SPCG-15: a prospective randomized study comparing primary radical prostatectomy and primary radiotherapy plus androgen deprivation therapy for locally advanced prostate cancer.
Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing.
Dasatinib and navitoclax act synergistically to target NUP98-NSD1+/FLT3-ITD+ acute myeloid leukemia.
Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing.
Birth cohort effects on the quantity and heritability of alcohol consumption in adulthood: A Finnish longitudinal twin study.
Genetic Association and Altered Gene Expression of CYBB in Multiple Sclerosis Patients.
The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study.
Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies.
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.
Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours.
Integrated Analysis of Drug Sensitivity and Selectivity to Predict Synergistic Drug Combinations and Target Coaddictions in Cancer.
Cellularity in low-grade Pseudomyxoma peritonei impacts recurrence-free survival following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
Long-term real-world results of ibrutinib therapy in patients with relapsed or refractory chronic lymphocytic leukemia: 30-month follow-up of the Swedish compassionate use cohort.
Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults.
Pre-oil spill baseline profiling for contaminants in Southern Resident killer whale fecal samples indicates possible exposure to vessel exhaust.
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.
Response to: The GPRC5A frameshift variant c.183del is not associated with increased breast cancer risk in BRCA1 mutation carriers.
Feasibility, Safety, and Efficacy of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) for Peritoneal Metastasis: A Registry Study.
Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer.
The Relationship Between Sleep Characteristics and Unmet Physical Activity Need in Older Women.
Does Evaluation of Tumour Budding in Diagnostic Biopsies have a Clinical Relevance? A Systematic Review.
Self- reported fitness and objectively measured physical activity profile among older adults: a twin study.
Brain death and postmortem organ donation: report of a questionnaire from the CENTER-TBI study.
Age, Sex, and Genetic and Environmental Effects on Unintentional Injuries in Young and Adult Twins.
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism.
Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa.
Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation.
Infant regulatory behavior problems during first month of life and neurobehavioral outcomes in early childhood.
Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers.
Combined epithelial marker analysis of tumour budding in stage II colorectal cancer.
Guideline-based and bioinformatic reassessment of lesion-associated gene and variant pathogenicity in focal human epilepsies.
Is Brain Derived Neurotrophic Factor (Bdnf) Associated With Smoking Initiation? Replication Using a Large Finnish Population Sample.
Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes: a longitudinal population-based study in Finland.
Phenome-wide association studies across large population cohorts support drug target validation.
Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity.
Immediate verbal recall and familial dementia risk: population-based study of over 4000 twins.
Neonatal regulatory behavior problems are predicted by maternal early pregnancy overweight and obesity: findings from the prospective PREDO Study.
Development of an AmpliSeqTM Panel for Next-Generation Sequencing of a Set of Genetic Predictors of Persisting Pain.
A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants.
Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts.
Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC).
Impact of obesity on angiogenic and inflammatory markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort.
T-cell inflamed tumor microenvironment predicts favorable prognosis in primary testicular lymphoma.
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Drug Target Commons 2.0: a community platform for systematic analysis of drug-target interaction profiles.
Prevention of gestational diabetes with a prepregnancy lifestyle intervention - findings from a randomized controlled trial.
Transient modification of lin28b expression - Permanent effects on zebrafish growth.
The effect of low-dose aspirin on serum placental growth factor levels in a high-risk PREDO cohort.
Meta-analysis of exome array data identifies six novel genetic loci for lung function.
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.
Increased Body Fat Mass and Androgen Metabolism - a Twin Study in Healthy Young Women.
Children's propensity to consume sugar and fat predicts regular alcohol consumption in adolescence.
Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.
Quantitative assessment of radiation-induced changes of bladder and rectum collagen structure using optical methods.
Increased HSF1 expression predicts shorter disease-specific survival of prostate cancer patients following radical prostatectomy.
Clonal heterogeneity influences drug responsiveness in renal cancer assessed by ex vivo drug testing of multiple patient-derived cancer cells.
Ibrutinib induces rapid down-regulation of inflammatory markers and altered transcription of chronic lymphocytic leukaemia-related genes in blood and lymph nodes.
Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Diagnostics of rare disorders: whole-exome sequencing deciphering locus heterogeneity in telomere biology disorders.
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.
A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents.
Machine learning and feature selection for drug response prediction in precision oncology applications.
Objectively measured physical activity profile and cognition in Finnish elderly twins.
Validation and Automation of a High-Throughput Multitargeted Method for Semiquantification of Endogenous Metabolites from Different Biological Matrices Using Tandem Mass Spectrometry.
Healthcare costs and outcomes in adult patients with juvenile idiopathic arthritis: a population-based study.
Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib.
Effect of a lifestyle intervention during pregnancy-findings from the Finnish gestational diabetes prevention trial (RADIEL).
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study.
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.
Gene expression changes related to immune processes associate with cognitive endophenotypes of schizophrenia.
PD-L1+ tumor-associated macrophages and PD-1+ tumor infiltrating lymphocytes predict survival in primary testicular lymphoma.
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells.
Early adolescent aggression predicts antisocial personality disorder in young adults: a population-based study.
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
The prognostic significance of tall cells in papillary thyroid carcinoma: A case-control study.
Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).
Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts.
Corrigendum to "Searching for drug synergy in complex dose-response landscapes using an interaction potency model" [Comput. Struct. Biotechnol. J. 13 (2015) 504-513].
Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths.
Age at first birth in women is genetically associated with increased risk of schizophrenia.
Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.
Environmental properties of cells improve machine learning-based phenotype recognition accuracy.
Prediction of pre-eclampsia and its subtypes in high-risk cohort: hyperglycosylated human chorionic gonadotropin in multivariate models.
Drug sensitivity screening and genomic characterization of 45 HPV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy.
Improving genomics-based predictions for precision medicine through active elicitation of expert knowledge.
Phenotypic Image Analysis Software Tools for Exploring and Understanding Big Image Data from Cell-Based Assays.
The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.
Beyond the tip of the iceberg: Adolescent weight development of women and men with features of binge eating disorder.
Long-term leisure-time physical activity and other health habits as predictors of objectively monitored late-life physical activity - A 40-year twin study.
Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML.
A suitable protocol for measuring alveolar nitric oxide in asthma with differing severity to assess peripheral airways inflammation.
Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative).
ePCR: an R-package for survival and time-to-event prediction in advanced prostate cancer, applied to real-world patient cohorts.
Plasma metabolites reveal distinct profiles associating with different metabolic risk factors in monozygotic twin pairs.
Simultaneous measurement of folate cycle intermediates in different biological matrices using liquid chromatography-tandem mass spectrometry.
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.
Prognostic, predictive and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer.
Aggressive behaviour in childhood and adolescence: the role of smoking during pregnancy, evidence from four twin cohorts in the EU-ACTION consortium.
Absence of NEFL in patient-specific neurons in early-onset Charcot-Marie-Tooth neuropathy.
A Multiplexed Screening Assay to Evaluate Chemotherapy-Induced Myelosuppression Using Healthy Peripheral Blood and Bone Marrow.
Assessing Statewide All-Cause Future One-Year Mortality: Prospective Study With Implications for Quality of Life, Resource Utilization, and Medical Futility.
Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum.
Intake of Different Dietary Proteins and Risk of Heart Failure in Men: The Kuopio Ischaemic Heart Disease Risk Factor Study.
Association between birth weight and educational attainment: an individual-based pooled analysis of nine twin cohorts.
Non-invasive monitoring of hydraulic surge propagation in a wounded tobacco plant.
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3-16 years from multiple raters in six cohorts in the EU-ACTION project.
Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity.
Angiogenic profile in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort.
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error.
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.
Genetic Influences on Patient Oriented Outcomes in TBI: A Living Systematic Review of Non-APOE Single Nucleotide Polymorphisms.
Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts.
Air Activated Self-Decontaminating Polydicyclopentadiene PolyHIPE Foams for Rapid Decontamination of Chemical Warfare Agents.
Tumor volume as a prognostic marker in p16-positive and p16-negative oropharyngeal cancer patients treated with definitive intensity-modulated radiotherapy.
Adverse lipid profile elevates risk for subarachnoid hemorrhage: A prospective population-based cohort study.
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.
Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents.
If you drink, don't smoke: Joint associations between risky health behaviors and labor market outcomes.
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families.
Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland.
The Epigenetic Clock at Birth: Associations With Maternal Antenatal Depression and Child Psychiatric Problems.
Characterizing the Key Metabolic Pathways of the Neonatal Mouse Heart Using a Quantitative Combinatorial Omics Approach.
Maternal early pregnancy obesity and related pregnancy and pre-pregnancy disorders: associations with child developmental milestones in the prospective PREDO Study.
From Narratives to Numbers: Data Work and Patient-Generated Health Data in Consultations.
Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.
Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts.
Maternal depressive symptoms during and after pregnancy and child developmental milestones.
Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project.
Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TB
Case studies investigating genetic heterogeneity between anatomically distinct bone marrow compartments in acute myeloid leukemia.
Genetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African children.
Reproducibility and repeatability of six high-throughput 16S rDNA sequencing protocols for microbiota profiling.
Successful weight maintainers among young adults-A ten-year prospective population study.
Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway.
Mobility and muscle strength in male former elite endurance and power athletes aged 66-91 years.
Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.
Toward universal protein post-translational modification detection in high throughput format.
Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma.
The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families.
Patient-customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients.
The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis.
Interleukin 8 activity influences the efficacy of adenoviral oncolytic immunotherapy in cancer patients.
Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis.
New prostate cancer grade grouping system predicts survival after radical prostatectomy.
Spatial Aspects of Oncogenic Signaling Determine Response to Combination Therapy in Slice Explants from Kras-driven Lung Tumors.
Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins.
A 250 plastome phylogeny of the grass family (Poaceae): topological support under different data partitions.
Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples.
ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer.
Visualization and Quantitative Analysis of the Actin Cytoskeleton Upon B Cell Activation.
Prediction of Incident Hypertension Within the Next Year: Prospective Study Using Statewide Electronic Health Records and Machine Learning.
Hsp70-associated chaperones have a critical role in buffering protein production costs.
Mass spectrometry of circulating lipid species highlights similarity of familial hyperlipidemias and hyperlipidemias in the general population.
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems.
Maternal early pregnancy obesity and depressive symptoms during and after pregnancy.
Last updated: 08.01.2018 - 09:01