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FIMM Publications 2017

Last updated: 14.12.2016 - 13:21
A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.

Rimpelä JM, Kontula KK, Fyhrquist F, Donner KM, Tuiskula AM, Sarin AP, Mohney RP, Stirdivant SM, Hiltunen TP.

Pharmacogenomics. 2017 Apr;18(5):445-458. doi: 10.2217/pgs-2016-0204. Epub 2017 Mar 29. 

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Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers.

Sokolenko AP, Savonevich EL, Ivantsov AO, Raskin GA, Kuligina ES, Gorodnova TV, Preobrazhenskaya EV, Kleshchov MA, Tiurin VI, Mukhina MS, Kotiv KB, Shulga AV, Kuznetsov SG, Berlev IV, Imyanitov EN.

Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers. Cancer Lett. 2017 Jul 1;397:127-132. doi: 10.1016/j.canlet.2017.03.036.
Epub 2017 Apr 1. 

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Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project.

Jelenkovic A, Yokoyama Y, Sund R, Pietiläinen KH, Hur YM, Willemsen G, Bartels M, van Beijsterveldt TC, Ooki S, Saudino KJ, Stazi MA, Fagnani C, D'Ippolito C, Nelson TL, Whitfield KE, Knafo-Noam A, Mankuta D, Abramson L, Heikkilä K, Cutler TL, Hopper JL, Wardle J, Llewellyn CH, Fisher A, Corley RP, Huibregtse BM, Derom CA, Vlietinck RF, Loos RJ, Bjerregaard-Andersen M, Beck-Nielsen H, Sodemann M, Tarnoki AD, Tarnoki DL, Burt SA, Klump KL, Ordoñana JR, Sánchez-Romera JF, Colodro-Conde L, Dubois L, Boivin M, Brendgen M, Dionne G, Vitaro F, Harris JR, Brandt I, Nilsen TS, Craig JM, Saffery R, Rasmussen F, Tynelius P, Bayasgalan G, Narandalai D, Haworth CM, Plomin R, Ji F, Ning F, Pang Z, Rebato E, Krueger RF, McGue M, Pahlen S, Boomsma DI, Sørensen TI, Kaprio J, Silventoinen K.

Int J Epidemiol. 2017 Mar 19. doi: 10.1093/ije/dyx031. [Epub ahead of print].

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Association of the DBH polymorphism rs3025343 with smoking cessation in a large population-based sample.

Nicotine Tob Res. 2017 Mar 22. doi: 10.1093/ntr/ntx066. [Epub ahead of print].

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Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.

Pfisterer SG, Gateva G, Horvath P, Pirhonen J, Salo VT, Karhinen L, Varjosalo M, Ryhänen SJ, Lappalainen P, Ikonen E.

Nat Commun. 2017 Mar 31;8:14858. doi: 10.1038/ncomms14858.

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Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response.

Jernström S, Hongisto V, Leivonen SK, Due EU, Tadele DS, Edgren H, Kallioniemi O, Perälä M, Mælandsmo GM, Sahlberg KK.

Breast Cancer (Dove Med Press). 2017 Mar 21;9:185-198. doi: 10.2147/BCTT.S115600. eCollection 2017.

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"Holy anorexia"-Relevant or relic? Religiosity and anorexia nervosa among Finnish women.

Sipilä P, Harrasova G, Mustelin L, Rose RJ, Kaprio J, Keski-Rahkonen A.

Int J Eat Disord. 2017 Apr;50(4):406-414. doi: 10.1002/eat.22698. Epub 2017 Mar 27.

 

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Family aggregation of cardiovascular disease mortality: a register-based prospective study of pooled Nordic twin cohorts.

Silventoinen K, Hjelmborg J, Möller S, Ripatti S, Skythe A, Tikkanen E, Pedersen NL, Magnusson PK, Christensen K, Kaprio J.

Int J Epidemiol. 2017 Feb 28. doi: 10.1093/ije/dyx012. [Epub ahead of print].

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Cardiorespiratory fitness and adiposity as determinants of metabolic health - pooled analysis of two twin cohorts.

Jukarainen S, Holst R, Dalgård C, Piirilä P, Lundbom J, Hakkarainen A, Lundbom N, Rissanen A, Kaprio J, Kyvik KO, Sørensen TIA, Pietiläinen KH.

J Clin Endocrinol Metab. 2017 May 1;102(5):1520-1528. doi: 10.1210/jc.2016-3435. 

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High-Throughput Dual Screening method for Ras Activities and Inhibitors.

Kopra K, van Adrichem AJ, Salo-Ahen OMH, Peltonen J, Wennerberg K, Härmä H.

Anal Chem. 2017 Apr 18;89(8):4508-4516. doi: 10.1021/acs.analchem.6b04904. Epub 2017 Mar 29.

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Prospective associations between dietary patterns and high sensitivity C-reactive protein in European children: the IDEFICS study.

González-Gil EM, Tognon G, Lissner L, Intemann T, Pala V, Galli C, Wolters M, Siani A, Veidebaum T, Michels N, Molnar D, Kaprio J, Kourides Y, Fraterman A, Iacoviello L, Picó C, Fernández-Alvira JM, Moreno Aznar LA

Eur J Nutr. 2017 Mar 18. doi: 10.1007/s00394-017-1419-x. [Epub ahead of print] 

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Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock.

Vilander LM, Kaunisto MA, Vaara ST, Pettilä V; FINNAKI study group.. Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock.

Crit Care. 2017 Mar 8;21(1):47. doi: 10.1186/s13054-017-1631-3.

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Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics.

Vorrink SU, Ullah S, Schmidt S, Nandania J, Velagapudi V, Beck O, Ingelman-Sundberg M, Lauschke VM.

FASEB J. 2017 Mar 6. pii: fj.201601375R. doi: 10.1096/fj.201601375R. [Epub ahead of print]

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Gene-environment interplay in depressive symptoms: moderation by age, sex, and physical illness.

Petkus AJ, Beam CR, Johnson W, Kaprio J, Korhonen T, McGue M, Neiderhiser JM, Pedersen NL, Reynolds CA, Gatz M; IGEMS Consortium.

Psychol Med. 2017 Feb 16:1-12. doi: 10.1017/S0033291717000290. [Epub ahead of print]

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Aging and serum exomiR content in women-effects of estrogenic hormone replacement therapy.

Kangas R, Törmäkangas T, Fey V, Pursiheimo J, Miinalainen I, Alen M, Kaprio J, Sipilä S, Säämänen AM, Kovanen V, Laakkonen EK.

Sci Rep. 2017 Feb 14;7:42702. doi: 10.1038/srep42702.

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Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy.

Sillanpää E, Niskala P, Laakkonen EK, Ponsot E, Alén M, Kaprio J, Kadi F, Kovanen V, Sipilä S.

Twin Res Hum Genet. 2017 Feb 14:1-13. doi:10.1017/thg.2017.1. [Epub ahead of print]

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CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.

Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI.

J Cell Biol. 2017 Mar 6;216(3):675-693. doi: 10.1083/jcb.201607019.

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Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors.

Pietarinen PO, Eide CA, Ayuda-Durán P, Potdar S, Kuusanmäki H, Andersson EI, Mpindi JP, Pemovska T, Kontro M, Heckman CA, Kallioniemi O, Wennerberg K, Hjorth-Hansen H, Druker BJ, Enserink JM, Tyner JW, Mustjoki S, Porkka K.

Oncotarget. 2017 Feb 7. doi: 10.18632/oncotarget.15146. [Epub ahead of print]

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TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer.

Fagerholm R, Khan S, Schmidt MK, García-Closas M, Heikkilä P, Saarela J, Beesley J, Jamshidi M, Aittomäki K, Liu J, Ali HR, Andrulis IL, Beckmann MW, Behrens S, Blows FM, Brenner H, Chang-Claude J, Couch FJ, Czene K, Fasching PA, Figueroa J, Floris G, Glendon G, Guo Q, Hall P, Hallberg E, Hamann U, Holleczek B, Hooning MJ, Hopper JL, Jager A, Kabisch M; kConFab/AOCS Investigators., Keeman R, Kosma VM, Lambrechts D, Lindblom A, Mannermaa A, Margolin S, Provenzano E, Shah M, Southey MC, Dennis J, Lush M, Michailidou K, Wang Q, Bolla MK, Dunning AM, Easton DF, Pharoah PD, Chenevix-Trench G, Blomqvist C, Nevanlinna H.

Oncotarget. 2017 Feb 5. doi: 10.18632/oncotarget.15110. [Epub ahead of print]

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Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.

Stringer S, Minică CC, Verweij KJ, Mbarek H, Bernard M, Derringer J, van Eijk KR, Isen JD, Loukola A, Maciejewski DF, Mihailov E, van der Most PJ, Sánchez-Mora C, Roos L, Sherva R, Walters R, Ware JJ, Abdellaoui A, Bigdeli TB, Branje SJ, Brown SA, Bruinenberg M, Casas M, Esko T, Garcia-Martinez I, Gordon SD, Harris JM, Hartman CA, Henders AK, Heath AC, Hickie IB, Hickman M, Hopfer CJ, Hottenga JJ, Huizink AC, Irons DE, Kahn RS, Korhonen T, Kranzler HR, Krauter K, van Lier PA, Lubke GH, Madden PA, Mägi R, McGue MK, Medland SE, Meeus WH, Miller MB, Montgomery GW, Nivard MG, Nolte IM, Oldehinkel AJ, Pausova Z, Qaiser B, Quaye L, Ramos-Quiroga JA, Richarte V, Rose RJ, Shin J, Stallings MC, Stiby AI, Wall TL, Wright MJ, Koot HM, Paus T, Hewitt JK, Ribasés M, Kaprio J, Boks MP, Snieder H, Spector T, Munafò MR, Metspalu A, Gelernter J, Boomsma DI, Iacono WG, Martin NG, Gillespie NA, Derks EM, Vink JM.

Transl Psychiatry. 2016 Mar 29;6:e769. doi: 10.1038/tp.2016.36.

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Rare and low-frequency coding variants alter human adult height.

Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rüeger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, Turcot V, Young KL, Winkler TW, Esko T, Karaderi T, Locke AE, Masca NG, Ng MC, Mudgal P, Rivas MA, Vedantam S, Mahajan A, Guo X, Abecasis G, Aben KK, Adair LS, Alam DS, Albrecht E, Allin KH, Allison M, Amouyel P, Appel EV, Arveiler D, Asselbergs FW, Auer PL, Balkau B, Banas B, Bang LE, Benn M, Bergmann S, Bielak LF, Blüher M, Boeing H, Boerwinkle E, Böger CA, Bonnycastle LL, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Burt AA, Butterworth AS, Carey DJ, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Galbany JC, Cox AJ, Cuellar-Partida G, Danesh J, Davies G, de Bakker PI, de Borst GJ, de Denus S, de Groot MC, de Mutsert R, Deary IJ, Dedoussis G, Demerath EW, den Hollander AI, Dennis JG, Di Angelantonio E, Drenos F, Du M, Dunning AM, Easton DF, Ebeling T, Edwards TL, Ellinor PT, Elliott P, Evangelou E, Farmaki AE, Faul JD, Feitosa MF, Feng S, Ferrannini E, Ferrario MM, Ferrieres J, Florez JC, Ford I, Fornage M, Franks PW, Frikke-Schmidt R, Galesloot TE, Gan W, Gandin I, Gasparini P, Giedraitis V, Giri A, Girotto G, Gordon SD, Gordon-Larsen P, Gorski M, Grarup N, Grove ML, Gudnason V, Gustafsson S, Hansen T, Harris KM, Harris TB, Hattersley AT, Hayward C, He L, Heid IM, Heikkilä K, Helgeland Ø, Hernesniemi J, Hewitt AW, Hocking LJ, Hollensted M, Holmen OL, Hovingh GK, Howson JM, Hoyng CB, Huang PL, Hveem K, Ikram MA, Ingelsson E, Jackson AU, Jansson JH, Jarvik GP, Jensen GB, Jhun MA, Jia Y, Jiang X, Johansson S, Jørgensen ME, Jørgensen T, Jousilahti P, Jukema JW, Kahali B, Kahn RS, Kähönen M, Kamstrup PR, Kanoni S, Kaprio J, Karaleftheri M, Kardia SL, Karpe F, Kee F, Keeman R, Kiemeney LA, Kitajima H, Kluivers KB, Kocher T, Komulainen P, Kontto J, Kooner JS, Kooperberg C, Kovacs P, Kriebel J, Kuivaniemi H, Küry S, Kuusisto J, La Bianca M, Laakso M, Lakka TA, Lange EM, Lange LA, Langefeld CD, Langenberg C, Larson EB, Lee IT, Lehtimäki T, Lewis CE, Li H, Li J, Li-Gao R, Lin H, Lin LA, Lin X, Lind L, Lindström J, Linneberg A, Liu Y, Liu Y, Lophatananon A, Luan J, Lubitz SA, Lyytikäinen LP, Mackey DA, Madden PA, Manning AK, Männistö S, Marenne G, Marten J, Martin NG, Mazul AL, Meidtner K, Metspalu A, Mitchell P, Mohlke KL, Mook-Kanamori DO, Morgan A, Morris AD,

Morris AP, Müller-Nurasyid M, Munroe PB, Nalls MA, Nauck M, Nelson CP, Neville M, Nielsen SF, Nikus K, Njølstad PR, Nordestgaard BG, Ntalla I, O'Connel JR, Oksa H, Loohuis LM, Ophoff RA, Owen KR, Packard CJ, Padmanabhan S, Palmer CN, Pasterkamp G, Patel AP, Pattie A, Pedersen O, Peissig PL, Peloso GM, Pennell CE, Perola M, Perry JA, Perry JR, Person TN, Pirie A, Polasek O, Posthuma D, Raitakari OT, Rasheed A, Rauramaa R, Reilly DF, Reiner AP, Renström F, Ridker PM, Rioux JD, Robertson N, Robino A, Rolandsson O, Rudan I, Ruth KS, Saleheen D, Salomaa V, Samani NJ, Sandow K, Sapkota Y, Sattar N, Schmidt MK, Schreiner PJ, Schulze MB, Scott RA, Segura-Lepe MP, Shah S, Sim X, Sivapalaratnam S, Small KS, Smith AV, Smith JA, Southam L, Spector TD, Speliotes EK, Starr JM, Steinthorsdottir V, Stringham HM, Stumvoll M, Surendran P, 't Hart LM, Tansey KE, Tardif JC, Taylor KD, Teumer A, Thompson DJ, Thorsteinsdottir U, Thuesen BH, Tönjes A, Tromp G, Trompet S, Tsafantakis E, Tuomilehto J, Tybjaerg-Hansen A, Tyrer JP, Uher R, Uitterlinden AG, Ulivi S, van der Laan SW, Van Der Leij AR, van Duijn CM, van Schoor NM, van Setten J, Varbo A, Varga TV, Varma R, Edwards DR, Vermeulen SH, Vestergaard H, Vitart V, Vogt TF, Vozzi D, Walker M, Wang F, Wang CA, Wang S, Wang Y, Wareham NJ, Warren HR, Wessel J, Willems SM, Wilson JG, Witte DR, Woods MO, Wu Y, Yaghootkar H, Yao J, Yao P,
Yerges-Armstrong LM, Young R, Zeggini E, Zhan X, Zhang W, Zhao JH, Zhao W, Zhao W, Zheng H, Zhou W; EPIC-InterAct Consortium.; CHD Exome+ Consortium.; ExomeBP Consortium.; T2D-Genes Consortium.; GoT2D Genes Consortium.; Global Lipids Genetics Consortium.; ReproGen Consortium.; MAGIC Investigators., Rotter JI, Boehnke M, Kathiresan S, McCarthy MI, Willer CJ, Stefansson K, Borecki IB, Liu DJ, North KE, Heard-Costa NL, Pers TH, Lindgren CM, Oxvig C, Kutalik Z, Rivadeneira F, Loos RJ, Frayling TM, Hirschhorn JN, Deloukas P, Lettre G.

 

Nature. 2017 Feb 1. doi: 10.1038/nature21039. [Epub ahead of print].

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Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom.

Chheda H, Palta P, Pirinen M, McCarthy S, Walter K, Koskinen S, Salomaa V, Daly M, Durbin R, Palotie A, Aittokallio T, Ripatti S.

Eur J Hum Genet. 2017 Feb 1. doi: 10.1038/ejhg.2016.205.[Epub ahead of print].

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Does expecting more pain make it more intense? Factors associated with the first week pain trajectories after breast cancer surgery.

Sipilä RM, Haasio L, Meretoja TJ, Ripatti S, Estlander AM, Kalso EA.

Pain. 2017 Jan 27. doi: 10.1097/j.pain.0000000000000859. [Epub ahead of print]

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Familial Risk and Heritability of Colorectal Cancer in the Nordic Twin Study of Cancer.

Graff RE, Möller S, Passarelli MN, Witte JS, Skytthe A, Christensen K, Tan Q, Adami HO, Czene K, Harris JR, Pukkala E, Kaprio J, Giovannucci E, Mucci LA, Hjelmborg JB.

Clin Gastroenterol Hepatol. 2017 Jan 24. pii: S1542-3565(17)30064-2. doi: 10.1016/j.cgh.2016.12.041. [Epub ahead of print].

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MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls.

Cosgrove D, Harold D, Mothersill O, Anney R, Hill MJ, Bray NJ, Blokland G, Petryshen T; Wellcome Trust Case Control Consortium., Richards A, Mantripragada K, Owen M, O'Donovan MC, Gill M, Corvin A, Morris DW, Donohoe G.

Transl Psychiatry. 2017 Jan 24;7(1):e1012. doi:10.1038/tp.2016.286.

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Damaging heterozygous mutations in NFKB1 lead to diverse immunological phenotypes.

Kaustio M, Haapaniemi E, Göös H, Hautala T, Park G, Syrjänen J, Einarsdottir E, Sahu B, Kilpinen S, Rounioja S, Fogarty CL, Glumoff V, Kulmala P, Katayama S, Tamene F, Trotta L, Morgunova E, Krjutškov K, Nurmi K, Eklund K, Lagerstedt A, Helminen M, Martelius T, Mustjoki S, Taipale J, Saarela J, Kere J, Varjosalo M, Seppänen M.

J Allergy Clin Immunol. 2017 Jan 20. pii: S0091-6749(17)30053-2. doi: 10.1016/j.jaci.2016.10.054. [Epub ahead of print].

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Diversity of leisure-time sport activities in adolescence as a predictor of leisure-time physical activity in adulthood.

Mäkelä S, Aaltonen S, Korhonen T, Rose RJ, Kaprio J.

Scand J Med Sci Sports. 2017 Jan 20. doi: 10.1111/sms.12837. [Epub ahead of print].

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Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study.

Winsvold BS, Palta P, Eising E, Page CM; International Headache Genetics Consortium., van den Maagdenberg AM, Palotie A, Zwart JA.

Cephalalgia. 2017 Jan 1:333102417690111. doi: 10.1177/0333102417690111. [Epub ahead of print]

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Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells.

Haltia UM, Andersson N, Yadav B, Färkkilä A, Kulesskiy E, Kankainen M, Tang J, Bützow R, Riska A, Leminen A, Heikinheimo M, Kallioniemi O, Unkila-Kallio L, Wennerberg K, Aittokallio T, Anttonen M.

Gynecol Oncol. 2017 Jan 16. pii: S0090-8258(16)31681-X. doi: 10.1016/j.ygyno.2016.12.016. [Epub ahead of print].

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Erratum: Longitudinal modeling of ultrasensitive and traditional prostate-specific antigen and prediction of biochemical recurrence after radical prostatectomy.

Laajala TD, Seikkula H, Seyednasrollah F, Mirtti T, Boström PJ, Elo LL.

Sci Rep. 2017 Jan 19;7:40835. doi: 10.1038/srep40835

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Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1.

Nagaraj AS, Lahtela J, Hemmes A, Pellinen T, Blom S, Devlin JR, Salmenkivi K, Kallioniemi O, Mäyränpää MI, Närhi K, Verschuren EW.

Cell Rep. 2017 Jan 17;18(3):673-684. doi: 10.1016/j.celrep.2016.12.059. 

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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.

rampush JW, Yang ML, Yu J, Knowles E, Davies G, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Lencz T.

Mol Psychiatry. 2017 Jan 17. doi: 10.1038/mp.2016.244. 

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NEIL1 is a candidate gene associated with common variable immunodeficiency in a patient with a chromosome 15q24 deletion.

Romano R, Zaravinos A, Liadaki K, Caridha R, Lundin J, Carlsson G, Winiarski J, Pan-Hammarström Q, Hammarström L.

Clin Immunol. 2017 Jan 14;176:71-76. doi: 10.1016/j.clim.2017.01.006. [Epub ahead of print].

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SBI(2) HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium.

Hoffman AF, Simpson KJ, Horvath P, Lovitt C, Silver S, Easton E, LaBarbera DV, Mendez M, Rothenberg ME, Seldin J, Wardwell-Swanson J, Fennell

2017 Jan;15(1):1-7. doi: 10.1089/adt.2016.29054.afh.

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Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.

Aschard H, Tobin MD, Hancock DB, Skurnik D, Sood A, James A, Vernon Smith A, Manichaikul AW, Campbell A, Prins BP, Hayward C, Loth DW, Porteous DJ, Strachan DP, Zeggini E, O'Connor GT, Brusselle GG, Boezen HM, Schulz H, Deary IJ, Hall IP, Rudan I, Kaprio J, Wilson JF, Wilk JB, Huffman JE, Hua Zhao J, de Jong K, Lyytikäinen LP, Wain LV, Jarvelin MR, Kähönen M, Fornage M, Polasek O, Cassano PA, Barr RG, Rawal R, Harris SE, Gharib SA, Enroth S, Heckbert SR, Lehtimäki T, Gyllensten U, Society Scientific Group U, Jackson VE, Gudnason V, Tang W, Dupuis J, Soler Artigas M, Joshi AD, London SJ, Kraft P.

Int J Epidemiol. 2017 Jan 12. pii: dyw318. doi: 10.1093/ije/dyw318. [Epub ahead of print].

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Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae.

Tombline G, Millen JI, Polevoda B, Rapaport M, Baxter B, Van Meter M, Gilbertson M, Madrey J, Piazza GA, Rasmussen L, Wennerberg K, White EL, Nitiss JL, Goldfarb DS.

Aging (Albany NY). 2017 Jan 5. doi: 10.18632/aging.101114. [Epub ahead of print].

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Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.

Szibor M, Dhandapani PK, Dufour E, Holmström KM, Zhuang Y, Salwig I, Wittig I, Heidler J, Gizatullina Z, Gainutdinov T, Consortium GM, Fuchs H, Gailus-Durner V, de Angelis MH, Nandania J, Velagapudi V, Wietelmann A, Rustin P, Gellerich FN, Jacobs HT, Braun T.

Dis Model Mech. 2016 Dec 14. pii: dmm.027839. doi: 10.1242/dmm.027839. [Epub ahead of print

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Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC).

Jääskeläinen T, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Laivuori H.

BMJ Open. 2016 Nov 10;6(11):e013148. doi: 10.1136/bmjopen-2016-013148. 

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Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry.

Heikkinen T, Kämpjärvi K, Keskitalo S, von Nandelstadh P, Liu X, Rantanen V, Pitkänen E, Kinnunen M, Kuusanmäki H, Kontro M, Turunen M, Mäkinen N, Taipale J, Heckman C, Lehti K, Mustjoki S, Varjosalo M, Vahteristo P.

Hum Mutat. 2017 Jan 5. doi: 10.1002/humu.23157. [Epub ahead of print].

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Cohort Profile: The transition from childhood to adolescence in European children-how I.Family extends the IDEFICS cohort.

Ahrens W, Siani A, Adan R, De Henauw S, Eiben G, Gwozdz W, Hebestreit A, Hunsberger M, Kaprio J, Krogh V, Lissner L, Molnár D, Moreno LA, Page A, Picó C, Reisch L, Smith RM, Tornaritis M, Veidebaum T, Williams G, Pohlabeln H, Pigeot I.

Int J Epidemiol. 2016 Dec 31. pii: dyw317. doi: 10.1093/ije/dyw317. [Epub ahead of print].

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Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism.

Kuivanen S, Bespalov MM, Nandania J, Ianevski A, Velagapudi V, De Brabander JK, Kainov DE, Vapalahti O.

Antiviral Res. 2016 Dec 31;139:117-128. doi: 10.1016/j.antiviral.2016.12.022. [Epub ahead of print].

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