Genome-wide genotyping arrays

Our unit offers genotyping with all Illumina's genotyping arrays listed on the company's website

Today the most used array is the cost effective Global Screening Array (GSA) with over 700 000 markers. The content of this chip has been selected for high imputation accuracy for rare variants and it includes a clinical research content with established disease associations.

Other widely used arrays are the CoreExome array containing approximately 550 000 markers and the OmniExpress array containing approximately 710 000 markers.



Examples of analysis prices per sample:


University of Helsinki

(includes 0% VAT)

Other academic

(includes 24% VAT)

Global Screening Array *30.00 - 34.00 € *39.06 - 44.27 €
CoreExome 68.22 € 88.82 €
OmniExpress *99.44 - 168.88 € *124.48 - 219.88 €


*Price dependent on the number of samples.

For information about arrays that are not listed above or if you are a non-academic user please contact Päivi Lahermo or Kati Donner.


Service description

The laboratory work is done by dedicated personnel with nearly 12 years of experience in Illumina analysis methods. Our laboratory uses an electronic lab note book (ELN) for documentation of the laboratory workflow and an in-house made LIMS system for management of genotype and sample data.

Projects are managed and quality controlled by experienced specialists. The quality control includes manual checking of markers with GenomeStudio (Illumina) software based on selection criteria such as low call rates, bad cluster separation, low signal intensity, quality scores and heterozygote excess.

The control also includes quality checks done on the samples utilizing Plink 1.9 analysis toolset and in-house developed additional tools. These typically include sex-check, IBD check, duplicate check and Mendel error checks. Genotype data compatible with Plink 1.9 is released together with a report highlighting observations done during our quality control. On request genotype files suitable for imputation (genotypes files in PLUS strand orientation), raw data files and CNV analysis files can also be released.

All received and produced data is stored in a database at FIMM. FIMM guarantees the storage of your data for 5 years.


How to get started 

If you are interested in genotyping with Illumina arrays please contact Päivi Lahermo or Kati Donner. A meeting can be organized, where all project details can be discussed.

Customer provides

1) Documentation

A FIMM Service Agreement must be signed before the project can start in our laboratory. If your project is required by the law to have an ethical permit you need to supply us with a copy of it.


2) Sample information

Provide the sample information using FIMM basic information form. Note! You need to enable the included macros. The filename should be FIMM_Perustietojen_luovutus_v2010.xlsm for the macros to work.

Fill up this sample submission form, print it and bring or send it to the lab together with the samples. Please also remember to submit the form electronically!

The gender information requested for in the FIMM basic information form is optional but central for detection of possible sample mix-ups in our quality control.


3) DNA samples

For the analysis we need good quality DNA in a concentration of 50 ng/µl in a minimum volume of 15 µl. Illumina recommends that the samples are diluted 1 x TE (10m mM Tris-HCl, 1 mM EDTA, pH 8.0)).

Note! We recommend that the concentration is measured with two independent methods, e.g. in addition to NanoDrop spectrophotometer with PicoGreen or Qubit fluorometric quantification. If you use only one method it should be PicoGreen, Qubit or other similar method.

For quality control purposes we recommend that there should be one duplicate sample (duplicate pairs preferably located on different plates and in different positions on the plates) per 96 well plate in <500 sample projects. In projects with more than 500 samples the number of duplicates can be reduced. In case control studies the case and control samples should be evenly distributed / mixed on the plates.

Notice that the arrays are for specific amount of samples and thus the number of samples in a project should be dividable with the amount of samples that can be analyzed on one array (all array types) / obtainable in array kits (for other array types than GSA), otherwise also empty slots or unused arrays shall be invoiced.


DNA shipping instructions

Ship the DNA samples on 96-well plates.

Seal the plates securely using either an adhesive seal, strip caps or a removable heat-sealed lid. Use Adhesive PCR foil (e.g Cat. # AB-0626, Thermo Fisher Scientific Abgene) only for shipments at room temperature. Make sure to attach the foil seal properly to each well by rubbing the surface with soft cloth or lab wipe. Make sure to protect the seals from punches. If you stack multiple plates, put cardboard or wadding layer between the plates.

Note! If you send the plates on dry ice an adhesive foil seal should not be used. Use strip caps instead! 

Whenever possible, please avoid shipping on Thursdays and Fridays to avoid the samples arriving over the weekend. Pack the samples so that the plates or seals are not damaged during shipment. If you stack multiple plates put cardboard or wadding layer between the plates.

Please ask us for instructions before sending the samples via air courier!

Plate naming:

Mark the plate name (the same name as in the FIMM basic information form), sample concentration and date information clearly on the front side of the plate (see the image below for an example).

Frozen samples:

Frozen plates should be placed in the shipping container with enough dry ice/blocks to keep the samples frozen during shipment and any delays that may occur with the courier.

Shipping address:

FIMM Genotyping Lab
FIMM Technology Centre
Room: F215a
Biomedicum 2U
Tukholmankatu 8

Last updated: 07.05.2019 - 09:41