Kals M, Mägi R, Pärn K, Hämäläinen E, Huang H, Byrnes AE, Franke L, Huang J, Stergiakouli E, Lee PH, Sandor C, Webber C, Cader Z, Muller-Myhsok B, Schreiber S, Meitinger T, Eriksson JG, Salomaa V, Heikkilä K, Loehrer E, Uitterlinden AG, Hofman A, van Duijn CM, Cherkas L, Pedersen LM, Stubhaug A, Nielsen CS, Männikkö M, Mihailov E, Milani L, Göbel H, Esserlind AL, Christensen AF, Hansen TF, Werge T; International Headache Genetics Consortium., Kaprio J, Aromaa AJ, Raitakari O, Ikram MA, Spector T, Järvelin MR, Metspalu A, Kubisch C, Strachan DP, Ferrari MD, Belin AC, Dichgans M, Wessman M, van den Maagdenberg AM, Zwart JA, Boomsma DI, Smith GD, Stefansson K, Eriksson N, Daly MJ, Neale BM, Olesen J, Chasman DI, Nyholt DR, Palotie A.

Nat Genet. 2016 Sep 28;48(10):1296. doi: 10.1038/ng1016-1296c.

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Pseudoexons provide a mechanism for allele-specific expression of APC in familial adenomatous polyposis.

Nieminen TT, Pavicic W, Porkka N, Kankainen M, Järvinen HJ, Lepistö A, Peltomäki P.

Oncotarget. 2016 Oct 25;7(43):70685-70698. doi: 10.18632/oncotarget.12206.

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Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.

Anastasina M, Le May N, Bugai A, Fu Y, Söderholm S, Gaelings L, Ohman T, Tynell J, Kyttänen S, Barboric M, Nyman TA, Matikainen S, Julkunen I, Butcher SJ, Egly JM, Kainov DE.

Biochim Biophys Acta. 2016 Nov;1859(11):1440-1448. doi: 10.1016/j.bbagrm.2016.09.005.

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Targeted sequencing of 351 candidate genes for epileptic encephalopathy in a large cohort of patients.

de Kovel CG, Brilstra EH, van Kempen MJ, Van't Slot R, Nijman IJ, Afawi Z, De Jonghe P, Djémié T, Guerrini R, Hardies K, Helbig I, Hendrickx R, Kanaan M, Kramer U, Lehesjoki AE, Lemke JR, Marini C, Mei D, Møller RS, Pendziwiat M, Stamberger H, Suls A, Weckhuysen S

Genet Genomic Med. 2016 Jul 30;4(5):568-80. doi: 10.1002/mgg3.235.

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Genomic prediction of coronary heart disease.

Abraham G, Havulinna AS, Bhalala OG, Byars SG, De Livera AM, Yetukuri L, Tikkanen E, Perola M, Schunkert H, Sijbrands EJ, Palotie A, Samani NJ, Salomaa V, Ripatti S, Inouye M.

Eur Heart J. 2016 Nov 14;37(43):3267-3278. 

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Modified Atkins diet induces subacute selective ragged-red-fiber lysis in mitochondrial myopathy patients.

Ahola S, Auranen M, Isohanni P, Niemisalo S, Urho N, Buzkova J, Velagapudi V, Lundbom N, Hakkarainen A, Muurinen T, Piirilä P, Pietiläinen KH, Suomalainen A

EMBO Mol Med. 2016 Nov 2;8(11):1234-1247. doi: 10.15252/emmm.201606592.

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Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study.

Girchenko P, Hämäläinen E, Kajantie E, Pesonen AK, Villa P, Laivuori H, Räikkönen K.

Int J Epidemiol. 2016 Sep 17. pii: dyw154. [Epub ahead of print].

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Investigation of rare and low-frequency variants using high-throughput sequencing with pooled DNA samples.

Wang J, Skoog T, Einarsdottir E, Kaartokallio T, Laivuori H, Grauers A, Gerdhem P, Hytönen M, Lohi H, Kere J, Jiao H.

Sci Rep. 2016 Sep 16;6:33256. doi: 10.1038/srep33256.

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A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion.

Andritschke D, Dilling S, Emmenlauer M, Welz T, Schmich F, Misselwitz B, Rämö P, Rottner K, Kerkhoff E, Wada T, Penninger JM, Beerenwinkel N, Horvath P, Dehio C, Hardt WD.

PLoS One. 2016 Sep 14;11(9):e0161965. doi: 10.1371/journal.pone.0161965.

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Screening out irrelevant cell-based models of disease.

Horvath P, Aulner N, Bickle M, Davies AM, Nery ED, Ebner D, Montoya MC, Östling P, Pietiäinen V, Price LS, Shorte SL, Turcatti G, von Schantz C, Carragher NO.

Nat Rev Drug Discov. 2016 Nov;15(11):751-769. doi: 10.1038/nrd.2016.175.

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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M, Mihailov E, Liu C, Kraja AT, Nielsen SF, Rasheed A, Samuel M, Zhao W, Bonnycastle LL, Jackson AU, Narisu N, Swift AJ, Southam L, Marten J, Huyghe JR, Stančáková A, Fava C, Ohlsson T, Matchan A, Stirrups KE, Bork-Jensen J, Gjesing AP, Kontto J, Perola M, Shaw-Hawkins S, Havulinna AS, Zhang H, Donnelly LA, Groves CJ, Rayner NW, Neville MJ, Robertson NR, Yiorkas AM, Herzig KH, Kajantie E, Zhang W, Willems SM, Lannfelt L, Malerba G, Soranzo N, Trabetti E, Verweij N, Evangelou E, Moayyeri A, Vergnaud AC, Nelson CP, Poveda A, Varga TV, Caslake M, de Craen AJ, Trompet S, Luan J, Scott RA, Harris SE, Liewald DC, Marioni R, Menni C, Farmaki AE, Hallmans G, Renström F, Huffman JE, Hassinen M, Burgess S, Vasan RS, Felix JF; CHARGE-Heart Failure Consortium., Uria-Nickelsen M, Malarstig A, Reilly DF, Hoek M, Vogt TF, Lin H, Lieb W; EchoGen Consortium., Traylor M, Markus HS; METASTROKE Consortium., Highland HM, Justice AE, Marouli E; GIANT Consortium., Lindström J, Uusitupa M, Komulainen P, Lakka TA, Rauramaa R, Polasek O, Rudan I, Rolandsson O, Franks PW, Dedoussis G, Spector TD; EPIC-InterAct Consortium., Jousilahti P, Männistö S, Deary IJ, Starr JM, Langenberg C, Wareham NJ, Brown MJ, Dominiczak AF, Connell JM, Jukema JW, Sattar N, Ford I, Packard CJ, Esko T, Mägi R, Metspalu A, de Boer RA, van der Meer P, van der Harst P; Lifelines Cohort Study., Gambaro G, Ingelsson E, Lind L, de Bakker PI, Numans ME, Brandslund I, Christensen C, Petersen ER, Korpi-Hyövälti E, Oksa H, Chambers JC, Kooner JS, Blakemore AI, Franks S, Jarvelin MR, Husemoen LL, Linneberg A, Skaaby T, Thuesen B, Karpe F, Tuomilehto J, Doney AS, Morris AD, Palmer CN, Holmen OL, Hveem K, Willer CJ, Tuomi T, Groop L, Käräjämäki A, Palotie A, Ripatti S, Salomaa V, Alam DS, Majumder AA, Di Angelantonio E, Chowdhury R, McCarthy MI, Poulter N, Stanton AV, Sever P, Amouyel P, Arveiler D, Blankenberg S, Ferrières J, Kee F, Kuulasmaa K, Müller-Nurasyid M, Veronesi G, Virtamo J, Deloukas P; Wellcome Trust Case Control Consortium., Elliott P; Understanding Society Scientific Group., Zeggini E, Kathiresan S, Melander O, Kuusisto J, Laakso M, Padmanabhan S, Porteous DJ, Hayward C, Scotland G, Collins FS, Mohlke KL, Hansen T, Pedersen O, Boehnke M, Stringham HM; EPIC-CVD Consortium.,

Frossard P, Newton-Cheh C; CHARGE+ Exome Chip Blood Pressure Consortium., Tobin MD, Nordestgaard BG; T2D-GENES Consortium.; GoT2DGenes Consortium.; ExomeBP Consortium.; CHD Exome+ Consortium., Caulfield MJ, Mahajan A, Morris AP, Tomaszewski M, Samani NJ, Saleheen D, Asselbergs FW, Lindgren CM, Danesh J, Wain LV, Butterworth AS, Howson JM, Munroe PB.

 

Nat Genet. 2016 Oct;48(10):1151-61. doi: 10.1038/ng.3654.

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Sequence variation between 462 human individuals fine-tunes functional sites of RNA processing.

Ferreira PG, Oti M, Barann M, Wieland T, Ezquina S, Friedländer MR, Rivas MA, Esteve-Codina A; GEUVADIS Consortium., Rosenstiel P, Strom TM, Lappalainen T, Guigó R, Sammeth M.

Sci Rep. 2016 Sep 12;6:32406. doi: 10.1038/srep32406.

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Fecal and serum metabolomics in pediatric inflammatory bowel disease.

Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V.

J Crohns Colitis. 2016 Sep 8. pii: jjw158. [Epub ahead of print].

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Fetal sex-specific differences in gestational age at delivery in pre-eclampsia: a meta-analysis.

Global Pregnancy Collaboration:., Schalekamp-Timmermans S, Arends LR, Alsaker E, Chappell L, Hansson S, Harsem NK, Jälmby M, Jeyabalan A, Laivuori H, Lawlor DA, Macdonald-Wallis C, Magnus P, Myers J, Olsen J, Poston L, Redman CW, Staff AC, Villa P, Roberts JM, Steegers EA.

Int J Epidemiol. 2016 Sep 7. pii: dyw178. [Epub ahead of print].

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Outcome of surgery for patients with renal cell carcinoma and tumour thrombus in the era of modern targeted therapy.

Tornberg SV, Nisen H, Visapää H, Kilpeläinen TP, Järvinen R, Mirtti T, Kantonen I, Simpanen J, Bono P, Taari K, Järvinen P.

Scand J Urol. 2016 Oct;50(5):380-6. doi: 10.1080/21681805.2016.1217558.

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Stanniocalcin-1 hormone in non-preeclamptic and preeclamptic pregnancy: clinical, life-style and genetic modulators.

Juhanson P, Rull K, Kikas T, Laivuori H, Vaas P, Kajantie E, Heinonen S, Laan M.

J Clin Endocrinol Metab. 2016 Dec;101(12):4799-4807.

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Genome-wide association study of antisocial personality disorder.

Rautiainen MR, Paunio T, Repo-Tiihonen E, Virkkunen M, Ollila HM, Sulkava S, Jolanki O, Palotie A, Tiihonen J.

Transl Psychiatry. 2016 Sep 6;6(9):e883. doi: 10.1038/tp.2016.155.

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Midlife Physical Activity and Cognition Later in Life: A Prospective Twin Study.

Iso-Markku P, Waller K, Vuoksimaa E, Heikkilä K, Rinne J, Kaprio J, Kujala UM.

J Alzheimers Dis. 2016 Oct 18;54(4):1303-1317. 

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Drug response prediction by inferring pathway-response associations with kernelized Bayesian matrix factorization.

Ammad-Ud-Din M, Khan SA, Malani D, Murumägi A, Kallioniemi O, Aittokallio T, Kaski S.

Bioinformatics. 2016 Sep 1;32(17):i455-i463. doi: 10.1093/bioinformatics/btw433.

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High Throughput siRNA Screening Using Reverse Transfection.

von Schantz C, Saarela J.

Methods Mol Biol. 2016;1470:25-37. doi: 10.1007/978-1-4939-6337-9_3.

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Hormonal Status As Determinant Of Serum Exosomal MicroRNA Content In Pre- And Postmenopausal Women: 2278 Board #3 June 2, 3: 15 PM - 5: 15 PM.

Kangas R, Fey V, Pursiheimo J, Alen M, Kaprio J, Sipilä S, Säämänen AM, Kovanen V, Pöllänen E.

Med Sci Sports Exerc. 2016 May;48(5 Suppl 1):634. doi: 10.1249/01.mss.0000486899.84090.e9.

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An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation.

Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, Kaprio J, Toulopoulou T, Hulshoff Pol HE, Bohlken MM, Kahn RS, Nenadic I, Hultman CM, Murray RM, Collier DA, Bass N, Gurling H, McQuillin A, Schalkwyk L, Mill J.

Genome Biol. 2016 Aug 30;17(1):176. doi: 10.1186/s13059-016-1041-x. 

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Genetic support for the causal role of insulin in coronary heart disease.

Tikkanen E, Pirinen M, Sarin AP, Havulinna AS, Männistö S, Saltevo J, Lokki ML, Sinisalo J, Lundqvist A, Jula A, Salomaa V, Ripatti S.

Diabetologia. 2016 Nov;59(11):2369-77. doi: 10.1007/s00125-016-4081-6. 

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Accurate Morphology Preserving Segmentation of Overlapping Cells based on Active Contours.

Molnar C, Jermyn IH, Kato Z, Rahkama V, Östling P, Mikkonen P, Pietiäinen V, Horvath P

Sci Rep. 2016 Aug 26;6:32412. doi: 10.1038/srep32412.

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Loss of PTEN expression in ERG-negative prostate cancer predicts secondary therapies and leads to shorter disease-specific survival time after radical prostatectomy.

Lahdensuo K, Erickson A, Saarinen I, Seikkula H, Lundin J, Lundin M, Nordling S, Bützow A, Vasarainen H, Boström PJ, Taimen P, Rannikko A, Mirtti T

Mod Pathol. 2016 Aug 26. doi: 10.1038/modpathol.2016.154. [Epub ahead of print]

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An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women.

Karppanen T, Kaartokallio T, Klemetti MM, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Staff AC, Laivuori H

BMC Genet. 2016 Aug 24;17(1):121. doi: 10.1186/s12863-016-0428-8.

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Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.

Sieberts SK, Zhu F, García-García J, Stahl E, Pratap A, Pandey G, Pappas D, Aguilar D, Anton B, Bonet J, Eksi R, Fornés O, Guney E, Li H, Marín MA, Panwar B, Planas-Iglesias J, Poglayen D, Cui J, Falcao AO, Suver C, Hoff B, Balagurusamy VS, Dillenberger D, Neto EC, Norman T, Aittokallio T, Ammad-Ud-Din M, Azencott CA, Bellón V, Boeva V, Bunte K, Chheda H, Cheng L, Corander J, Dumontier M, Goldenberg A, Gopalacharyulu P, Hajiloo M, Hidru D, Jaiswal A, Kaski S, Khalfaoui B, Khan SA, Kramer ER, Marttinen P, Mezlini AM, Molparia B, Pirinen M, Saarela J, Samwald M, Stoven V, Tang H, Tang J, Torkamani A, Vert JP, Wang B, Wang T, Wennerberg K, Wineinger NE, Xiao G, Xie Y, Yeung R, Zhan X, Zhao C; Members of the Rheumatoid Arthritis Challenge Consortium, Greenberg J, Kremer J, Michaud K, Barton A, Coenen M, Mariette X, Miceli C, Shadick N, Weinblatt M, de Vries N, Tak PP, Gerlag D, Huizinga TW, Kurreeman F, Allaart CF, Louis Bridges S Jr, Criswell L, Moreland L, Klareskog L, Saevarsdottir S, Padyukov L, Gregersen PK, Friend S, Plenge R, Stolovitzky G, Oliva B, Guan Y, Mangravite LM, Bridges SL, Criswell L, Moreland L, Klareskog L, Saevarsdottir S, Padyukov L, Gregersen PK, Friend S, Plenge R, Stolovitzky G, Oliva B, Guan Y, Mangravite LM

Nat Commun. 2016 Aug 23;7:12460. doi: 10.1038/ncomms12460.

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Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.

Chan KT, Paavolainen L, Hannan KM, George AJ, Hannan RD, Simpson KJ, Horvath P, Pearson RB

Assay Drug Dev Technol. 2016 Sep;14(7):416-28. doi: 10.1089/adt.2016.739.

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Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.

Muona M, Ishimura R, Laari A, Ichimura Y, Linnankivi T, Keski-Filppula R, Herva R, Rantala H, Paetau A, Pöyhönen M, Obata M, Uemura T, Karhu T, Bizen N, Takebayashi H, McKee S, Parker MJ, Akawi N, McRae J, Hurles ME; DDD Study, Kuismin O, Kurki MI, Anttonen AK, Tanaka K, Palotie A, Waguri S, Lehesjoki AE, Komatsu M

Am J Hum Genet. 2016 Aug 17. pii: S0002-9297(16)30224-5. doi: 10.1016/j.ajhg.2016.06.020. [Epub ahead of print]

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A reference panel of 64,976 haplotypes for genotype imputation.

McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, Luo Y, Sidore C, Kwong A, Timpson N, Koskinen S, Vrieze S, Scott LJ, Zhang H, Mahajan A, Veldink J, Peters U, Pato C, van Duijn CM, Gillies CE, Gandin I, Mezzavilla M, Gilly A, Cocca M, Traglia M, Angius A, Barrett JC, Boomsma D, Branham K, Breen G, Brummett CM, Busonero F, Campbell H, Chan A, Chen S, Chew E, Collins FS, Corbin LJ, Smith GD, Dedoussis G, Dorr M, Farmaki AE, Ferrucci L, Forer L, Fraser RM, Gabriel S, Levy S, Groop L, Harrison T, Hattersley A, Holmen OL, Hveem K, Kretzler M, Lee JC, McGue M, Meitinger T, Melzer D, Min JL, Mohlke KL, Vincent JB, Nauck M, Nickerson D, Palotie A, Pato M, Pirastu N, McInnis M, Richards JB, Sala C, Salomaa V, Schlessinger D, Schoenherr S, Slagboom PE, Small K, Spector T, Stambolian D, Tuke M, Tuomilehto J, Van den Berg LH, Van Rheenen W, Volker U, Wijmenga C, Toniolo D, Zeggini E, Gasparini P, Sampson MG, Wilson JF, Frayling T, de Bakker PI, Swertz MA, McCarroll S, Kooperberg C, Dekker A, Altshuler D, Willer C, Iacono W, Ripatti S, Soranzo N, Walter K, Swaroop A, Cucca F, Anderson CA, Myers RM, Boehnke M, McCarthy MI, Durbin R; Haplotype Reference Consortium

Nat Genet. 2016 Aug 22. doi: 10.1038/ng.3643. [Epub ahead of print]

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The Pentose Phosphate Pathway Regulates the Circadian Clock.

Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O'Neill JS, Reddy AB

Cell Metab. 2016 Aug 17. pii: S1550-4131(16)30375-8. doi: 10.1016/j.cmet.2016.07.024. [Epub ahead of print]

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Migraine genetics: from genome-wide association studies to translational insights.

Gormley P, Winsvold BS, Nyholt DR, Kallela M, Chasman DI, Palotie A

Genome Med. 2016 Aug 19;8(1):86. doi: 10.1186/s13073-016-0346-4.

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Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability.

Grozeva D, Carss K, Spasic-Boskovic O, Tejada MI, Gecz J, Shaw M, Corbett M, Haan E, Thompson E, Friend K, Hussain Z, Hackett A, Field M, Renieri A, Stevenson R, Schwartz C, Floyd JA, Bentham J, Cosgrove C, Keavney B, Bhattacharya S; Italian X-linked Mental Retardation Project; UK10K Consortium; GOLD Consortium, Hurles M, Raymond FL

Hum Mutat. 2015 Dec;36(12):1197-204. doi: 10.1002/humu.22901. Epub 2015 Sep 30.

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Analysis of protein-coding genetic variation in 60,706 humans.

Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, Zhao F, Zou J, Pierce-Hoffman E, Berghout J, Cooper DN, Deflaux N, DePristo M, Do R, Flannick J, Fromer M, Gauthier L, Goldstein J, Gupta N, Howrigan D, Kiezun A, Kurki MI, Moonshine AL, Natarajan P, Orozco L, Peloso GM, Poplin R, Rivas MA, Ruano-Rubio V, Rose SA, Ruderfer DM, Shakir K, Stenson PD, Stevens C, Thomas BP, Tiao G, Tusie-Luna MT, Weisburd B, Won HH, Yu D, Altshuler DM, Ardissino D, Boehnke M, Danesh J, Donnelly S, Elosua R, Florez JC, Gabriel SB, Getz G, Glatt SJ, Hultman CM, Kathiresan S, Laakso M, McCarroll S, McCarthy MI, McGovern D, McPherson R, Neale BM, Palotie A, Purcell SM, Saleheen D, Scharf JM, Sklar P, Sullivan PF, Tuomilehto J, Tsuang MT, Watkins HC, Wilson JG, Daly MJ, MacArthur DG; Exome Aggregation Consortium

Nature. 2016 Aug 17;536(7616):285-91. doi: 10.1038/nature19057.

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Country-specific chemical signatures of persistent organic pollutants (POPs) in breast milk of French, Danish and Finnish women.

Antignac JP, Main KM, Virtanen HE, Boquien CY, Marchand P, Venisseau A, Guiffard I, Bichon E, Wohlfahrt-Veje C, Legrand A, Boscher C, Skakkebæk NE, Toppari J, Le Bizec B

Environ Pollut. 2016 Aug 9. pii: S0269-7491(16)30644-3. doi: 10.1016/j.envpol.2016.07.069. [Epub ahead of print]

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The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort.

Kallela J, Jääskeläinen T, Kortelainen E, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Laivuori H

BMC Pregnancy Childbirth. 2016 Aug 12;16(1):221.

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Incidence of subarachnoid hemorrhage is decreasing together with decreasing smoking rates.

Korja M, Lehto H, Juvela S, Kaprio J

Neurology. 2016 Aug 12. pii: 10.1212/WNL.0000000000003091. [Epub ahead of print]

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Genetic Associations Between Personality Traits and Lifetime Reproductive Success in Humans.

Berg V, Lummaa V, Rickard IJ, Silventoinen K, Kaprio J, Jokela M

Behav Genet. 2016 Aug 9. [Epub ahead of print]

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A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Rivas MA, Graham D, Sulem P, Stevens C, Desch AN, Goyette P, Gudbjartsson D, Jonsdottir I, Thorsteinsdottir U, Degenhardt F, Mucha S, Kurki MI, Li D, D'Amato M, Annese V, Vermeire S, Weersma RK, Halfvarson J, Paavola-Sakki P, Lappalainen M, Lek M, Cummings B, Tukiainen T, Haritunians T, Halme L, Koskinen LL, Ananthakrishnan AN, Luo Y, Heap GA, Visschedijk MC; UK IBD Genetics Consortium; NIDDK IBD Genetics Consortium, MacArthur DG, Neale BM, Ahmad T, Anderson CA, Brant SR, Duerr RH, Silverberg MS, Cho JH, Palotie A, Saavalainen P, Kontula K, Färkkilä M, McGovern DP, Franke A, Stefansson K, Rioux JD, Xavier RJ, Daly MJ, Barrett J, de Lane K, Edwards C, Hart A, Hawkey C, Jostins L, Kennedy N, Lamb C, Lee J, Lees C, Mansfield J, Mathew C, Mowatt C, Newman B, Nimmo E, Parkes M, Pollard M, Prescott N, Randall J, Rice D, Satsangi J, Simmons A, Tremelling M, Uhlig H, Wilson D, Abraham C, Achkar JP, Bitton A, Boucher G, Croitoru K, Fleshner P, Glas J, Kugathasan S, Limbergen JV, Milgrom R, Proctor D, Regueiro M, Schumm PL, Sharma Y, Stempak JM, Targan SR, Wang MH

Nat Commun. 2016 Aug 9;7:12342. doi: 10.1038/ncomms12342.

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HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia.

Kontro M, Kumar A, Majumder MM, Eldfors S, Parsons A, Pemovska T, Saarela J, Yadav B, Malani D, Fløisand Y, Höglund M, Remes K, Gjertsen BT, Kallioniemi O, Wennerberg K, Heckman CA, Porkka K

Leukemia. 2016 Aug 8. doi: 10.1038/leu.2016.222. [Epub ahead of print]

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Association between education and future leisure-time physical inactivity: a study of Finnish twins over a 35-year follow-up.

Piirtola M, Kaprio J, Kujala UM, Heikkilä K, Koskenvuo M, Svedberg P, Silventoinen K, Ropponen A

BMC Public Health. 2016 Aug 4;16(1):720.

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The hydroxysteroid (17β) dehydrogenase family gene HSD17B12 is involved in the prostaglandin synthesis pathway, the ovarian function, and regulation of fertility.

Kemiläinen H, Adam M, Mäki-Jouppila J, Damdimopoulou P, Damdimopoulos AE, Kere J, Hovatta O, Laajala TD, Aittokallio T, Adamski J, Ryberg H, Ohlsson C, Strauss L, Poutanen M

Endocrinology. 2016 Aug 4:en20161252. [Epub ahead of print]

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Smoking status and abdominal obesity among normal- and overweight/obese adults: Population-based FINRISK study.

Tuovinen EL, Saarni SE, Männistö S, Borodulin K, Patja K, Kinnunen TH, Kaprio J, Korhonen T

Prev Med Rep. 2016 Jul 11;4:324-30. doi: 10.1016/j.pmedr.2016.07.003. eCollection 2016 Dec.

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Phosphoproteomics to characterize host response during influenza A virus infection of human macrophages.

Soderholm S, Kainov DE, Ohman T, Denisova OV, Schepens B, Kulesskiy E, Imanishi SY, Corthals G, Hintsanen P, Aittokallio T, Saelens X, Matikainen S, Nyman TA

Mol Cell Proteomics. 2016 Aug 2. pii: mcp.M116.057984. [Epub ahead of print]

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Optimized design and analysis of preclinical intervention studies in vivo.

Laajala TD, Jumppanen M, Huhtaniemi R, Fey V, Kaur A, Knuuttila M, Aho E, Oksala R, Westermarck J, Mäkelä S, Poutanen M, Aittokallio T

Sci Rep. 2016 Aug 2;6:30723. doi: 10.1038/srep30723.

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Evaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes.

Lal D, Reinthaler EM, Dejanovic B, May P, Thiele H, Lehesjoki AE, Schwarz G, Riesch E, Ikram MA, van Duijn CM, Uitterlinden AG, Hofman A, Steinböck H, Gruber-Sedlmayr U, Neophytou B, Zara F, Hahn A; Genetic Commission of the Italian League against Epilepsy; EuroEPINOMICS CoGIE Consortium, Gormley P, Becker F, Weber YG, Cilio MR, Kunz WS, Krause R, Zimprich F, Lemke JR, Nürnberg P, Sander T, Lerche H, Neubauer BA

PLoS One. 2016 Mar 18;11(3):e0150426. doi: 10.1371/journal.pone.0150426. eCollection 2016.

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DIC image reconstruction using an energy minimization framework to visualize optical path length distribution.

Koos K, Molnár J, Kelemen L, Tamás G, Horvath P

Sci Rep. 2016 Jul 25;6:30420. doi: 10.1038/srep30420.

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Sex, Smoking, and Risk for Subarachnoid Hemorrhage.

Lindbohm JV, Kaprio J, Jousilahti P, Salomaa V, Korja M

Stroke. 2016 Aug;47(8):1975-81. doi: 10.1161/STROKEAHA.116.012957. 

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The effects of parental education on exercise behavior in childhood and youth: a study in Dutch and Finnish twins.

Huppertz C, Bartels M, de Geus EJ, van Beijsterveldt CE, Rose RJ, Kaprio J, Silventoinen K

Scand J Med Sci Sports. 2016 Jul 25. doi: 10.1111/sms.12727. [Epub ahead of print]

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Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia.

Eldfors S, Kuusanmäki H, Kontro M, Majumder MM, Parsons A, Edgren H, Pemovska T, Kallioniemi O, Wennerberg K, Gökbuget N, Burmeister T, Porkka K, Heckman CA

Leukemia. 2016 Jul 27. doi: 10.1038/leu.2016.202. [Epub ahead of print]

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Pitfalls in genetic testing: the story of missed SCN1A mutations.

Djémié T, Weckhuysen S, von Spiczak S, Carvill GL, Jaehn J, Anttonen AK, Brilstra E, Caglayan HS, de Kovel CG, Depienne C, Gaily E, Gennaro E, Giraldez BG, Gormley P, Guerrero-López R, Guerrini R, Hämäläinen E, Hartmann C, Hernandez-Hernandez L, Hjalgrim H, Koeleman BP, Leguern E, Lehesjoki AE, Lemke JR, Leu C, Marini C, McMahon JM, Mei D, Møller RS, Muhle H, Myers CT, Nava C, Serratosa JM, Sisodiya SM, Stephani U, Striano P, van Kempen MJ, Verbeek NE, Usluer S, Zara F, Palotie A, Mefford HC, Scheffer IE, De Jonghe P, Helbig I, Suls A; EuroEPINOMICS‐RES Dravet working group

Mol Genet Genomic Med. 2016 Apr 14;4(4):457-64. doi: 10.1002/mgg3.217. eCollection 2016 Jul.

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JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses.

Fu Y, Gaelings L, Söderholm S, Belanov S, Nandania J, Nyman TA, Matikainen S, Anders S, Velagapudi V, Kainov DE

Antiviral Res. 2016 Jul 20;133:23-31. doi: 10.1016/j.antiviral.2016.07.008. [Epub ahead of print]

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Protein profiling of nasopharyngeal aspirates of hospitalized and outpatients revealed cytokines associated with severe influenza A(H1N1)pdm09 virus infections: A pilot study.

Fu Y, Gaelings L, Jalovaara P, Kakkola L, Kinnunen MT, Kallio-Kokko H, Valkonen M, Kantele A, Kainov DE

Cytokine. 2016 Jul 18;86:10-14. doi: 10.1016/j.cyto.2016.07.003. [Epub ahead of print]

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Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts.

Kirschner G, Balla B, Horváth P, Kövesdi A, Lakatos G, Takács I, Nagy Z, Tóbiás B, Árvai K, Kósa JP, Lakatos P

Mol Med Rep. 2016 Jun 30. doi: 10.3892/mmr.2016.5459. [Epub ahead of print]

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Psychometric properties of the Symptom Checklist-90 in adolescent psychiatric inpatients and age- and gender-matched community youth.

Rytilä-Manninen M, Fröjd S, Haravuori H, Lindberg N, Marttunen M, Kettunen K, Therman S

Child Adolesc Psychiatry Ment Health. 2016 Jul 15;10:23. doi: 10.1186/s13034-016-0111-x. eCollection 2016.

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Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries.

Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Blomberg Jensen M, Matulevicius V, Zilaitiene B, Olesen IA, Perheentupa A, Punab M, Salzbrunn A, Toppari J, Virtanen HE, Juul A, Skakkebæk NE, Jørgensen N

Eur Urol. 2016 Jul 13. pii: S0302-2838(16)30396-7. doi: 10.1016/j.eururo.2016.06.044. [Epub ahead of print]

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Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODAT

Silventoinen K, Jelenkovic A, Sund R, Hur YM, Yokoyama Y, Honda C, Hjelmborg JV, Möller S, Ooki S, Aaltonen S, Ji F, Ning F, Pang Z, Rebato E, Busjahn A, Kandler C, Saudino KJ, Jang KL, Cozen W, Hwang AE, Mack TM, Gao W, Yu C, Li L, Corley RP, Huibregtse BM, Christensen K, Skytthe A, Kyvik KO, Derom CA, Vlietinck RF, Loos RJ, Heikkilä K, Wardle J, Llewellyn CH, Fisher A, McAdams TA, Eley TC, Gregory AM, He M, Ding X, Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Tarnoki AD, Tarnoki DL, Stazi MA, Fagnani C, D'Ippolito C, Knafo-Noam A, Mankuta D, Abramson L, Burt SA, Klump KL, Silberg JL, Eaves LJ, Maes HH, Krueger RF, McGue M, Pahlen S, Gatz M, Butler DA, Bartels M, van Beijsterveldt TC, Craig JM, Saffery R, Freitas DL, Maia JA, Dubois L, Boivin M, Brendgen M, Dionne G, Vitaro F, Martin NG, Medland SE, Montgomery GW, Chong Y, Swan GE, Krasnow R, Magnusson PK, Pedersen NL, Tynelius P, Lichtenstein P, Haworth CM, Plomin R, Bayasgalan G, Narandalai D, Harden KP, Tucker-Drob EM, Öncel SY, Aliev F, Spector T, Mangino M, Lachance G, Baker LA, Tuvblad C, Duncan GE, Buchwald D, Willemsen G, Rasmussen F, Goldberg JH, Sørensen TI, Boomsma DI, Kaprio J

Am J Clin Nutr. 2016 Jul 13. pii: ajcn130252. [Epub ahead of print]

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Mood Changes After Indoor Tanning Among College Women: Associations with Psychiatric/Addictive Symptoms.

Heckman C, Darlow S, Cohen-Filipic J, Kloss J

Health Psychol Res. 2016 Jun 23;4(1):5453. doi: 10.4081/hpr.2016.5453. eCollection 2016 Jun 23.

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An interactive genome browser of association results from the UK10K cohorts project.

Geihs M, Yan Y, Walter K, Huang J, Memari Y, Min JL, Mead D; UK10K Consortium, Hubbard TJ, Timpson NJ, Down TA, Soranzo N

Bioinformatics. 2015 Dec 15;31(24):4029-31. doi: 10.1093/bioinformatics/btv491. Epub 2015 Aug 26.

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Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants.

Kaartokallio T, Wang J, Heinonen S, Kajantie E, Kivinen K, Pouta A, Gerdhem P, Jiao H, Kere J, Laivuori H

Sci Rep. 2016 Jul 7;6:29085. doi: 10.1038/srep29085.

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Hypoxia Marker GLUT-1 (Glucose Transporter 1) is an Independent Prognostic Factor for Survival in Bladder Cancer Patients Treated with Radical Cystectomy.

Boström PJ, Thoms J, Sykes J, Ahmed O, Evans A, van Rhijn BW, Mirtti T, Stakhovskyi O, Laato M, Margel D, Pintilie M, Kuk C, Milosevic M, Zlotta AR, Bristow RG

Bl Cancer. 2016 Jan 7;2(1):101-109.

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Benefit of Adjuvant Chemotherapy and Pelvic Lymph Node Dissection in pT3 and Node Positive Bladder Cancer Patients Treated with Radical Cystectomy.

Boström PJ, Mirtti T, van Rhijn B, Fleshner NE, Finelli A, Laato M, Jewett MA, Moore MJ, Sridhar S, Nurmi M, Tannock IF, Zlotta AR

Bl Cancer. 2016 Apr 27;2(2):263-272.

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Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer.

Kangaspeska S, Hultsch S, Jaiswal A, Edgren H, Mpindi JP, Eldfors S, Brück O, Aittokallio T, Kallioniemi O

BMC Cancer. 2016 Jul 4;16(1):378.

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Education and alcohol use: A study of gene-environment interaction in young adulthood.

Barr PB, Salvatore JE, Maes H, Aliev F, Latvala A, Viken R, Rose RJ, Kaprio J, Dick DM.

Soc Sci Med. 2016 Jun 22;162:158-167. doi:10.1016/j.socscimed.2016.06.031. [Epub ahead of print]

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Meconium-Stained Amniotic Fluid and Neonatal Morbidity in Low-Risk Pregnancies at Term: The Effect of Gestational Age.

Hiersch L, Krispin E, Linder N, Aviram A, Gabbay-Benziv R, Yogev Y, Ashwal E.

Am J Perinatol. 2016 Jul 1. [Epub ahead of print]

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Altered Monocyte Subtype Profiles Following High Intensity Exercise in Obese Children: 2657 Board #180 June 3, 9: 30 AM - 11: 00 AM.

Chiu A, Ganesan G, Horvath P, Galassetti PR

Med Sci Sports Exerc. 2016 May;48(5 Suppl 1):742. doi: 10.1249/01.mss.0000487226.58617.ca.

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Leisure-time Physical Activity And Academic Performance: Cross-lagged Associations From Adolescence To Young Adulthood: 848 Board #164 June 1, 3: 30 PM - 5: 00 PM.

Aaltonen S, Latvala A, Kujala UM, Kaprio J, Silventoinen K.

Med Sci Sports Exerc. 2016 May;48(5 Suppl 1):236. doi: 10.1249/01.mss.0000485711.10033.11.

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Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Scharnagl H, Shi J, Smith AV, Southam L, Stančáková A, Steinthorsdottir V, Strawbridge RJ, Sung YJ, Tachmazidou I, Tanaka T, Thorleifsson G, Trompet S, Pervjakova N, Tyrer JP, Vandenput L, van der Laan SW, van der Velde N, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Vlachopoulou E, Waite LL, Wang SR, Wang Z, Wild SH, Willenborg C, Wilson JF, Wong A, Yang J, Yengo L, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Andersson EA, Bakker SJ, Baldassarre D, Banasik K, Barcella M, Barlassina C, Bellis C, Benaglio P, Blangero J, Blüher M, Bonnet F, Bonnycastle LL, Boyd HA, Bruinenberg M, Buchman AS, Campbell H, Chen YI, Chines PS, Claudi-Boehm S, Cole J, Collins FS, de Geus EJ, de Groot LC, Dimitriou M, Duan J, Enroth S, Eury E, Farmaki AE, Forouhi NG, Friedrich N, Gejman PV, Gigante B, Glorioso N, Go AS, Gottesman O, Gräßler J, Grallert H, Grarup N, Gu YM, Broer L, Ham AC, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Heath AC, Henders AK, Hernandez D, Hillege H, Holmen O, Hovingh KG, Hui J, Husemoen LL, Hutri-Kähönen N, Hysi PG, Illig T, De Jager PL, Jalilzadeh S, Jørgensen T, Jukema JW, Juonala M, Kanoni S, Karaleftheri M, Khaw KT, Kinnunen L, Kittner SJ, Koenig W, Kolcic I, Kovacs P, Krarup NT, Kratzer W, Krüger J, Kuh D, Kumari M, Kyriakou T, Langenberg C, Lannfelt L, Lanzani C, Lotay V, Launer LJ, Leander K, Lindström J, Linneberg A, Liu YP, Lobbens S, Luben R, Lyssenko V, Männistö S, Magnusson PK, McArdle WL, Menni C, Merg

PLoS Genet. 2016 Jun 29;12(6):e1006166. doi: 10.1371/journal.pgen.1006166. eCollection 2016 Jun

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The "Martian" flora: new collections of vascular plants, lichens, fungi, algae, and cyanobacteria from the Mars Desert Research Station, Utah.

Sokoloff PC, Freebury CE, Hamilton PB, Saarela JM

Biodivers Data J. 2016 Jun 9;(4):e8176. doi:10.3897/BDJ.4.e8176. eCollection 2016.

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Alcohol intake, drinking patterns, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins.

Dickerman BA, Markt SC, Koskenvuo M, Pukkala E, Mucci LA, Kaprio J

Cancer Causes Control. 2016 Jun 28.[Epub ahead of print]

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Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts.

Jelenkovic A, Sund R, Hur YM, Yokoyama Y, Hjelmborg JV, Möller S, Honda C, Magnusson PK, Pedersen NL, Ooki S, Aaltonen S, Stazi MA, Fagnani C, D'Ippolito C, Freitas DL, Maia JA, Ji F, Ning F, Pang Z, Rebato E, Busjahn A, Kandler C, Saudino KJ, Jang KL, Cozen W, Hwang AE, Mack TM, Gao W, Yu C, Li L, Corley RP, Huibregtse BM, Derom CA, Vlietinck RF, Loos RJ, Heikkilä K, Wardle J, Llewellyn CH, Fisher A, McAdams TA, Eley TC, Gregory AM, He M, Ding X, Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Tarnoki AD, Tarnoki DL, Knafo-Noam A, Mankuta D, Abramson L, Burt SA, Klump KL, Silberg JL, Eaves LJ, Maes HH, Krueger RF, McGue M, Pahlen S, Gatz M, Butler DA, Bartels M, van Beijsterveldt TC, Craig JM, Saffery R, Dubois L, Boivin M, Brendgen M, Dionne G, Vitaro F, Martin NG, Medland SE, Montgomery GW, Swan GE, Krasnow R, Tynelius P, Lichtenstein P, Haworth CM, Plomin R, Bayasgalan G, Narandalai D, Harden KP, Tucker-Drob EM, Spector T, Mangino M, Lachance G, Baker LA, Tuvblad C, Duncan GE, Buchwald D, Willemsen G, Skytthe A, Kyvik KO, Christensen K, Öncel SY, Aliev F, Rasmussen F, Goldberg JH, Sørensen TI, Boomsma DI, Kaprio J, Silventoinen K

Sci Rep. 2016 Jun 23;6:28496. doi: 10.1038/srep28496.

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Next-generation sequencing of common osteogenesis imperfecta-related genes in clinical practice.

Árvai K, Horváth P, Balla B, Tobiás B, Kató K, Kirschner G, Klujber V, Lakatos P, Kósa JP

Sci Rep. 2016 Jun 23;6:28417. doi: 10.1038/srep28417

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Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.

Jarvis D, Mitchell JS, Law PJ, Palin K, Tuupanen S, Gylfe A, Hänninen UA, Cajuso T, Tanskanen T, Kondelin J, Kaasinen E, Sarin AP, Kaprio J, Eriksson JG, Rissanen H, Knekt P, Pukkala E, Jousilahti P, Salomaa V, Ripatti S, Palotie A, Järvinen H, Renkonen-Sinisalo L, Lepistö A, Böhm J, Meklin JP, Al-Tassan NA, Palles C, Martin L, Barclay E, Farrington SM, Timofeeva MN, Meyer BF, Wakil SM, Campbell H, Smith CG, Idziaszczyk S, Maughan TS, Kaplan R, Kerr R, Kerr D, Buchanan DD, Win AK, Hopper JL, Jenkins MA, Lindor NM, Newcomb PA, Gallinger S, Conti D, Schumacher F, Casey G, Taipale J, Aaltonen LA, Cheadle JP, Dunlop MG, Tomlinson IP, Houlston RS

Br J Cancer. 2016 Jun 23. doi: 10.1038/bjc.2016.188. [Epub ahead of print]

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Admixture into and within sub-Saharan Africa.

Busby GB, Band G, Si Le Q, Jallow M, Bougama E, Mangano VD, Amenga-Etego LN, Enimil A, Apinjoh T, Ndila CM, Manjurano A, Nyirongo V, Doumba O, Rockett KA, Kwiatkowski DP, Spencer CC; Malaria Genomic Epidemiology Network

Elife. 2016 Jun 21;5. pii: e15266. doi: 10.7554/eLife.15266.

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Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis.

Loh PR, Bhatia G, Gusev A, Finucane HK, Bulik-Sullivan BK, Pollack SJ; Schizophrenia Working Group of Psychiatric Genomics Consortium, de Candia TR, Lee SH, Wray NR, Kendler KS, O'Donovan MC, Neale BM, Patterson N, Price AL

Nat Genet. 2015 Dec;47(12):1385-92. doi: 10.1038/ng.3431. Epub 2015 Nov 2.

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The effects of social anxiety on alcohol and cigarette use across adolescence: Results from a longitudinal twin study in Finland.

Savage JE, Kaprio J, Korhonen T, Pulkkinen L, Rose RJ, Verhulst B, Dick DM

Psychol Addict Behav. 2016 Jun;30(4):462-74. doi: 10.1037/adb0000183.

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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Kurth T, Ingason A, McMahon G, Ligthart L, Terwindt GM, Kallela M, Freilinger TM, Ran C, Gordon SG, Stam AH, Steinberg S, Borck G, Koiranen M, Quaye L, Adams HH, Lehtimäki T, Sarin AP, Wedenoja J, Hinds DA, Buring JE, Schürks M, Ridker PM, Hrafnsdottir MG, Stefansson H, Ring SM, Hottenga JJ, Penninx BW, Färkkilä M, Artto V, Kaunisto M, Vepsäläinen S, Malik R, Heath AC, Madden PA, Martin NG, Montgomery GW, Kurki MI, Kals M, Mägi R, Pärn K, Hämäläinen E, Huang H, Byrnes AE, Franke L, Huang J, Stergiakouli E, Lee PH, Sandor C, Webber C, Cader Z, Muller-Myhsok B, Schreiber S, Meitinger T, Eriksson JG, Salomaa V, Heikkilä K, Loehrer E, Uitterlinden AG, Hofman A, van Duijn CM, Cherkas L, Pedersen LM, Stubhaug A, Nielsen CS, Männikkö M, Mihailov E, Milani L, Göbel H, Esserlind AL, Christensen AF, Hansen TF, Werge T; International Headache Genetics Consortium, Kaprio J, Aromaa AJ, Raitakari O, Ikram MA, Spector T, Järvelin MR, Metspalu A, Kubisch C, Strachan DP, Ferrari MD, Belin AC, Dichgans M, Wessman M, van den Maagdenberg AM, Zwart JA, Boomsma DI, Smith GD, Stefansson K, Eriksson N, Daly MJ, Neale BM, Olesen J, Chasman DI, Nyholt DR, Palotie A

Nat Genet. 2016 Jun 20. doi: 10.1038/ng.3598. [Epub ahead of print]

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BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine.

Gu Y, Helenius M, Väänänen K, Bulanova D, Saarela J, Sokolenko A, Martens J, Imyanitov E, Kuznetsov S

Sci Rep. 2016 Jun 17;6:28217. doi: 10.1038/srep28217.

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Association of MMP-8 with obesity, smoking and insulin resistance.

Lauhio A, Färkkilä E, Pietiläinen KH, Åström P, Winkelmann A, Tervahartiala T, Pirilä E, Rissanen A, Kaprio J, Sorsa TA, Salo T

Eur J Clin Invest. 2016 Jun 14. doi: 10.1111/eci.12649. [Epub ahead of print]

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Truncation of POC1A associated with short stature and extreme insulin resistance.

Chen JH, Segni M, Payne F, Huang-Doran I, Sleigh A, Adams C; UK10K Consortium, Savage DB, O'Rahilly S, Semple RK, Barroso I

J Mol Endocrinol. 2015 Oct;55(2):147-58. doi: 10.1530/JME-15-0090.

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Erratum to: Absorption, distribution and excretion of intravenously injected (68)Ge/(68)Ga generator eluate in healthy rats, and estimation of human radiation dosimetry.

Autio A, Virtanen H, Tolvanen T, Liljenbäck H, Oikonen V, Saanijoki T, Siitonen R, Käkelä M, Schüssele A, Teräs M, Roivainen A

EJNMMI Res. 2016 Dec;6(1):51. doi: 10.1186/s13550-016-0205-8. Epub 2016 Jun 13.

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The Eating Disorder Inventory in the screening for DSM-5 binge eating disorder.

Mustelin L, Kärkkäinen U, Kaprio J, Keski-Rahkonen A

Eat Behav. 2016 Jun 3;22:145-148. doi: 10.1016/j.eatbeh.2016.06.011. [Epub ahead of print]

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Liquid chromatography with mass spectrometry enantioseparation of pomalidomide on cyclodextrin-bonded chiral stationary phases and the elucidation of the chiral recognition mechanisms by NMR spectroscopy and molecular modeling.

Szabó ZI, Szőcs L, Horváth P, Komjáti B, Nagy J, Jánoska Á, Muntean DL, Noszál B, Tóth G

J Sep Sci. 2016 Jun 9. doi: 10.1002/jssc.201600354. [Epub ahead of print]

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Intrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signaling.

Brunen D, García-Barchino MJ, Malani D, Basheer NJ, Lieftink C, Beijersbergen RL, Murumägi A, Porkka K, Wolf M, Zwaan CM, Fornerod M, Kallioniemi O, Martínez-Climent JÁ, Bernards R

Oncotarget. 2016 Jun 5. doi: 10.18632/oncotarget.9822. [Epub ahead of print]

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CRY1 and CRY2 genetic variants in seasonality: A longitudinal and cross-sectional study.

Kovanen L, Donner K, Kaunisto M, Partonen T

Psychiatry Res. 2016 May 30;242:101-110. doi: 10.1016/j.psychres.2016.05.044. [Epub ahead of print]

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Anisometropia of ocular refractive and biometric measures among 66- to 79-year-old female twins.

Pärssinen O, Kauppinen M, Kaprio J, Rantanen T

Acta Ophthalmol. 2016 Jun 8. doi: 10.1111/aos.13125. [Epub ahead of print]

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Timing, rates and spectra of human germline mutation.

Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB, Al Turki S, Dominiczak A, Morris A, Porteous D, Smith B, Stratton MR; UK10K Consortium, Hurles ME

Nat Genet. 2016 Feb;48(2):126-33. doi: 10.1038/ng.3469. Epub 2015 Dec 14.

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Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children.

Kenyan Bacteraemia Study Group; Wellcome Trust Case Control Consortium 2 (WTCCC2), Rautanen A, Pirinen M, Mills TC, Rockett KA, Strange A, Ndungu AW, Naranbhai V, Gilchrist JJ, Bellenguez C, Freeman C, Band G, Bumpstead SJ, Edkins S, Giannoulatou E, Gray E, Dronov S, Hunt SE, Langford C, Pearson RD, Su Z, Vukcevic D, Macharia AW, Uyoga S, Ndila C, Mturi N, Njuguna P, Mohammed S, Berkley JA, Mwangi I, Mwarumba S, Kitsao BS, Lowe BS, Morpeth SC, Khandwalla I; Kilifi Bacteraemia Surveillance Group, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CN, Plomin R, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Deloukas P, Peltonen L, Williams TN, Scott JA, Chapman SJ, Donnelly P, Hill AV, Spencer CC

Am J Hum Genet. 2016 Jun 2;98(6):1092-100. doi: 10.1016/j.ajhg.2016.03.025. Epub 2016 May 26.

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The Contribution of GWAS Loci in Familial Dyslipidemias.

Ripatti P, Rämö JT, Söderlund S, Surakka I, Matikainen N, Pirinen M, Pajukanta P, Sarin AP, Service SK, Laurila PP, Ehnholm C, Salomaa V, Wilson RK, Palotie A, Freimer NB, Taskinen MR, Ripatti S

PLoS Genet. 2016 May 26;12(5):e1006078. doi: 10.1371/journal.pgen.1006078. eCollection 2016 May.

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Genome-wide association study identifies 74 loci associated with educational attainment.

Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P, Chen GB, Emilsson V, Meddens SF, Oskarsson S, Pickrell JK, Thom K, Timshel P, de Vlaming R, Abdellaoui A, Ahluwalia TS, Bacelis J, Baumbach C, Bjornsdottir G, Brandsma JH, Pina Concas M, Derringer J, Furlotte NA, Galesloot TE, Girotto G, Gupta R, Hall LM, Harris SE, Hofer E, Horikoshi M, Huffman JE, Kaasik K, Kalafati IP, Karlsson R, Kong A, Lahti J, van der Lee SJ, deLeeuw C, Lind PA, Lindgren KO, Liu T, Mangino M, Marten J, Mihailov E, Miller MB, van der Most PJ, Oldmeadow C, Payton A, Pervjakova N, Peyrot WJ, Qian Y, Raitakari O, Rueedi R, Salvi E, Schmidt B, Schraut KE, Shi J, Smith AV, Poot RA, St Pourcain B, Teumer A, Thorleifsson G, Verweij N, Vuckovic D, Wellmann J, Westra HJ, Yang J, Zhao W, Zhu Z, Alizadeh BZ, Amin N, Bakshi A, Baumeister SE, Biino G, Bønnelykke K, Boyle PA, Campbell H, Cappuccio FP, Davies G, De Neve JE, Deloukas P, Demuth I, Ding J, Eibich P, Eisele L, Eklund N, Evans DM, Faul JD, Feitosa MF, Forstner AJ, Gandin I, Gunnarsson B, Halldórsson BV, Harris TB, Heath AC, Hocking LJ, Holliday EG, Homuth G, Horan MA, Hottenga JJ, de Jager PL, Joshi PK, Jugessur A, Kaakinen MA, Kähönen M, Kanoni S, Keltigangas-Järvinen L, Kiemeney LA, Kolcic I, Koskinen S, Kraja AT, Kroh M, Kutalik Z, Latvala A, Launer LJ, Lebreton MP, Levinson DF, Lichtenstein P, Lichtner P, Liewald DC; LifeLines Cohort Study, Loukola A, Madden PA, Mägi R, Mäki-Opas T, Marioni RE, Marques-Vidal P, Meddens GA, McMahon G, Meisinger C, Meitinger T, Milaneschi Y, Milani L, Montgomery GW, Myhre R, Nelson CP, Nyholt DR, Ollier WE, Palotie A, Paternoster L, Pedersen NL, Petrovic KE, Porteous DJ, Räikkönen K, Ring SM, Robino A, Rostapshova O, Rudan I, Rustichini A, Salomaa V, Sanders AR, Sarin AP, Schmidt H, Scott RJ, Smith BH, Smith JA, Staessen JA, Steinhagen-Thiessen E, Strauch K, Terracciano A, Tobin MD, Ulivi S, Vaccargiu S, Quaye L, van Rooij FJ, Venturini C, Vinkhuyzen AA, Völker U, Völzke H, Vonk JM, Vozzi D, Waage J, Ware EB, Willemsen G, Attia JR, Bennett DA, Berger K, Bertram L, Bisgaard H, Boomsma DI, Borecki IB, Bültmann U, Chabris CF, Cucca F, Cusi D, Deary IJ, Dedoussis GV, van Duijn CM, Eriksson JG, Franke B, Franke L, Gasparini P, Gejman PV, Gieger C, Grabe HJ, Gratten J, Groenen PJ, Gudnason V, van der Harst P, Hayward C, Hinds DA, Hoffmann W, Hyppönen E, Iacono WG, Jacobsson B, Järvelin MR, Jöckel KH, Kaprio J, Kardia SL, Lehtimäki T, Lehrer SF, Magnusson PK, Martin NG, McGue

Nature. 2016 May 11;533(7604):539-42. doi: 10.1038/nature17671.

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Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes.

Grotenfelt NE, Wasenius NS, Rönö K, Laivuori H, Stach-Lempinen B, Orho-Melander M, Schulz CA, Kautiainen H, Koivusalo SB, Eriksson JG

Diabetologia. 2016 Aug;59(8):1655-8. doi: 10.1007/s00125-016-3989-1. Epub 2016 May 21.

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Real--world results of ibrutinib in patients with relapsed or refractory chronic lymphocytic leukemia: Data from 95 consecutive patients treated in a compassionate use program.

Winqvist M, Asklid A, Andersson PO, Karlsson K, Karlsson C, Lauri B, Lundin J, Mattsson M, Norin S, Standstedt A, Hansson L, Österborg A

Haematologica. 2016 May 19. pii: haematol.2016.144576. [Epub ahead of print]

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Modulation in persistent organic pollutant concentration and profile by prey availability and reproductive status in Southern Resident killer whale scat samples.

Lundin JI, Ylitalo GM, Booth RK, Anulacion B, Hempelmann JA, Parsons KM, Giles DA, Seely EA, Hanson MB, Emmons CK, Wasser SK

Environ Sci Technol. 2016 Jun 21;50(12):6506-16. doi: 10.1021/acs.est.6b00825. Epub 2016 Jun 8.

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Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.

Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J

Mol Psychiatry. 2016 May 17. doi: 10.1038/mp.2016.71. [Epub ahead of print]

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Prolonged dry apnoea: effects on brain activity and physiological functions in breath-hold divers and non-divers.

Ratmanova P, Semenyuk R, Popov D, Kuznetsov S, Zelenkova I, Napalkov D, Vinogradova O

Eur J Appl Physiol. 2016 Jul;116(7):1367-77. doi: 10.1007/s00421-016-3390-2. Epub 2016 May 17.

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Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium.

Fan Q, Guo X, Tideman JW, Williams KM, Yazar S, Hosseini SM, Howe LD, Pourcain BS, Evans DM, Timpson NJ, McMahon G, Hysi PG, Krapohl E, Wang YX, Jonas JB, Baird PN, Wang JJ, Cheng CY, Teo YY, Wong TY, Ding X, Wojciechowski R, Young TL, Pärssinen O, Oexle K, Pfeiffer N, Bailey-Wilson JE, Paterson AD, Klaver CC, Plomin R, Hammond CJ, Mackey DA, He M, Saw SM, Williams C, Guggenheim JA; CREAM Consortium

Sci Rep. 2016 May 13;6:25853. doi: 10.1038/srep25853.

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Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells.

Gautam P, Karhinen L, Szwajda A, Jha SK, Yadav B, Aittokallio T, Wennerberg K

Mol Cancer. 2016 May 10;15(1):34. doi: 10.1186/s12943-016-0517-3.

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Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer.

Saeed K, Rahkama V, Eldfors S, Bychkov D, Mpindi JP, Yadav B, Paavolainen L, Aittokallio T, Heckman C, Wennerberg K, Peehl DM, Horvath P, Mirtti T, Rannikko A, Kallioniemi O, Östling P, Af Hällström TM

Eur Urol. 2017 Mar;71(3):319-327. doi:10.1016/j.eururo.2016.04.019.  Epub 2016 May 6.

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Genetic Relationship between Schizophrenia and Nicotine Dependence.

Chen J, Bacanu SA, Yu H, Zhao Z, Jia P, Kendler KS, Kranzler HR, Gelernter J, Farrer L, Minica C, Pool R, Milaneschi Y, Boomsma DI, Penninx BW, Tyndale RF, Ware JJ, Vink JM, Kaprio J, Munafò M, Chen X

Sci Rep. 2016 May 10;6:25671. doi: 10.1038/srep25671.

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Gene-Environment Interactions Between Depressive Symptoms and Smoking Quantity.

Keskitalo-Vuokko K, Korhonen T, Kaprio J

Twin Res Hum Genet. 2016 May 10:1-8. [Epub ahead of print]

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Fusarium mycotoxin enniatin B: Cytotoxic effects and changes in gene expression profile.

Jonsson M, Jestoi M, Anthoni M, Welling A, Loivamaa I, Hallikainen V, Kankainen M, Lysøe E, Koivisto P, Peltonen K

Toxicol In Vitro. 2016  Aug;34:309-20. doi: 10.1016/j.tiv.2016.04.017. Epub 2016 May 6.

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Purine metabolism is dysregulated in patients with major depressive disorder.

Ali-Sisto T, Tolmunen T, Toffol E, Viinamäki H, Mäntyselkä P, Valkonen-Korhonen M, Honkalampi K, Ruusunen A, Velagapudi V, Lehto SM

Psychoneuroendocrinology. 2016 Aug;70:25-32. doi: 10.1016/j.psyneuen.2016.04.017. Epub 2016 Apr 30.

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Young Adults' Developmental Task-Related Goals Modify the Association between Self-Focused Goals and Depressive Symptoms.

Salmela-Aro K, Read S, Korhonen T, Vuoksimaa E, Rose RJ, Kaprio J

Appl Psychol Health Well Being. 2012 Mar;4(1):106-25. doi: 10.1111/j.1758-0854.2011.01064.x. Epub 2011 Dec 8.

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metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis.

Cichonska A, Rousu J, Marttinen P, Kangas AJ, Soininen P, Lehtimäki T, Raitakari OT, Järvelin MR, Salomaa V, Ala-Korpela M, Ripatti S, Pirinen M

Bioinformatics. 2016 Jul 1;32(13):1981-9. doi: 10.1093/bioinformatics/btw052. Epub 2016 Feb 19.

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Enrichment of rare variants in population isolates: single AICDA mutation responsible for hyper-IgM syndrome type 2 in Finland.

Trotta L, Hautala T, Hämäläinen S, Syrjänen J, Viskari H, Almusa H, Lepisto M, Kaustio M, Porkka K, Palotie A, Seppänen M, Saarela J

Eur J Hum Genet. 2016 May 4. doi: 10.1038/ejhg.2016.37. [Epub ahead of print]

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The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection.

Ritchie SC, Würtz P, Nath AP, Abraham G, Havulinna AS, Fearnley LG, Sarin AP, Kangas AJ, Soininen P, Aalto K, Seppälä I, Raitoharju E, Salmi M, Maksimow M, Männistö S, Kähönen M, Juonala M, Ripatti S, Lehtimäki T, Jalkanen S, Perola M, Raitakari O, Salomaa V, Ala-Korpela M, Kettunen J, Inouye M

Cell Syst. 2015 Oct 28;1(4):293-301. doi: 10.1016/j.cels.2015.09.007. Epub 2015 Oct 22.

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Genome-wide time-to-event analysis on smoking progression stages in a family-based study.

He L, Pitkäniemi J, Heikkilä K, Chou YL, Madden PA, Korhonen T, Sarin AP, Ripatti S, Kaprio J, Loukola A

Brain Behav. 2016 Apr 22;6(5):e00462. doi: 10.1002/brb3.462. eCollection 2016 May.

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Persistent leisure-time physical activity in adulthood and use of antidepressants: A follow-up study among twins.

Waller K, Kaprio J, Korhonen T, Tuulio-Henriksson A, Kujala UM

J Affect Disord. 2016 Aug;200:172-7. doi: 10.1016/j.jad.2016.04.036. Epub 2016 Apr 21.

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Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.

Mbarek H, Steinberg S, Nyholt DR, Gordon SD, Miller MB, McRae AF, Hottenga JJ, Day FR, Willemsen G, de Geus EJ, Davies GE, Martin HC, Penninx BW, Jansen R, McAloney K, Vink JM, Kaprio J, Plomin R, Spector TD, Magnusson PK, Reversade B, Harris RA, Aagaard K, Kristjansson RP, Olafsson I, Eyjolfsson GI, Sigurdardottir O, Iacono WG, Lambalk CB, Montgomery GW, McGue M, Ong KK, Perry JR, Martin NG, Stefánsson H, Stefánsson K, Boomsma DI

Am J Hum Genet. 2016 May 5;98(5):898-908. doi: 10.1016/j.ajhg.2016.03.008. Epub 2016 Apr 28.

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Leisure-time physical activity and intra-abdominal fat in young adulthood: A monozygotic co-twin control study.

Rottensteiner M, Leskinen T, Järvelä-Reijonen E, Väisänen K, Aaltonen S, Kaprio J, Kujala UM

Obesity (Silver Spring). 2016 May;24(5):1185-91. doi: 10.1002/oby.21465.

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Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes.

Kaartokallio T, Lokki AI, Peterson H, Kivinen K, Hiltunen L, Salmela E, Lappalainen T, Maanselkä P, Heino S, Knuutila S, Sayed A, Poston L, Brennecke SP, Johnson MP, Morgan L, Moses EK, Kere J, Laivuori H

Ann Med. 2016 Apr 25:1-7. [Epub ahead of print]

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All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs.

Schork AJ, Thompson WK, Pham P, Torkamani A, Roddey JC, Sullivan PF, Kelsoe JR, O'Donovan MC, Furberg H; Tobacco and Genetics Consortium; Bipolar Disorder Psychiatric Genomics Consortium; Schizophrenia Psychiatric Genomics Consortium, Schork NJ, Andreassen OA, Dale AM

PLoS Genet. 2013 Apr;9(4):e1003449. doi: 10.1371/journal.pgen.1003449. Epub 2013 Apr 25.

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Birth order and mortality in two ethno-linguistic groups: Register-based evidence from Finland.

Saarela J, Cederström A, Rostila M

Soc Sci Med. 2016 Jun;158:8-13. doi: 10.1016/j.socscimed.2016.04.008. Epub 2016 Apr 14.

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Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma.

Rautiola J, Lampinen A, Mirtti T, Ristimäki A, Joensuu H, Bono P, Saharinen P

PLoS One. 2016 Apr 21;11(4):e0153745. doi: 10.1371/journal.pone.0153745. eCollection 2016.

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CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection.

Côme C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimentel JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Chen Z, Lahesmaa R, Westermarck J

PLoS One. 2016 Apr 21;11(4):e0152996. doi: 10.1371/journal.pone.0152996. eCollection 2016.

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iGEMS: an integrated model for identification of alternative exon usage events.

Sood S, Szkop KJ, Nakhuda A, Gallagher IJ, Murie C, Brogan RJ, Kaprio J, Kainulainen H, Atherton PJ, Kujala UM, Gustafsson T, Larsson O, Timmons JA

Nucleic Acids Res. 2016 Jun 20;44(11):e109. doi: 10.1093/nar/gkw263. Epub 2016 Apr 19.

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Tumor Heterogeneity of Fibroblast Growth Factor Receptor 3 (FGFR3) Mutations in Invasive Bladder Cancer: Implications for Peri-Operative anti-FGFR3 Treatment.

Pouessel D, Neuzillet Y, Mertens LS, van der Heijden MS, de Jong J, Sanders J, Peters D, Leroy K, Manceau A, Maille P, Soyeux P, Moktefi A, Semprez F, Vordos D, de la Taille A, Hurst CD, Tomlinson DC, Harnden P, Bostrom PJ, Mirtti T, Horenblas S, Loriot Y, Houédé N, Chevreau C, Beuzeboc P, Shariat SF, Sagalowsky AI, Ashfaq R, Burger M, Jewett MA, Zlotta AR, Broeks A, Bapat B, Knowles MA, Lotan Y, van der Kwast TH, Culine S, Allory Y, van Rhijn BW

Ann Oncol. 2016 Jul;27(7):1311-6. doi: 10.1093/annonc/mdw170. Epub 2016 Apr 18.

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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Okbay A, Baselmans BM, De Neve JE, Turley P, Nivard MG, Fontana MA, Meddens SF, Linnér RK, Rietveld CA, Derringer J, Gratten J, Lee JJ, Liu JZ, de Vlaming R, Ahluwalia TS, Buchwald J, Cavadino A, Frazier-Wood AC, Furlotte NA, Garfield V, Geisel MH, Gonzalez JR, Haitjema S, Karlsson R, van der Laan SW, Ladwig KH, Lahti J, van der Lee SJ, Lind PA, Liu T, Matteson L, Mihailov E, Miller MB, Minica CC, Nolte IM, Mook-Kanamori D, van der Most PJ, Oldmeadow C, Qian Y, Raitakari O, Rawal R, Realo A, Rueedi R, Schmidt B, Smith AV, Stergiakouli E, Tanaka T, Taylor K, Wedenoja J, Wellmann J, Westra HJ, Willems SM, Zhao W; LifeLines Cohort Study, Amin N, Bakshi A, Boyle PA, Cherney S, Cox SR, Davies G, Davis OS, Ding J, Direk N, Eibich P, Emeny RT, Fatemifar G, Faul JD, Ferrucci L, Forstner A, Gieger C, Gupta R, Harris TB, Harris JM, Holliday EG, Hottenga JJ, De Jager PL, Kaakinen MA, Kajantie E, Karhunen V, Kolcic I, Kumari M, Launer LJ, Franke L, Li-Gao R, Koini M, Loukola A, Marques-Vidal P, Montgomery GW, Mosing MA, Paternoster L, Pattie A, Petrovic KE, Pulkki-Råback L, Quaye L, Räikkönen K, Rudan I, Scott RJ, Smith JA, Sutin AR, Trzaskowski M, Vinkhuyzen AE, Yu L, Zabaneh D, Attia JR, Bennett DA, Berger K, Bertram L, Boomsma DI, Snieder H, Chang SC, Cucca F, Deary IJ, van Duijn CM, Eriksson JG, Bültmann U, de Geus EJ, Groenen PJ, Gudnason V, Hansen T, Hartman CA, Haworth CM, Hayward C, Heath AC, Hinds DA, Hyppönen E, Iacono WG, Järvelin MR, Jöckel KH, Kaprio J, Kardia SL, Keltikangas-Järvinen L, Kraft P, Kubzansky LD, Lehtimäki T, Magnusson PK, Martin NG, McGue M, Metspalu A, Mills M, de Mutsert R, Oldehinkel AJ, Pasterkamp G, Pedersen NL, Plomin R, Polasek O, Power C, Rich SS, Rosendaal FR, den Ruijter HM, Schlessinger D, Schmidt H, Svento R, Schmidt R, Alizadeh BZ, Sørensen TI, Spector TD, Steptoe A, Terracciano A, Thurik AR, Timpson NJ, Tiemeier H, Uitterlinden AG, Vollenweider P, Wagner GG, Weir DR, Yang J, Conley DC, Smith GD, Hofman A, Johannesson M, Laibson DI, Medland SE, Meyer MN, Pickrell JK, Esko T, Krueger RF, Beauchamp JP, Koellinger PD, Benjamin DJ, Bartels M, Cesarini D

Nat Genet. 2016 Jun;48(6):624-33. doi: 10.1038/ng.3552. Epub 2016 Apr 18.

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A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.

Bodea CA, Neale BM, Ripke S; International IBD Genetics Consortium, Daly MJ, Devlin B, Roeder K

Am J Hum Genet. 2016 May 5;98(5):857-68. doi: 10.1016/j.ajhg.2016.02.025. Epub 2016 Apr 14.

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Cholesterol as a Risk Factor for Subarachnoid Hemorrhage: A Systematic Review.

Lindbohm JV, Kaprio J, Korja M

PLoS One. 2016 Apr 14;11(4):e0152568. doi: 10.1371/journal.pone.0152568. eCollection 2016.

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Collective motion patterns of swarms with delay coupling: Theory and experiment.

Szwaykowska K, Schwartz IB, Mier-Y-Teran Romero L, Heckman CR, Mox D, Hsieh MA

Phys Rev E. 2016 Mar;93(3-1):032307. Epub 2016 Mar 7.

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Genetic analysis for a shared biological basis between migraine and coronary artery disease.

Winsvold BS, Nelson CP, Malik R, Gormley P, Anttila V, Vander Heiden J, Elliott KS, Jacobsen LM, Palta P, Amin N, de Vries B, Hämäläinen E, Freilinger T, Ikram MA, Kessler T, Koiranen M, Ligthart L, McMahon G, Pedersen LM, Willenborg C, Won HH, Olesen J, Artto V, Assimes TL, Blankenberg S, Boomsma DI, Cherkas L, Davey Smith G, Epstein SE, Erdmann J, Ferrari MD, Göbel H, Hall AS, Jarvelin MR, Kallela M, Kaprio J, Kathiresan S, Lehtimäki T, McPherson R, März W, Nyholt DR, O'Donnell CJ, Quaye L, Rader DJ, Raitakari O, Roberts R, Schunkert H, Schürks M, Stewart AF, Terwindt GM, Thorsteinsdottir U, van den Maagdenberg AM, van Duijn C, Wessman M, Kurth T, Kubisch C, Dichgans M, Chasman DI, Cotsapas C, Zwart JA, Samani NJ, Palotie A; CARDIoGRAM Consortium and the International Headache Genetics Consortium

Neurol Genet. 2015 Jul 2;1(1):e10. doi: 10.1212/NXG.0000000000000010. eCollection 2015 Jun.

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Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy.

Muona M, Fukata Y, Anttonen AK, Laari A, Palotie A, Pihko H, Lönnqvist T, Valanne L, Somer M, Fukata M, Lehesjoki AE

Neurol Genet. 2016 Jan 21;2(1):e46. doi: 10.1212/NXG.0000000000000046. eCollection 2016 Feb.

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A loss-of-function genetic screening identifies novel mediators of thyroid cancer cell viability.

Cantisani MC, Parascandolo A, Perälä M, Allocca C, Fey V, Sahlberg N, Merolla F, Basolo F, Laukkanen MO, Kallioniemi OP, Santoro M, Castellone MD

Oncotarget. 2016 Apr 4. doi: 10.18632/oncotarget.8577. [Epub ahead of print]

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Pancreas-preserving surgical management of grade-C pancreatic fistulas after pancreatic head resection by external wirsungostomy.

Horvath P, Beckert S, Nadalin S, Königsrainer A, Königsrainer I

Langenbecks Arch Surg. 2016 Jun;401(4):457-62. doi: 10.1007/s00423-016-1423-2. Epub 2016 Apr 7.

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Body Mass Index and Depressive Symptoms: Testing for Adverse and Protective Associations in Two Twin Cohort Studies.

Jokela M, Berg V, Silventoinen K, Batty GD, Singh-Manoux A, Kaprio J, Davey Smith G, Kivimäki M

Twin Res Hum Genet. 2016 Apr 8:1-6. [Epub ahead of print]

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Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas.

Lundberg M, Renkonen S, Haglund C, Mattila PS, Leivo I, Hagström J, Mäkitie AA

Acta Otolaryngol. 2016 May;136(5):501-5. doi: 10.3109/00016489.2015.1122227. Epub 2016 Jan 12.

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Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism.

Kettunen KM, Karikoski R, Hämäläinen RH, Toivonen TT, Antonenkov VD, Kulesskaya N, Voikar V, Hölttä-Vuori M, Ikonen E, Sainio K, Jalanko A, Karlberg S, Karlberg N, Lipsanen-Nyman M, Toppari J, Jauhiainen M, Hiltunen JK, Jalanko H, Lehesjoki AE

Biol Open. 2016 May 15;5(5):584-95. doi: 10.1242/bio.016246.

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Risky drinking behaviors among women with eating disorders-A longitudinal community-based study.

Mustelin L, Latvala A, Raevuori A, Rose RJ, Kaprio J, Keski-Rahkonen A

Int J Eat Disord. 2016 Jun;49(6):563-71. doi: 10.1002/eat.22526. Epub 2016 Apr 1.

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Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.

van Leeuwen EM, Sabo A, Bis JC, Huffman JE, Manichaikul A, Smith AV, Feitosa MF, Demissie S, Joshi PK, Duan Q, Marten J, van Klinken JB, Surakka I, Nolte IM, Zhang W, Mbarek H, Li-Gao R, Trompet S, Verweij N, Evangelou E, Lyytikäinen LP, Tayo BO, Deelen J, van der Most PJ, van der Laan SW, Arking DE, Morrison A, Dehghan A, Franco OH, Hofman A, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Mychaleckyj JC, Campbell A, Hocking LJ, Padmanabhan S, Brody JA, Rice KM, White CC, Harris T, Isaacs A, Campbell H, Lange LA, Rudan I, Kolcic I, Navarro P, Zemunik T, Salomaa V; LifeLines Cohort Study, Kooner AS, Kooner JS, Lehne B, Scott WR, Tan ST, de Geus EJ, Milaneschi Y, Penninx BW, Willemsen G, de Mutsert R, Ford I, Gansevoort RT, Segura-Lepe MP, Raitakari OT, Viikari JS, Nikus K, Forrester T, McKenzie CA, de Craen AJ, de Ruijter HM; CHARGE Lipids Working Group, Pasterkamp G, Snieder H, Oldehinkel AJ, Slagboom PE, Cooper RS, Kähönen M, Lehtimäki T, Elliott P, van der Harst P, Jukema JW, Mook-Kanamori DO, Boomsma DI, Chambers JC, Swertz M, Ripatti S, Willems van Dijk K, Vitart V, Polasek O, Hayward C, Wilson JG, Wilson JF, Gudnason V, Rich SS, Psaty BM, Borecki IB, Boerwinkle E, Rotter JI, Cupples LA, van Duijn CM

J Med Genet. 2016 Jul;53(7):441-9. doi: 10.1136/jmedgenet-2015-103439. Epub 2016 Apr 1.

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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.

Fan Q, Verhoeven VJ, Wojciechowski R, Barathi VA, Hysi PG, Guggenheim JA, Höhn R, Vitart V, Khawaja AP, Yamashiro K, Hosseini SM, Lehtimäki T, Lu Y, Haller T, Xie J, Delcourt C, Pirastu M, Wedenoja J, Gharahkhani P, Venturini C, Miyake M, Hewitt AW, Guo X, Mazur J, Huffman JE, Williams KM, Polasek O, Campbell H, Rudan I, Vatavuk Z, Wilson JF, Joshi PK, McMahon G, St Pourcain B, Evans DM, Simpson CL, Schwantes-An TH, Igo RP, Mirshahi A, Cougnard-Gregoire A, Bellenguez C, Blettner M, Raitakari O, Kähönen M, Seppala I, Zeller T, Meitinger T; Consortium for Refractive Error and Myopia (CREAM), Ried JS, Gieger C, Portas L, van Leeuwen EM, Amin N, Uitterlinden AG, Rivadeneira F, Hofman A, Vingerling JR, Wang YX, Wang X, Tai-Hui Boh E, Ikram MK, Sabanayagam C, Gupta P, Tan V, Zhou L, Ho CE, Lim W, Beuerman RW, Siantar R, Tai ES, Vithana E, Mihailov E, Khor CC, Hayward C, Luben RN, Foster PJ, Klein BE, Klein R, Wong HS, Mitchell P, Metspalu A, Aung T, Young TL, He M, Pärssinen O, van Duijn CM, Jin Wang J, Williams C, Jonas JB, Teo YY, Mackey DA, Oexle K, Yoshimura N, Paterson AD, Pfeiffer N, Wong TY, Baird PN, Stambolian D, Wilson JE, Cheng CY, Hammond CJ, Klaver CC, Saw SM, Rahi JS, Korobelnik JF, Kemp JP, Timpson NJ, Smith GD, Craig JE, Burdon KP, Fogarty RD, Iyengar SK, Chew E, Janmahasatian S, Martin NG, MacGregor S, Xu L, Schache M, Nangia V, Panda-Jonas S, Wright AF, Fondran JR, Lass JH, Feng S, Zhao JH, Khaw KT, Wareham NJ, Rantanen T, Kaprio J, Pang CP, Chen LJ, Tam PO, Jhanji V, Young AL, Döring A, Raffel LJ, Cotch MF, Li X, Yip SP, Yap MK, Biino G, Vaccargiu S, Fossarello M, Fleck B, Yazar S, Tideman JW, Tedja M, Deangelis MM, Morrison M, Farrer L, Zhou X, Chen W, Mizuki N, Meguro A, Mäkelä KM

Nat Commun. 2016 Mar 29;7:11008. doi: 10.1038/ncomms11008.

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Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.

Stringer S, Minică CC, Verweij KJ, Mbarek H, Bernard M, Derringer J, van Eijk KR, Isen JD, Loukola A, Maciejewski DF, Mihailov E, van der Most PJ, Sánchez-Mora C, Roos L, Sherva R, Walters R, Ware JJ, Abdellaoui A, Bigdeli TB, Branje SJ, Brown SA, Bruinenberg M, Casas M, Esko T, Garcia-Martinez I, Gordon SD, Harris JM, Hartman CA, Henders AK, Heath AC, Hickie IB, Hickman M, Hopfer CJ, Hottenga JJ, Huizink AC, Irons DE, Kahn RS, Korhonen T, Kranzler HR, Krauter K, van Lier PA, Lubke GH, Madden PA, Mägi R, McGue MK, Medland SE, Meeus WH, Miller MB, Montgomery GW, Nivard MG, Nolte IM, Oldehinkel AJ, Pausova Z, Qaiser B, Quaye L, Ramos-Quiroga JA, Richarte V, Rose RJ, Shin J, Stallings MC, Stiby AI, Wall TL, Wright MJ, Koot HM, Paus T, Hewitt JK, Ribasés M, Kaprio J, Boks MP, Snieder H, Spector T, Munafò MR, Metspalu A, Gelernter J, Boomsma DI, Iacono WG, Martin NG, Gillespie NA, Derks EM, Vink JM

Transl Psychiatry. 2016 Mar 29;6:e769. doi: 10.1038/tp.2016.36.

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Are There Differences in Neurocognition and Social Cognition Among Adolescents with Schizophrenia, a Pervasive Developmental Disorder, and Both Disorders?

Waris P, Tani P, Lindberg N, Lipsanen J, Kettunen K, Kaltiala-Heino R, Saarimaa LK, Reinvall O, Voutilainen A, Hokkanen L

Appl Neuropsychol Child. 2016 Mar 25:1-8. [Epub ahead of print]

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The DSM-5 diagnostic criteria for anorexia nervosa may change its population prevalence and prognostic value.

Mustelin L, Silén Y, Raevuori A, Hoek HW, Kaprio J, Keski-Rahkonen A

J Psychiatr Res. 2016 Jun;77:85-91. doi: 10.1016/j.jpsychires.2016.03.003. Epub 2016 Mar 10.

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Age and gender specific estimation of visceral adipose tissue amounts from radiological images in morbidly obese patients.

Linder N, Schaudinn A, Garnov N, Blüher M, Dietrich A, Schütz T, Lehmann S, Retschlag U, Karlas T, Kahn T, Busse H

Sci Rep. 2016 Mar 24;6:22261. doi: 10.1038/srep22261.

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Diagnosing Depression in Chronic Pain Patients: DSM-IV Major Depressive Disorder vs. Beck Depression Inventory (BDI).

Knaster P, Estlander AM, Karlsson H, Kaprio J, Kalso E

PLoS One. 2016 Mar 23;11(3):e0151982. doi: 10.1371/journal.pone.0151982. eCollection 2016.

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Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.

Orlando G, Law PJ, Palin K, Tuupanen S, Gylfe A, Hänninen UA, Cajuso T, Tanskanen T, Kondelin J, Kaasinen E, Sarin AP, Kaprio J, Eriksson JG, Rissanen H, Knekt P, Pukkala E, Jousilahti P, Salomaa V, Ripatti S, Palotie A, Järvinen H, Renkonen-Sinisalo L, Lepistö A, Böhm J, Mecklin JP, Al-Tassan NA, Palles C, Martin L, Barclay E, Tenesa A, Farrington S, Timofeeva MN, Meyer BF, Wakil SM, Campbell H, Smith CG, Idziaszczyk S, Maughan TS, Kaplan R, Kerr R, Kerr D, Buchanan DD, Ko Win A, Hopper J, Jenkins M, Lindor NM, Newcomb PA, Gallinger S, Conti D, Schumacher F, Casey G, Taipale J, Cheadle JP, Dunlop MG, Tomlinson IP, Aaltonen LA, Houlston RS

Hum Mol Genet. 2016 Mar 22. pii: ddw087. [Epub ahead of print]

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Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

Kettunen J, Demirkan A, Würtz P, Draisma HH, Haller T, Rawal R, Vaarhorst A, Kangas AJ, Lyytikäinen LP, Pirinen M, Pool R, Sarin AP, Soininen P, Tukiainen T, Wang Q, Tiainen M, Tynkkynen T, Amin N, Zeller T, Beekman M, Deelen J, van Dijk KW, Esko T, Hottenga JJ, van Leeuwen EM, Lehtimäki T, Mihailov E, Rose RJ, de Craen AJ, Gieger C, Kähönen M, Perola M, Blankenberg S, Savolainen MJ, Verhoeven A, Viikari J, Willemsen G, Boomsma DI, van Duijn CM, Eriksson J, Jula A, Järvelin MR, Kaprio J, Metspalu A, Raitakari O, Salomaa V, Slagboom PE, Waldenberger M, Ripatti S, Ala-Korpela M

Nat Commun. 2016 Mar 23;7:11122. doi: 10.1038/ncomms11122.

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Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project.

Yokoyama Y, Jelenkovic A, Sund R, Sung J, Hopper JL, Ooki S, Heikkilä K, Aaltonen S, Tarnoki AD, Tarnoki DL, Willemsen G, Bartels M, van Beijsterveldt TC, Saudino KJ, Cutler TL, Nelson TL, Whitfield KE, Wardle J, Llewellyn CH, Fisher A, He M, Ding X, Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Song YM, Yang S, Lee K, Jeong HU, Knafo-Noam A, Mankuta D, Abramson L, Burt SA, Klump KL, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Harris JR, Brandt I, Nilsen TS, Craig JM, Saffery R, Ji F, Ning F, Pang Z, Dubois L, Boivin M, Brendgen M, Dionne G, Vitaro F, Martin NG, Medland SE, Montgomery GW, Magnusson PK, Pedersen NL, Aslan AK, Tynelius P, Haworth CM, Plomin R, Rebato E, Rose RJ, Goldberg JH, Rasmussen F, Hur YM, Sørensen TI, Boomsma DI, Kaprio J, Silventoinen K

Twin Res Hum Genet. 2016 Apr;19(2):112-24. doi: 10.1017/thg.2016.11.

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Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies.

Demirkan A, Lahti J, Direk N, Viktorin A, Lunetta KL, Terracciano A, Nalls MA, Tanaka T, Hek K, Fornage M, Wellmann J, Cornelis MC, Ollila HM, Yu L, Smith JA, Pilling LC, Isaacs A, Palotie A, Zhuang WV, Zonderman A, Faul JD, Sutin A, Meirelles O, Mulas A, Hofman A, Uitterlinden A, Rivadeneira F, Perola M, Zhao W, Salomaa V, Yaffe K, Luik AI; NABEC, Liu Y, Ding J, Lichtenstein P, Landén M, Widen E, Weir DR, Llewellyn DJ, Murray A, Kardia SL, Eriksson JG, Koenen K, Magnusson PK, Ferrucci L, Mosley TH, Cucca F, Oostra BA, Bennett DA, Paunio T, Berger K, Harris TB, Pedersen NL, Murabito JM, Tiemeier H, van Duijn CM, Räikkönen K

Psychol Med. 2016 Jun;46(8):1613-23. doi: 10.1017/S0033291715002081. Epub 2016 Mar 21.

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High variability in flavonoid contents and composition between different North-European currant (Ribes spp.) varieties.

Mattila PH, Hellström J, Karhu S, Pihlava JM, Veteläinen M

Food Chem. 2016 Aug 1;204:14-20. doi: 10.1016/j.foodchem.2016.02.056. Epub 2016 Feb 10.

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Transcriptional response networks for elucidating mechanisms of action of multitargeted agents.

Kibble M, Khan SA, Saarinen N, Iorio F, Saez-Rodriguez J, Mäkelä S, Aittokallio T

Drug Discov Today. 2016 Jul;21(7):1063-75. doi: 10.1016/j.drudis.2016.03.001. Epub 2016 Mar 12. Review.

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Genetic Risk Scores Predict Recurrence of Acute Coronary Syndrome.

Vaara S, Tikkanen E, Parkkonen O, Lokki ML, Ripatti S, Perola M, Nieminen MS, Sinisalo J

Circ Cardiovasc Genet. 2016 Apr;9(2):172-8. doi: 10.1161/CIRCGENETICS.115.001271. Epub 2016 Mar 15.

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Leisure-time physical inactivity and association with body mass index: a Finnish Twin Study with a 35-year follow-up.

Piirtola M, Kaprio J, Waller K, Heikkilä K, Koskenvuo M, Svedberg P, Silventoinen K, Kujala UM, Ropponen A

Int J Epidemiol. 2016 Mar 15. pii: dyw007. [Epub ahead of print]

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Phase I study with ONCOS-102 for the treatment of solid tumors - an evaluation of clinical response and exploratory analyses of immune markers.

Ranki T, Pesonen S, Hemminki A, Partanen K, Kairemo K, Alanko T, Lundin J, Linder N, Turkki R, Ristimäki A, Jäger E, Karbach J, Wahle C, Kankainen M, Backman C, von Euler M, Haavisto E, Hakonen T, Heiskanen R, Jaderberg M, Juhila J, Priha P, Suoranta L, Vassilev L, Vuolanto A, Joensuu T

J Immunother Cancer. 2016 Mar 15;4:17. doi: 10.1186/s40425-016-0121-5. eCollection 2016.

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GATA4 regulates blood-testis barrier function and lactate metabolism in mouse Sertoli cells.

Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez VM, Otte K, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M

Endocrinology. 2016 Jun;157(6):2416-31. doi: 10.1210/en.2015-1927. Epub 2016 Mar 14.

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Connecting the dots, genome-wide association studies in substance use.

Nivard MG, Verweij KJ, Minică CC, Treur JL; International Cannabis Consortium, Vink JM, Boomsma DI

Mol Psychiatry. 2016 Jun;21(6):733-5. doi: 10.1038/mp.2016.14. Epub 2016 Mar 15.

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Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders.

Singh T, Kurki MI, Curtis D, Purcell SM, Crooks L, McRae J, Suvisaari J, Chheda H, Blackwood D, Breen G, Pietiläinen O, Gerety SS, Ayub M, Blyth M, Cole T, Collier D, Coomber EL, Craddock N, Daly MJ, Danesh J, DiForti M, Foster A, Freimer NB, Geschwind D, Johnstone M, Joss S, Kirov G, Körkkö J, Kuismin O, Holmans P, Hultman CM, Iyegbe C, Lönnqvist J, Männikkö M, McCarroll SA, McGuffin P, McIntosh AM, McQuillin A, Moilanen JS, Moore C, Murray RM, Newbury-Ecob R, Ouwehand W, Paunio T, Prigmore E, Rees E, Roberts D, Sambrook J, Sklar P, Clair DS, Veijola J, Walters JT, Williams H; Swedish Schizophrenia Study; INTERVAL Study; DDD Study; UK10 K Consortium, Sullivan PF, Hurles ME, O'Donovan MC, Palotie A, Owen MJ, Barrett JC

Nat Neurosci. 2016 Apr;19(4):571-7. doi: 10.1038/nn.4267. Epub 2016 Mar 14.

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Cancer stem cell drugs target K-ras signaling in a stemness context.

Najumudeen AK, Jaiswal A, Lectez B, Oetken-Lindholm C, Guzmán C, Siljamäki E, Posada IM, Lacey E, Aittokallio T, Abankwa D

Oncogene. 2016 Mar 14. doi: 10.1038/onc.2016.59.[Epub ahead of print]

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Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.

Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ; CHD Exome+ Consortium; CARDIoGRAM Exome Consortium; Global Lipids Genetics Consortium

Science. 2016 Mar 11;351(6278):1166-71. doi: 10.1126/science.aad3517.

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Antiarrhythmic Action of Flecainide in Polymorphic Ventricular Arrhythmias Caused by a Gain-of-Function Mutation in the Nav 1.5 Sodium Channel.

Amarouch MY, Swan H, Leinonen J, Marjamaa A, Lahtinen AM, Kontula K, Toivonen L, Widen E, Abriel H

Ann Noninvasive Electrocardiol. 2015 Oct 7. doi: 10.1111/anec.12312. [Epub ahead of print]

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Extending the scope of pooled analyses of individual patient biomarker data from heterogeneous laboratory platforms and cohorts using merging algorithms.

Burke Ó, Benton S, Szafranski P, von Dadelszen P, Buhimschi SC, Cetin I, Chappell L, Figueras F, Galindo A, Herraiz I, Holzman C, Hubel C, Knudsen U, Kronborg C, Laivuori H, Lapaire O, McElrath T, Moertl M, Myers J, Ness RB, Oliveira L, Olson G, Poston L, Ris-Stalpers C, Roberts JM, Schalekamp-Timmermans S, Schlembach D, Steegers E, Stepan H, Tsatsaris V, van der Post JA, Verlohren S, Villa PM, Williams D, Zeisler H, Redman CW, Staff AC; Global Pregnancy Collaboration

Pregnancy Hypertens. 2016 Jan;6(1):53-9. doi: 10.1016/j.preghy.2015.12.002. Epub 2016 Jan 12.

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Compensated reduction in Leydig cell function is associated with lower semen quality variables: a study of 8182 European young men.

Jørgensen N, Joensen UN, Toppari J, Punab M, Erenpreiss J, Zilaitiene B, Paasch U, Salzbrunn A, Fernandez MF, Virtanen HE, Matulevicius V, Olea N, Jensen TK, Petersen JH, Skakkebæk NE, Andersson AM

Hum Reprod. 2016 May;31(5):947-57. doi: 10.1093/humrep/dew021. Epub 2016 Mar 2.

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Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?

Sillanpää E, Törmäkangas T, Rantanen T, Kaprio J, Sipilä S

Age (Dordr). 2016 Apr;38(2):34. doi: 10.1007/s11357-016-9898-x. Epub 2016 Mar 4.

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Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.

Nikkanen J, Forsström S, Euro L, Paetau I, Kohnz RA, Wang L, Chilov D, Viinamäki J, Roivainen A, Marjamäki P, Liljenbäck H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lönnqvist T, Sajantila A, Isohanni P, Tyynismaa H, Nomura DK, Battersby BJ, Velagapudi V, Carroll CJ, Suomalainen A

Cell Metab. 2016 Apr 12;23(4):635-48. doi: 10.1016/j.cmet.2016.01.019. Epub 2016 Feb 25.

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A Smartphone App and Cloud-Based Consultation System for Burn Injury Emergency Care.

Wallis LA, Fleming J, Hasselberg M, Laflamme L, Lundin J

PLoS One. 2016 Feb 26;11(2):e0147253. doi: 10.1371/journal.pone.0147253. eCollection 2016.

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Maternal Prenatal Positive Affect, Depressive and Anxiety Symptoms and Birth Outcomes: The PREDO Study.

Pesonen AK, Lahti M, Kuusinen T, Tuovinen S, Villa P, Hämäläinen E, Laivuori H, Kajantie E, Räikkönen K

PLoS One. 2016 Feb 26;11(2):e0150058. doi: 10.1371/journal.pone.0150058. eCollection 2016.

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Schizophrenia risk from complex variation of complement component 4.

Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly MJ, Carroll MC, Stevens B, McCarroll SA

Nature. 2016 Feb 11;530(7589):177-83. doi: 10.1038/nature16549. Epub 2016 Jan 27.

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Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas.

Eising E, Huisman SM, Mahfouz A, Vijfhuizen LS, Anttila V, Winsvold BS, Kurth T, Ikram MA, Freilinger T, Kaprio J, Boomsma DI, van Duijn CM, Järvelin MR, Zwart JA, Quaye L, Strachan DP, Kubisch C, Dichgans M, Davey Smith G, Stefansson K, Palotie A, Chasman DI, Ferrari MD, Terwindt GM, de Vries B, Nyholt DR, Lelieveldt BP, van den Maagdenberg AM, Reinders MJ

Hum Genet. 2016 Apr;135(4):425-39. doi: 10.1007/s00439-016-1638-x. Epub 2016 Feb 22.

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Abdominal obesity and circulating metabolites: A twin study approach.

Bogl LH, Kaye SM, Rämö JT, Kangas AJ, Soininen P, Hakkarainen A, Lundbom J, Lundbom N, Ortega-Alonso A, Rissanen A, Ala-Korpela M, Kaprio J, Pietiläinen KH.

Metabolism. 2016 Mar;65(3):111-21. doi: 10.1016/j.metabol.2015.10.027. Epub 2015 Oct 31.

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Increased expression of fibroblast growth factor 13 (FGF13) in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy.

Yu L, Toriseva M, Tuomala M, Seikkula H, Elo T, Tuomela J, Kallajoki M, Mirtti T, Taimen P, Boström PJ, Alanen K, Nurmi M, Nees M, Härkönen P.


Int J Cancer. 2016 Feb 17. doi: 10.1002/ijc.30048. [Epub ahead of print]

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Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication.

Balistreri G, Viiliäinen J, Turunen M, Diaz R, Lyly L, Pekkonen P, Rantala J, Ojala K, Sarek G, Teesalu M, Denisova O, Peltonen K, Julkunen I, Varjosalo M, Kainov D, Kallioniemi O, Laiho M, Taipale J, Hautaniemi S, Ojala PM.

PLoS Pathog. 2016 Feb 18;12(2):e1005424. doi:10.1371/journal.ppat.1005424. eCollection 2016 Feb.

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Constant B-cell lymphocytosis since early age in a patient with CARD11 mutation: A 20-year follow-up.

Outinen T, Syrjänen J, Rounioja S, Saarela J, Kaustio M, Helminen M.

Clin Immunol. 2016 Feb 6. pii: S1521-6616(16)30018-3. doi: 10.1016/j.clim.2016.02.002. [Epub ahead of print]

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Long-term physical activity modulates brain processing of somatosensory stimuli: evidence from young male twins.

Tarkka IM, Savić A, Pekkola E, Rottensteiner M, Leskinen T, Kaprio J, Kujala UM.

Biol Psychol. 2016 Feb 6. pii: S0301-0511(16)30029-1. doi: 10.1016/j.biopsycho.2016.02.001. [Epub ahead of print]

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Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.

Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJ, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Yao Y, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Psychosis Endophenotypes International Consortium; Wellcome Trust Case Control Consortium 2; Enigma Consortium, O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF.

Nat Neurosci. 2016 Feb 1. doi: 10.1038/nn.4228. [Epub ahead of print]

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Napping and the risk of type 2 diabetes: a population-based prospective study.

Hublin C, Lehtovirta M, Partinen M, Koskenvuo M, Kaprio J.

Sleep Med. 2016 Jan;17:144-8. doi: 10.1016/j.sleep.2015.11.004. Epub 2015 Dec 2.

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Ideals versus reality: Are weight ideals associated with weight change in the population?

Kärkkäinen U, Mustelin L, Raevuori A, Kaprio J, Keski-Rahkonen A.

Obesity (Silver Spring). 2016 Feb 3. doi: 10.1002/oby.21417. [Epub ahead of print]

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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Kilpeläinen TO, Carli JF, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, Pers TH, Schick U, Grarup N, Kutalik Z, Trompet S, Mangino M, Kristiansson K, Beekman M, Lyytikäinen LP, Eriksson J, Henneman P, Lahti J, Tanaka T, Luan J, Greco M FD, Pasko D, Renström F, Willems SM, Mahajan A, Rose LM, Guo X, Liu Y, Kleber ME, Pérusse L, Gaunt T, Ahluwalia TS, Ju Sung Y, Ramos YF, Amin N, Amuzu A, Barroso I, Bellis C, Blangero J, Buckley BM, Böhringer S, I Chen YD, de Craen AJ, Crosslin DR, Dale CE, Dastani Z, Day FR, Deelen J, Delgado GE, Demirkan A, Finucane FM, Ford I, Garcia ME, Gieger C, Gustafsson S, Hallmans G, Hankinson SE, Havulinna AS, Herder C, Hernandez D, Hicks AA, Hunter DJ, Illig T, Ingelsson E, Ioan-Facsinay A, Jansson JO, Jenny NS, Jørgensen ME, Jørgensen T, Karlsson M, Koenig W, Kraft P, Kwekkeboom J, Laatikainen T, Ladwig KH, LeDuc CA, Lowe G, Lu Y, Marques-Vidal P, Meisinger C, Menni C, Morris AP, Myers RH, Männistö S, Nalls MA, Paternoster L, Peters A, Pradhan AD, Rankinen T, Rasmussen-Torvik LJ, Rathmann W, Rice TK, Brent Richards J, Ridker PM, Sattar N, Savage DB, Söderberg S, Timpson NJ, Vandenput L, van Heemst D, Uh HW, Vohl MC, Walker M, Wichmann HE, Widén E, Wood AR, Yao J, Zeller T, Zhang Y, Meulenbelt I, Kloppenburg M, Astrup A, Sørensen TI, Sarzynski MA, Rao DC, Jousilahti P, Vartiainen E, Hofman A, Rivadeneira F, Uitterlinden AG, Kajantie E, Osmond C, Palotie A, Eriksson JG, Heliövaara M, Knekt PB, Koskinen S, Jula A, Perola M, Huupponen RK, Viikari JS, Kähönen M, Lehtimäki T, Raitakari OT, Mellström D, Lorentzon M, Casas JP, Bandinelli S, März W, Isaacs A, van Dijk KW, van Duijn CM, Harris TB, Bouchard C, Allison MA, Chasman DI, Ohlsson C, Lind L, Scott RA, Langenberg C, Wareham NJ, Ferrucci L, Frayling TM, Pramstaller PP, Borecki IB, Waterworth DM, Bergmann S, Waeber G, Vollenweider P, Vestergaard H, Hansen T, Pedersen O, Hu FB, Eline Slagboom P, Grallert H, Spector TD, Jukema JW, Klein RJ, Schadt EE, Franks PW, Lindgren CM, Leibel RL, Loos RJ.

Nat Commun. 2016 Feb 1;7:10494. doi: 10.1038/ncomms10494.

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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z, Drong AW, Esko T, Evans DM, Falchi M, Feitosa MF, Ferreira T, Hedman ÅK, Haring R, Hysi PG, Iles MM, Justice AE, Kanoni S, Lagou V, Li R, Li X, Locke A, Lu C, Mägi R, Perry JR, Pers TH, Qi Q, Sanna M, Schmidt EM, Scott WR, Shungin D, Teumer A, Vinkhuyzen AA, Walker RW, Westra HJ, Zhang M, Zhang W, Zhao JH, Zhu Z, Afzal U, Ahluwalia TS, Bakker SJ, Bellis C, Bonnefond A, Borodulin K, Buchman AS, Cederholm T, Choh AC, Choi HJ, Curran JE, de Groot LC, De Jager PL, Dhonukshe-Rutten RA, Enneman AW, Eury E, Evans DS, Forsen T, Friedrich N, Fumeron F, Garcia ME, Gärtner S, Han BG, Havulinna AS, Hayward C, Hernandez D, Hillege H, Ittermann T, Kent JW, Kolcic I, Laatikainen T, Lahti J, Mateo Leach I, Lee CG, Lee JY, Liu T, Liu Y, Lobbens S, Loh M, Lyytikäinen LP, Medina-Gomez C, Michaëlsson K, Nalls MA, Nielson CM, Oozageer L, Pascoe L, Paternoster L, Polašek O, Ripatti S, Sarzynski MA, Shin CS, Narančić NS, Spira D, Srikanth P, Steinhagen-Thiessen E, Sung YJ, Swart KM, Taittonen L, Tanaka T, Tikkanen E, van der Velde N, van Schoor NM, Verweij N, Wright AF, Yu L, Zmuda JM, Eklund N, Forrester T, Grarup N, Jackson AU, Kristiansson K, Kuulasmaa T, Kuusisto J, Lichtner P, Luan J, Mahajan A, Männistö S, Palmer CD, Ried JS, Scott RA, Stancáková A, Wagner PJ, Demirkan A, Döring A, Gudnason V, Kiel DP, Kühnel B, Mangino M, Mcknight B, Menni C, O'Connell JR, Oostra BA, Shuldiner AR, Song K, Vandenput L, van Duijn CM, Vollenweider P, White CC, Boehnke M, Boettcher Y, Cooper RS, Forouhi NG, Gieger C, Grallert H, Hingorani A, Jørgensen T, Jousilahti P, Kivimaki M, Kumari M, Laakso M, Langenberg C, Linneberg A, Luke A, Mckenzie CA, Palotie A, Pedersen O, Peters A, Strauch K, Tayo BO, Wareham NJ, Bennett DA, Bertram L, Blangero J, Blüher M, Bouchard C, Campbell H, Cho NH, Cummings SR, Czerwinski SA, Demuth I, Eckardt R, Eriksson JG, Ferrucci L, Franco OH, Froguel P, Gansevoort RT, Hansen T, Harris TB, Hastie N, Heliövaara M, Hofman A, Jordan JM, Jula A, Kähönen M, Kajantie E, Knekt PB, Koskinen S, Kovacs P, Lehtimäki T, Lind L, Liu Y, Orwoll ES, Osmond C, Perola M, Pérusse L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Rivadeneira F, Rudan I, Salomaa V, Sørensen TI, Stumvoll M, Tönjes A, Towne B, Tranah GJ, Tremblay A, Uitterlinden AG, van der Harst P, Vartiainen E, Viikari JS, Vitart V, Vohl MC, Völzke H, Walker M, Wallaschofski H, Wild S, Wilson JF, Yengo L, Bishop DT, Borecki IB, Chambe

Nat Commun. 2016 Feb 1;7:10495. doi: 10.1038/ncomms10495.

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Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2.

Ware JJ, Chen X, Vink J, Loukola A, Minica C, Pool R, Milaneschi Y, Mangino M, Menni C, Chen J, Peterson RE, Auro K, Lyytikäinen LP, Wedenoja J, Stiby AI, Hemani G, Willemsen G, Hottenga JJ, Korhonen T, Heliövaara M, Perola M, Rose RJ, Paternoster L, Timpson N, Wassenaar CA, Zhu AZ, Davey Smith G, T Raitakari O, Lehtimäki T, Kähönen M, Koskinen S, Spector T, Penninx BW, Salomaa V, Boomsma DI, Tyndale RF, Kaprio J, Munafò MR.

Sci Rep. 2016 Feb 1;6:20092. doi: 10.1038/srep20092.

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The Salivary Scavenger and Agglutinin (SALSA) in Healthy and Complicated Pregnancy.

Reichhardt MP, Jarva H, Lokki AI, Laivuori H; FINNPEC study group, Vuorela P, Loimaranta V, Glasner A, Siwetz M, Huppertz B, Meri S.

PLoS One. 2016 Feb 1;11(2):e0147867. doi: 10.1371/journal.pone.0147867. eCollection 2016.

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Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers.

Tumiati M, Munne PM, Edgren H, Eldfors S, Hemmes A, Kuznetsov SG.

Oncogene. 2016 Jan 25. doi:10.1038/onc.2015.528. [Epub ahead of print]

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USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M.

Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015.

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Dietary Intake at 9 Years and Subsequent Body Mass Index in Adolescent Boys and Girls: A Study of Monozygotic Twin Pairs.

Dubois L, Diasparra M, Bogl LH, Fontaine-Bisson B, Bédard B, Tremblay RE, Kaprio J, Boivin M.

Twin Res Hum Genet. 2016 Feb;19(1):47-59. doi: 10.1017/thg.2015.97.

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Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer.

Cajanus K, Holmström EJ, Wessman M, Anttila V, Kaunisto MA, Kalso E.

Pain. 2016 Feb;157(2):361-9. doi: 10.1097/j.pain.0000000000000398.

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Longitudinal heritability of childhood aggression.

Porsch RM, Middeldorp CM, Cherny SS, Krapohl E, van Beijsterveldt CE, Loukola A, Korhonen T, Pulkkinen L, Corley R, Rhee S, Kaprio J, Rose RR, Hewitt JK, Sham P, Plomin R, Boomsma DI, Bartels M.

Am J Med Genet B Neuropsychiatr Genet. 2016 Jan 19. doi: 10.1002/ajmg.b.32420. [Epub ahead of print]

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Stability and change of body mass index as a predictor of disability pension.

Ropponen A, Silventoinen K, Koskenvuo M, Svedberg P, Kaprio J.

Scand J Public Health. 2016 Jan 19. pii: 1403494815622849. [Epub ahead of print]

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Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.

Zinkevičienė A, Kainov D, Lastauskienė E, Kvedarienė V, Bychkov D, Byrne M, Girkontaitė I.

Int Arch Allergy Immunol. 2016 Jan 21;168(3):161-164. [Epub ahead of print]

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FINEMAP: Efficient variable selection using summary data from genome-wide association studies.

Benner C, Spencer CC, Havulinna AS, Salomaa V, Ripatti S, Pirinen M.

Bioinformatics. 2016 Jan 14. pii: btw018. [Epub ahead of print]

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Predictors of fibromyalgia: a population-based twin cohort study.

Markkula RA, Kalso EA, Kaprio JA.

BMC Musculoskelet Disord. 2016 Jan 15;17(1):29. doi: 10.1186/s12891-016-0873-6.

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Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses.

Varghese FS, Kaukinen P, Gläsker S, Bespalov M, Hanski L, Wennerberg K, Kümmerer BM, Ahola T.

Antiviral Res. 2016 Jan 2. pii: S0166-3542(15)30051-6. doi: 10.1016/j.antiviral.2015.12.012. [Epub ahead of print]

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Role of overlapping genetic and environmental factors in the relationship between early adolescent conduct problems and substance use in young adulthood.

Verweij KJ, Creemers HE, Korhonen T, Latvala A, Dick DM, Rose RJ, Huizink AC, Kaprio J.

Addiction. 2016 Jan 8. doi: 10.1111/add.13303. [Epub ahead of print]

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Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Zimmer J, Tacconi EM, Folio C, Badie S, Porru M, Klare K, Tumiati M, Markkanen E, Halder S, Ryan A, Jackson SP, Ramadan K, Kuznetsov SG, Biroccio A, Sale JE, Tarsounas M.

Mol Cell. 2015 Dec 29. pii: S1097-2765(15)00938-7. doi: 10.1016/j.molcel.2015.12.004. [Epub ahead of print]

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Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.

Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration.

JAMA. 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703.

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Heterogeneity of maternal characteristics and impact on gestational diabetes (GDM) risk-Implications for universal GDM screening?

Huvinen E, Grotenfelt NE, Eriksson JG, Rönö K, Klemetti MM, Roine R, Pöyhönen-Alho M, Tiitinen A, Andersson S, Laivuori H, Knip M, Valkama A, Meinilä J, Kautiainen H, Stach-Lempinen B, Koivusalo SB.

Ann Med. 2016 Jan 8:1-7. [Epub ahead of print]

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Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.

Söderholm S, Anastasina M, Islam MM, Tynell J, Poranen MM, Bamford DH, Stenman J, Julkunen I, Šaulienė I, De Brabander JK, Matikainen S, Nyman TA, Saelens X, Kainov D.

Antiviral Res. 2015 Dec 29;126:69-80. doi: 10.1016/j.antiviral.2015.12.011. [Epub ahead of print]

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Long-term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.

Hayes TK, Neel NF, Hu C, Gautam P, Chenard M, Long B, Aziz M, Kassner M, Bryant KL, Pierobon M, Marayati R, Kher S, George SD, Xu M, Wang-Gillam A, Samatar AA, Maitra A, Wennerberg K, Petricoin EF 3rd, Yin HH, Nelkin B, Cox AD, Yeh JJ, Der CJ.

Cancer Cell. 2015 Dec 22. pii: S1535-6108(15)00433-X. doi: 10.1016/j.ccell.2015.11.011. [Epub ahead of print]

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Precision Cancer Medicine in the Acoustic Dispensing Era: Ex Vivo Primary Cell Drug Sensitivity Testing.

Kulesskiy E, Saarela J, Turunen L, Wennerberg K

J Lab Autom. 2015 Dec 2. pii: 2211068215618869. [Epub ahead of print]

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Last updated: 04.01.2016 - 14:07