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Chemical Libraries

HTB maintains a collection of about 140 000 small molecule compounds including knowndrugs, bioactives, and diversified sets of chemicals. The drugs and known bioactives are ideal for biological profiling, drug repositioning and personalized medicine-type of screens, while the larger chemical diversity collections are best suited for molecular probe discovery. Available chemical collections are listed in a table below.

 

Drug aliquots, DSRT- and custom drug plates

Being a partner of the DDCB network, a national infrastructure for drug discovery and chemical biology research in Finland, FIMM/HTB distributes aliquots of available chemical compounds to academic research groups in Finland for a small fee covering the actual compound costs and handling. 

 

Aliquots are given every second Wednesday:

Spring: 9.1.2019, 23.1.2019, 6.2.2019, 20.2.2019, 6.3.2019, 20.3.2019, 3.4.2019, 17.4.2019, 30.5.2019 (Tue), 15.5.2019, 29.5.2019, 12.6.2019, 26.6.2019 

Autumn: 7.8.2019, 21.8.2019, 4.9.2019, 18.9.2019, 2.10.2019, 16.10.2019, 30.10.2019, 13.11.2019, 27.11.2019, 11.12.2019

 

Inquiries and requests for aliquots and drug plates should be sent to laura.turunen(a)fimm.fi, maria.nurmi(a)fimm.fi or elina.z.lehtinen(a)fimm.fi. Use the following instructions for HTB services.

HTB libraries

Library No of compounds Description
FIMM oncology set 527 Set of approved and emerging investigational drugs (mostly oncology drugs)
GSK published kinase inhibitor set 355 Published Kinase Inhibitor Set (PKIS)
Enzo FDA-approved drugs 640 FDA-approved drugs
MicroSource Spectrum 2 000 Drug Components (50%), Natural products (30%),Other bioactive components (20%)
NCI (National Cancer Institute) collection 2500 Cancer drug derivative collection and natural products
NIH Clinical collection 446 The NCC consists almost entirely of drugs that have been in phase I-III clinical trials and have not been represented in other arrayed collections
ChemBridge DIVERSet and CNS-Set 30 000 Combinatorial chemistry collection
ChemDiv diversity collection 50 040 Combinatorial chemistry collection
Tripos collection 6 000 Combinatorial chemistry collection (old)
Specs consortium collection 30 000 Combinatorial chemistry collection (modern)
Sigma LOPAC1280 1 280 Library of pharmacologically active compounds. Is most commonly used to validate new drug discovery assays and characterize orphan receptors
Tocris Tocriscreen Mini 1 120 Many compounds are unique to Tocris
ChemDiv Peptidomimetic library 15 614 Peptide mimicking small compounds

 

 

Last updated: 09.01.2019 - 16:25