HTB maintains a collection of about 140 000 small molecule compounds including knowndrugs, bioactives, and diversified sets of chemicals. The drugs and known bioactives are ideal for biological profiling, drug repositioning and personalized medicine-type of screens, while the larger chemical diversity collections are best suited for molecular probe discovery. Available chemical collections are listed in a table below.
Drug aliquots, DSRT- and custom drug plates
Being a partner of the DDCB network, a national infrastructure for drug discovery and chemical biology research in Finland, FIMM/HTB distributes aliquots of available chemical compounds to academic research groups in Finland for a small fee covering the actual compound costs and handling.
Aliquots are given every second Wednesday:
Spring: 9.1.2019, 23.1.2019, 6.2.2019, 20.2.2019, 6.3.2019, 20.3.2019, 3.4.2019, 17.4.2019, 30.5.2019 (Tue), 15.5.2019, 29.5.2019, 12.6.2019, 26.6.2019
Autumn: 7.8.2019, 21.8.2019, 4.9.2019, 18.9.2019, 2.10.2019, 16.10.2019, 30.10.2019, 13.11.2019, 27.11.2019, 11.12.2019
Inquiries and requests for aliquots and drug plates should be sent to laura.turunen(a)fimm.fi, maria.nurmi(a)fimm.fi or elina.z.lehtinen(a)fimm.fi. Use the following instructions for HTB services.
|Library||No of compounds||Description|
|FIMM oncology set||527||Set of approved and emerging investigational drugs (mostly oncology drugs)|
|GSK published kinase inhibitor set||355||Published Kinase Inhibitor Set (PKIS)|
|Enzo FDA-approved drugs||640||FDA-approved drugs|
|MicroSource Spectrum||2 000||Drug Components (50%), Natural products (30%),Other bioactive components (20%)|
|NCI (National Cancer Institute) collection||2500||Cancer drug derivative collection and natural products|
|NIH Clinical collection||446||The NCC consists almost entirely of drugs that have been in phase I-III clinical trials and have not been represented in other arrayed collections|
|ChemBridge DIVERSet and CNS-Set||30 000||Combinatorial chemistry collection|
|ChemDiv diversity collection||50 040||Combinatorial chemistry collection|
|Tripos collection||6 000||Combinatorial chemistry collection (old)|
|Specs consortium collection||30 000||Combinatorial chemistry collection (modern)|
|Sigma LOPAC1280||1 280||Library of pharmacologically active compounds. Is most commonly used to validate new drug discovery assays and characterize orphan receptors|
|Tocris Tocriscreen Mini||1 120||Many compounds are unique to Tocris|
|ChemDiv Peptidomimetic library||15 614||Peptide mimicking small compounds|